Tamrintamab / 6vgr

A4DAB254_6vgr_C_D | Source PDB: 6vgr | Chains: C, D | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6527
Max Score
2.0612
Min Score
-3.6271
Total Score
-281.29
Score CDR
-0.1378
Score non-CDR
-0.7218

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYWIEWVRQAPGQGLEWMGEILPGSGNTYYNERFKDRVTITADESTSTAYMELSSLRSEDTAVYYCARRAAAYYSNPEWFAYWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPEIVLTQSPATLSLSPGERATLSCTASSSVNSFYLHWYQQKPGLAPRLLIYSTSNLASGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCHQYHRSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) C (Heavy), D (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6271
Maximum Score 2.0612
Average Score -0.6527
Total Score -281.293

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q C -1.5174 Soluble
2 V C -0.9279 Soluble
3 Q C -1.1768 Soluble
4 L C 0.0000 Buried
5 V C 0.0795 Aggregation-prone
6 Q C 0.0000 Buried
7 S C -0.5243 Soluble
8 G C -0.5204 Soluble
9 A C -0.0485 Soluble
11 E C -0.5132 Soluble
12 V C -0.2657 Soluble
13 K C -1.6023 Soluble
14 K C -2.3765 Soluble
15 P C -1.8496 Soluble
16 G C -1.4089 Soluble
17 S C -1.1764 Soluble
18 S C -1.2155 Soluble
19 V C 0.0000 Buried
20 K C -1.9808 Soluble
21 V C 0.0000 Buried
22 S C -0.5609 Soluble
23 C C 0.0000 Buried
24 K C -0.7552 Soluble
25 A C -0.5703 Soluble
26 S C -0.9424 Soluble
27 G C -1.2289 Soluble
28 G C -0.9391 Soluble
29 T C -0.5425 Soluble
30 F C -0.7327 Soluble
35 S C -0.5959 Soluble
36 S C -0.1713 Soluble
37 Y C -0.0136 Soluble
38 W C 0.0000 Buried
39 I C 0.0000 Buried
40 E C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C -0.5021 Soluble
45 A C -0.9033 Soluble
46 P C -0.9679 Soluble
47 G C -1.3647 Soluble
48 Q C -1.8819 Soluble
49 G C -1.3859 Soluble
50 L C 0.0000 Buried
51 E C -0.6265 Soluble
52 W C 0.0000 Buried
53 M C 0.0000 Buried
54 G C 0.0000 Buried
55 E C 0.0000 Buried
56 I C 0.0000 Buried
57 L C -0.2375 Soluble
58 P C 0.0000 Buried
59 G C -1.1762 Soluble
62 S C -0.8632 Soluble
63 G C -1.1478 Soluble
64 N C -0.9895 Soluble
65 T C 0.0158 Aggregation-prone
66 Y C 0.5263 Aggregation-prone
67 Y C -0.7090 Soluble
68 N C -1.7453 Soluble
69 E C -3.4767 Soluble
70 R C -3.4973 Soluble
71 F C 0.0000 Buried
72 K C -3.5464 Soluble
74 D C -3.2107 Soluble
75 R C -1.9500 Soluble
76 V C 0.0000 Buried
77 T C -0.9226 Soluble
78 I C 0.0000 Buried
79 T C -0.7367 Soluble
80 A C -1.1200 Soluble
81 D C -1.8700 Soluble
82 E C -2.4227 Soluble
83 S C -1.3574 Soluble
84 T C -1.1022 Soluble
85 S C -1.3186 Soluble
86 T C 0.0000 Buried
87 A C 0.0000 Buried
88 Y C -0.6075 Soluble
89 M C 0.0000 Buried
90 E C -1.5101 Soluble
91 L C 0.0000 Buried
92 S C -1.1883 Soluble
93 S C -1.0818 Soluble
94 L C 0.0000 Buried
95 R C -2.1606 Soluble
96 S C -1.9577 Soluble
97 E C -2.2329 Soluble
98 D C 0.0000 Buried
99 T C -0.7400 Soluble
100 A C 0.0000 Buried
101 V C 0.2854 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C 0.0000 Buried
107 R C -0.2008 Soluble
108 A C 0.2154 Aggregation-prone
109 A C 0.4522 Aggregation-prone
110 A C 0.9198 Aggregation-prone
111 Y C 1.9352 Aggregation-prone
111A Y C 2.0612 Aggregation-prone
112B S C 0.7353 Aggregation-prone
112A N C 0.6648 Aggregation-prone
112 P C -0.3445 Soluble
113 E C -0.3132 Soluble
114 W C 0.0000 Buried
115 F C 0.0000 Buried
116 A C -0.2528 Soluble
117 Y C -0.0276 Soluble
118 W C -0.0426 Soluble
119 G C 0.0000 Buried
120 Q C -0.8271 Soluble
121 G C -0.1678 Soluble
122 T C 0.0000 Buried
123 L C 0.7015 Aggregation-prone
124 V C 0.0000 Buried
125 T C 0.0000 Buried
126 V C 0.0000 Buried
127 S C -1.4166 Soluble
128 S C -0.8781 Soluble
129 A C -0.6451 Soluble
130 S C -0.7366 Soluble
131 T C -0.5813 Soluble
132 K C -1.0455 Soluble
133 G C -1.2235 Soluble
134 P C -0.5126 Soluble
135 S C -0.1964 Soluble
136 V C 0.0000 Buried
137 F C 0.0000 Buried
138 P C -1.2103 Soluble
139 L C 0.0000 Buried
140 A C -0.5234 Soluble
141 P C -0.3007 Soluble
142 S C -0.2168 Soluble
143 G C -0.6189 Soluble
144 T C -0.4539 Soluble
145 A C -0.1557 Soluble
146 A C 0.0000 Buried
147 L C 0.0000 Buried
148 G C 0.0000 Buried
149 C C 0.0000 Buried
150 L C 0.0000 Buried
151 V C 0.0000 Buried
152 K C 0.0000 Buried
153 D C -0.3248 Soluble
154 Y C 0.0000 Buried
155 F C 0.0000 Buried
156 P C 0.0000 Buried
157 E C -0.3553 Soluble
158 P C -0.6982 Soluble
159 V C -0.5105 Soluble
160 T C -0.6689 Soluble
161 V C -0.2871 Soluble
162 S C -0.4538 Soluble
163 W C 0.0000 Buried
164 N C -0.7708 Soluble
165 S C -0.7158 Soluble
166 G C -0.5710 Soluble
167 A C -0.2091 Soluble
168 L C 0.0700 Aggregation-prone
169 T C -0.0691 Soluble
170 S C -0.1004 Soluble
171 G C -0.0286 Soluble
172 V C 0.2393 Aggregation-prone
173 H C -0.1322 Soluble
174 T C 0.0054 Aggregation-prone
175 F C 0.0000 Buried
176 P C -0.3102 Soluble
177 A C 0.4277 Aggregation-prone
178 V C 0.5568 Aggregation-prone
179 L C 1.3285 Aggregation-prone
180 Q C 0.3526 Aggregation-prone
181 S C -0.1157 Soluble
182 S C -0.1618 Soluble
183 G C 0.1279 Aggregation-prone
184 L C 0.1559 Aggregation-prone
185 Y C 0.4603 Aggregation-prone
186 S C 0.3403 Aggregation-prone
187 L C 0.3446 Aggregation-prone
188 S C 0.0000 Buried
189 S C 0.0000 Buried
190 V C 0.0000 Buried
191 V C 0.0000 Buried
192 T C -0.0187 Soluble
193 V C 0.0262 Aggregation-prone
194 P C -0.3310 Soluble
195 S C -0.4170 Soluble
196 S C -0.4326 Soluble
197 S C -0.3235 Soluble
198 L C -0.2543 Soluble
199 G C -0.7939 Soluble
200 T C -0.5569 Soluble
201 Q C -0.9129 Soluble
202 T C -1.0031 Soluble
203 Y C 0.0000 Buried
204 I C -1.2444 Soluble
205 C C 0.0000 Buried
206 N C -1.4014 Soluble
207 V C 0.0000 Buried
208 N C -1.9614 Soluble
209 H C 0.0000 Buried
210 K C -2.7300 Soluble
211 P C -1.5948 Soluble
212 S C -1.8676 Soluble
213 N C -2.3820 Soluble
214 T C -1.8422 Soluble
215 K C -2.2768 Soluble
216 V C -0.4763 Soluble
217 D C -2.1039 Soluble
218 K C -1.6418 Soluble
219 K C -2.6235 Soluble
220 V C 0.0000 Buried
221 E C -2.2763 Soluble
222 P C -1.0974 Soluble
1 E D -1.5633 Soluble
2 I D 0.0000 Buried
3 V D 1.1114 Aggregation-prone
4 L D 0.0000 Buried
5 T D -0.0233 Soluble
6 Q D 0.0000 Buried
7 S D -0.4143 Soluble
8 P D -0.3753 Soluble
9 A D -0.5379 Soluble
10 T D -0.5186 Soluble
11 L D -0.3192 Soluble
12 S D -0.5178 Soluble
13 L D -0.9726 Soluble
14 S D -1.6787 Soluble
15 P D -2.2089 Soluble
16 G D -2.4899 Soluble
17 E D -2.9553 Soluble
18 R D -3.0159 Soluble
19 A D 0.0000 Buried
20 T D -0.5449 Soluble
21 L D 0.0000 Buried
22 S D -0.6067 Soluble
23 C D 0.0000 Buried
24 T D -0.6187 Soluble
25 A D 0.0000 Buried
26 S D -0.0385 Soluble
27 S D -0.4056 Soluble
28 S D -0.9530 Soluble
29 V D 0.0000 Buried
30 N D -0.3138 Soluble
36 S D 0.1854 Aggregation-prone
37 F D 1.8122 Aggregation-prone
38 Y D 0.8701 Aggregation-prone
39 L D 0.0000 Buried
40 H D 0.0000 Buried
41 W D 0.0000 Buried
42 Y D 0.0000 Buried
43 Q D 0.0000 Buried
44 Q D 0.0000 Buried
45 K D -0.6662 Soluble
46 P D -0.6936 Soluble
47 G D -0.4233 Soluble
48 L D -0.0399 Soluble
49 A D -0.3224 Soluble
50 P D 0.0000 Buried
51 R D -1.1134 Soluble
52 L D 0.0000 Buried
53 L D 0.0000 Buried
54 I D 0.0000 Buried
55 Y D 0.2236 Aggregation-prone
56 S D 0.5808 Aggregation-prone
57 T D 0.0000 Buried
65 S D -0.4630 Soluble
66 N D -0.8310 Soluble
67 L D -0.3578 Soluble
68 A D -0.2981 Soluble
69 S D -0.3508 Soluble
70 G D -0.5537 Soluble
71 I D -0.3165 Soluble
72 P D -0.9364 Soluble
74 D D -2.1522 Soluble
75 R D -1.8697 Soluble
76 F D 0.0000 Buried
77 S D -0.7971 Soluble
78 G D -0.5222 Soluble
79 S D -0.8809 Soluble
80 G D -1.0881 Soluble
83 S D -1.0086 Soluble
84 G D -1.1896 Soluble
85 T D -1.3383 Soluble
86 D D -2.0893 Soluble
87 F D 0.0000 Buried
88 T D -0.6972 Soluble
89 L D 0.0000 Buried
90 T D -0.7867 Soluble
91 I D 0.0000 Buried
92 S D -2.5618 Soluble
93 R D -3.4449 Soluble
94 L D 0.0000 Buried
95 E D -2.5440 Soluble
96 P D -1.8812 Soluble
97 E D -2.2494 Soluble
98 D D 0.0000 Buried
99 F D -0.8990 Soluble
100 A D 0.0000 Buried
101 V D -0.5402 Soluble
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 H D 0.0000 Buried
106 Q D 0.0000 Buried
107 Y D -0.1512 Soluble
108 H D -0.6580 Soluble
109 R D -1.6621 Soluble
114 S D -1.1865 Soluble
115 P D -1.2655 Soluble
116 Y D -0.3678 Soluble
117 T D -0.2709 Soluble
118 F D 0.0000 Buried
119 G D 0.0000 Buried
120 Q D -1.7159 Soluble
121 G D 0.0000 Buried
122 T D 0.0000 Buried
123 K D -1.3898 Soluble
124 L D 0.0000 Buried
125 E D -0.8682 Soluble
126 I D -0.8066 Soluble
127 K D -1.3413 Soluble
128 R D -1.1323 Soluble
129 T D -0.2298 Soluble
130 V D 0.2775 Aggregation-prone
131 A D -0.2285 Soluble
132 A D -0.1577 Soluble
133 P D 0.0000 Buried
134 S D -0.0074 Soluble
135 V D 0.1126 Aggregation-prone
136 F D 0.2707 Aggregation-prone
137 I D 0.1999 Aggregation-prone
138 F D 0.0000 Buried
139 P D -0.6595 Soluble
140 P D 0.0000 Buried
141 S D -1.6472 Soluble
142 D D -3.0184 Soluble
143 E D -3.2319 Soluble
144 Q D 0.0000 Buried
145 L D -2.3871 Soluble
146 K D -2.8702 Soluble
147 S D -1.7544 Soluble
148 G D -1.2534 Soluble
149 T D -0.7552 Soluble
150 A D 0.0000 Buried
151 S D 0.0000 Buried
152 V D 0.0000 Buried
153 V D 0.0000 Buried
154 C D 0.0000 Buried
155 L D 0.0000 Buried
156 L D 0.0000 Buried
157 N D 0.0000 Buried
158 N D -0.7824 Soluble
159 F D 0.0000 Buried
160 Y D 0.0000 Buried
161 P D -1.6933 Soluble
162 R D -2.9489 Soluble
163 E D -3.0977 Soluble
164 A D -2.3158 Soluble
165 K D -2.3351 Soluble
166 V D -1.4894 Soluble
167 Q D -0.9580 Soluble
168 W D 0.0000 Buried
169 K D -0.7813 Soluble
170 V D 0.0000 Buried
171 D D -1.4576 Soluble
172 N D -1.3394 Soluble
173 A D -0.4693 Soluble
174 L D 0.0114 Aggregation-prone
175 Q D -0.4875 Soluble
176 S D -0.5882 Soluble
177 G D -0.8367 Soluble
178 N D -0.6971 Soluble
179 S D -1.0704 Soluble
180 Q D -1.2408 Soluble
181 E D -1.9120 Soluble
182 S D -0.8276 Soluble
183 V D -0.8995 Soluble
184 T D -1.1605 Soluble
185 E D -2.2147 Soluble
186 Q D -1.8434 Soluble
187 D D -1.8484 Soluble
188 S D -1.7351 Soluble
189 K D -2.3511 Soluble
190 D D -1.9851 Soluble
191 S D -1.8019 Soluble
192 T D 0.0000 Buried
193 Y D 0.0000 Buried
194 S D 0.0000 Buried
195 L D 0.0000 Buried
196 S D 0.0000 Buried
197 S D 0.0000 Buried
198 T D -0.5859 Soluble
199 L D 0.0000 Buried
200 T D -0.1674 Soluble
201 L D -0.2824 Soluble
202 S D -0.9607 Soluble
203 K D -2.2759 Soluble
204 A D -1.6266 Soluble
205 D D -2.2050 Soluble
206 Y D 0.0000 Buried
207 E D -3.6271 Soluble
208 K D -3.4779 Soluble
209 H D -2.7713 Soluble
210 K D -2.7950 Soluble
211 V D -1.1216 Soluble
212 Y D 0.0000 Buried
213 A D 0.0000 Buried
214 C D 0.0000 Buried
215 E D -0.9676 Soluble
216 V D 0.0000 Buried
217 T D -1.2921 Soluble
218 H D 0.0000 Buried
219 Q D -1.5780 Soluble
220 G D -0.5091 Soluble
221 L D -0.2650 Soluble
222 S D -0.4760 Soluble
223 S D -0.4387 Soluble
224 P D -0.5149 Soluble
225 V D 0.0012 Aggregation-prone
226 T D -0.5420 Soluble
227 K D -0.8282 Soluble
228 S D -0.5977 Soluble
229 F D -0.9936 Soluble
230 N D -2.0551 Soluble
231 R D -2.6080 Soluble
232 G D -2.2871 Soluble
233 E D -2.3573 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6009 3.7179 CSV PDB
4.5 -0.6463 3.729 CSV PDB
5.0 -0.7018 3.746 CSV PDB
5.5 -0.7567 3.7624 CSV PDB
6.0 -0.7991 3.7726 CSV PDB
6.5 -0.8182 3.777 CSV PDB
7.0 -0.8114 3.7786 CSV PDB
7.5 -0.7861 3.7791 CSV PDB
8.0 -0.7506 3.7791 CSV PDB
8.5 -0.7086 3.7785 CSV PDB
9.0 -0.6611 3.7766 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH