Galegenimab / 7sjo

A4DAB122_7sjo_H_L | Source PDB: 7sjo | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7841
Max Score
1.1672
Min Score
-3.6326
Total Score
-338.72
Score CDR
-0.7416
Score non-CDR
-0.789

Calculation Parameters

Chain Sequence(s) EVQLVQSGAEVKKPGASVKVSCKASGYKFTDSEMHWVRQAPGQGLEWIGGVDPETEGAAYNQKFKGRATITRDTSTSTAYLELSSLRSEDTAVYYCTRGYDYDYALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSDIQMTQSPSSLSASVGDRVTITCRASSSVEFIHWYQQKPGKAPKPLISATSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSAPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6326
Maximum Score 1.1672
Average Score -0.7841
Total Score -338.7221

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.0089 Soluble
2 V H -0.9865 Soluble
3 Q H -1.0621 Soluble
4 L H 0.0000 Buried
5 V H 0.7391 Aggregation-prone
7 S H -0.3945 Soluble
8 G H -0.2122 Soluble
9 A H 0.0702 Aggregation-prone
11 E H -0.1166 Soluble
12 V H 0.5396 Aggregation-prone
13 K H -1.0376 Soluble
14 K H -2.1813 Soluble
15 P H -1.8841 Soluble
16 G H -1.6960 Soluble
17 A H -1.1498 Soluble
18 S H -0.9378 Soluble
19 V H 0.0000 Buried
20 K H -1.3133 Soluble
21 V H 0.0000 Buried
22 S H -0.2596 Soluble
23 C H 0.0000 Buried
24 K H -0.6511 Soluble
25 A H 0.0000 Buried
26 S H -1.0120 Soluble
27 G H -1.2456 Soluble
28 Y H -1.3659 Soluble
29 K H -2.1739 Soluble
30 F H 0.0000 Buried
35 T H -2.2290 Soluble
36 D H -2.5577 Soluble
37 S H 0.0000 Buried
38 E H -1.5485 Soluble
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.4759 Soluble
45 A H -1.0130 Soluble
46 P H -0.8267 Soluble
47 G H -1.2157 Soluble
48 Q H -1.8181 Soluble
49 G H -1.2128 Soluble
50 L H 0.0000 Buried
51 E H -0.4472 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 G H 0.0000 Buried
56 V H 0.0000 Buried
57 D H -2.3209 Soluble
58 P H 0.0000 Buried
59 E H -3.1364 Soluble
62 T H -2.0599 Soluble
63 E H -2.8942 Soluble
64 G H -1.5597 Soluble
65 A H -0.5584 Soluble
66 A H -0.3603 Soluble
67 Y H -0.8845 Soluble
68 N H 0.0000 Buried
69 Q H -2.9242 Soluble
70 K H -2.9855 Soluble
71 F H -1.9941 Soluble
72 K H -2.8477 Soluble
74 G H -1.7819 Soluble
75 R H -1.5156 Soluble
76 A H 0.0000 Buried
77 T H -0.6721 Soluble
78 I H 0.0000 Buried
79 T H -0.7319 Soluble
80 R H -1.6038 Soluble
81 D H -1.4547 Soluble
82 T H -1.4699 Soluble
83 S H -0.8763 Soluble
84 T H -0.9334 Soluble
85 S H -1.1611 Soluble
86 T H -0.6332 Soluble
87 A H 0.0000 Buried
88 Y H -0.3851 Soluble
89 L H 0.0000 Buried
90 E H -1.0845 Soluble
91 L H 0.0000 Buried
92 S H -0.9795 Soluble
93 S H -1.0330 Soluble
94 L H 0.0000 Buried
95 R H -2.9732 Soluble
96 S H -2.1130 Soluble
97 E H -2.5391 Soluble
98 D H 0.0000 Buried
99 T H -0.5859 Soluble
100 A H 0.0000 Buried
101 V H 0.3230 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 T H 0.0000 Buried
106 R H 0.0000 Buried
107 G H 0.0581 Aggregation-prone
108 Y H 0.3877 Aggregation-prone
109 D H -0.5576 Soluble
110 Y H 0.2553 Aggregation-prone
112 D H -1.2747 Soluble
113 Y H -0.3341 Soluble
114 A H 0.0000 Buried
115 L H 0.0000 Buried
116 D H -0.0061 Soluble
117 Y H 0.5095 Aggregation-prone
118 W H -0.1828 Soluble
119 G H 0.0000 Buried
120 Q H -1.2471 Soluble
121 G H -0.6165 Soluble
122 T H 0.0000 Buried
123 L H 0.4334 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -0.7386 Soluble
128 S H -0.5008 Soluble
129 A H -0.6372 Soluble
130 S H -0.5684 Soluble
131 T H -0.7224 Soluble
132 K H -1.2897 Soluble
133 G H -1.3050 Soluble
134 P H -0.7688 Soluble
135 S H -0.6113 Soluble
136 V H 0.0000 Buried
137 F H -0.6264 Soluble
138 P H -1.1218 Soluble
139 L H 0.0000 Buried
140 A H -0.9084 Soluble
141 P H -0.8548 Soluble
142 S H -1.0193 Soluble
143 S H -1.5009 Soluble
144 K H -1.9083 Soluble
145 S H -1.1189 Soluble
146 T H -1.1413 Soluble
147 S H -1.1385 Soluble
148 G H -1.0332 Soluble
149 G H -0.9016 Soluble
150 T H -0.6386 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.8154 Soluble
160 Y H 0.0000 Buried
161 F H -0.3466 Soluble
162 P H 0.0000 Buried
163 E H -0.5860 Soluble
164 P H -0.8066 Soluble
165 V H -0.4709 Soluble
166 T H -0.4066 Soluble
167 V H 0.0000 Buried
168 S H -0.4536 Soluble
169 W H 0.0000 Buried
170 N H -0.5291 Soluble
171 S H -0.6684 Soluble
172 G H -0.4992 Soluble
173 A H -0.1580 Soluble
174 L H 0.1126 Aggregation-prone
175 T H -0.1317 Soluble
176 S H -0.1551 Soluble
177 G H -0.3366 Soluble
178 V H 0.1747 Aggregation-prone
179 H H -0.1829 Soluble
180 T H -0.2765 Soluble
181 F H 0.0000 Buried
182 P H -0.2699 Soluble
183 A H 0.1831 Aggregation-prone
184 V H 0.1666 Aggregation-prone
185 L H 0.6909 Aggregation-prone
186 Q H -0.1684 Soluble
187 S H -0.4282 Soluble
188 S H -0.3108 Soluble
189 G H -0.0479 Soluble
190 L H -0.0686 Soluble
191 Y H 0.1260 Aggregation-prone
192 S H 0.0560 Aggregation-prone
193 L H 0.0000 Buried
194 S H -0.0271 Soluble
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.1058 Soluble
199 V H 0.0000 Buried
200 P H -0.5579 Soluble
201 S H -0.6689 Soluble
202 S H -0.6391 Soluble
203 S H -0.6610 Soluble
204 L H 0.0000 Buried
205 G H -1.3462 Soluble
206 T H -0.7987 Soluble
207 Q H -1.2457 Soluble
208 T H -1.1655 Soluble
209 Y H 0.0000 Buried
210 I H -0.8735 Soluble
211 C H 0.0000 Buried
212 N H -1.3283 Soluble
213 V H 0.0000 Buried
214 N H -2.3605 Soluble
215 H H 0.0000 Buried
216 K H -2.7662 Soluble
217 P H -1.7293 Soluble
218 S H -1.9158 Soluble
219 N H -2.6150 Soluble
220 T H -2.1906 Soluble
221 K H -2.5853 Soluble
222 V H -1.1653 Soluble
223 D H -1.5379 Soluble
224 K H -1.8443 Soluble
225 K H -2.3566 Soluble
226 V H -1.8277 Soluble
227 E H -2.7994 Soluble
228 P H -1.9132 Soluble
229 K H -2.3757 Soluble
230 S H -1.1750 Soluble
1 D L -2.3857 Soluble
2 I L -1.2085 Soluble
3 Q L -1.7917 Soluble
4 M L 0.0000 Buried
5 T L -1.1822 Soluble
6 Q L 0.0000 Buried
7 S L -0.7776 Soluble
8 P L -0.6951 Soluble
9 S L -0.6737 Soluble
10 S L -0.5996 Soluble
11 L L -0.1669 Soluble
12 S L -0.4124 Soluble
13 A L -0.8644 Soluble
14 S L -0.9114 Soluble
15 V L -0.3883 Soluble
16 G L -1.4381 Soluble
17 D L -2.7233 Soluble
18 R L -2.7806 Soluble
19 V L 0.0000 Buried
20 T L -0.7878 Soluble
21 I L 0.0000 Buried
22 T L -1.0459 Soluble
23 C L 0.0000 Buried
24 R L -2.6412 Soluble
25 A L -1.6282 Soluble
26 S L -1.1499 Soluble
27 S L -0.8914 Soluble
28 S L -1.1945 Soluble
29 V L 0.0000 Buried
37 E L -1.7780 Soluble
38 F L -0.8572 Soluble
39 I L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.7638 Soluble
46 P L -1.3426 Soluble
47 G L -1.6328 Soluble
48 K L -2.5734 Soluble
49 A L -1.5765 Soluble
50 P L 0.0000 Buried
51 K L -1.6438 Soluble
52 P L -0.5432 Soluble
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 S L 0.0000 Buried
56 A L 0.0000 Buried
57 T L -0.6139 Soluble
65 S L -0.9525 Soluble
66 N L -1.4555 Soluble
67 L L -0.4857 Soluble
68 A L -0.5683 Soluble
69 S L -0.5886 Soluble
70 G L -0.4811 Soluble
71 V L -0.2004 Soluble
72 P L -0.4488 Soluble
74 S L -0.4817 Soluble
75 R L -0.6002 Soluble
76 F L 0.0000 Buried
77 S L -0.3065 Soluble
78 G L -0.4451 Soluble
79 S L -0.6838 Soluble
80 G L -1.2531 Soluble
83 S L -1.3043 Soluble
84 G L -1.5198 Soluble
85 T L -1.9640 Soluble
86 D L -2.5932 Soluble
87 F L 0.0000 Buried
88 T L -0.9137 Soluble
89 L L 0.0000 Buried
90 T L -0.6333 Soluble
91 I L 0.0000 Buried
92 S L -1.2651 Soluble
93 S L -1.2721 Soluble
94 L L 0.0000 Buried
95 Q L -1.0486 Soluble
96 P L -1.0735 Soluble
97 E L -2.0399 Soluble
98 D L 0.0000 Buried
99 F L -0.6171 Soluble
100 A L 0.0000 Buried
101 T L -0.5251 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 W L 0.1479 Aggregation-prone
108 S L -0.3017 Soluble
109 S L -0.5061 Soluble
114 A L -0.3773 Soluble
115 P L -0.7743 Soluble
116 W L -0.1909 Soluble
117 T L -0.4690 Soluble
118 F L -0.1801 Soluble
119 G L 0.0000 Buried
120 Q L -1.2779 Soluble
121 G L -0.9154 Soluble
122 T L 0.0000 Buried
123 K L -0.6968 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.1402 Soluble
127 K L 0.0000 Buried
128 R L -1.2992 Soluble
129 T L -0.1530 Soluble
130 V L 1.1672 Aggregation-prone
131 A L 0.6066 Aggregation-prone
132 A L 0.0354 Aggregation-prone
133 P L 0.0000 Buried
134 S L 0.0449 Aggregation-prone
135 V L 0.3774 Aggregation-prone
136 F L 0.1955 Aggregation-prone
137 I L 0.0945 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.9104 Soluble
140 P L -1.0327 Soluble
141 S L -1.7670 Soluble
142 D L -2.9707 Soluble
143 E L -3.0565 Soluble
144 Q L 0.0000 Buried
145 L L 0.0000 Buried
146 K L -2.9587 Soluble
147 S L -1.7602 Soluble
148 G L -1.6587 Soluble
149 T L -1.0799 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.4698 Soluble
159 F L 0.0000 Buried
160 Y L -0.5502 Soluble
161 P L -1.0863 Soluble
162 R L -2.1488 Soluble
163 E L -2.8848 Soluble
164 A L -2.1253 Soluble
165 K L -2.1895 Soluble
166 V L -1.1811 Soluble
167 Q L -0.5976 Soluble
168 W L 0.0000 Buried
169 K L -0.7799 Soluble
170 V L -1.3022 Soluble
171 D L -2.4257 Soluble
172 N L -1.8378 Soluble
173 A L -0.6798 Soluble
174 L L 0.4055 Aggregation-prone
175 Q L -0.4484 Soluble
176 S L -0.8432 Soluble
177 G L -1.3758 Soluble
178 N L -1.6458 Soluble
179 S L -1.7723 Soluble
180 Q L -2.2089 Soluble
181 E L -2.0740 Soluble
182 S L -1.0236 Soluble
183 V L -0.5078 Soluble
184 T L -0.9150 Soluble
185 E L -2.0821 Soluble
186 Q L -1.7760 Soluble
187 D L -2.2961 Soluble
188 S L -1.9940 Soluble
189 K L -2.6414 Soluble
190 D L -2.3387 Soluble
191 S L -2.0012 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.9540 Soluble
199 L L 0.0000 Buried
200 T L -0.3399 Soluble
201 L L -0.4540 Soluble
202 S L -0.8988 Soluble
203 K L -2.1743 Soluble
204 A L -1.7674 Soluble
205 D L -2.7432 Soluble
206 Y L -2.6373 Soluble
207 E L -3.6326 Soluble
208 K L -3.6292 Soluble
209 H L -3.1549 Soluble
210 K L -2.9682 Soluble
211 V L -1.3642 Soluble
212 Y L 0.0000 Buried
213 A L -0.7755 Soluble
214 C L 0.0000 Buried
215 E L -0.4946 Soluble
216 V L 0.0000 Buried
217 T L -0.7301 Soluble
218 H L 0.0000 Buried
219 Q L -1.3608 Soluble
220 G L -0.5834 Soluble
221 L L -0.2796 Soluble
222 S L -0.4140 Soluble
223 S L -0.4353 Soluble
224 P L -0.2668 Soluble
225 V L -0.0419 Soluble
226 T L -0.3914 Soluble
227 K L -0.5457 Soluble
228 S L -0.5548 Soluble
229 F L -1.1740 Soluble
230 N L -2.4979 Soluble
231 R L -3.0926 Soluble
232 G L -2.4369 Soluble
233 E L -2.7131 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7637 1.9234 CSV PDB
4.5 -0.8185 1.6325 CSV PDB
5.0 -0.8828 1.6047 CSV PDB
5.5 -0.9437 1.6047 CSV PDB
6.0 -0.9872 1.6047 CSV PDB
6.5 -1.0026 1.6047 CSV PDB
7.0 -0.9904 1.6047 CSV PDB
7.5 -0.9607 1.6047 CSV PDB
8.0 -0.9215 1.6047 CSV PDB
8.5 -0.8752 1.6047 CSV PDB
9.0 -0.8215 1.6047 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH