Cilgavimab / 7l7e

A4DAB064_7l7e_O_P | Source PDB: 7l7e | Chains: O, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7357
Max Score
1.5664
Min Score
-3.5311
Total Score
-333.29
Score CDR
-0.5064
Score non-CDR
-0.7728

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVKPGGSLRLSCAASGFTFRDVWMSWVRQAPGKGLEWVGRIKSKIDGGTTDYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTAGSYYYDTVGPGLPEGKFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLMYWASTRESGVPDRFSGSGSGAEFTLTISSLQAEDVAIYYCQQYYSTLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNRGEC input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5311
Maximum Score 1.5664
Average Score -0.7357
Total Score -333.2911

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E O -2.4404 Soluble
2 V O 0.0000 Buried
3 Q O -1.3664 Soluble
4 L O 0.0000 Buried
5 V O -0.0757 Soluble
6 E O 0.0000 Buried
7 S O -0.5045 Soluble
8 G O -0.6142 Soluble
9 G O -0.3394 Soluble
11 G O -0.1401 Soluble
12 L O 0.0315 Aggregation-prone
13 V O -0.7240 Soluble
14 K O -1.9536 Soluble
15 P O -1.6613 Soluble
16 G O -1.5751 Soluble
17 G O -1.3129 Soluble
18 S O -1.4480 Soluble
19 L O -1.0355 Soluble
20 R O -1.7395 Soluble
21 L O 0.0000 Buried
22 S O -0.4816 Soluble
23 C O 0.0000 Buried
24 A O -0.4038 Soluble
25 A O 0.0000 Buried
26 S O -1.1377 Soluble
27 G O -1.3798 Soluble
28 F O -0.8248 Soluble
29 T O -0.6928 Soluble
30 F O 0.0000 Buried
35 R O -2.3458 Soluble
36 D O -1.2030 Soluble
37 V O 0.0000 Buried
38 W O -0.6987 Soluble
39 M O 0.0000 Buried
40 S O 0.0000 Buried
41 W O 0.0000 Buried
42 V O 0.0000 Buried
43 R O 0.0000 Buried
44 Q O -0.7975 Soluble
45 A O -1.2400 Soluble
46 P O -0.9988 Soluble
47 G O -1.5020 Soluble
48 K O -2.2776 Soluble
49 G O -1.4372 Soluble
50 L O 0.0000 Buried
51 E O -0.9898 Soluble
52 W O 0.0000 Buried
53 V O 0.0000 Buried
54 G O 0.0000 Buried
55 R O -0.5922 Soluble
56 I O 0.0000 Buried
57 K O -1.1633 Soluble
58 S O 0.0000 Buried
59 K O -1.7437 Soluble
60 I O 0.2233 Aggregation-prone
61 D O -0.6673 Soluble
62 G O -0.9182 Soluble
63 G O -1.0330 Soluble
64 T O -0.9794 Soluble
65 T O -0.6367 Soluble
66 D O -1.0567 Soluble
67 Y O -0.8918 Soluble
68 A O -0.9952 Soluble
69 A O -0.9727 Soluble
70 P O -0.9327 Soluble
71 V O 0.0000 Buried
72 K O -2.1018 Soluble
74 G O -1.6197 Soluble
75 R O -1.5939 Soluble
76 F O 0.0000 Buried
77 T O -1.0588 Soluble
78 I O 0.0000 Buried
79 S O -0.3824 Soluble
80 R O -1.2864 Soluble
81 D O -1.6402 Soluble
82 D O -2.1474 Soluble
83 S O -1.7093 Soluble
84 K O -2.2852 Soluble
85 N O -1.9562 Soluble
86 T O 0.0000 Buried
87 L O 0.0000 Buried
88 Y O -0.5147 Soluble
89 L O 0.0000 Buried
90 Q O -1.2646 Soluble
91 M O 0.0000 Buried
92 N O -2.0333 Soluble
93 S O -1.5566 Soluble
94 L O 0.0000 Buried
95 K O -2.2985 Soluble
96 T O -1.8083 Soluble
97 E O -2.2464 Soluble
98 D O 0.0000 Buried
99 T O -0.7151 Soluble
100 A O 0.0000 Buried
101 V O 0.1528 Aggregation-prone
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 T O 0.0000 Buried
106 T O 0.0000 Buried
107 A O 0.0000 Buried
108 G O 0.1343 Aggregation-prone
109 S O 0.0000 Buried
110 Y O 0.3880 Aggregation-prone
111 Y O 0.6105 Aggregation-prone
111A Y O 0.5104 Aggregation-prone
111B D O 0.2328 Aggregation-prone
111C T O 0.0526 Aggregation-prone
111D V O 0.2420 Aggregation-prone
112E G O -0.3018 Soluble
112D P O -0.5362 Soluble
112C G O -0.8732 Soluble
112B L O -0.8394 Soluble
112A P O -1.5337 Soluble
112 E O -2.3773 Soluble
113 G O -1.5500 Soluble
114 K O -1.2142 Soluble
115 F O 0.0000 Buried
116 D O -0.4097 Soluble
117 Y O -0.2719 Soluble
118 W O -0.5093 Soluble
119 G O 0.0000 Buried
120 Q O -1.4307 Soluble
121 G O -0.6828 Soluble
122 T O -0.1928 Soluble
123 L O 0.0618 Aggregation-prone
124 V O 0.0000 Buried
125 T O 0.0000 Buried
126 V O 0.0000 Buried
127 S O -1.0619 Soluble
128 S O -0.8458 Soluble
129 A O -0.4859 Soluble
130 S O -0.5709 Soluble
131 T O -0.6330 Soluble
132 K O -1.1277 Soluble
133 G O -1.3375 Soluble
134 P O -0.5145 Soluble
135 S O -0.1714 Soluble
136 V O 0.0000 Buried
137 F O -0.4791 Soluble
138 P O 0.0000 Buried
139 L O 0.0000 Buried
140 A O -1.2268 Soluble
141 P O 0.0000 Buried
142 S O -0.9531 Soluble
143 S O -0.6901 Soluble
144 K O -0.5485 Soluble
145 S O 0.0000 Buried
146 T O -0.5527 Soluble
147 S O -0.7116 Soluble
148 G O -0.8563 Soluble
149 G O -0.9282 Soluble
150 T O -0.6456 Soluble
151 A O 0.0000 Buried
152 A O 0.0000 Buried
153 L O 0.0000 Buried
154 G O 0.0000 Buried
155 C O 0.0000 Buried
156 L O 0.0000 Buried
157 V O 0.0000 Buried
158 K O 0.0000 Buried
159 D O -0.2900 Soluble
160 Y O 0.0000 Buried
161 F O -0.0387 Soluble
162 P O 0.0000 Buried
163 E O -0.4099 Soluble
164 P O -0.5767 Soluble
165 V O -0.3721 Soluble
166 T O -0.5286 Soluble
167 V O -0.0887 Soluble
168 S O -0.3041 Soluble
169 W O 0.0000 Buried
170 N O -0.6344 Soluble
171 S O -0.5590 Soluble
172 G O -0.3973 Soluble
173 A O -0.1766 Soluble
174 L O 0.0700 Aggregation-prone
175 T O -0.1361 Soluble
176 S O -0.1688 Soluble
177 G O -0.1300 Soluble
178 V O 0.1809 Aggregation-prone
179 H O -0.2473 Soluble
180 T O -0.0458 Soluble
181 F O 0.0000 Buried
182 P O -0.3298 Soluble
183 A O 0.3920 Aggregation-prone
184 V O 0.7120 Aggregation-prone
185 L O 1.5664 Aggregation-prone
186 Q O 0.4390 Aggregation-prone
187 S O -0.0372 Soluble
188 S O -0.1716 Soluble
189 G O 0.1661 Aggregation-prone
190 L O 0.3649 Aggregation-prone
191 Y O 0.7702 Aggregation-prone
192 S O 0.0000 Buried
193 L O 0.2320 Aggregation-prone
194 S O 0.0000 Buried
195 S O 0.0000 Buried
196 V O 0.0000 Buried
197 V O 0.0000 Buried
198 T O -0.1892 Soluble
199 V O 0.0000 Buried
200 P O -0.6754 Soluble
201 S O -0.6974 Soluble
202 S O -0.6113 Soluble
203 S O -0.6972 Soluble
204 L O -0.8034 Soluble
205 G O -0.9995 Soluble
206 T O -0.8542 Soluble
207 Q O -1.5266 Soluble
208 T O -1.2355 Soluble
209 Y O 0.0000 Buried
210 I O -1.1756 Soluble
211 C O 0.0000 Buried
212 N O -1.3400 Soluble
213 V O 0.0000 Buried
214 N O -1.8925 Soluble
215 H O 0.0000 Buried
216 K O -2.7327 Soluble
217 P O -1.4920 Soluble
218 S O -1.7611 Soluble
219 N O -2.5658 Soluble
220 T O -2.0455 Soluble
221 K O -2.6075 Soluble
222 V O -1.5014 Soluble
223 D O -2.1756 Soluble
224 K O -1.8125 Soluble
225 K O -2.3614 Soluble
226 V O 0.0000 Buried
227 E O -2.8062 Soluble
228 P O -1.9090 Soluble
229 K O -2.2129 Soluble
230 S O -1.2725 Soluble
231 C O -1.1307 Soluble
1 D P -1.4921 Soluble
2 I P 0.0000 Buried
3 V P 0.7514 Aggregation-prone
4 M P 0.0000 Buried
5 T P -0.7784 Soluble
6 Q P -1.7359 Soluble
7 S P -1.5409 Soluble
8 P P -1.4910 Soluble
9 D P -2.3999 Soluble
10 S P -1.4760 Soluble
11 L P -0.6471 Soluble
12 A P -0.6208 Soluble
13 V P -0.8616 Soluble
14 S P -0.8902 Soluble
15 L P -0.0681 Soluble
16 G P -1.0801 Soluble
17 E P -2.4789 Soluble
18 R P -2.6837 Soluble
19 A P 0.0000 Buried
20 T P -0.6772 Soluble
21 I P 0.0000 Buried
22 N P -1.9651 Soluble
23 C P 0.0000 Buried
24 K P -2.6855 Soluble
25 S P 0.0000 Buried
26 S P -0.9816 Soluble
27 Q P -1.4793 Soluble
28 S P -0.9390 Soluble
29 V P 0.0000 Buried
30 L P -0.1058 Soluble
31 Y P -0.0316 Soluble
32 S P -0.6479 Soluble
33 S P -0.8402 Soluble
34 N P -1.4442 Soluble
35 N P -1.7465 Soluble
36 K P -1.1383 Soluble
37 N P -0.4359 Soluble
38 Y P 0.0000 Buried
39 L P 0.0000 Buried
40 A P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 Q P 0.0000 Buried
45 K P -2.1626 Soluble
46 P P -1.6510 Soluble
47 G P -1.4598 Soluble
48 Q P -1.9209 Soluble
49 P P -1.4412 Soluble
50 P P 0.0000 Buried
51 K P -1.6990 Soluble
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 M P 0.0000 Buried
55 Y P -0.0765 Soluble
56 W P -0.0959 Soluble
57 A P 0.0000 Buried
65 S P -0.6189 Soluble
66 T P -0.7018 Soluble
67 R P -1.7010 Soluble
68 E P 0.0000 Buried
69 S P -0.9242 Soluble
70 G P -1.0962 Soluble
71 V P 0.0000 Buried
72 P P -1.4314 Soluble
74 D P -2.2848 Soluble
75 R P -1.6193 Soluble
76 F P 0.0000 Buried
77 S P -0.9878 Soluble
78 G P -0.5479 Soluble
79 S P -0.7887 Soluble
80 G P -1.3954 Soluble
83 S P -1.2748 Soluble
84 G P -1.1766 Soluble
85 A P -1.8936 Soluble
86 E P -2.9969 Soluble
87 F P 0.0000 Buried
88 T P -1.2651 Soluble
89 L P 0.0000 Buried
90 T P -0.6892 Soluble
91 I P 0.0000 Buried
92 S P -1.7656 Soluble
93 S P -1.7314 Soluble
94 L P 0.0000 Buried
95 Q P -1.3663 Soluble
96 A P -1.7935 Soluble
97 E P -2.6878 Soluble
98 D P 0.0000 Buried
99 V P -1.1902 Soluble
100 A P 0.0000 Buried
101 I P -0.6830 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 Q P 0.0000 Buried
106 Q P 0.0000 Buried
107 Y P 0.0000 Buried
108 Y P 0.2251 Aggregation-prone
114 S P -0.3228 Soluble
115 T P -0.4307 Soluble
116 L P 0.0000 Buried
117 T P -0.0512 Soluble
118 F P 0.0000 Buried
119 G P 0.0000 Buried
120 G P -1.1745 Soluble
121 G P -1.2070 Soluble
122 T P 0.0000 Buried
123 K P -1.5906 Soluble
124 V P 0.0000 Buried
125 E P -0.5700 Soluble
126 I P 0.0000 Buried
127 K P -1.0853 Soluble
128 R P -0.6262 Soluble
129 T P -0.0043 Soluble
130 V P 0.4981 Aggregation-prone
131 A P -0.0311 Soluble
132 A P -0.3449 Soluble
133 P P 0.0000 Buried
134 S P -0.2683 Soluble
135 V P 0.0000 Buried
136 F P -0.1227 Soluble
137 I P 0.0000 Buried
138 F P 0.0000 Buried
139 P P -0.5724 Soluble
140 P P -0.5943 Soluble
141 S P -1.4126 Soluble
142 D P -2.4030 Soluble
143 E P -2.0929 Soluble
144 Q P 0.0000 Buried
145 L P -1.9376 Soluble
146 K P -2.5091 Soluble
147 S P -1.5998 Soluble
148 G P -1.3529 Soluble
149 T P -1.1940 Soluble
150 A P 0.0000 Buried
151 S P 0.0000 Buried
152 V P 0.0000 Buried
153 V P 0.0000 Buried
154 C P 0.0000 Buried
155 L P 0.0000 Buried
156 L P 0.0000 Buried
157 N P -0.5886 Soluble
158 N P -1.3298 Soluble
159 F P 0.0000 Buried
160 Y P 0.0000 Buried
161 P P 0.0000 Buried
162 R P -2.1705 Soluble
163 E P -2.9126 Soluble
164 A P -2.2209 Soluble
165 K P -2.3940 Soluble
166 V P -1.1742 Soluble
167 Q P -0.7383 Soluble
168 W P 0.0000 Buried
169 K P -0.6295 Soluble
170 V P 0.0000 Buried
171 D P -1.5037 Soluble
172 N P -1.4007 Soluble
173 A P -0.2737 Soluble
174 L P 0.4925 Aggregation-prone
175 Q P -0.5716 Soluble
176 S P -0.7650 Soluble
177 G P -1.2949 Soluble
178 N P -1.6582 Soluble
179 S P -1.4744 Soluble
180 Q P -1.3069 Soluble
181 E P -1.7245 Soluble
182 S P 0.0000 Buried
183 V P -0.3304 Soluble
184 T P -1.0636 Soluble
185 E P -2.1267 Soluble
186 Q P -2.1931 Soluble
187 D P -2.4403 Soluble
188 S P -2.6654 Soluble
189 K P -2.8192 Soluble
190 D P -2.1427 Soluble
191 S P 0.0000 Buried
192 T P 0.0000 Buried
193 Y P 0.0000 Buried
194 S P 0.0000 Buried
195 L P 0.0000 Buried
196 S P 0.0000 Buried
197 S P 0.0000 Buried
198 T P 0.0000 Buried
199 L P 0.0000 Buried
200 T P -0.5790 Soluble
201 L P 0.0000 Buried
202 S P -1.1441 Soluble
203 K P -2.0058 Soluble
204 A P -1.9030 Soluble
205 D P -2.7604 Soluble
206 Y P 0.0000 Buried
207 E P -3.3050 Soluble
208 K P -3.5311 Soluble
209 H P -2.9033 Soluble
210 K P -3.1264 Soluble
211 V P -1.4583 Soluble
212 Y P 0.0000 Buried
213 A P 0.0000 Buried
214 C P 0.0000 Buried
215 E P -0.5216 Soluble
216 V P 0.0000 Buried
217 T P -1.3433 Soluble
218 H P 0.0000 Buried
219 Q P -1.9156 Soluble
220 G P -0.7864 Soluble
221 L P -0.9166 Soluble
222 R P -1.9757 Soluble
223 S P -1.0377 Soluble
224 P P -0.7634 Soluble
225 V P 0.0898 Aggregation-prone
226 T P -0.1839 Soluble
227 K P -0.3711 Soluble
228 S P -0.3709 Soluble
229 F P 0.0000 Buried
230 N P -1.8179 Soluble
231 R P -2.4632 Soluble
232 G P -2.0767 Soluble
233 E P -2.3737 Soluble
234 C P -1.4206 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7464 2.1639 CSV PDB
4.5 -0.7902 2.164 CSV PDB
5.0 -0.8417 2.1641 CSV PDB
5.5 -0.8897 2.1646 CSV PDB
6.0 -0.9213 2.166 CSV PDB
6.5 -0.9264 2.1696 CSV PDB
7.0 -0.9051 2.1764 CSV PDB
7.5 -0.8664 2.186 CSV PDB
8.0 -0.8185 2.1972 CSV PDB
8.5 -0.7642 2.2089 CSV PDB
9.0 -0.7041 2.2208 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH