Masavibart / 7zjl

A4DAB166_7zjl_l_k | Source PDB: 7zjl | Chains: l, k | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6699
Max Score
1.8858
Min Score
-3.837
Total Score
-295.45
Score CDR
-0.4644
Score non-CDR
-0.6968

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYAMYWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRTEDTAVYYCASGSDYGDYLLVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCQSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSKRPSGVSNRFSGSKSGNTASLTISGLQSEDEADYYCNSLTSISTWVFGGGTKLTVLGRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) l (Heavy), k (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.837
Maximum Score 1.8858
Average Score -0.6699
Total Score -295.4476

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q l -1.4872 Soluble
2 V l -0.9829 Soluble
3 Q l -1.0299 Soluble
4 L l 0.0000 Buried
5 V l 1.1024 Aggregation-prone
6 E l 0.0000 Buried
7 S l -0.1971 Soluble
8 G l -0.6085 Soluble
9 G l 0.2635 Aggregation-prone
11 G l 0.9888 Aggregation-prone
12 V l 1.7131 Aggregation-prone
13 V l -0.0662 Soluble
14 Q l -1.3995 Soluble
15 P l -2.1719 Soluble
16 G l -2.2177 Soluble
17 R l -2.7256 Soluble
18 S l -1.8527 Soluble
19 L l -0.9275 Soluble
20 R l -1.4114 Soluble
21 L l 0.0000 Buried
22 S l -0.2305 Soluble
23 C l 0.0000 Buried
24 A l -0.1124 Soluble
25 A l 0.0000 Buried
26 S l -0.8969 Soluble
27 G l -1.0103 Soluble
28 F l -0.5555 Soluble
29 T l -0.4492 Soluble
30 F l 0.0000 Buried
35 S l -1.3089 Soluble
36 N l -1.5378 Soluble
37 Y l -0.7542 Soluble
38 A l 0.0000 Buried
39 M l 0.0000 Buried
40 Y l 0.0000 Buried
41 W l 0.0000 Buried
42 V l 0.0000 Buried
43 R l 0.0000 Buried
44 Q l -0.6040 Soluble
45 A l -0.9920 Soluble
46 P l -0.8111 Soluble
47 G l -1.5305 Soluble
48 K l -2.2439 Soluble
49 G l -1.4469 Soluble
50 L l 0.0000 Buried
51 E l -0.8728 Soluble
52 W l 0.0000 Buried
53 V l 0.0000 Buried
54 A l 0.0000 Buried
55 V l 0.0000 Buried
56 I l 0.0000 Buried
57 S l -0.9405 Soluble
58 Y l -0.6393 Soluble
59 D l -2.0004 Soluble
62 G l -1.4616 Soluble
63 S l -1.4102 Soluble
64 N l -1.8019 Soluble
65 K l -1.1311 Soluble
66 Y l -0.4227 Soluble
67 Y l -0.8271 Soluble
68 A l 0.0000 Buried
69 D l -2.5434 Soluble
70 S l -1.8145 Soluble
71 V l 0.0000 Buried
72 K l -2.5481 Soluble
74 G l -1.7848 Soluble
75 R l -1.5065 Soluble
76 F l 0.0000 Buried
77 T l -0.7085 Soluble
78 I l 0.0000 Buried
79 S l -0.5400 Soluble
80 R l -1.0008 Soluble
81 D l -1.6790 Soluble
82 N l -1.9398 Soluble
83 S l -1.5871 Soluble
84 K l -2.3748 Soluble
85 N l -1.7729 Soluble
86 T l -0.9165 Soluble
87 L l 0.0000 Buried
88 Y l -0.3090 Soluble
89 L l 0.0000 Buried
90 Q l -0.8056 Soluble
91 M l 0.0000 Buried
92 N l -1.6960 Soluble
93 S l -1.8573 Soluble
94 L l 0.0000 Buried
95 R l -3.0178 Soluble
96 T l -2.0074 Soluble
97 E l -2.4538 Soluble
98 D l 0.0000 Buried
99 T l -0.4683 Soluble
100 A l 0.0000 Buried
101 V l 0.7148 Aggregation-prone
102 Y l 0.0000 Buried
103 Y l 0.0000 Buried
104 C l 0.0000 Buried
105 A l 0.0000 Buried
106 S l 0.0000 Buried
107 G l 0.0000 Buried
108 S l -0.9706 Soluble
109 D l -1.8764 Soluble
110 Y l -0.9334 Soluble
111 G l -0.7491 Soluble
112 D l -0.9707 Soluble
113 Y l -0.1531 Soluble
114 L l 0.0000 Buried
115 L l 0.0000 Buried
116 V l -0.0746 Soluble
117 Y l 0.1800 Aggregation-prone
118 W l -0.0684 Soluble
119 G l 0.0000 Buried
120 Q l -1.2178 Soluble
121 G l -0.3360 Soluble
122 T l 0.5151 Aggregation-prone
123 L l 1.6242 Aggregation-prone
124 V l 0.0000 Buried
125 T l 0.4263 Aggregation-prone
126 V l 0.0000 Buried
127 S l -0.4880 Soluble
128 S l -0.3940 Soluble
129 A l -0.3054 Soluble
130 S l -0.6381 Soluble
131 T l -0.7379 Soluble
132 K l -1.2947 Soluble
133 G l -1.4347 Soluble
134 P l -0.6506 Soluble
135 S l -0.2930 Soluble
136 V l 0.0000 Buried
137 F l 0.0000 Buried
138 P l -1.0425 Soluble
139 L l 0.0000 Buried
140 A l -1.1846 Soluble
141 P l 0.0000 Buried
142 S l 0.0000 Buried
143 S l -0.6978 Soluble
144 K l -0.9721 Soluble
145 S l 0.0000 Buried
146 T l -0.6231 Soluble
147 S l -0.7560 Soluble
148 G l -0.8437 Soluble
149 G l -0.8941 Soluble
150 T l -0.6073 Soluble
151 A l 0.0000 Buried
152 A l 0.0000 Buried
153 L l 0.0000 Buried
154 G l 0.0000 Buried
155 C l 0.0000 Buried
156 L l 0.0000 Buried
157 V l 0.0000 Buried
158 K l 0.0000 Buried
159 D l -0.3503 Soluble
160 Y l 0.0000 Buried
161 F l 0.0000 Buried
162 P l -0.5772 Soluble
163 E l -0.8599 Soluble
164 P l -1.0649 Soluble
165 V l -0.9086 Soluble
166 T l -0.7267 Soluble
167 V l -0.4370 Soluble
168 S l -0.4242 Soluble
169 W l 0.0000 Buried
170 N l -0.6913 Soluble
171 S l -0.6484 Soluble
172 G l -0.4480 Soluble
173 A l -0.2070 Soluble
174 L l 0.0371 Aggregation-prone
175 T l -0.1488 Soluble
176 S l -0.1840 Soluble
177 G l -0.2018 Soluble
178 V l 0.1370 Aggregation-prone
179 H l -0.2669 Soluble
180 T l -0.1527 Soluble
181 F l 0.0000 Buried
182 P l -0.5223 Soluble
183 A l 0.0732 Aggregation-prone
184 V l 0.3636 Aggregation-prone
185 L l 1.0197 Aggregation-prone
186 Q l 0.1088 Aggregation-prone
187 S l -0.2147 Soluble
188 S l -0.2179 Soluble
189 G l -0.0389 Soluble
190 L l 0.0441 Aggregation-prone
191 Y l 0.3315 Aggregation-prone
192 S l 0.0000 Buried
193 L l 0.0000 Buried
194 S l 0.0000 Buried
195 S l 0.0000 Buried
196 V l 0.0000 Buried
197 V l 0.0000 Buried
198 T l -0.1341 Soluble
199 V l 0.0000 Buried
200 P l -0.5238 Soluble
201 S l -0.5351 Soluble
202 S l -0.5126 Soluble
203 S l -0.4708 Soluble
204 L l -0.6558 Soluble
205 G l -1.0636 Soluble
206 T l -0.6203 Soluble
207 Q l -1.0653 Soluble
208 T l -0.9679 Soluble
209 Y l 0.0000 Buried
210 I l -1.1409 Soluble
211 C l 0.0000 Buried
212 N l -1.5683 Soluble
213 V l 0.0000 Buried
214 N l -2.2535 Soluble
215 H l 0.0000 Buried
216 K l -2.8404 Soluble
217 P l -1.7160 Soluble
218 S l -1.8682 Soluble
219 N l -2.6102 Soluble
220 T l -2.1666 Soluble
221 K l -2.8108 Soluble
222 V l -1.7264 Soluble
223 D l -2.5849 Soluble
224 K l -1.9169 Soluble
225 K l -2.1779 Soluble
226 V l 0.0000 Buried
227 E l -2.5429 Soluble
228 P l -1.5856 Soluble
229 K l -1.5877 Soluble
230 S l -0.9202 Soluble
231 C l -0.9812 Soluble
1 Q k -1.0106 Soluble
2 S k -0.4144 Soluble
3 A k -0.3977 Soluble
4 L k 0.0000 Buried
5 T k -0.3464 Soluble
6 Q k -0.4277 Soluble
7 P k -0.3131 Soluble
8 A k -0.2782 Soluble
9 S k -0.2721 Soluble
11 V k 0.0632 Aggregation-prone
12 S k -0.0922 Soluble
13 G k 0.0000 Buried
14 S k -0.6295 Soluble
15 P k -1.0720 Soluble
16 G k -1.3327 Soluble
17 Q k -1.6233 Soluble
18 S k -0.9534 Soluble
19 I k -0.2837 Soluble
20 T k -0.0671 Soluble
21 I k 0.0000 Buried
22 S k -0.3858 Soluble
23 C k 0.0000 Buried
24 T k -0.5504 Soluble
25 G k -0.5841 Soluble
26 T k -0.6243 Soluble
27 S k -0.7449 Soluble
28 S k -0.0805 Soluble
29 D k 0.0000 Buried
30 V k 0.0000 Buried
31 G k -1.1712 Soluble
35 G k -0.7665 Soluble
36 Y k -0.5171 Soluble
37 N k -1.2133 Soluble
38 Y k -0.4010 Soluble
39 V k 0.0000 Buried
40 S k 0.0000 Buried
41 W k 0.0000 Buried
42 Y k 0.0000 Buried
43 Q k 0.0000 Buried
44 Q k 0.0000 Buried
45 H k -1.5558 Soluble
46 P k -1.4759 Soluble
47 G k -1.4982 Soluble
48 K k -2.4362 Soluble
49 A k -1.4959 Soluble
50 P k 0.0000 Buried
51 K k -1.3120 Soluble
52 L k 0.0000 Buried
53 M k 0.0000 Buried
54 I k 0.0000 Buried
55 Y k 0.0000 Buried
56 D k -1.2094 Soluble
57 V k 0.0000 Buried
65 S k -1.5529 Soluble
66 K k -2.1726 Soluble
67 R k -1.8934 Soluble
68 P k -0.8218 Soluble
69 S k -0.7482 Soluble
70 G k -0.7649 Soluble
71 V k -0.7968 Soluble
72 S k -1.0168 Soluble
74 N k -1.6772 Soluble
75 R k -1.1852 Soluble
76 F k 0.0000 Buried
77 S k -1.0794 Soluble
78 G k -0.8750 Soluble
79 S k -1.0054 Soluble
80 K k -1.2631 Soluble
83 S k -0.9633 Soluble
84 G k -1.1916 Soluble
85 N k -1.2722 Soluble
86 T k -0.9195 Soluble
87 A k 0.0000 Buried
88 S k -0.4540 Soluble
89 L k 0.0000 Buried
90 T k -0.2614 Soluble
91 I k 0.0000 Buried
92 S k -1.0607 Soluble
93 G k -1.1161 Soluble
94 L k 0.0000 Buried
95 Q k -1.7501 Soluble
96 S k -1.5625 Soluble
97 E k -2.3178 Soluble
98 D k 0.0000 Buried
99 E k -1.5016 Soluble
100 A k 0.0000 Buried
101 D k -0.8294 Soluble
102 Y k 0.0000 Buried
103 Y k 0.0000 Buried
104 C k 0.0000 Buried
105 N k 0.0000 Buried
106 S k 0.0000 Buried
107 L k 0.4466 Aggregation-prone
108 T k 0.0000 Buried
109 S k 0.7052 Aggregation-prone
113 I k 1.8858 Aggregation-prone
114 S k 0.9988 Aggregation-prone
115 T k 0.4847 Aggregation-prone
116 W k 0.0000 Buried
117 V k 0.0000 Buried
118 F k 0.0000 Buried
119 G k 0.0000 Buried
120 G k -0.9193 Soluble
121 G k -0.8359 Soluble
122 T k 0.0000 Buried
123 K k -0.7825 Soluble
124 L k 0.0000 Buried
125 T k -0.4222 Soluble
126 V k 0.0000 Buried
127 L k 0.3501 Aggregation-prone
128 G k -0.4929 Soluble
129 R k -0.4859 Soluble
130 T k 0.1727 Aggregation-prone
131 V k 0.6052 Aggregation-prone
132 A k 0.1465 Aggregation-prone
133 A k -0.0962 Soluble
134 P k 0.0000 Buried
135 S k -0.2411 Soluble
136 V k 0.0000 Buried
137 F k 0.0000 Buried
138 I k 0.0000 Buried
139 F k 0.0000 Buried
140 P k -0.3939 Soluble
141 P k 0.0000 Buried
142 S k -1.3268 Soluble
143 D k -2.3600 Soluble
144 E k -2.5937 Soluble
145 Q k 0.0000 Buried
146 L k -2.0185 Soluble
147 K k -2.6982 Soluble
148 S k -1.7075 Soluble
149 G k -1.2684 Soluble
150 T k -1.2578 Soluble
151 A k 0.0000 Buried
152 S k 0.0000 Buried
153 V k 0.0000 Buried
154 V k 0.0000 Buried
155 C k 0.0000 Buried
156 L k 0.0000 Buried
157 L k 0.0000 Buried
158 N k 0.0000 Buried
159 N k -0.6352 Soluble
160 F k 0.0000 Buried
161 Y k 0.0000 Buried
162 P k 0.0000 Buried
163 R k -1.1925 Soluble
164 E k -1.7207 Soluble
165 A k -1.4011 Soluble
166 K k -1.9628 Soluble
167 V k -1.0888 Soluble
168 Q k -0.8126 Soluble
169 W k 0.0000 Buried
170 K k -0.6235 Soluble
171 V k 0.0000 Buried
172 D k -1.5312 Soluble
173 N k -1.4177 Soluble
174 A k -0.2855 Soluble
175 L k 0.3662 Aggregation-prone
176 Q k -0.5791 Soluble
177 S k -0.8290 Soluble
178 G k -1.2660 Soluble
179 N k -1.5897 Soluble
180 S k -1.5187 Soluble
181 Q k -1.5882 Soluble
182 E k -2.0700 Soluble
183 S k -0.9344 Soluble
184 V k -0.5543 Soluble
185 T k 0.0000 Buried
186 E k -2.1359 Soluble
187 Q k -1.8998 Soluble
188 D k -1.9894 Soluble
189 S k -1.7927 Soluble
190 K k -2.3690 Soluble
191 D k -1.9441 Soluble
192 S k -1.7284 Soluble
193 T k 0.0000 Buried
194 Y k -0.9071 Soluble
195 S k 0.0000 Buried
196 L k 0.0000 Buried
197 S k 0.0000 Buried
198 S k 0.0000 Buried
199 T k -0.7839 Soluble
200 L k 0.0000 Buried
201 T k -0.7268 Soluble
202 L k -1.0261 Soluble
203 S k -1.4717 Soluble
204 K k -2.3794 Soluble
205 A k -2.2560 Soluble
206 D k -3.1028 Soluble
207 Y k 0.0000 Buried
208 E k -3.8370 Soluble
209 K k -3.7222 Soluble
210 H k -2.9698 Soluble
211 K k -3.0279 Soluble
212 V k -1.3695 Soluble
213 Y k 0.0000 Buried
214 A k 0.0000 Buried
215 C k 0.0000 Buried
216 E k -0.7810 Soluble
217 V k 0.0000 Buried
218 T k -1.0269 Soluble
219 H k 0.0000 Buried
220 Q k -1.4577 Soluble
221 G k -0.4594 Soluble
222 L k -0.2198 Soluble
223 S k -0.4290 Soluble
224 S k -0.4119 Soluble
225 P k -0.5613 Soluble
226 V k -0.0331 Soluble
227 T k -0.4945 Soluble
228 K k -0.7910 Soluble
229 S k -0.6354 Soluble
230 F k 0.0000 Buried
231 N k -1.7442 Soluble
232 R k -1.9708 Soluble
233 G k -2.0162 Soluble
234 E k -2.2245 Soluble
235 C k -1.0795 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6824 2.2109 CSV PDB
4.5 -0.7215 2.2109 CSV PDB
5.0 -0.7668 2.2109 CSV PDB
5.5 -0.8101 2.2109 CSV PDB
6.0 -0.8414 2.2109 CSV PDB
6.5 -0.8521 2.2109 CSV PDB
7.0 -0.8412 2.2109 CSV PDB
7.5 -0.8149 2.2109 CSV PDB
8.0 -0.7791 2.2109 CSV PDB
8.5 -0.7362 2.2109 CSV PDB
9.0 -0.6871 2.2109 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH