Amivantamab / 6wvz

A4DAB012_6wvz_H_L | Source PDB: 6wvz | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7063
Max Score
1.101
Min Score
-3.6164
Total Score
-302.31
Score CDR
-0.2545
Score non-CDR
-0.7607

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGASVKVSCETSGYTFTSYGISWVRQAPGHGLEWMGWISAYNGYTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDLRGTNYFDYWGQGTLVTVSSASTKGPSVFPLAPGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDIQMTQSPSSVSASVGDRVTITCRASQGISNWLAWFQHKPGKAPKLLIYAASSLLSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6164
Maximum Score 1.101
Average Score -0.7063
Total Score -302.3109

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.3851 Soluble
2 V H -0.6459 Soluble
3 Q H -1.4407 Soluble
4 L H 0.0000 Buried
5 V H -0.7343 Soluble
6 Q H 0.0000 Buried
7 S H -0.9179 Soluble
8 G H -0.7723 Soluble
9 A H -0.3980 Soluble
11 E H -1.0595 Soluble
12 V H -0.3457 Soluble
13 K H -1.4843 Soluble
14 K H -2.2600 Soluble
15 P H -2.0439 Soluble
16 G H -1.6108 Soluble
17 A H -1.3170 Soluble
18 S H -1.6249 Soluble
19 V H 0.0000 Buried
20 K H -2.1519 Soluble
21 V H 0.0000 Buried
22 S H -0.8606 Soluble
23 C H 0.0000 Buried
24 E H -1.9214 Soluble
25 T H 0.0000 Buried
26 S H -1.1402 Soluble
27 G H -0.8743 Soluble
28 Y H -0.2521 Soluble
29 T H -0.0802 Soluble
30 F H 0.0000 Buried
35 T H 0.1176 Aggregation-prone
36 S H 0.1300 Aggregation-prone
37 Y H 0.0445 Aggregation-prone
38 G H 0.0000 Buried
39 I H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.3537 Soluble
44 Q H -0.6302 Soluble
45 A H -0.9279 Soluble
46 P H -0.7830 Soluble
47 G H -1.1249 Soluble
48 H H -1.6489 Soluble
49 G H -1.2160 Soluble
50 L H 0.0000 Buried
51 E H -0.7704 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 W H 0.0688 Aggregation-prone
56 I H 0.0000 Buried
57 S H -0.2515 Soluble
58 A H -0.0219 Soluble
59 Y H 0.4851 Aggregation-prone
62 N H -0.5357 Soluble
63 G H -0.2372 Soluble
64 Y H 0.4957 Aggregation-prone
65 T H 0.1323 Aggregation-prone
66 N H 0.0524 Aggregation-prone
67 Y H -0.5036 Soluble
68 A H 0.0000 Buried
69 Q H -2.6817 Soluble
70 K H -2.8702 Soluble
71 L H 0.0000 Buried
72 Q H -2.4160 Soluble
74 G H -1.7751 Soluble
75 R H -1.5414 Soluble
76 V H 0.0000 Buried
77 T H -0.6157 Soluble
78 M H 0.0000 Buried
79 T H -0.2369 Soluble
80 T H -0.2382 Soluble
81 D H -0.8672 Soluble
82 T H -0.3314 Soluble
83 S H -0.4617 Soluble
84 T H -0.7160 Soluble
85 S H -0.8147 Soluble
86 T H -0.9814 Soluble
87 A H 0.0000 Buried
88 Y H -0.5945 Soluble
89 M H 0.0000 Buried
90 E H -1.4599 Soluble
91 L H 0.0000 Buried
92 R H -1.8750 Soluble
93 S H -1.5496 Soluble
94 L H 0.0000 Buried
95 R H -2.7549 Soluble
96 S H -2.1577 Soluble
97 D H -2.3900 Soluble
98 D H 0.0000 Buried
99 T H -0.7862 Soluble
100 A H 0.0000 Buried
101 V H 0.2710 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 D H 0.0000 Buried
108 L H 0.1723 Aggregation-prone
109 R H -1.2425 Soluble
110 G H -1.0935 Soluble
112 T H -0.3556 Soluble
113 N H 0.0000 Buried
114 Y H 0.2511 Aggregation-prone
115 F H 0.0000 Buried
116 D H 0.1870 Aggregation-prone
117 Y H 0.3782 Aggregation-prone
118 W H -0.1867 Soluble
119 G H 0.0000 Buried
120 Q H -1.4894 Soluble
121 G H -0.7529 Soluble
122 T H 0.0000 Buried
123 L H 0.0611 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.2615 Soluble
128 S H -1.1772 Soluble
129 A H -0.7187 Soluble
130 S H -0.8556 Soluble
131 T H -0.8337 Soluble
132 K H -1.6305 Soluble
133 G H -1.6832 Soluble
134 P H -0.7497 Soluble
135 S H -0.2657 Soluble
136 V H 0.0000 Buried
137 F H -0.5699 Soluble
138 P H -1.1923 Soluble
139 L H 0.0000 Buried
140 A H -1.1990 Soluble
141 P H -0.7041 Soluble
142 G H -0.6232 Soluble
143 T H -0.4736 Soluble
144 A H 0.0000 Buried
145 A H 0.0000 Buried
146 L H 0.0000 Buried
147 G H 0.0000 Buried
148 C H 0.0000 Buried
149 L H 0.0000 Buried
150 V H 0.0000 Buried
151 K H 0.0000 Buried
152 D H -0.5392 Soluble
153 Y H 0.0000 Buried
154 F H 0.0000 Buried
155 P H 0.0000 Buried
156 E H -0.3866 Soluble
157 P H -0.7655 Soluble
158 V H -0.8151 Soluble
159 T H -0.6843 Soluble
160 V H -0.4579 Soluble
161 S H -0.4386 Soluble
162 W H 0.0000 Buried
163 N H -0.7791 Soluble
164 S H -0.6898 Soluble
165 G H -0.5163 Soluble
166 A H -0.2119 Soluble
167 L H 0.0449 Aggregation-prone
168 T H -0.1571 Soluble
169 S H -0.1925 Soluble
170 G H -0.2545 Soluble
171 V H 0.0962 Aggregation-prone
172 H H -0.3901 Soluble
173 T H -0.0158 Soluble
174 F H 0.0000 Buried
175 P H -0.4156 Soluble
176 A H 0.0717 Aggregation-prone
177 V H 0.2544 Aggregation-prone
178 L H 0.9643 Aggregation-prone
179 Q H 0.0882 Aggregation-prone
180 S H -0.1460 Soluble
181 S H -0.2461 Soluble
182 G H -0.0049 Soluble
183 L H -0.1019 Soluble
184 Y H 0.0000 Buried
185 S H 0.0000 Buried
186 L H 0.0000 Buried
187 S H 0.0000 Buried
188 S H 0.0000 Buried
189 V H 0.0000 Buried
190 V H 0.0000 Buried
191 T H -0.1567 Soluble
192 V H 0.0000 Buried
193 P H -0.4477 Soluble
194 S H -0.4675 Soluble
195 S H -0.5420 Soluble
196 S H -0.4830 Soluble
197 L H -0.6320 Soluble
198 G H -0.8634 Soluble
199 T H -0.5899 Soluble
200 Q H -0.9742 Soluble
201 T H -1.0791 Soluble
202 Y H 0.0000 Buried
203 I H -1.4900 Soluble
204 C H 0.0000 Buried
205 N H -1.5466 Soluble
206 V H 0.0000 Buried
207 N H -2.2014 Soluble
208 H H 0.0000 Buried
209 K H -2.8460 Soluble
210 P H -1.7229 Soluble
211 S H -1.9942 Soluble
212 N H -2.5532 Soluble
213 T H -2.1946 Soluble
214 K H -2.7486 Soluble
215 V H -1.7641 Soluble
216 D H -2.5960 Soluble
217 K H -2.1064 Soluble
218 R H -2.7230 Soluble
219 V H 0.0000 Buried
220 E H -2.8716 Soluble
221 P H -1.8027 Soluble
222 K H -2.1154 Soluble
223 S H -0.9490 Soluble
224 C H -0.0974 Soluble
1 D L -2.4646 Soluble
2 I L 0.0000 Buried
3 Q L -2.1226 Soluble
4 M L 0.0000 Buried
5 T L -1.3623 Soluble
6 Q L 0.0000 Buried
7 S L -0.5468 Soluble
8 P L -0.5277 Soluble
9 S L -0.8451 Soluble
10 S L -0.8532 Soluble
11 V L -0.4125 Soluble
12 S L -0.9391 Soluble
13 A L -0.9873 Soluble
14 S L -0.9518 Soluble
15 V L -0.0252 Soluble
16 G L -0.8964 Soluble
17 D L -1.8145 Soluble
18 R L -2.3862 Soluble
19 V L 0.0000 Buried
20 T L -0.4878 Soluble
21 I L 0.0000 Buried
22 T L -0.8444 Soluble
23 C L 0.0000 Buried
24 R L -2.6724 Soluble
25 A L -2.1326 Soluble
26 S L -2.0274 Soluble
27 Q L -2.2074 Soluble
28 G L -1.7629 Soluble
29 I L 0.0000 Buried
36 S L -1.1066 Soluble
37 N L -0.9205 Soluble
38 W L -0.1363 Soluble
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 F L 0.0000 Buried
43 Q L 0.0000 Buried
44 H L 0.0000 Buried
45 K L -1.3452 Soluble
46 P L -1.3405 Soluble
47 G L -1.5524 Soluble
48 K L -2.2276 Soluble
49 A L -1.3342 Soluble
50 P L 0.0000 Buried
51 K L -1.0504 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.5660 Aggregation-prone
56 A L 0.1593 Aggregation-prone
57 A L 0.0000 Buried
65 S L -0.0883 Soluble
66 S L 0.2347 Aggregation-prone
67 L L 0.6177 Aggregation-prone
68 L L 0.4433 Aggregation-prone
69 S L -0.0926 Soluble
70 G L -0.3488 Soluble
71 V L -0.1008 Soluble
72 P L -0.2393 Soluble
74 S L -0.4040 Soluble
75 R L -0.8328 Soluble
76 F L 0.0000 Buried
77 S L -0.3013 Soluble
78 G L -0.1907 Soluble
79 S L -0.7638 Soluble
80 G L -1.3322 Soluble
83 S L -1.1729 Soluble
84 G L -1.5134 Soluble
85 T L -2.1240 Soluble
86 D L -2.6947 Soluble
87 F L 0.0000 Buried
88 T L -0.8281 Soluble
89 L L 0.0000 Buried
90 T L -0.6489 Soluble
91 I L 0.0000 Buried
92 S L -1.5409 Soluble
93 S L -1.2785 Soluble
94 L L 0.0000 Buried
95 Q L -1.0197 Soluble
96 P L -1.0477 Soluble
97 E L -1.8712 Soluble
98 D L 0.0000 Buried
99 F L -0.7613 Soluble
100 A L -0.8894 Soluble
101 T L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 A L 0.0000 Buried
108 N L -0.9430 Soluble
109 S L -0.4415 Soluble
114 F L -0.0531 Soluble
115 P L -0.8454 Soluble
116 I L 0.0000 Buried
117 T L -0.8129 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.4994 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 R L -1.8351 Soluble
124 L L 0.0000 Buried
125 E L -1.5409 Soluble
126 I L -0.9410 Soluble
127 K L -1.6523 Soluble
128 R L -1.1322 Soluble
129 T L 0.0463 Aggregation-prone
130 V L 1.1010 Aggregation-prone
131 A L 0.4630 Aggregation-prone
132 A L 0.0962 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.0973 Soluble
135 V L 0.0000 Buried
136 F L 0.1961 Aggregation-prone
137 I L 0.1926 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.4817 Soluble
140 P L -0.7209 Soluble
141 S L -1.6725 Soluble
142 D L -2.8116 Soluble
143 E L -2.5714 Soluble
144 Q L 0.0000 Buried
145 L L -2.1596 Soluble
146 K L -2.8013 Soluble
147 S L -1.7358 Soluble
148 G L -1.1307 Soluble
149 T L -0.9873 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7744 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.7400 Soluble
162 R L -2.9532 Soluble
163 E L -3.1902 Soluble
164 A L -2.4087 Soluble
165 K L -2.4648 Soluble
166 V L -1.2375 Soluble
167 Q L -0.7292 Soluble
168 W L 0.0000 Buried
169 K L -0.5232 Soluble
170 V L 0.0000 Buried
171 D L -1.9430 Soluble
172 N L -1.6293 Soluble
173 A L -0.3162 Soluble
174 L L 0.6933 Aggregation-prone
175 Q L -0.1119 Soluble
176 S L -0.5479 Soluble
177 G L -0.9115 Soluble
178 N L -0.8499 Soluble
179 S L -1.3583 Soluble
180 Q L -1.8207 Soluble
181 E L -2.1516 Soluble
182 S L -0.9615 Soluble
183 V L -0.8717 Soluble
184 T L -1.0323 Soluble
185 E L -2.1536 Soluble
186 Q L -1.9659 Soluble
187 D L -1.9674 Soluble
188 S L -1.7173 Soluble
189 K L -2.2001 Soluble
190 D L -1.6171 Soluble
191 S L -1.8436 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7856 Soluble
199 L L 0.0000 Buried
200 T L -0.3304 Soluble
201 L L -0.6271 Soluble
202 S L -1.0986 Soluble
203 K L -2.1143 Soluble
204 A L -1.9259 Soluble
205 D L -2.7937 Soluble
206 Y L 0.0000 Buried
207 E L -3.4632 Soluble
208 K L -3.6164 Soluble
209 H L -3.0795 Soluble
210 K L -3.2559 Soluble
211 V L -1.6242 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.6748 Soluble
216 V L 0.0000 Buried
217 T L -1.2312 Soluble
218 H L 0.0000 Buried
219 Q L -1.8062 Soluble
220 G L -0.4403 Soluble
221 L L -0.1068 Soluble
222 S L -0.4065 Soluble
223 S L -0.3838 Soluble
224 P L -0.5621 Soluble
225 V L 0.0219 Aggregation-prone
226 T L -0.5056 Soluble
227 K L -0.8358 Soluble
228 S L -0.6823 Soluble
229 F L -0.8479 Soluble
230 N L -1.8314 Soluble
231 R L -2.4978 Soluble
232 G L -2.1422 Soluble
233 E L -2.3443 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7535 1.92 CSV PDB
4.5 -0.796 1.8693 CSV PDB
5.0 -0.8452 1.7899 CSV PDB
5.5 -0.8915 1.6948 CSV PDB
6.0 -0.9239 1.5997 CSV PDB
6.5 -0.934 1.5196 CSV PDB
7.0 -0.9223 1.5262 CSV PDB
7.5 -0.8962 1.6082 CSV PDB
8.0 -0.862 1.6928 CSV PDB
8.5 -0.8214 1.7772 CSV PDB
9.0 -0.7745 1.8584 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH