Galegenimab / 7sjo

A4DAB122_7sjo_I_J | Source PDB: 7sjo | Chains: I, J | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7865
Max Score
0.9974
Min Score
-3.6031
Total Score
-339.75
Score CDR
-0.8505
Score non-CDR
-0.779

Calculation Parameters

Chain Sequence(s) EVQLVQSGAEVKKPGASVKVSCKASGYKFTDSEMHWVRQAPGQGLEWIGGVDPETEGAAYNQKFKGRATITRDTSTSTAYLELSSLRSEDTAVYYCTRGYDYDYALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSDIQMTQSPSSLSASVGDRVTITCRASSSVEFIHWYQQKPGKAPKPLISATSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSAPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) I (Heavy), J (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6031
Maximum Score 0.9974
Average Score -0.7865
Total Score -339.7527

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E I -2.0327 Soluble
2 V I -1.0231 Soluble
3 Q I -1.3910 Soluble
4 L I 0.0000 Buried
5 V I 0.2290 Aggregation-prone
7 S I -0.6259 Soluble
8 G I -0.3203 Soluble
9 A I -0.0010 Soluble
11 E I -0.4136 Soluble
12 V I 0.1500 Aggregation-prone
13 K I -1.1437 Soluble
14 K I -2.1298 Soluble
15 P I -1.7017 Soluble
16 G I -1.4521 Soluble
17 A I -1.0711 Soluble
18 S I -1.1225 Soluble
19 V I 0.0000 Buried
20 K I -1.7057 Soluble
21 V I 0.0000 Buried
22 S I -0.4254 Soluble
23 C I 0.0000 Buried
24 K I -0.7725 Soluble
25 A I 0.0000 Buried
26 S I -1.0737 Soluble
27 G I -1.2207 Soluble
28 Y I -1.0959 Soluble
29 K I -2.2293 Soluble
30 F I 0.0000 Buried
35 T I -2.2207 Soluble
36 D I -2.6274 Soluble
37 S I -1.6170 Soluble
38 E I -1.5912 Soluble
39 M I 0.0000 Buried
40 H I 0.0000 Buried
41 W I 0.0000 Buried
42 V I 0.0000 Buried
43 R I 0.0000 Buried
44 Q I -0.4899 Soluble
45 A I -1.0265 Soluble
46 P I -0.8334 Soluble
47 G I -1.4038 Soluble
48 Q I -1.9052 Soluble
49 G I -1.3905 Soluble
50 L I 0.0000 Buried
51 E I -0.6071 Soluble
52 W I 0.0000 Buried
53 I I 0.0000 Buried
54 G I 0.0000 Buried
55 G I -0.4359 Soluble
56 V I 0.0000 Buried
57 D I -2.5774 Soluble
58 P I 0.0000 Buried
59 E I -3.2052 Soluble
62 T I -2.2163 Soluble
63 E I -2.8579 Soluble
64 G I -1.7431 Soluble
65 A I -0.5837 Soluble
66 A I -0.4156 Soluble
67 Y I -0.8307 Soluble
68 N I 0.0000 Buried
69 Q I -2.7019 Soluble
70 K I -2.4934 Soluble
71 F I -1.7778 Soluble
72 K I -2.7416 Soluble
74 G I -1.7848 Soluble
75 R I -1.5748 Soluble
76 A I -0.9956 Soluble
77 T I -0.6274 Soluble
78 I I -0.2649 Soluble
79 T I -0.8779 Soluble
80 R I -1.8259 Soluble
81 D I -1.1370 Soluble
82 T I -1.2330 Soluble
83 S I -0.8361 Soluble
84 T I -0.8956 Soluble
85 S I -1.1768 Soluble
86 T I -0.6677 Soluble
87 A I 0.0000 Buried
88 Y I -0.3026 Soluble
89 L I 0.0000 Buried
90 E I -1.1858 Soluble
91 L I 0.0000 Buried
92 S I -0.9747 Soluble
93 S I -0.8419 Soluble
94 L I 0.0000 Buried
95 R I -2.1133 Soluble
96 S I -1.7062 Soluble
97 E I -2.3122 Soluble
98 D I 0.0000 Buried
99 T I -0.6298 Soluble
100 A I 0.0000 Buried
101 V I 0.4679 Aggregation-prone
102 Y I 0.0000 Buried
103 Y I 0.0000 Buried
104 C I 0.0000 Buried
105 T I 0.0000 Buried
106 R I 0.0000 Buried
107 G I -0.0369 Soluble
108 Y I 0.1265 Aggregation-prone
109 D I -1.1266 Soluble
110 Y I -0.0820 Soluble
112 D I -1.3809 Soluble
113 Y I -0.6749 Soluble
114 A I 0.0000 Buried
115 L I 0.0000 Buried
116 D I -0.1250 Soluble
117 Y I 0.3496 Aggregation-prone
118 W I 0.0000 Buried
119 G I 0.0000 Buried
120 Q I -1.4109 Soluble
121 G I -0.6844 Soluble
122 T I 0.0000 Buried
123 L I 0.7422 Aggregation-prone
124 V I 0.0000 Buried
125 T I -0.0490 Soluble
126 V I 0.0000 Buried
127 S I -0.9231 Soluble
128 S I -0.3314 Soluble
129 A I -0.7000 Soluble
130 S I -0.6300 Soluble
131 T I -0.8343 Soluble
132 K I -1.3552 Soluble
133 G I -1.2760 Soluble
134 P I 0.0000 Buried
135 S I -0.7599 Soluble
136 V I 0.0000 Buried
137 F I -0.8208 Soluble
138 P I -1.1928 Soluble
139 L I 0.0000 Buried
140 A I -0.9434 Soluble
141 P I -0.9377 Soluble
142 S I -1.0543 Soluble
143 S I -1.4905 Soluble
144 K I -1.9197 Soluble
145 S I -1.1123 Soluble
146 T I -1.1371 Soluble
147 S I -1.1305 Soluble
148 G I -1.0466 Soluble
149 G I -0.8979 Soluble
150 T I -0.6206 Soluble
151 A I 0.0000 Buried
152 A I 0.0000 Buried
153 L I 0.0000 Buried
154 G I 0.0000 Buried
155 C I 0.0000 Buried
156 L I 0.0000 Buried
157 V I 0.0000 Buried
158 K I 0.0000 Buried
159 D I -0.8080 Soluble
160 Y I 0.0000 Buried
161 F I 0.0000 Buried
162 P I -0.7570 Soluble
163 E I -0.9297 Soluble
164 P I -0.9987 Soluble
165 V I -1.0046 Soluble
166 T I -0.7871 Soluble
167 V I 0.0000 Buried
168 S I -0.6395 Soluble
169 W I 0.0000 Buried
170 N I -0.7896 Soluble
171 S I -0.6510 Soluble
172 G I -0.6617 Soluble
173 A I -0.2085 Soluble
174 L I 0.0545 Aggregation-prone
175 T I -0.1128 Soluble
176 S I -0.3135 Soluble
177 G I -0.2454 Soluble
178 V I 0.3274 Aggregation-prone
179 H I -0.2806 Soluble
180 T I -0.2138 Soluble
181 F I 0.0000 Buried
182 P I -0.4535 Soluble
183 A I 0.0210 Aggregation-prone
184 V I 0.3874 Aggregation-prone
185 L I 0.8882 Aggregation-prone
186 Q I 0.1045 Aggregation-prone
187 S I -0.3038 Soluble
188 S I -0.2711 Soluble
189 G I -0.0557 Soluble
190 L I -0.0935 Soluble
191 Y I 0.1603 Aggregation-prone
192 S I 0.1496 Aggregation-prone
193 L I 0.0000 Buried
194 S I -0.1839 Soluble
195 S I 0.0000 Buried
196 V I 0.0000 Buried
197 V I 0.0000 Buried
198 T I -0.0884 Soluble
199 V I 0.0000 Buried
200 P I -0.5250 Soluble
201 S I -0.6266 Soluble
202 S I -0.6119 Soluble
203 S I -0.5920 Soluble
204 L I 0.0000 Buried
205 G I -1.2794 Soluble
206 T I -0.6682 Soluble
207 Q I -0.9711 Soluble
208 T I -0.8014 Soluble
209 Y I -0.5960 Soluble
210 I I -0.9083 Soluble
211 C I 0.0000 Buried
212 N I -1.7188 Soluble
213 V I 0.0000 Buried
214 N I -2.6028 Soluble
215 H I 0.0000 Buried
216 K I -2.8815 Soluble
217 P I -1.6985 Soluble
218 S I -1.9718 Soluble
219 N I -2.6216 Soluble
220 T I -2.1434 Soluble
221 K I -2.7527 Soluble
222 V I -1.5005 Soluble
223 D I -2.4787 Soluble
224 K I -2.0760 Soluble
225 K I -2.1396 Soluble
226 V I 0.0000 Buried
227 E I -2.6824 Soluble
228 P I -2.0090 Soluble
229 K I -2.4110 Soluble
230 S I -1.3614 Soluble
1 D J -2.3648 Soluble
2 I J -1.2810 Soluble
3 Q J -1.6756 Soluble
4 M J 0.0000 Buried
5 T J -1.2324 Soluble
6 Q J 0.0000 Buried
7 S J -0.8290 Soluble
8 P J -0.5115 Soluble
9 S J -0.6937 Soluble
10 S J -0.5248 Soluble
11 L J -0.0451 Soluble
12 S J -0.3289 Soluble
13 A J -0.4840 Soluble
14 S J -0.1302 Soluble
15 V J 0.7827 Aggregation-prone
16 G J -1.0514 Soluble
17 D J -2.4982 Soluble
18 R J -2.6900 Soluble
19 V J 0.0000 Buried
20 T J -0.7836 Soluble
21 I J 0.0000 Buried
22 T J -0.9632 Soluble
23 C J 0.0000 Buried
24 R J -2.3206 Soluble
25 A J -1.5003 Soluble
26 S J -1.1379 Soluble
27 S J -0.7060 Soluble
28 S J -1.1276 Soluble
29 V J -0.9293 Soluble
37 E J -1.8047 Soluble
38 F J -1.0565 Soluble
39 I J 0.0000 Buried
40 H J 0.0000 Buried
41 W J 0.0000 Buried
42 Y J 0.0000 Buried
43 Q J 0.0000 Buried
44 Q J 0.0000 Buried
45 K J -2.0161 Soluble
46 P J -1.5315 Soluble
47 G J -1.7480 Soluble
48 K J -2.6560 Soluble
49 A J -1.6351 Soluble
50 P J 0.0000 Buried
51 K J -1.4182 Soluble
52 P J -0.4975 Soluble
53 L J 0.0000 Buried
54 I J 0.0000 Buried
55 S J 0.0000 Buried
56 A J -0.8132 Soluble
57 T J 0.0000 Buried
65 S J -1.0476 Soluble
66 N J -1.2437 Soluble
67 L J -0.4543 Soluble
68 A J 0.0000 Buried
69 S J -0.4925 Soluble
70 G J -0.4721 Soluble
71 V J -0.1766 Soluble
72 P J -0.4055 Soluble
74 S J -0.5440 Soluble
75 R J -0.4890 Soluble
76 F J 0.0000 Buried
77 S J -0.4853 Soluble
78 G J -0.5176 Soluble
79 S J -0.8416 Soluble
80 G J -1.1436 Soluble
83 S J -1.2202 Soluble
84 G J -1.4326 Soluble
85 T J -1.7837 Soluble
86 D J -2.1726 Soluble
87 F J 0.0000 Buried
88 T J -0.7745 Soluble
89 L J 0.0000 Buried
90 T J -0.6702 Soluble
91 I J 0.0000 Buried
92 S J -1.2779 Soluble
93 S J -1.0981 Soluble
94 L J 0.0000 Buried
95 Q J -0.9105 Soluble
96 P J -0.8362 Soluble
97 E J -2.0481 Soluble
98 D J 0.0000 Buried
99 F J -0.4822 Soluble
100 A J 0.0000 Buried
101 T J -0.6018 Soluble
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 Q J 0.0000 Buried
106 Q J 0.0000 Buried
107 W J 0.0000 Buried
108 S J -0.3423 Soluble
109 S J -0.3297 Soluble
114 A J -0.4167 Soluble
115 P J 0.0000 Buried
116 W J -0.3209 Soluble
117 T J -0.6421 Soluble
118 F J 0.0000 Buried
119 G J 0.0000 Buried
120 Q J -1.6252 Soluble
121 G J -1.0815 Soluble
122 T J 0.0000 Buried
123 K J -0.6815 Soluble
124 V J 0.0000 Buried
125 E J 0.0000 Buried
126 I J 0.5944 Aggregation-prone
127 K J 0.0000 Buried
128 R J -1.2171 Soluble
129 T J -0.1558 Soluble
130 V J 0.9974 Aggregation-prone
131 A J 0.3580 Aggregation-prone
132 A J 0.0375 Aggregation-prone
133 P J 0.0000 Buried
134 S J -0.0807 Soluble
135 V J 0.3241 Aggregation-prone
136 F J 0.1479 Aggregation-prone
137 I J 0.1431 Aggregation-prone
138 F J 0.0000 Buried
139 P J -0.6007 Soluble
140 P J -0.8553 Soluble
141 S J -1.7573 Soluble
142 D J -3.3030 Soluble
143 E J -3.2373 Soluble
144 Q J 0.0000 Buried
145 L J 0.0000 Buried
146 K J -3.1335 Soluble
147 S J -1.8819 Soluble
148 G J -1.6900 Soluble
149 T J -1.1388 Soluble
150 A J 0.0000 Buried
151 S J 0.0000 Buried
152 V J 0.0000 Buried
153 V J 0.0000 Buried
154 C J 0.0000 Buried
155 L J 0.0000 Buried
156 L J 0.0000 Buried
157 N J -0.1570 Soluble
158 N J -0.4036 Soluble
159 F J 0.0000 Buried
160 Y J -0.4397 Soluble
161 P J -1.0980 Soluble
162 R J -1.6299 Soluble
163 E J -2.6739 Soluble
164 A J -1.9841 Soluble
165 K J -2.3369 Soluble
166 V J 0.0000 Buried
167 Q J -1.0206 Soluble
168 W J 0.0000 Buried
169 K J -0.8391 Soluble
170 V J -1.3565 Soluble
171 D J -2.3533 Soluble
172 N J -1.8173 Soluble
173 A J -0.6907 Soluble
174 L J 0.3705 Aggregation-prone
175 Q J -0.8151 Soluble
176 S J -1.0199 Soluble
177 G J -1.4493 Soluble
178 N J -1.8259 Soluble
179 S J -1.4885 Soluble
180 Q J -1.2887 Soluble
181 E J -1.4846 Soluble
182 S J -0.6234 Soluble
183 V J -0.1778 Soluble
184 T J -0.8892 Soluble
185 E J -2.1886 Soluble
186 Q J -1.9755 Soluble
187 D J -2.8054 Soluble
188 S J -2.2512 Soluble
189 K J -2.8409 Soluble
190 D J -2.4717 Soluble
191 S J -2.0553 Soluble
192 T J -1.5074 Soluble
193 Y J 0.0000 Buried
194 S J 0.0000 Buried
195 L J 0.0000 Buried
196 S J 0.0000 Buried
197 S J 0.0000 Buried
198 T J -0.6613 Soluble
199 L J 0.0000 Buried
200 T J -0.2560 Soluble
201 L J -0.4652 Soluble
202 S J -1.0916 Soluble
203 K J -2.3950 Soluble
204 A J -1.7098 Soluble
205 D J -2.6692 Soluble
206 Y J -2.5739 Soluble
207 E J -3.6031 Soluble
208 K J -3.5812 Soluble
209 H J -3.1500 Soluble
210 K J -2.9514 Soluble
211 V J -1.2872 Soluble
212 Y J -0.8357 Soluble
213 A J -0.6028 Soluble
214 C J 0.0000 Buried
215 E J -0.5348 Soluble
216 V J 0.0000 Buried
217 T J -0.7638 Soluble
218 H J -1.3368 Soluble
219 Q J -1.2663 Soluble
220 G J -0.5534 Soluble
221 L J -0.2541 Soluble
222 S J -0.4087 Soluble
223 S J -0.2767 Soluble
224 P J -0.2120 Soluble
225 V J 0.0999 Aggregation-prone
226 T J -0.2450 Soluble
227 K J -0.2979 Soluble
228 S J -0.4550 Soluble
229 F J -0.8380 Soluble
230 N J -1.9690 Soluble
231 R J -1.8808 Soluble
232 G J -1.8391 Soluble
233 E J -2.3687 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.742 1.8997 CSV PDB
4.5 -0.7973 1.703 CSV PDB
5.0 -0.8629 1.5662 CSV PDB
5.5 -0.9262 1.5662 CSV PDB
6.0 -0.973 1.5662 CSV PDB
6.5 -0.9933 1.5662 CSV PDB
7.0 -0.9869 1.5662 CSV PDB
7.5 -0.9623 1.5662 CSV PDB
8.0 -0.9273 1.5662 CSV PDB
8.5 -0.8842 1.5664 CSV PDB
9.0 -0.8331 1.6352 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH