Crexavibart / 7k90

A4DAB075_7k90_M_N | Source PDB: 7k90 | Chains: M, N | Done
99.59
Yes
10 Å
Yes
Avg A4D Score
-0.515
Max Score
1.4735
Min Score
-2.8252
Total Score
-122.05
Score CDR
-0.2945
Score non-CDR
-0.5931

Calculation Parameters

Chain Sequence(s) VQLVESGGGLIQPGGSLRLSCAASGFTVSNNYMSWVRQAPGKGLEWVSVIYSGGSTYYADSVKGRFTISRDKSKNTLYLQMNRLRAEDTAVYYCAREGEVEGYNDFWSGYSRDRYYFDYWGQGTLVTVSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSSTRVFGTGTKVTVL input.pdb
Selected Chain(s) M (Heavy), N (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.8252
Maximum Score 1.4735
Average Score -0.515
Total Score -122.0491

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V M 1.1827 Aggregation-prone
3 Q M -0.1886 Soluble
4 L M 0.0000 Buried
5 V M 0.3534 Aggregation-prone
6 E M 0.0000 Buried
7 S M -0.4742 Soluble
8 G M -0.8749 Soluble
9 G M 0.0038 Aggregation-prone
11 G M 0.8835 Aggregation-prone
12 L M 1.4735 Aggregation-prone
13 I M 0.1045 Aggregation-prone
14 Q M -1.3539 Soluble
15 P M -1.9016 Soluble
16 G M -1.7624 Soluble
17 G M -1.3604 Soluble
18 S M -1.5164 Soluble
19 L M -1.3997 Soluble
20 R M -2.2887 Soluble
21 L M 0.0000 Buried
22 S M -0.5993 Soluble
23 C M 0.0000 Buried
24 A M -0.3919 Soluble
25 A M 0.0000 Buried
26 S M -0.2582 Soluble
27 G M -0.2026 Soluble
28 F M 0.0000 Buried
29 T M -1.1272 Soluble
30 V M 0.0000 Buried
35 S M -1.2263 Soluble
36 N M -1.4333 Soluble
37 N M 0.0000 Buried
38 Y M -0.5008 Soluble
39 M M 0.0000 Buried
40 S M 0.0000 Buried
41 W M 0.0000 Buried
42 V M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M -0.8126 Soluble
45 A M -1.1550 Soluble
46 P M -0.8665 Soluble
47 G M -1.5035 Soluble
48 K M -2.2465 Soluble
49 G M -1.4467 Soluble
50 L M 0.0000 Buried
51 E M -1.2663 Soluble
52 W M 0.0000 Buried
53 V M 0.0000 Buried
54 S M 0.0000 Buried
55 V M 0.0000 Buried
56 I M 0.0000 Buried
57 Y M -0.1066 Soluble
58 S M -0.6459 Soluble
59 G M -0.8344 Soluble
63 G M -0.6049 Soluble
64 S M -0.1050 Soluble
65 T M 0.2102 Aggregation-prone
66 Y M 0.3817 Aggregation-prone
67 Y M -0.4895 Soluble
68 A M 0.0000 Buried
69 D M -2.3941 Soluble
70 S M -1.8310 Soluble
71 V M 0.0000 Buried
72 K M -2.4968 Soluble
74 G M -1.9552 Soluble
75 R M -2.1456 Soluble
76 F M 0.0000 Buried
77 T M -0.8548 Soluble
78 I M 0.0000 Buried
79 S M -0.8824 Soluble
80 R M -1.4564 Soluble
81 D M -2.2678 Soluble
82 K M -2.8252 Soluble
83 S M -2.1861 Soluble
84 K M -2.6911 Soluble
85 N M -2.1530 Soluble
86 T M 0.0000 Buried
87 L M 0.0000 Buried
88 Y M -0.8361 Soluble
89 L M 0.0000 Buried
90 Q M -1.5929 Soluble
91 M M 0.0000 Buried
92 N M -2.1324 Soluble
93 R M -2.7346 Soluble
94 L M 0.0000 Buried
95 R M -2.6556 Soluble
96 A M -1.7360 Soluble
97 E M -2.2611 Soluble
98 D M 0.0000 Buried
99 T M -0.4388 Soluble
100 A M 0.0000 Buried
101 V M 0.5371 Aggregation-prone
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 R M 0.0000 Buried
107 E M 0.0000 Buried
108 G M 0.0000 Buried
109 E M -1.2783 Soluble
110 V M -0.5865 Soluble
111 E M -0.5065 Soluble
111A G M -0.6541 Soluble
111B Y M -0.0114 Soluble
111C N M -0.4519 Soluble
111D D M -0.8740 Soluble
111E F M 1.3291 Aggregation-prone
111F W M 1.2453 Aggregation-prone
112F S M 0.4108 Aggregation-prone
112E G M 0.1183 Aggregation-prone
112D Y M 0.2340 Aggregation-prone
112C S M -0.6381 Soluble
112B R M -1.8684 Soluble
112A D M -1.3588 Soluble
112 R M -1.1208 Soluble
113 Y M -0.6011 Soluble
114 Y M 0.0000 Buried
115 F M 0.0000 Buried
116 D M 0.0000 Buried
117 Y M 1.1181 Aggregation-prone
118 W M 0.0000 Buried
119 G M 0.0000 Buried
120 Q M -1.2700 Soluble
121 G M -0.4070 Soluble
122 T M 0.3294 Aggregation-prone
123 L M 1.3836 Aggregation-prone
124 V M 0.0000 Buried
125 T M 0.2494 Aggregation-prone
126 V M 0.0000 Buried
127 S M -0.7230 Soluble
3 A N 0.0635 Aggregation-prone
4 L N 0.0000 Buried
5 T N -0.1460 Soluble
6 Q N 0.0000 Buried
7 P N -0.2323 Soluble
8 A N -0.2583 Soluble
9 S N -0.4465 Soluble
11 V N -0.0923 Soluble
12 S N -0.0313 Soluble
13 G N 0.0636 Aggregation-prone
14 S N -0.0625 Soluble
15 P N -0.6574 Soluble
16 G N -1.3896 Soluble
17 Q N -1.6794 Soluble
18 S N -0.9345 Soluble
19 I N -0.2690 Soluble
20 T N -0.0525 Soluble
21 I N 0.0000 Buried
22 S N -0.2729 Soluble
23 C N 0.0000 Buried
24 T N -0.4878 Soluble
25 G N -0.4362 Soluble
26 T N -0.5756 Soluble
27 S N -0.7030 Soluble
28 S N -0.3801 Soluble
29 D N 0.0000 Buried
30 V N 0.0000 Buried
31 G N -1.0769 Soluble
35 G N -0.6435 Soluble
36 Y N -0.0187 Soluble
37 N N -0.9568 Soluble
38 Y N -0.3506 Soluble
39 V N 0.0000 Buried
40 S N 0.0000 Buried
41 W N 0.0000 Buried
42 Y N 0.0000 Buried
43 Q N 0.0000 Buried
44 Q N 0.0000 Buried
45 H N -1.7344 Soluble
46 P N -1.3397 Soluble
47 G N -1.5870 Soluble
48 K N -2.3986 Soluble
49 A N -1.3468 Soluble
50 P N 0.0000 Buried
51 K N -0.9445 Soluble
52 L N -0.1220 Soluble
53 M N 0.0000 Buried
54 I N 0.0000 Buried
55 Y N 0.0000 Buried
56 D N -0.9601 Soluble
57 V N 0.0000 Buried
65 S N -0.8665 Soluble
66 N N -1.1110 Soluble
67 R N -0.9181 Soluble
68 P N 0.0000 Buried
69 S N -0.4771 Soluble
70 G N -0.6443 Soluble
71 V N -0.4467 Soluble
72 S N -0.8927 Soluble
74 N N -1.6338 Soluble
75 R N -1.1897 Soluble
76 F N 0.0000 Buried
77 S N -0.7703 Soluble
78 G N -0.5594 Soluble
79 S N -0.7202 Soluble
80 K N -1.0487 Soluble
83 S N -0.8347 Soluble
84 G N -1.0607 Soluble
85 N N -1.0704 Soluble
86 T N -0.7749 Soluble
87 A N 0.0000 Buried
88 S N -0.3791 Soluble
89 L N 0.0000 Buried
90 T N -0.2416 Soluble
91 I N 0.0000 Buried
92 S N -1.0419 Soluble
93 G N -1.1362 Soluble
94 L N 0.0000 Buried
95 Q N -1.6378 Soluble
96 A N -1.3176 Soluble
97 E N -2.4783 Soluble
98 D N 0.0000 Buried
99 E N -2.1939 Soluble
100 A N 0.0000 Buried
101 D N -0.9911 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 S N 0.0000 Buried
106 S N 0.0000 Buried
107 Y N 0.0582 Aggregation-prone
108 T N 0.0000 Buried
109 S N -0.0602 Soluble
113 S N -0.1520 Soluble
114 S N 0.0000 Buried
115 T N -0.1152 Soluble
116 R N 0.0000 Buried
117 V N 0.0348 Aggregation-prone
118 F N 0.0000 Buried
119 G N 0.0000 Buried
120 T N -0.5979 Soluble
121 G N 0.0000 Buried
122 T N 0.0000 Buried
123 K N -1.1710 Soluble
124 V N 0.0000 Buried
125 T N -0.2461 Soluble
126 V N 0.0628 Aggregation-prone
127 L N 1.3062 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5212 5.6195 CSV PDB
4.5 -0.5506 5.4339 CSV PDB
5.0 -0.5842 5.2249 CSV PDB
5.5 -0.6159 5.0072 CSV PDB
6.0 -0.6388 4.7872 CSV PDB
6.5 -0.6471 4.5686 CSV PDB
7.0 -0.641 4.3536 CSV PDB
7.5 -0.6258 4.157 CSV PDB
8.0 -0.6055 4.0333 CSV PDB
8.5 -0.5811 3.9273 CSV PDB
9.0 -0.5526 3.8531 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH