Teropavimab / 7n28

A4DAB261_7n28_S_U | Source PDB: 7n28 | Chains: S, U | Done
99.55
Yes
10 Å
Yes
Avg A4D Score
-0.8048
Max Score
0.8463
Min Score
-3.4892
Total Score
-338.0
Score CDR
-0.7255
Score non-CDR
-0.8129

Calculation Parameters

Chain Sequence(s) QVQLLQSGAAVTKPGASVRVSCEASGYNIRDYFIHWWRQAPGQGLQWVGWINPKTGQPNNPRQFQGRVSLTRHASWDFDTYSFYMDLKALRSDDTAVYFCARQRSDYWDFDVWGSGTQVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPDIQMTQSPSSLSASVGDTVTITCQANGYLNWYQQRRGKAPKLLIYDGSKLERGVPSRFSGRRWGQEYNLTINNLQPEDIATYFCQVYEFVVPGTRLDLKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) S (Heavy), U (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4892
Maximum Score 0.8463
Average Score -0.8048
Total Score -338.0023

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q S -1.1839 Soluble
2 V S -0.4623 Soluble
3 Q S -0.7129 Soluble
4 L S 0.0000 Buried
5 L S 0.4540 Aggregation-prone
6 Q S 0.0000 Buried
7 S S -0.6324 Soluble
8 G S -0.6549 Soluble
9 A S -0.2843 Soluble
11 A S 0.0363 Aggregation-prone
12 V S 0.5924 Aggregation-prone
13 T S -0.5197 Soluble
14 K S -1.8870 Soluble
15 P S -1.5269 Soluble
16 G S -1.6827 Soluble
17 A S -1.4215 Soluble
18 S S -1.6148 Soluble
19 V S 0.0000 Buried
20 R S -2.0352 Soluble
21 V S 0.0000 Buried
22 S S -0.6342 Soluble
23 C S 0.0000 Buried
24 E S -0.9001 Soluble
25 A S 0.0000 Buried
26 S S -0.9574 Soluble
27 G S -0.9080 Soluble
28 Y S -1.1143 Soluble
29 N S -1.9004 Soluble
30 I S 0.0000 Buried
35 R S -2.7151 Soluble
36 D S -2.4135 Soluble
37 Y S -1.0174 Soluble
38 F S -0.1905 Soluble
39 I S 0.0000 Buried
40 H S 0.0000 Buried
41 W S 0.0000 Buried
42 W S 0.0000 Buried
43 R S 0.0000 Buried
44 Q S -0.7441 Soluble
45 A S -1.0362 Soluble
46 P S -0.9514 Soluble
47 G S -1.5002 Soluble
48 Q S -1.7531 Soluble
49 G S -1.1014 Soluble
50 L S 0.0000 Buried
51 Q S -0.6639 Soluble
52 W S -0.1345 Soluble
53 V S 0.0000 Buried
54 G S 0.0000 Buried
55 W S -0.2190 Soluble
56 I S 0.0000 Buried
57 N S -1.4514 Soluble
58 P S 0.0000 Buried
59 K S -2.5234 Soluble
62 T S -1.6225 Soluble
63 G S -1.5950 Soluble
64 Q S -1.8851 Soluble
65 P S -1.2923 Soluble
66 N S -1.5001 Soluble
67 N S -1.7417 Soluble
68 P S -1.9520 Soluble
69 R S -2.9778 Soluble
70 Q S -2.8150 Soluble
71 F S 0.0000 Buried
72 Q S -3.0680 Soluble
74 G S -2.5706 Soluble
75 R S -3.2190 Soluble
76 V S 0.0000 Buried
77 S S -1.5126 Soluble
78 L S 0.0000 Buried
79 T S -0.7599 Soluble
80 R S -1.3957 Soluble
81 H S -1.0519 Soluble
82 A S -0.8727 Soluble
83 S S -0.1848 Soluble
84 W S 0.3385 Aggregation-prone
85 D S -1.0764 Soluble
85A F S -0.7564 Soluble
85B D S -1.5439 Soluble
85C T S -1.1144 Soluble
85D Y S 0.0000 Buried
86 S S -0.7163 Soluble
87 F S 0.0000 Buried
88 Y S -0.7194 Soluble
89 M S 0.0000 Buried
90 D S -1.7452 Soluble
91 L S 0.0000 Buried
92 K S -2.9159 Soluble
93 A S -2.0135 Soluble
94 L S 0.0000 Buried
95 R S -2.8429 Soluble
96 S S -2.1429 Soluble
97 D S -2.3189 Soluble
98 D S 0.0000 Buried
99 T S -0.8560 Soluble
100 A S 0.0000 Buried
101 V S -0.5561 Soluble
102 Y S 0.0000 Buried
103 F S 0.0000 Buried
104 C S 0.0000 Buried
105 A S 0.0000 Buried
106 R S -0.1066 Soluble
107 Q S -0.5126 Soluble
108 R S -0.8425 Soluble
109 S S -0.9852 Soluble
110 D S -1.5395 Soluble
112 Y S -0.1875 Soluble
113 W S -0.2167 Soluble
114 D S 0.0000 Buried
115 F S 0.0000 Buried
116 D S -0.8122 Soluble
117 V S -0.2756 Soluble
118 W S -0.3717 Soluble
119 G S 0.0000 Buried
120 S S -0.4522 Soluble
121 G S -0.6646 Soluble
122 T S 0.0000 Buried
123 Q S -1.0841 Soluble
124 V S 0.0000 Buried
125 T S 0.0000 Buried
126 V S 0.0000 Buried
127 S S -1.1185 Soluble
128 S S -0.8073 Soluble
129 A S -0.6601 Soluble
130 S S -0.6436 Soluble
131 T S -0.5169 Soluble
132 K S -1.2573 Soluble
133 G S -1.5352 Soluble
134 P S 0.0000 Buried
135 S S -0.9434 Soluble
136 V S 0.0000 Buried
137 F S 0.0000 Buried
138 P S -1.0621 Soluble
139 L S 0.0000 Buried
140 A S 0.0000 Buried
141 P S 0.0000 Buried
142 S S -0.8501 Soluble
143 T S -0.2767 Soluble
144 A S -0.1202 Soluble
145 A S 0.0000 Buried
146 L S 0.0000 Buried
147 G S 0.0000 Buried
148 C S 0.0000 Buried
149 L S 0.0000 Buried
150 V S 0.0000 Buried
151 K S -0.6948 Soluble
152 D S -1.1801 Soluble
153 Y S 0.0000 Buried
154 F S 0.0000 Buried
155 P S 0.0000 Buried
156 E S -0.8122 Soluble
157 P S -0.8958 Soluble
158 V S -0.9291 Soluble
159 T S -0.5596 Soluble
160 V S 0.1809 Aggregation-prone
161 S S 0.0404 Aggregation-prone
162 W S 0.0000 Buried
163 N S -0.5464 Soluble
164 S S -0.4251 Soluble
165 G S -0.2582 Soluble
166 A S -0.0456 Soluble
167 L S 0.3522 Aggregation-prone
168 T S 0.1874 Aggregation-prone
169 S S 0.1136 Aggregation-prone
170 G S 0.1663 Aggregation-prone
171 V S 0.7982 Aggregation-prone
172 H S -0.0344 Soluble
173 T S -0.0623 Soluble
174 F S 0.0000 Buried
175 P S -0.3198 Soluble
176 A S 0.0871 Aggregation-prone
177 V S 0.1758 Aggregation-prone
178 L S 0.1817 Aggregation-prone
179 Q S -0.4566 Soluble
180 S S -0.3736 Soluble
181 S S -0.4661 Soluble
182 G S 0.0000 Buried
183 L S -0.4649 Soluble
184 Y S 0.0000 Buried
185 S S 0.0000 Buried
186 L S 0.0000 Buried
187 S S -0.0525 Soluble
188 S S 0.0000 Buried
189 V S 0.0000 Buried
190 V S 0.0000 Buried
191 T S -0.0438 Soluble
192 V S 0.0000 Buried
193 P S -0.3823 Soluble
194 S S -0.4515 Soluble
195 S S -0.4102 Soluble
196 S S -0.4354 Soluble
197 L S -0.3799 Soluble
198 G S -0.6717 Soluble
199 T S -0.6912 Soluble
200 Q S -0.9575 Soluble
201 T S -1.0702 Soluble
202 Y S 0.0000 Buried
203 I S -1.0230 Soluble
204 C S 0.0000 Buried
205 N S -1.2215 Soluble
206 V S 0.0000 Buried
207 N S -2.0527 Soluble
208 H S 0.0000 Buried
209 K S -2.7718 Soluble
210 P S -1.5382 Soluble
211 S S -1.8435 Soluble
212 N S -2.6530 Soluble
213 T S -2.1073 Soluble
214 K S -2.6302 Soluble
215 V S -1.2917 Soluble
216 D S -1.9207 Soluble
217 K S -1.9725 Soluble
218 K S -2.3920 Soluble
219 V S 0.0000 Buried
220 E S -1.9035 Soluble
221 P S -1.0218 Soluble
1 D U -1.8978 Soluble
2 I U -0.9312 Soluble
3 Q U -1.3899 Soluble
4 M U -0.4432 Soluble
5 T U -0.6819 Soluble
6 Q U -0.6949 Soluble
7 S U 0.0000 Buried
8 P U -0.5335 Soluble
9 S U -0.6495 Soluble
10 S U -0.5229 Soluble
11 L U -0.3156 Soluble
12 S U -0.6369 Soluble
13 A U 0.0000 Buried
14 S U -0.4903 Soluble
15 V U 0.3660 Aggregation-prone
16 G U -1.3700 Soluble
17 D U -1.8558 Soluble
18 T U -1.1896 Soluble
19 V U -0.4729 Soluble
20 T U -0.1181 Soluble
21 I U 0.0000 Buried
22 T U -0.6907 Soluble
23 C U 0.0000 Buried
24 Q U -1.9945 Soluble
25 A U 0.0000 Buried
27 N U -2.0151 Soluble
28 G U -0.4959 Soluble
38 Y U 0.5122 Aggregation-prone
39 L U 0.0000 Buried
40 N U 0.0000 Buried
41 W U 0.0000 Buried
42 Y U 0.0000 Buried
43 Q U -0.9299 Soluble
44 Q U 0.0000 Buried
45 R U -2.9502 Soluble
46 R U -3.2957 Soluble
47 G U -2.6394 Soluble
48 K U -3.0381 Soluble
49 A U -1.7951 Soluble
50 P U 0.0000 Buried
51 K U -2.1490 Soluble
52 L U 0.0000 Buried
53 L U 0.0000 Buried
54 I U 0.0000 Buried
55 Y U 0.1758 Aggregation-prone
56 D U 0.0000 Buried
57 G U 0.0000 Buried
65 S U -1.3625 Soluble
66 K U -1.3961 Soluble
67 L U -0.2873 Soluble
68 E U -1.0544 Soluble
69 R U -2.0572 Soluble
70 G U -1.2476 Soluble
71 V U -0.5980 Soluble
72 P U -0.6566 Soluble
74 S U -0.6595 Soluble
75 R U -1.0306 Soluble
76 F U 0.0000 Buried
77 S U -1.0118 Soluble
78 G U -1.4636 Soluble
79 R U -2.7991 Soluble
80 R U -2.6840 Soluble
83 W U -0.9681 Soluble
84 G U -1.5012 Soluble
85 Q U -2.2421 Soluble
86 E U -2.3271 Soluble
87 Y U 0.0000 Buried
88 N U -1.4021 Soluble
89 L U 0.0000 Buried
90 T U -0.7545 Soluble
91 I U 0.0000 Buried
92 N U -2.1269 Soluble
93 N U -2.3732 Soluble
94 L U 0.0000 Buried
95 Q U -1.6889 Soluble
96 P U -1.2339 Soluble
97 E U -2.2014 Soluble
98 D U 0.0000 Buried
99 I U -0.8318 Soluble
100 A U 0.0000 Buried
101 T U -0.9316 Soluble
102 Y U 0.0000 Buried
103 F U 0.0000 Buried
104 C U 0.0000 Buried
105 Q U 0.0000 Buried
106 V U 0.0000 Buried
107 Y U 0.5420 Aggregation-prone
116 E U -0.2134 Soluble
117 F U 0.8463 Aggregation-prone
118 V U 0.5444 Aggregation-prone
119 V U 0.0000 Buried
120 P U -0.6532 Soluble
121 G U 0.0000 Buried
122 T U 0.0000 Buried
123 R U -1.0575 Soluble
124 L U 0.0000 Buried
125 D U 0.0000 Buried
126 L U -0.5307 Soluble
127 K U -1.1381 Soluble
128 R U -1.6758 Soluble
129 T U -0.5402 Soluble
130 V U 0.6887 Aggregation-prone
131 A U 0.1900 Aggregation-prone
132 A U 0.0994 Aggregation-prone
133 P U 0.0000 Buried
134 S U -0.1643 Soluble
135 V U 0.0000 Buried
136 F U 0.0930 Aggregation-prone
137 I U -0.0440 Soluble
138 F U 0.0000 Buried
139 P U 0.0000 Buried
140 P U 0.0000 Buried
141 S U -1.8733 Soluble
142 D U -3.1393 Soluble
143 E U -3.3674 Soluble
144 Q U -2.2532 Soluble
145 L U -2.5576 Soluble
146 K U -3.0861 Soluble
147 S U -1.8420 Soluble
148 G U -1.9317 Soluble
149 T U -1.4662 Soluble
150 A U 0.0000 Buried
151 S U 0.0000 Buried
152 V U 0.0000 Buried
153 V U 0.0000 Buried
154 C U 0.0000 Buried
155 L U 0.0000 Buried
156 L U 0.0000 Buried
157 N U -0.4145 Soluble
158 N U -0.6951 Soluble
159 F U 0.0000 Buried
160 Y U -1.0603 Soluble
161 P U -1.5752 Soluble
162 R U -2.5857 Soluble
163 E U -3.0153 Soluble
164 A U -2.1936 Soluble
165 K U -2.3269 Soluble
166 V U -1.2562 Soluble
167 Q U -0.9391 Soluble
168 W U 0.0000 Buried
169 K U 0.0000 Buried
170 V U -1.5935 Soluble
171 D U -2.5129 Soluble
172 N U -1.8563 Soluble
173 A U -0.4131 Soluble
174 L U 0.7858 Aggregation-prone
175 Q U -0.2860 Soluble
176 S U -0.6682 Soluble
177 G U -1.2901 Soluble
178 N U -1.5464 Soluble
179 S U -1.4480 Soluble
180 Q U -1.6524 Soluble
181 E U -1.3766 Soluble
182 S U -0.7780 Soluble
183 V U -0.6843 Soluble
184 T U -0.9990 Soluble
185 E U -2.2604 Soluble
186 Q U -1.7797 Soluble
187 D U -1.8875 Soluble
188 S U -1.8702 Soluble
189 K U -2.5529 Soluble
190 D U -2.1583 Soluble
191 S U -1.5490 Soluble
192 T U 0.0000 Buried
193 Y U 0.0000 Buried
194 S U 0.0000 Buried
195 L U 0.0000 Buried
196 S U 0.0000 Buried
197 S U 0.0000 Buried
198 T U -0.7456 Soluble
199 L U 0.0000 Buried
200 T U -0.4114 Soluble
201 L U -0.9038 Soluble
202 S U -1.4633 Soluble
203 K U -2.7528 Soluble
204 A U -2.0664 Soluble
205 D U -2.2250 Soluble
206 Y U -2.3791 Soluble
207 E U -3.4892 Soluble
208 K U -3.3575 Soluble
209 H U -2.9065 Soluble
210 K U -3.1461 Soluble
211 V U -1.9847 Soluble
212 Y U 0.0000 Buried
213 A U -1.0595 Soluble
214 C U 0.0000 Buried
215 E U -1.4382 Soluble
216 V U 0.0000 Buried
217 T U -1.1649 Soluble
218 H U 0.0000 Buried
219 Q U -1.4967 Soluble
220 G U -0.6789 Soluble
221 L U -0.0484 Soluble
222 S U -0.4622 Soluble
223 S U -0.4235 Soluble
224 P U -0.6383 Soluble
225 V U -0.1730 Soluble
226 T U -0.7476 Soluble
227 K U -0.9593 Soluble
228 S U -0.8138 Soluble
229 F U 0.0000 Buried
230 N U -2.1954 Soluble
231 R U -2.1728 Soluble
232 G U -1.3699 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7716 3.8171 CSV PDB
4.5 -0.8165 3.5947 CSV PDB
5.0 -0.8691 3.3517 CSV PDB
5.5 -0.9192 3.1072 CSV PDB
6.0 -0.9553 2.8701 CSV PDB
6.5 -0.9693 2.6378 CSV PDB
7.0 -0.9622 2.4019 CSV PDB
7.5 -0.9411 2.3449 CSV PDB
8.0 -0.9117 2.3332 CSV PDB
8.5 -0.8755 2.3292 CSV PDB
9.0 -0.8318 2.3276 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH