Sipavibart / 8suo

A4DAB241_8suo_H_L | Source PDB: 8suo | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6979
Max Score
1.6167
Min Score
-3.1185
Total Score
-304.27
Score CDR
-0.4232
Score non-CDR
-0.7375

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGRSLRLSCAASGFPFDDYAIHWVRLAPGKGLEWVSSISWDSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKGAFPGYSSGWYYGLEVWGQGTTVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCSVVTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIFEVSKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYAGNKGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1185
Maximum Score 1.6167
Average Score -0.6979
Total Score -304.2705

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.0495 Soluble
2 V H -1.1112 Soluble
3 Q H -1.4059 Soluble
4 L H 0.0000 Buried
5 V H -0.1048 Soluble
6 E H 0.0000 Buried
7 S H -0.6111 Soluble
8 G H -0.8350 Soluble
9 G H -0.6861 Soluble
11 G H -0.5405 Soluble
12 L H -0.2177 Soluble
13 V H 0.0000 Buried
14 Q H -2.1109 Soluble
15 P H -2.0966 Soluble
16 G H -2.2813 Soluble
17 R H -2.5495 Soluble
18 S H -1.8709 Soluble
19 L H -1.2828 Soluble
20 R H -1.7690 Soluble
21 L H 0.0000 Buried
22 S H -0.5080 Soluble
23 C H 0.0000 Buried
24 A H -0.3925 Soluble
25 A H -0.8310 Soluble
26 S H -0.8987 Soluble
27 G H -1.2105 Soluble
28 F H -0.8911 Soluble
29 P H -1.1175 Soluble
30 F H 0.0000 Buried
35 D H -2.7035 Soluble
36 D H -1.9261 Soluble
37 Y H -0.5768 Soluble
38 A H 0.0000 Buried
39 I H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 L H -0.3395 Soluble
45 A H -1.0544 Soluble
46 P H -1.1110 Soluble
47 G H -1.3954 Soluble
48 K H -2.1232 Soluble
49 G H -1.2241 Soluble
50 L H 0.0000 Buried
51 E H -0.5089 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 S H 0.0000 Buried
56 I H 0.0000 Buried
57 S H 0.0000 Buried
58 W H -1.1428 Soluble
59 D H -2.0889 Soluble
62 S H -1.1182 Soluble
63 G H -0.8514 Soluble
64 S H -0.3479 Soluble
65 I H 0.2712 Aggregation-prone
66 G H -0.4716 Soluble
67 Y H -0.8430 Soluble
68 A H 0.0000 Buried
69 D H -2.5099 Soluble
70 S H -1.8393 Soluble
71 V H 0.0000 Buried
72 K H -2.6336 Soluble
74 G H -1.7344 Soluble
75 R H -1.5196 Soluble
76 F H 0.0000 Buried
77 T H -0.6596 Soluble
78 I H 0.0000 Buried
79 S H -0.2941 Soluble
80 R H -1.1915 Soluble
81 D H -1.5535 Soluble
82 N H -2.2754 Soluble
83 A H -1.5882 Soluble
84 K H -2.4127 Soluble
85 N H -2.0577 Soluble
86 S H -1.2448 Soluble
87 L H 0.0000 Buried
88 Y H -0.5139 Soluble
89 L H 0.0000 Buried
90 Q H -1.1404 Soluble
91 M H 0.0000 Buried
92 N H -1.7621 Soluble
93 S H -1.8127 Soluble
94 L H 0.0000 Buried
95 R H -3.0774 Soluble
96 A H -1.9807 Soluble
97 E H -2.4284 Soluble
98 D H 0.0000 Buried
99 T H -0.9205 Soluble
100 A H 0.0000 Buried
101 L H 0.0891 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 K H 0.0000 Buried
107 G H 0.0000 Buried
108 A H 0.5728 Aggregation-prone
109 F H 1.6167 Aggregation-prone
110 P H 0.3396 Aggregation-prone
111 G H 0.3826 Aggregation-prone
111A Y H -0.0560 Soluble
111B S H -0.3421 Soluble
112C S H 0.6778 Aggregation-prone
112B G H 0.0000 Buried
112A W H 0.0000 Buried
112 Y H 0.6847 Aggregation-prone
113 Y H 0.2310 Aggregation-prone
114 G H 0.0000 Buried
115 L H 0.0000 Buried
116 E H -1.2170 Soluble
117 V H -0.9463 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.6701 Soluble
121 G H -0.8194 Soluble
122 T H -0.3781 Soluble
123 T H -0.3616 Soluble
124 V H 0.0000 Buried
125 T H -0.6717 Soluble
126 V H 0.0000 Buried
127 S H -0.8081 Soluble
128 S H -0.7187 Soluble
129 A H -0.5278 Soluble
130 S H -0.6798 Soluble
131 T H -0.9642 Soluble
132 K H -1.7860 Soluble
133 G H -1.7529 Soluble
134 P H 0.0000 Buried
135 S H -0.3740 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.0544 Soluble
139 L H 0.0000 Buried
140 A H -0.8901 Soluble
141 P H 0.0000 Buried
142 S H -0.8895 Soluble
143 S H -0.7934 Soluble
144 G H -0.6099 Soluble
145 T H -0.4729 Soluble
146 A H -0.3179 Soluble
147 A H -0.0730 Soluble
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H 0.0000 Buried
154 D H -0.5255 Soluble
155 Y H 0.0000 Buried
156 F H -0.5793 Soluble
157 P H 0.0000 Buried
158 E H -1.1959 Soluble
159 P H -1.0729 Soluble
160 V H -0.8008 Soluble
161 T H -0.5848 Soluble
162 V H -0.1274 Soluble
163 S H -0.3944 Soluble
164 W H 0.0000 Buried
165 N H -0.8490 Soluble
166 S H -0.6791 Soluble
167 G H -0.4571 Soluble
168 A H -0.2280 Soluble
169 L H -0.0207 Soluble
170 T H -0.1799 Soluble
171 S H -0.2331 Soluble
172 G H -0.2916 Soluble
173 V H 0.1856 Aggregation-prone
174 H H -0.1203 Soluble
175 T H 0.0271 Aggregation-prone
176 F H 0.0000 Buried
177 P H -0.0763 Soluble
178 A H 0.1490 Aggregation-prone
179 V H 0.0000 Buried
180 L H 1.2916 Aggregation-prone
181 Q H 0.2966 Aggregation-prone
182 S H -0.0994 Soluble
183 S H -0.2214 Soluble
184 G H 0.0533 Aggregation-prone
185 L H -0.1165 Soluble
186 Y H 0.2032 Aggregation-prone
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.1879 Soluble
194 V H 0.0000 Buried
195 P H -0.5069 Soluble
196 S H -0.6127 Soluble
197 S H -0.6387 Soluble
198 S H -0.6189 Soluble
199 L H 0.0000 Buried
200 G H -0.9475 Soluble
201 T H -0.6559 Soluble
202 Q H -0.9800 Soluble
203 T H -1.0461 Soluble
204 Y H 0.0000 Buried
205 I H -1.3542 Soluble
206 C H 0.0000 Buried
207 N H -1.4773 Soluble
208 V H 0.0000 Buried
209 N H -1.8754 Soluble
210 H H 0.0000 Buried
211 K H -2.8809 Soluble
212 P H -1.7956 Soluble
213 S H -2.0072 Soluble
214 N H -2.7050 Soluble
215 T H -2.1773 Soluble
216 K H -2.7241 Soluble
217 V H -1.6767 Soluble
218 D H -2.5953 Soluble
219 K H -2.1601 Soluble
220 R H -2.6000 Soluble
221 V H 0.0000 Buried
222 E H -2.2328 Soluble
223 P H -1.2881 Soluble
224 K H -1.3746 Soluble
225 S H -0.6274 Soluble
226 C H 0.1423 Aggregation-prone
2 S L 0.4772 Aggregation-prone
3 V L 1.5413 Aggregation-prone
4 V L 0.0000 Buried
5 T L 0.1411 Aggregation-prone
6 Q L 0.0000 Buried
7 P L -0.6485 Soluble
8 P L -0.9687 Soluble
9 S L -1.0951 Soluble
11 A L -0.7821 Soluble
12 S L -0.4082 Soluble
13 G L -0.3135 Soluble
14 S L -0.2520 Soluble
15 L L -0.4280 Soluble
16 G L -1.1045 Soluble
17 Q L -1.4679 Soluble
18 S L -0.9506 Soluble
19 V L -0.2822 Soluble
20 T L -0.1062 Soluble
21 I L 0.0000 Buried
22 S L -0.2221 Soluble
23 C L 0.0000 Buried
24 T L -0.2639 Soluble
25 G L -0.1707 Soluble
26 T L -0.4297 Soluble
27 S L -0.6931 Soluble
28 S L -0.4625 Soluble
29 D L 0.0000 Buried
30 V L 0.0000 Buried
31 G L -1.0317 Soluble
35 G L -0.6070 Soluble
36 Y L -0.1921 Soluble
37 N L -0.9103 Soluble
38 Y L 0.0511 Aggregation-prone
39 V L 0.0000 Buried
40 S L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -1.0813 Soluble
44 Q L 0.0000 Buried
45 H L -1.6337 Soluble
46 P L -1.3726 Soluble
47 G L -1.6834 Soluble
48 K L -2.5861 Soluble
49 A L -1.7212 Soluble
50 P L 0.0000 Buried
51 K L -1.8691 Soluble
52 L L 0.0000 Buried
53 M L 0.0000 Buried
54 I L 0.0000 Buried
55 F L -0.9411 Soluble
56 E L -0.9673 Soluble
57 V L -0.9086 Soluble
65 S L -1.6272 Soluble
66 K L -2.7711 Soluble
67 R L -3.1031 Soluble
68 P L -1.6477 Soluble
69 S L -1.0730 Soluble
70 G L -1.1111 Soluble
71 V L 0.0000 Buried
72 P L -1.6384 Soluble
74 D L -2.6651 Soluble
75 R L -1.5146 Soluble
76 F L 0.0000 Buried
77 S L -1.3972 Soluble
78 G L -0.9088 Soluble
79 S L -0.7942 Soluble
80 K L -0.9668 Soluble
83 S L -0.8153 Soluble
84 G L -1.0479 Soluble
85 N L -1.0101 Soluble
86 T L -0.7263 Soluble
87 A L 0.0000 Buried
88 S L -0.3190 Soluble
89 L L 0.0000 Buried
90 T L -0.2178 Soluble
91 V L 0.0000 Buried
92 S L -1.1464 Soluble
93 G L -1.1923 Soluble
94 L L 0.0000 Buried
95 Q L -1.6209 Soluble
96 A L -1.3302 Soluble
97 E L -2.3013 Soluble
98 D L 0.0000 Buried
99 E L -1.2952 Soluble
100 A L 0.0000 Buried
101 D L -1.2624 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 S L 0.0000 Buried
106 S L 0.0000 Buried
107 Y L -0.2112 Soluble
108 A L -0.5017 Soluble
109 G L -0.9552 Soluble
114 N L -1.5356 Soluble
115 K L -1.2319 Soluble
116 G L 0.0000 Buried
117 V L 0.2695 Aggregation-prone
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.4155 Soluble
121 G L -1.1306 Soluble
122 T L 0.0000 Buried
123 K L -2.0653 Soluble
124 L L 0.0000 Buried
125 T L -0.6006 Soluble
126 V L 0.0000 Buried
127 L L 0.5312 Aggregation-prone
128 G L -0.4509 Soluble
129 Q L -0.6488 Soluble
130 P L -1.0496 Soluble
131 K L -2.2616 Soluble
132 A L -1.3121 Soluble
133 A L -0.8469 Soluble
134 P L -0.5935 Soluble
135 S L -0.2393 Soluble
136 V L -0.3647 Soluble
137 T L -0.1060 Soluble
138 L L -0.2465 Soluble
139 F L 0.0000 Buried
140 P L -0.2622 Soluble
141 P L 0.0000 Buried
142 S L -0.9068 Soluble
143 S L -1.4762 Soluble
144 E L -2.3051 Soluble
145 E L 0.0000 Buried
146 L L -1.9615 Soluble
147 Q L -2.3146 Soluble
148 A L -1.8324 Soluble
149 N L -2.5687 Soluble
150 K L -2.3776 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.6348 Soluble
159 D L -1.2827 Soluble
160 F L 0.0000 Buried
161 Y L -1.0901 Soluble
162 P L -0.7406 Soluble
163 G L -0.5211 Soluble
164 A L -0.1343 Soluble
165 V L -0.0128 Soluble
166 T L -0.0379 Soluble
167 V L 0.1201 Aggregation-prone
168 A L -0.4449 Soluble
169 W L 0.0000 Buried
170 K L -1.2539 Soluble
171 A L 0.0000 Buried
172 D L -1.7902 Soluble
173 S L -1.0989 Soluble
174 S L -0.7619 Soluble
175 P L -0.9879 Soluble
176 V L -0.8814 Soluble
177 K L -1.6093 Soluble
178 A L -0.7444 Soluble
179 G L -0.5326 Soluble
180 V L -0.2934 Soluble
181 E L -0.1644 Soluble
182 T L 0.1138 Aggregation-prone
183 T L 0.0849 Aggregation-prone
184 T L -0.1095 Soluble
185 P L -0.2344 Soluble
186 S L -0.5459 Soluble
187 K L -1.1192 Soluble
188 Q L -1.3237 Soluble
189 S L -1.2166 Soluble
190 N L -1.4002 Soluble
191 N L -1.5309 Soluble
192 K L -1.4189 Soluble
193 Y L -0.7207 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.4599 Soluble
201 L L 0.0000 Buried
202 T L -1.8085 Soluble
203 P L -2.4128 Soluble
204 E L -3.1185 Soluble
205 Q L -2.5190 Soluble
206 W L 0.0000 Buried
207 K L -3.0937 Soluble
208 S L -2.5466 Soluble
209 H L -2.5863 Soluble
210 R L -2.8195 Soluble
211 S L -1.9748 Soluble
212 Y L 0.0000 Buried
213 S L 0.0000 Buried
214 C L 0.0000 Buried
215 Q L -1.0214 Soluble
216 V L 0.0000 Buried
217 T L -0.6676 Soluble
218 H L 0.0000 Buried
219 E L -2.3026 Soluble
220 G L -1.4438 Soluble
221 S L -0.9488 Soluble
222 T L -0.8296 Soluble
223 V L -0.6849 Soluble
224 E L -1.9386 Soluble
225 K L -1.6539 Soluble
226 T L -1.0425 Soluble
227 V L 0.0000 Buried
228 A L 0.0000 Buried
229 P L -1.5451 Soluble
230 T L -1.2890 Soluble
231 E L -1.7111 Soluble
232 C L -0.8038 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.634 5.0022 CSV PDB
4.5 -0.6741 4.936 CSV PDB
5.0 -0.7215 4.8551 CSV PDB
5.5 -0.7671 4.7709 CSV PDB
6.0 -0.7995 4.6925 CSV PDB
6.5 -0.8091 4.6274 CSV PDB
7.0 -0.7956 4.5766 CSV PDB
7.5 -0.7678 4.5345 CSV PDB
8.0 -0.7327 4.4968 CSV PDB
8.5 -0.6928 4.4631 CSV PDB
9.0 -0.6478 4.4358 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH