Bexatamig / 6ias

A4DAB045_6ias_H_L | Source PDB: 6ias | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7594
Max Score
1.1548
Min Score
-3.7461
Total Score
-325.04
Score CDR
-0.5553
Score non-CDR
-0.7846

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGSSVKVSCKASGYTFSDYVINWVRQAPGQGLEWMGEIYPGSGTNYYNEKFKAKATITADKSTSTAYMELSSLRSEDTAVYYCARRGRYGLYAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTGGTAALGCLVKDYFPEPVTVSWNSGALTGGVHTFPAVLQSSGLYSLSSVVTVPSSSTQTYICNVNHKPSNTKVDKRVEPDIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQQGNTRPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7461
Maximum Score 1.1548
Average Score -0.7594
Total Score -325.0374

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.5658 Soluble
2 V H -1.0775 Soluble
3 Q H -1.4000 Soluble
4 L H 0.0000 Buried
5 V H 0.4908 Aggregation-prone
6 Q H 0.0000 Buried
7 S H -0.6053 Soluble
8 G H -1.2344 Soluble
9 A H -1.1470 Soluble
11 E H -1.6312 Soluble
12 V H -1.0649 Soluble
13 K H -1.9378 Soluble
14 K H -2.7072 Soluble
15 P H -2.4146 Soluble
16 G H -1.7395 Soluble
17 S H -1.4037 Soluble
18 S H -1.4513 Soluble
19 V H 0.0000 Buried
20 K H -2.0165 Soluble
21 V H 0.0000 Buried
22 S H -0.5781 Soluble
23 C H 0.0000 Buried
24 K H -1.0302 Soluble
25 A H 0.0000 Buried
26 S H -0.9547 Soluble
27 G H -1.0910 Soluble
28 Y H -0.7145 Soluble
29 T H -0.8685 Soluble
30 F H 0.0000 Buried
35 S H -1.5883 Soluble
36 D H -2.0449 Soluble
37 Y H 0.0000 Buried
38 V H 0.0000 Buried
39 I H 0.0000 Buried
40 N H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.6099 Soluble
45 A H 0.0000 Buried
46 P H -1.1004 Soluble
47 G H -1.2875 Soluble
48 Q H -1.7390 Soluble
49 G H -1.1346 Soluble
50 L H 0.0000 Buried
51 E H -0.7737 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 E H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H -0.3048 Soluble
58 P H 0.0000 Buried
59 G H -1.2340 Soluble
62 S H -0.6763 Soluble
63 G H -0.8962 Soluble
64 T H -0.2795 Soluble
65 N H -0.1079 Soluble
66 Y H -0.1060 Soluble
67 Y H -0.9516 Soluble
68 N H 0.0000 Buried
69 E H -3.3285 Soluble
70 K H -3.0043 Soluble
71 F H 0.0000 Buried
72 K H -2.5530 Soluble
74 A H -1.4121 Soluble
75 K H -1.3712 Soluble
76 A H 0.0000 Buried
77 T H -0.9059 Soluble
78 I H 0.0000 Buried
79 T H -0.5496 Soluble
80 A H -1.1195 Soluble
81 D H -1.9539 Soluble
82 K H -2.3933 Soluble
83 S H -1.3190 Soluble
84 T H -1.1749 Soluble
85 S H -1.3833 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.7037 Soluble
89 M H 0.0000 Buried
90 E H -1.6296 Soluble
91 L H 0.0000 Buried
92 S H -1.1109 Soluble
93 S H -1.2483 Soluble
94 L H 0.0000 Buried
95 R H -3.1656 Soluble
96 S H -2.3842 Soluble
97 E H -2.5857 Soluble
98 D H 0.0000 Buried
99 T H -1.1114 Soluble
100 A H 0.0000 Buried
101 V H 0.0924 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 R H 0.0000 Buried
108 G H 0.0000 Buried
109 R H -1.5323 Soluble
110 Y H 0.1586 Aggregation-prone
111 G H -0.0054 Soluble
112 L H -0.1018 Soluble
113 Y H 0.2898 Aggregation-prone
114 A H 0.0000 Buried
115 M H 0.0000 Buried
116 D H 0.0000 Buried
117 Y H -0.1781 Soluble
118 W H -0.3885 Soluble
119 G H 0.0000 Buried
120 Q H -1.3631 Soluble
121 G H -0.6941 Soluble
122 T H 0.0000 Buried
123 T H -0.4128 Soluble
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.3806 Soluble
128 S H -1.0231 Soluble
129 A H -0.6427 Soluble
130 S H -0.7823 Soluble
131 T H -0.9741 Soluble
132 K H -1.2771 Soluble
133 G H -1.3796 Soluble
134 P H 0.0000 Buried
135 S H -0.3884 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1602 Soluble
139 L H 0.0000 Buried
140 A H -0.8719 Soluble
141 P H 0.0000 Buried
142 S H -0.9075 Soluble
143 S H -1.2224 Soluble
144 K H -1.9582 Soluble
145 S H -1.2652 Soluble
146 T H -0.9791 Soluble
147 G H -0.6608 Soluble
148 G H -0.5806 Soluble
149 T H -0.4703 Soluble
150 A H -0.5572 Soluble
151 A H 0.0000 Buried
152 L H 0.0000 Buried
153 G H 0.0000 Buried
154 C H 0.0000 Buried
155 L H 0.0000 Buried
156 V H 0.0000 Buried
157 K H 0.0000 Buried
158 D H -0.4046 Soluble
159 Y H 0.0000 Buried
160 F H 0.0000 Buried
161 P H 0.0000 Buried
162 E H -0.5990 Soluble
163 P H -0.8941 Soluble
164 V H -0.6136 Soluble
165 T H -0.5031 Soluble
166 V H -0.1364 Soluble
167 S H -0.3689 Soluble
168 W H 0.0000 Buried
169 N H -0.7334 Soluble
170 S H -0.6522 Soluble
171 G H -0.5172 Soluble
172 A H -0.2673 Soluble
173 L H -0.0387 Soluble
174 T H -0.2773 Soluble
175 G H -0.4243 Soluble
176 G H -0.3271 Soluble
177 V H 0.0832 Aggregation-prone
178 H H -0.3292 Soluble
179 T H -0.1464 Soluble
180 F H 0.0000 Buried
181 P H -0.3504 Soluble
182 A H 0.2767 Aggregation-prone
183 V H 0.6342 Aggregation-prone
184 L H 1.1548 Aggregation-prone
185 Q H 0.2902 Aggregation-prone
186 S H -0.0670 Soluble
187 S H -0.2271 Soluble
188 G H 0.0144 Aggregation-prone
189 L H 0.1272 Aggregation-prone
190 Y H 0.4109 Aggregation-prone
191 S H 0.0000 Buried
192 L H 0.0000 Buried
193 S H 0.0000 Buried
194 S H 0.0000 Buried
195 V H 0.0000 Buried
196 V H 0.0000 Buried
197 T H -0.2211 Soluble
198 V H 0.0000 Buried
199 P H -0.4857 Soluble
200 S H -0.5777 Soluble
201 S H -0.6202 Soluble
202 S H -0.9074 Soluble
203 T H -0.6807 Soluble
204 Q H -1.3972 Soluble
205 T H -1.2346 Soluble
206 Y H 0.0000 Buried
207 I H -1.1981 Soluble
208 C H 0.0000 Buried
209 N H -1.4492 Soluble
210 V H 0.0000 Buried
211 N H -1.8096 Soluble
212 H H 0.0000 Buried
213 K H -2.9148 Soluble
214 P H -1.9151 Soluble
215 S H -1.9132 Soluble
216 N H -2.6492 Soluble
217 T H -2.0400 Soluble
218 K H -2.6174 Soluble
219 V H -1.6087 Soluble
220 D H -2.5688 Soluble
221 K H -2.1542 Soluble
222 R H -2.7556 Soluble
223 V H 0.0000 Buried
224 E H -2.5426 Soluble
225 P H -1.4050 Soluble
1 D L -2.6768 Soluble
2 I L 0.0000 Buried
3 Q L -2.2717 Soluble
4 M L 0.0000 Buried
5 T L -1.3541 Soluble
6 Q L -1.0073 Soluble
7 S L -0.6933 Soluble
8 P L -0.5266 Soluble
9 S L -0.6822 Soluble
10 S L -0.7286 Soluble
11 L L -0.5713 Soluble
12 S L -0.8347 Soluble
13 A L -1.2116 Soluble
14 S L -1.0711 Soluble
15 V L -0.1786 Soluble
16 G L -0.9199 Soluble
17 D L -1.9940 Soluble
18 R L -2.4821 Soluble
19 V L 0.0000 Buried
20 T L -0.6714 Soluble
21 I L 0.0000 Buried
22 T L -0.8363 Soluble
23 C L 0.0000 Buried
24 R L -3.0111 Soluble
25 A L 0.0000 Buried
26 S L -2.3786 Soluble
27 Q L -3.0558 Soluble
28 D L -2.9860 Soluble
29 I L 0.0000 Buried
36 S L -1.1798 Soluble
37 N L -0.6377 Soluble
38 Y L -0.0137 Soluble
39 L L 0.0000 Buried
40 N L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.7990 Soluble
46 P L -1.4656 Soluble
47 G L -1.6094 Soluble
48 K L -2.4939 Soluble
49 A L -1.5967 Soluble
50 P L 0.0000 Buried
51 K L -1.4603 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.0000 Buried
56 Y L 0.1203 Aggregation-prone
57 T L 0.0000 Buried
65 S L -0.8791 Soluble
66 R L -1.4499 Soluble
67 L L -0.4740 Soluble
68 H L -0.6436 Soluble
69 S L -0.5226 Soluble
70 G L -0.4947 Soluble
71 V L -0.3302 Soluble
72 P L -0.3506 Soluble
74 S L -0.5585 Soluble
75 R L -0.7673 Soluble
76 F L 0.0000 Buried
77 S L -0.5978 Soluble
78 G L -0.5231 Soluble
79 S L -0.7844 Soluble
80 G L -1.0062 Soluble
83 S L -1.2671 Soluble
84 G L -1.8411 Soluble
85 T L -2.3701 Soluble
86 D L -2.4165 Soluble
87 F L 0.0000 Buried
88 T L -0.7587 Soluble
89 F L 0.0000 Buried
90 T L -0.6053 Soluble
91 I L 0.0000 Buried
92 S L -1.3726 Soluble
93 S L -1.2524 Soluble
94 L L 0.0000 Buried
95 Q L -1.1123 Soluble
96 P L -1.4019 Soluble
97 E L -1.8492 Soluble
98 D L 0.0000 Buried
99 I L 0.0000 Buried
100 A L 0.0000 Buried
101 T L -0.7402 Soluble
102 Y L 0.0000 Buried
103 F L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 G L 0.0000 Buried
108 N L -1.0743 Soluble
109 T L -1.1103 Soluble
114 R L -1.6467 Soluble
115 P L -1.5903 Soluble
116 W L 0.0000 Buried
117 T L -0.8718 Soluble
118 F L -0.2606 Soluble
119 G L 0.0000 Buried
120 G L -1.0885 Soluble
121 G L -0.6300 Soluble
122 T L 0.0000 Buried
123 K L -1.2456 Soluble
124 V L 0.0000 Buried
125 E L -1.3850 Soluble
126 I L 0.0000 Buried
127 K L -1.5890 Soluble
128 R L -1.0342 Soluble
129 T L -0.2073 Soluble
130 V L 0.1932 Aggregation-prone
131 A L 0.0977 Aggregation-prone
132 A L -0.1329 Soluble
133 P L 0.0000 Buried
134 S L -0.1400 Soluble
135 V L 0.0000 Buried
136 F L -0.0467 Soluble
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.8112 Soluble
140 P L -0.9088 Soluble
141 S L -1.4859 Soluble
142 D L -2.7608 Soluble
143 E L -2.6060 Soluble
144 Q L 0.0000 Buried
145 L L -2.1612 Soluble
146 K L -2.7403 Soluble
147 S L -1.7187 Soluble
148 G L -1.2556 Soluble
149 T L -1.0446 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.8573 Soluble
159 F L 0.0000 Buried
160 Y L -1.1085 Soluble
161 P L -1.7638 Soluble
162 R L -2.8895 Soluble
163 E L -3.1979 Soluble
164 A L -2.2280 Soluble
165 K L -2.0389 Soluble
166 V L -0.8857 Soluble
167 Q L -0.4557 Soluble
168 W L 0.0000 Buried
169 K L -0.5262 Soluble
170 V L 0.0000 Buried
171 D L -1.8672 Soluble
172 N L -1.5103 Soluble
173 A L -0.2470 Soluble
174 L L 0.7314 Aggregation-prone
175 Q L -0.0949 Soluble
176 S L -0.4690 Soluble
177 G L -0.8590 Soluble
178 N L -0.7296 Soluble
179 S L -0.9415 Soluble
180 Q L -1.1142 Soluble
181 E L -1.4230 Soluble
182 S L -0.7732 Soluble
183 V L -0.7460 Soluble
184 T L -1.0916 Soluble
185 E L -2.0913 Soluble
186 Q L 0.0000 Buried
187 D L -1.8904 Soluble
188 S L -2.1520 Soluble
189 K L -2.5010 Soluble
190 D L -1.7154 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.5497 Soluble
199 L L 0.0000 Buried
200 T L -0.4357 Soluble
201 L L -0.7323 Soluble
202 S L -1.1568 Soluble
203 K L -2.1961 Soluble
204 A L -2.0207 Soluble
205 D L -2.7498 Soluble
206 Y L 0.0000 Buried
207 E L -3.6753 Soluble
208 K L -3.7461 Soluble
209 H L -3.1553 Soluble
210 K L -3.5671 Soluble
211 V L -1.9775 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.6505 Soluble
216 V L 0.0000 Buried
217 T L -1.1578 Soluble
218 H L 0.0000 Buried
219 Q L -1.7085 Soluble
220 G L -0.4247 Soluble
221 L L -0.2760 Soluble
222 S L -0.4478 Soluble
223 S L -0.4461 Soluble
224 P L -0.6019 Soluble
225 V L -0.1016 Soluble
226 T L -0.5031 Soluble
227 K L -0.7180 Soluble
228 S L -0.8952 Soluble
229 F L -1.4307 Soluble
230 N L -2.5640 Soluble
231 R L -3.2549 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.9015 1.6783 CSV PDB
4.5 -0.9457 1.6185 CSV PDB
5.0 -0.995 1.536 CSV PDB
5.5 -1.0393 1.4878 CSV PDB
6.0 -1.0672 1.4878 CSV PDB
6.5 -1.0702 1.4878 CSV PDB
7.0 -1.0494 1.4878 CSV PDB
7.5 -1.0132 1.4878 CSV PDB
8.0 -0.9683 1.4878 CSV PDB
8.5 -0.9169 1.4878 CSV PDB
9.0 -0.859 1.4878 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH