Larcaviximab / 5ken

A4DAB152_5ken_N_O | Source PDB: 5ken | Chains: N, O | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6094
Max Score
1.5183
Min Score
-3.0793
Total Score
-137.11
Score CDR
0.002
Score non-CDR
-0.7665

Calculation Parameters

Chain Sequence(s) EVQLQESGPELEMPGASVKISCKASGSSFTGFSMNWVKQSNGKSLEWIGNIDTYYGGTTYNQKFKGKATLTVDKSSSTAYMQLKSLTSEDSAVYYCARSAYYGSTFAYWGQGTLVTVSDIQMTQSPASLSASVGETVTITCRASENIYSYLAWYQQKQGKSPQLLVYNAKTLIEGVPSRFSGSGSGTQFSLKINSLQPEDFGSYFCQHHFGTPFTFGSGTELEIK input.pdb
Selected Chain(s) N (Heavy), O (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.0793
Maximum Score 1.5183
Average Score -0.6094
Total Score -137.1111

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E N -1.9601 Soluble
2 V N -1.2743 Soluble
3 Q N -1.8684 Soluble
4 L N 0.0000 Buried
5 Q N -2.2451 Soluble
6 E N -1.6956 Soluble
7 S N -1.1330 Soluble
8 G N -1.2644 Soluble
9 P N -0.9506 Soluble
11 E N -1.2277 Soluble
12 L N 0.2140 Aggregation-prone
13 E N -0.1434 Soluble
14 M N 0.6039 Aggregation-prone
15 P N -0.2613 Soluble
16 G N -0.8177 Soluble
17 A N -0.4500 Soluble
18 S N -1.1446 Soluble
19 V N -1.1752 Soluble
20 K N -1.7619 Soluble
21 I N 0.0000 Buried
22 S N -0.8903 Soluble
23 C N 0.0000 Buried
24 K N -2.2498 Soluble
25 A N 0.0000 Buried
26 S N -1.4764 Soluble
27 G N -0.9985 Soluble
28 S N -0.6814 Soluble
29 S N -0.6343 Soluble
30 F N 0.0000 Buried
35 T N -0.2130 Soluble
36 G N -0.3584 Soluble
37 F N 0.0000 Buried
38 S N -0.1150 Soluble
39 M N 0.0000 Buried
40 N N 0.0000 Buried
41 W N 0.0000 Buried
42 V N 0.0000 Buried
43 K N 0.0000 Buried
44 Q N 0.0000 Buried
45 S N -1.8899 Soluble
46 N N -2.3580 Soluble
47 G N -1.9925 Soluble
48 K N -2.5536 Soluble
49 S N -1.5273 Soluble
50 L N 0.0000 Buried
51 E N -1.6272 Soluble
52 W N 0.0000 Buried
53 I N 0.0000 Buried
54 G N 0.0000 Buried
55 N N -0.2652 Soluble
56 I N 0.0000 Buried
57 D N -0.0852 Soluble
58 T N 0.0000 Buried
59 Y N 1.3519 Aggregation-prone
62 Y N 1.4492 Aggregation-prone
63 G N 0.3713 Aggregation-prone
64 G N -0.0605 Soluble
65 T N -0.1380 Soluble
66 T N -0.2355 Soluble
67 Y N -0.3964 Soluble
68 N N 0.0000 Buried
69 Q N -2.3077 Soluble
70 K N -2.9878 Soluble
71 F N -2.2444 Soluble
72 K N -3.0793 Soluble
74 G N -2.4980 Soluble
75 K N -2.5106 Soluble
76 A N -1.3824 Soluble
77 T N -0.7667 Soluble
78 L N -0.1952 Soluble
79 T N -0.1673 Soluble
80 V N 0.0332 Aggregation-prone
81 D N -0.8142 Soluble
82 K N -1.0793 Soluble
83 S N -0.8814 Soluble
84 S N -0.9625 Soluble
85 S N -1.1932 Soluble
86 T N -1.2530 Soluble
87 A N 0.0000 Buried
88 Y N -0.2955 Soluble
89 M N 0.0000 Buried
90 Q N -1.3235 Soluble
91 L N 0.0000 Buried
92 K N -2.3234 Soluble
93 S N -1.2857 Soluble
94 L N 0.0000 Buried
95 T N -1.2584 Soluble
96 S N -1.3663 Soluble
97 E N -2.3846 Soluble
98 D N -1.7566 Soluble
99 S N -1.2037 Soluble
100 A N 0.0000 Buried
101 V N -0.3484 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 A N 0.0000 Buried
106 R N 0.2509 Aggregation-prone
107 S N 0.0000 Buried
108 A N 0.0000 Buried
109 Y N 1.3156 Aggregation-prone
110 Y N 1.1683 Aggregation-prone
112 G N 0.2650 Aggregation-prone
113 S N 0.0486 Aggregation-prone
114 T N 0.3193 Aggregation-prone
115 F N 0.7717 Aggregation-prone
116 A N 0.0000 Buried
117 Y N 0.4210 Aggregation-prone
118 W N 0.0000 Buried
119 G N -1.3142 Soluble
120 Q N -1.3616 Soluble
121 G N -1.1123 Soluble
122 T N 0.0000 Buried
123 L N -0.2485 Soluble
124 V N 0.0000 Buried
125 T N -0.5629 Soluble
126 V N 0.0000 Buried
127 S N 0.1024 Aggregation-prone
1 D O -2.5294 Soluble
2 I O 0.0000 Buried
3 Q O -2.1949 Soluble
4 M O -1.4763 Soluble
5 T O -0.7484 Soluble
6 Q O 0.0000 Buried
7 S O -0.5091 Soluble
8 P O -0.3328 Soluble
9 A O -0.3389 Soluble
10 S O -0.6910 Soluble
11 L O -0.3826 Soluble
12 S O -0.4531 Soluble
13 A O 0.0000 Buried
14 S O -0.1245 Soluble
15 V O 0.3944 Aggregation-prone
16 G O -0.3302 Soluble
17 E O -0.8210 Soluble
18 T O -0.7894 Soluble
19 V O 0.0000 Buried
20 T O -0.5891 Soluble
21 I O 0.0000 Buried
22 T O -0.7367 Soluble
23 C O 0.0000 Buried
24 R O -2.1788 Soluble
25 A O 0.0000 Buried
26 S O -2.3692 Soluble
27 E O -3.0672 Soluble
28 N O -1.9680 Soluble
29 I O 0.0000 Buried
36 Y O 0.9125 Aggregation-prone
37 S O 0.0664 Aggregation-prone
38 Y O 0.8267 Aggregation-prone
39 L O 0.0000 Buried
40 A O 0.0000 Buried
41 W O 0.0000 Buried
42 Y O 0.0000 Buried
43 Q O -0.9726 Soluble
44 Q O 0.0000 Buried
45 K O -2.5206 Soluble
46 Q O -2.5035 Soluble
47 G O -2.2556 Soluble
48 K O -2.8685 Soluble
49 S O 0.0000 Buried
50 P O 0.0000 Buried
51 Q O -0.7443 Soluble
52 L O 0.0000 Buried
53 L O 0.0000 Buried
54 V O 0.0000 Buried
55 Y O 0.1878 Aggregation-prone
56 N O -0.0714 Soluble
57 A O 0.0000 Buried
65 K O -1.8510 Soluble
66 T O -0.7753 Soluble
67 L O -0.3014 Soluble
68 I O -0.3517 Soluble
69 E O -1.7556 Soluble
70 G O -1.1381 Soluble
71 V O -0.5844 Soluble
72 P O -0.5414 Soluble
74 S O -0.4706 Soluble
75 R O -0.8981 Soluble
76 F O 0.0000 Buried
77 S O -0.9116 Soluble
78 G O -1.1973 Soluble
79 S O -1.4116 Soluble
80 G O -1.3929 Soluble
83 S O -1.1277 Soluble
84 G O 0.0000 Buried
85 T O -2.1095 Soluble
86 Q O -2.2310 Soluble
87 F O 0.0000 Buried
88 S O -1.0967 Soluble
89 L O 0.0000 Buried
90 K O -1.1335 Soluble
91 I O 0.0000 Buried
92 N O -1.2456 Soluble
93 S O -0.8120 Soluble
94 L O 0.0000 Buried
95 Q O -0.7787 Soluble
96 P O -0.7494 Soluble
97 E O -2.0100 Soluble
98 D O 0.0000 Buried
99 F O 0.0000 Buried
100 G O 0.0000 Buried
101 S O -1.2211 Soluble
102 Y O 0.0000 Buried
103 F O 0.0000 Buried
104 C O 0.0000 Buried
105 Q O 0.0000 Buried
106 H O 0.0000 Buried
107 H O 0.0000 Buried
108 F O 1.5183 Aggregation-prone
109 G O 0.5698 Aggregation-prone
114 T O -0.0588 Soluble
115 P O -0.4895 Soluble
116 F O 0.0000 Buried
117 T O -0.7447 Soluble
118 F O 0.0000 Buried
119 G O 0.0000 Buried
120 S O -0.8961 Soluble
121 G O -0.7390 Soluble
122 T O 0.0000 Buried
123 E O -1.4564 Soluble
124 L O 0.0000 Buried
125 E O -0.6151 Soluble
126 I O 0.8351 Aggregation-prone
127 K O -0.8572 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6395 3.4068 CSV PDB
4.5 -0.6781 3.4068 CSV PDB
5.0 -0.7261 3.4068 CSV PDB
5.5 -0.7724 3.4068 CSV PDB
6.0 -0.8021 3.4067 CSV PDB
6.5 -0.8026 3.4067 CSV PDB
7.0 -0.7727 3.4067 CSV PDB
7.5 -0.722 3.4066 CSV PDB
8.0 -0.6606 3.4064 CSV PDB
8.5 -0.5938 3.4056 CSV PDB
9.0 -0.524 3.403 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH