Porgaviximab / 5kel

A4DAB211_5kel_Q_U | Source PDB: 5kel | Chains: Q, U | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6718
Max Score
2.0047
Min Score
-2.9084
Total Score
-152.51
Score CDR
-0.4363
Score non-CDR
-0.735

Calculation Parameters

Chain Sequence(s) EVQLQESGGGLMQPGGSMKLSCVASGFTFSNYWMNWVRQSPEKGLEWVAEIRLKSNNYATHYAESVKGRFTISRDDSKRSVYLQMNTLRAEDTGIYYCTRGNGNYRAMDYWGQGTSVTVSDIQMTQSPASLSVSVGETVSITCRASENIYSSLAWYQQKQGKSPQLLVYSATILADGVPSRFSGSGSGTQYSLKINSLQSEDFGTYYCQHFWGTPYTFGGGTKLEIK input.pdb
Selected Chain(s) Q (Heavy), U (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.9084
Maximum Score 2.0047
Average Score -0.6718
Total Score -152.5051

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E Q -2.0512 Soluble
2 V Q -1.3021 Soluble
3 Q Q -1.7900 Soluble
4 L Q 0.0000 Buried
5 Q Q -1.5963 Soluble
6 E Q -1.1227 Soluble
7 S Q -0.9648 Soluble
8 G Q -0.9487 Soluble
9 G Q -0.5814 Soluble
11 G Q 0.2930 Aggregation-prone
12 L Q 1.1294 Aggregation-prone
13 M Q -0.0607 Soluble
14 Q Q -1.3087 Soluble
15 P Q -1.6734 Soluble
16 G Q -1.6723 Soluble
17 G Q -1.2577 Soluble
18 S Q -1.4489 Soluble
19 M Q -1.1584 Soluble
20 K Q -2.0194 Soluble
21 L Q 0.0000 Buried
22 S Q -0.6798 Soluble
23 C Q 0.0000 Buried
24 V Q -0.4433 Soluble
25 A Q 0.0000 Buried
26 S Q -1.2244 Soluble
27 G Q -1.1576 Soluble
28 F Q -0.8373 Soluble
29 T Q -0.6599 Soluble
30 F Q 0.0000 Buried
35 S Q -1.2059 Soluble
36 N Q -1.5773 Soluble
37 Y Q 0.0000 Buried
38 W Q -0.5476 Soluble
39 M Q 0.0000 Buried
40 N Q 0.0000 Buried
41 W Q 0.0000 Buried
42 V Q 0.0000 Buried
43 R Q 0.0000 Buried
44 Q Q -0.9435 Soluble
45 S Q -1.6415 Soluble
46 P Q -1.6855 Soluble
47 E Q -2.8792 Soluble
48 K Q -2.9084 Soluble
49 G Q -1.7030 Soluble
50 L Q 0.0000 Buried
51 E Q -0.6741 Soluble
52 W Q 0.0000 Buried
53 V Q 0.0000 Buried
54 A Q 0.0000 Buried
55 E Q 0.0000 Buried
56 I Q 0.0000 Buried
57 R Q -0.8475 Soluble
58 L Q -1.3341 Soluble
59 K Q -2.2466 Soluble
60 S Q -1.7115 Soluble
61 N Q -1.8096 Soluble
62 N Q -2.0279 Soluble
63 Y Q -0.8980 Soluble
64 A Q -0.6993 Soluble
65 T Q -0.3050 Soluble
66 H Q -0.9926 Soluble
67 Y Q -1.3372 Soluble
68 A Q -1.6406 Soluble
69 E Q -2.7012 Soluble
70 S Q -1.6895 Soluble
71 V Q 0.0000 Buried
72 K Q -2.8969 Soluble
74 G Q -1.9599 Soluble
75 R Q -1.9406 Soluble
76 F Q 0.0000 Buried
77 T Q -0.8920 Soluble
78 I Q -0.1760 Soluble
79 S Q -0.2505 Soluble
80 R Q -0.6412 Soluble
81 D Q -1.4279 Soluble
82 D Q -1.8464 Soluble
83 S Q -1.7005 Soluble
84 K Q -2.3680 Soluble
85 R Q -1.8868 Soluble
86 S Q -1.0865 Soluble
87 V Q 0.0000 Buried
88 Y Q -0.3139 Soluble
89 L Q 0.0000 Buried
90 Q Q -1.2917 Soluble
91 M Q 0.0000 Buried
92 N Q -1.8905 Soluble
93 T Q -1.6154 Soluble
94 L Q 0.0000 Buried
95 R Q -2.7801 Soluble
96 A Q -2.0120 Soluble
97 E Q -2.1929 Soluble
98 D Q 0.0000 Buried
99 T Q -0.3452 Soluble
100 G Q 0.0000 Buried
101 I Q 0.1012 Aggregation-prone
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 T Q 0.0000 Buried
106 R Q 0.0000 Buried
107 G Q 0.0000 Buried
108 N Q -1.3137 Soluble
109 G Q -1.3570 Soluble
110 N Q -1.4951 Soluble
112 Y Q -0.5530 Soluble
113 R Q -0.8580 Soluble
114 A Q 0.0000 Buried
115 M Q 0.0000 Buried
116 D Q -0.4875 Soluble
117 Y Q -0.0608 Soluble
118 W Q -0.1017 Soluble
119 G Q 0.0000 Buried
120 Q Q -1.6362 Soluble
121 G Q -0.9990 Soluble
122 T Q -0.6790 Soluble
123 S Q -0.0851 Soluble
124 V Q 0.0000 Buried
125 T Q -0.0492 Soluble
126 V Q -0.6034 Soluble
127 S Q -0.6856 Soluble
1 D U -1.9816 Soluble
2 I U -1.5370 Soluble
3 Q U -1.8424 Soluble
4 M U -1.1405 Soluble
5 T U -0.6712 Soluble
6 Q U 0.0000 Buried
7 S U -0.5439 Soluble
8 P U -0.3649 Soluble
9 A U -0.4555 Soluble
10 S U -0.5484 Soluble
11 L U -0.2221 Soluble
12 S U -0.3110 Soluble
13 V U 0.0000 Buried
14 S U 0.3663 Aggregation-prone
15 V U 1.2136 Aggregation-prone
16 G U -0.1340 Soluble
17 E U -0.4123 Soluble
18 T U -0.8211 Soluble
19 V U 0.0000 Buried
20 S U -0.7272 Soluble
21 I U 0.0000 Buried
22 T U -0.6877 Soluble
23 C U 0.0000 Buried
24 R U -1.8206 Soluble
25 A U -1.5887 Soluble
26 S U -1.6821 Soluble
27 E U -1.7639 Soluble
28 N U 0.0000 Buried
29 I U 1.8375 Aggregation-prone
36 Y U 1.3812 Aggregation-prone
37 S U 0.5682 Aggregation-prone
38 S U 0.0000 Buried
39 L U 0.0000 Buried
40 A U 0.0000 Buried
41 W U 0.0000 Buried
42 Y U 0.0000 Buried
43 Q U 0.0000 Buried
44 Q U -1.2618 Soluble
45 K U -1.8762 Soluble
46 Q U -1.9854 Soluble
47 G U -1.7809 Soluble
48 K U -2.0041 Soluble
49 S U -1.2725 Soluble
50 P U 0.0000 Buried
51 Q U -0.7664 Soluble
52 L U 0.0000 Buried
53 L U 0.0000 Buried
54 V U 0.0000 Buried
55 Y U 0.5410 Aggregation-prone
56 S U 0.5474 Aggregation-prone
57 A U 0.4801 Aggregation-prone
65 T U 0.8762 Aggregation-prone
66 I U 2.0047 Aggregation-prone
67 L U 0.8470 Aggregation-prone
68 A U 0.0000 Buried
69 D U -1.6122 Soluble
70 G U -1.2129 Soluble
71 V U -0.5911 Soluble
72 P U -0.6240 Soluble
74 S U -0.5549 Soluble
75 R U -1.1139 Soluble
76 F U 0.0000 Buried
77 S U -0.5414 Soluble
78 G U -0.3436 Soluble
79 S U -0.8332 Soluble
80 G U -1.1441 Soluble
83 S U -0.7162 Soluble
84 G U -0.7157 Soluble
85 T U -1.6196 Soluble
86 Q U -2.0658 Soluble
87 Y U 0.0000 Buried
88 S U -0.9019 Soluble
89 L U 0.0000 Buried
90 K U -1.3706 Soluble
91 I U 0.0000 Buried
92 N U -1.8352 Soluble
93 S U -1.0014 Soluble
94 L U 0.0000 Buried
95 Q U -1.1085 Soluble
96 S U -0.7847 Soluble
97 E U -2.1300 Soluble
98 D U 0.0000 Buried
99 F U -0.6338 Soluble
100 G U -1.2158 Soluble
101 T U -0.9754 Soluble
102 Y U 0.0000 Buried
103 Y U 0.0000 Buried
104 C U 0.0000 Buried
105 Q U 0.0000 Buried
106 H U 0.0000 Buried
107 F U 0.0000 Buried
108 W U 0.6876 Aggregation-prone
109 G U 0.0103 Aggregation-prone
114 T U -0.3087 Soluble
115 P U -0.6483 Soluble
116 Y U -0.2080 Soluble
117 T U -0.4098 Soluble
118 F U -0.1131 Soluble
119 G U 0.0000 Buried
120 G U -1.0344 Soluble
121 G U -0.8155 Soluble
122 T U 0.0000 Buried
123 K U -1.3350 Soluble
124 L U 0.0000 Buried
125 E U -0.4713 Soluble
126 I U 0.9328 Aggregation-prone
127 K U -0.6844 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6555 3.1892 CSV PDB
4.5 -0.6896 3.1425 CSV PDB
5.0 -0.7314 3.091 CSV PDB
5.5 -0.7714 3.0378 CSV PDB
6.0 -0.7982 2.984 CSV PDB
6.5 -0.8031 2.9302 CSV PDB
7.0 -0.7856 2.8766 CSV PDB
7.5 -0.7526 2.8241 CSV PDB
8.0 -0.7113 2.7747 CSV PDB
8.5 -0.6652 2.7328 CSV PDB
9.0 -0.6156 2.7041 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH