Teropavimab

A4DAB261 | Phase-II
HIV-1 gp120 CD4bs
G1 / None
Gilead
Phase-II
Whole mAb
3BNC 117 3BNC-117 GS-5423 GS 5423 GS5423 Lafuvitug
—
Avg A4D Score
-0.7814
Score Range
-0.89 to -0.73
Structures
29
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB261_8gje_G_J 8gje 99% -0.7962 8.5 4.0 -0.7461 -0.807
A4DAB261_9bew_C_D 9bew 99% -0.8086 8.0 4.0 -0.7909 -0.8125
A4DAB261_5v8m_S_U 5v8m 99% -0.735 8.0 4.0 -0.7646 -0.7286
A4DAB261_8gje_H_L 8gje 99% -0.7878 8.5 4.0 -0.7585 -0.7941
A4DAB261_5v8m_R_T 5v8m 99% -0.7471 8.0 4.0 -0.7844 -0.739
A4DAB261_5v8l_I_M 5v8l 99% -0.7355 8.0 4.0 -0.7205 -0.7387
A4DAB261_7n28_S_U 7n28 99% -0.8048 6.5 4.0 -0.7255 -0.8129
A4DAB261_4lsv_H_L 4lsv 99% -0.7843 6.5 4.0 -0.7523 -0.7875
A4DAB261_7pc2_G_H 7pc2 99% -0.7505 8.5 4.0 -0.7129 -0.7587
A4DAB261_9bew_F_I 9bew 99% -0.8084 8.0 4.0 -0.78 -0.8147
A4DAB261_7ly9_A_M 7ly9 99% -0.7523 8.0 4.0 -0.7338 -0.7564
A4DAB261_7pc2_K_L 7pc2 99% -0.804 8.5 4.0 -0.7513 -0.8155
A4DAB261_7n28_C_D 7n28 99% -0.7832 6.5 4.0 -0.6675 -0.795
A4DAB261_7ly9_E_I 7ly9 99% -0.7999 8.0 4.0 -0.7703 -0.8064
A4DAB261_5v8m_H_L 5v8m 99% -0.7384 8.0 4.0 -0.7672 -0.7321
A4DAB261_7pc2_I_J 7pc2 99% -0.7252 8.5 4.0 -0.6506 -0.7413
A4DAB261_7n28_J_K 7n28 99% -0.7601 6.5 4.0 -0.8044 -0.7555
A4DAB261_4jpv_H_L 4jpv 99% -0.7866 6.5 4.0 -0.7826 -0.787
A4DAB261_5v8l_G_K 5v8l 99% -0.775 8.0 4.0 -0.7777 -0.7744
A4DAB261_7ly9_H_L 7ly9 0% -0.885 8.0 4.0 N/A N/A
A4DAB261_8c8t_R_T 8c8t 100% -0.7641 8.0 4.0 -0.7262 -0.7725
A4DAB261_8gje_I_K 8gje 99% -0.7842 8.5 4.0 -0.744 -0.7929
A4DAB261_7ly9_B_C 7ly9 99% -0.8252 8.0 4.0 -0.8051 -0.8296
A4DAB261_7mxd_J_K 7mxd 99% -0.7857 6.5 4.0 -0.7969 -0.7846
A4DAB261_9bew_O_P 9bew 99% -0.8203 7.5 4.0 -0.7911 -0.8267
A4DAB261_7mxd_C_D 7mxd 99% -0.8198 6.5 4.0 -0.716 -0.8304
A4DAB261_8c8t_S_U 8c8t 100% -0.7765 7.0 4.0 -0.7949 -0.7724
A4DAB261_5v8l_H_L 5v8l 99% -0.7253 8.0 4.0 -0.723 -0.7259
A4DAB261_7mxd_S_U 7mxd 99% -0.792 6.5 4.0 -0.7635 -0.7949