Cilgavimab / 8d8q

A4DAB064_8d8q_H_L | Source PDB: 8d8q | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6825
Max Score
1.2079
Min Score
-2.9066
Total Score
-166.53
Score CDR
-0.4785
Score non-CDR
-0.7535

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVKPGGSLRLSCAASGFTFRDVWMSWVRQAPGKGLEWVGRIKSKIDGGTTDYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTAGSYYYDTVGPGLPEGKFDYWGQGTLVTVSDIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLMYWASTRESGVPDRFSGSGSGAEFTLTISSLQAEDVAIYYCQQYYSTLTFGGGTKVEIKRT input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.9066
Maximum Score 1.2079
Average Score -0.6825
Total Score -166.5271

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.4367 Soluble
2 V H 0.0000 Buried
3 Q H -1.3653 Soluble
4 L H 0.1469 Aggregation-prone
5 V H 1.1972 Aggregation-prone
6 E H 0.1925 Aggregation-prone
7 S H -0.3885 Soluble
8 G H -0.8607 Soluble
9 G H -0.1043 Soluble
11 G H 0.6481 Aggregation-prone
12 L H 1.2079 Aggregation-prone
13 V H -0.2942 Soluble
14 K H -1.7207 Soluble
15 P H -1.6946 Soluble
16 G H -1.4984 Soluble
17 G H -1.2784 Soluble
18 S H -1.3450 Soluble
19 L H -1.1032 Soluble
20 R H -2.0375 Soluble
21 L H 0.0000 Buried
22 S H -0.4176 Soluble
23 C H 0.0000 Buried
24 A H 0.0886 Aggregation-prone
25 A H -0.4431 Soluble
26 S H -0.5734 Soluble
27 G H -0.9718 Soluble
28 F H -0.6860 Soluble
29 T H -0.5548 Soluble
30 F H 0.0000 Buried
35 R H -1.8415 Soluble
36 D H -1.2511 Soluble
37 V H 0.0000 Buried
38 W H 0.0000 Buried
39 M H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.6791 Soluble
45 A H -1.0094 Soluble
46 P H -0.9023 Soluble
47 G H -1.4602 Soluble
48 K H -2.2906 Soluble
49 G H -1.4303 Soluble
50 L H 0.0000 Buried
51 E H -1.0457 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 G H 0.0000 Buried
55 R H -0.4299 Soluble
56 I H 0.0000 Buried
57 K H -1.0959 Soluble
58 S H 0.0000 Buried
59 K H -1.6711 Soluble
60 I H 0.3139 Aggregation-prone
61 D H -0.8231 Soluble
62 G H -0.9437 Soluble
63 G H -1.0422 Soluble
64 T H -0.9100 Soluble
65 T H -0.5148 Soluble
66 D H -0.7516 Soluble
67 Y H -0.9704 Soluble
68 A H 0.0000 Buried
69 A H -1.1085 Soluble
70 P H -0.9718 Soluble
71 V H 0.0000 Buried
72 K H -2.0972 Soluble
74 G H -1.5576 Soluble
75 R H -1.3956 Soluble
76 F H 0.0000 Buried
77 T H -0.8781 Soluble
78 I H 0.0000 Buried
79 S H -0.5207 Soluble
80 R H -1.1653 Soluble
81 D H -1.7295 Soluble
82 D H -1.9950 Soluble
83 S H -1.6320 Soluble
84 K H -2.3152 Soluble
85 N H -1.9294 Soluble
86 T H -1.0451 Soluble
87 L H 0.0000 Buried
88 Y H -0.5040 Soluble
89 L H 0.0000 Buried
90 Q H -1.1053 Soluble
91 M H 0.0000 Buried
92 N H -1.4359 Soluble
93 S H -1.3279 Soluble
94 L H 0.0000 Buried
95 K H -2.2391 Soluble
96 T H -1.7959 Soluble
97 E H -2.2436 Soluble
98 D H 0.0000 Buried
99 T H -0.4133 Soluble
100 A H 0.0000 Buried
101 V H 0.5338 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 T H 0.0000 Buried
106 T H 0.0000 Buried
107 A H 0.0000 Buried
108 G H 0.0000 Buried
109 S H 0.0000 Buried
110 Y H 0.5605 Aggregation-prone
111 Y H 0.7227 Aggregation-prone
111A Y H 0.7626 Aggregation-prone
111B D H 0.3107 Aggregation-prone
111C T H 0.3707 Aggregation-prone
111D V H 0.2410 Aggregation-prone
112E G H -0.2783 Soluble
112D P H -0.5594 Soluble
112C G H -0.8242 Soluble
112B L H -0.7348 Soluble
112A P H -1.3495 Soluble
112 E H -1.8704 Soluble
113 G H -1.3275 Soluble
114 K H -1.1220 Soluble
115 F H 0.0000 Buried
116 D H 0.0000 Buried
117 Y H 0.0000 Buried
118 W H -0.4812 Soluble
119 G H 0.0000 Buried
120 Q H -1.1965 Soluble
121 G H -0.2767 Soluble
122 T H 0.2756 Aggregation-prone
123 L H 1.0937 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.1999 Aggregation-prone
126 V H 0.0000 Buried
127 S H -0.8512 Soluble
1 D L -1.2501 Soluble
2 I L 0.0711 Aggregation-prone
3 V L 1.0015 Aggregation-prone
4 M L 0.0000 Buried
5 T L -0.9015 Soluble
6 Q L -1.4748 Soluble
7 S L -1.6280 Soluble
8 P L -1.4255 Soluble
9 D L -2.3134 Soluble
10 S L -1.4850 Soluble
11 L L -0.7056 Soluble
12 A L -1.0811 Soluble
13 V L 0.0000 Buried
14 S L -1.4586 Soluble
15 L L -0.8314 Soluble
16 G L -1.3664 Soluble
17 E L -2.5083 Soluble
18 R L -2.7291 Soluble
19 A L 0.0000 Buried
20 T L -0.6493 Soluble
21 I L 0.0000 Buried
22 N L -1.9604 Soluble
23 C L 0.0000 Buried
24 K L -2.3654 Soluble
25 S L 0.0000 Buried
26 S L -0.6634 Soluble
27 Q L -0.7942 Soluble
28 S L -0.7388 Soluble
29 V L 0.0000 Buried
30 L L -0.3240 Soluble
31 Y L -0.4097 Soluble
32 S L -0.9653 Soluble
33 S L -1.3356 Soluble
34 N L -2.2407 Soluble
35 N L -2.3631 Soluble
36 K L -1.9362 Soluble
37 N L -1.0158 Soluble
38 Y L 0.0000 Buried
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.2463 Soluble
46 P L -1.1217 Soluble
47 G L -1.4801 Soluble
48 Q L -2.0924 Soluble
49 P L -1.4377 Soluble
50 P L 0.0000 Buried
51 K L -1.4957 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 M L 0.0000 Buried
55 Y L 0.1361 Aggregation-prone
56 W L -0.0965 Soluble
57 A L 0.0000 Buried
65 S L -0.5696 Soluble
66 T L -0.6448 Soluble
67 R L -1.2894 Soluble
68 E L 0.0000 Buried
69 S L -0.9001 Soluble
70 G L -0.9269 Soluble
71 V L -0.8570 Soluble
72 P L -1.3119 Soluble
74 D L -2.2543 Soluble
75 R L -1.7951 Soluble
76 F L 0.0000 Buried
77 S L -0.8629 Soluble
78 G L -0.4483 Soluble
79 S L -0.8416 Soluble
80 G L -1.3057 Soluble
83 S L -1.2832 Soluble
84 G L -1.2079 Soluble
85 A L -1.6555 Soluble
86 E L -2.9066 Soluble
87 F L 0.0000 Buried
88 T L -1.2487 Soluble
89 L L 0.0000 Buried
90 T L -0.6880 Soluble
91 I L 0.0000 Buried
92 S L -1.6470 Soluble
93 S L -1.7168 Soluble
94 L L 0.0000 Buried
95 Q L -1.6912 Soluble
96 A L -1.0696 Soluble
97 E L -1.8826 Soluble
98 D L 0.0000 Buried
99 V L -0.7632 Soluble
100 A L 0.0000 Buried
101 I L -0.6003 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 Y L 0.3266 Aggregation-prone
114 S L -0.2324 Soluble
115 T L -0.3532 Soluble
116 L L 0.0000 Buried
117 T L -0.0057 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -1.1891 Soluble
121 G L -1.1736 Soluble
122 T L 0.0000 Buried
123 K L -1.6253 Soluble
124 V L 0.0000 Buried
125 E L -1.7088 Soluble
126 I L -1.3515 Soluble
127 K L -2.2340 Soluble
128 R L -2.4593 Soluble
129 T L -1.2217 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6568 2.0857 CSV PDB
4.5 -0.7011 2.0858 CSV PDB
5.0 -0.7523 2.086 CSV PDB
5.5 -0.8009 2.0868 CSV PDB
6.0 -0.8361 2.0889 CSV PDB
6.5 -0.8488 2.0942 CSV PDB
7.0 -0.8379 2.1041 CSV PDB
7.5 -0.8112 2.1177 CSV PDB
8.0 -0.7759 2.1334 CSV PDB
8.5 -0.7338 2.1499 CSV PDB
9.0 -0.6854 2.1664 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH