Calculation Parameters
| Chain Sequence(s) |
EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWMNWVRQAPGKGLEWVAAINQDGSEKYYVGSVKGRFTISRDNAKNSLYLQMNSLRVEDTAVYYCVRDYYDILTDYYIHYWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPCTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC
input.pdb
|
| Selected Chain(s) | A (Heavy), B (Light) |
| Distance of Aggregation | 10 Å |
| FoldX Energy Minimization | Yes |
| pH Calculations | Yes |
| Downloads | Download all data (.tar.gz) |
Aggrescan4D Profile
Per-Residue A4D Scores
Download CSVResidues with A4D score > 0.0 are highlighted as aggregation-prone.
| Index | Residue | Chain | A4D Score | Classification |
|---|---|---|---|---|
| 1 | E | A | -1.7997 | Soluble |
| 2 | V | A | -0.6763 | Soluble |
| 3 | Q | A | -0.9899 | Soluble |
| 4 | L | A | 0.0000 | Buried |
| 5 | V | A | 0.4680 | Aggregation-prone |
| 6 | E | A | 0.0000 | Buried |
| 7 | S | A | -0.5417 | Soluble |
| 8 | G | A | -0.9420 | Soluble |
| 9 | G | A | -0.4844 | Soluble |
| 11 | G | A | -0.2210 | Soluble |
| 12 | L | A | 0.0634 | Aggregation-prone |
| 13 | V | A | -0.3598 | Soluble |
| 14 | Q | A | -1.2895 | Soluble |
| 15 | P | A | -1.1775 | Soluble |
| 16 | G | A | -1.1671 | Soluble |
| 17 | G | A | -1.0460 | Soluble |
| 18 | S | A | -1.2135 | Soluble |
| 19 | L | A | -1.0500 | Soluble |
| 20 | R | A | -2.1517 | Soluble |
| 21 | L | A | 0.0000 | Buried |
| 22 | S | A | -0.4766 | Soluble |
| 23 | C | A | 0.0000 | Buried |
| 24 | A | A | -0.1859 | Soluble |
| 25 | A | A | 0.0000 | Buried |
| 26 | S | A | -0.6765 | Soluble |
| 27 | G | A | -0.8672 | Soluble |
| 28 | F | A | -0.3864 | Soluble |
| 29 | T | A | -0.3344 | Soluble |
| 30 | F | A | 0.0000 | Buried |
| 35 | S | A | -1.1472 | Soluble |
| 36 | N | A | -0.8728 | Soluble |
| 37 | Y | A | -0.3768 | Soluble |
| 38 | W | A | -0.4798 | Soluble |
| 39 | M | A | 0.0000 | Buried |
| 40 | N | A | 0.0000 | Buried |
| 41 | W | A | 0.0000 | Buried |
| 42 | V | A | 0.0000 | Buried |
| 43 | R | A | 0.0000 | Buried |
| 44 | Q | A | -0.8177 | Soluble |
| 45 | A | A | -1.1679 | Soluble |
| 46 | P | A | -0.9462 | Soluble |
| 47 | G | A | -1.4847 | Soluble |
| 48 | K | A | -2.4140 | Soluble |
| 49 | G | A | -1.6507 | Soluble |
| 50 | L | A | 0.0000 | Buried |
| 51 | E | A | -1.1525 | Soluble |
| 52 | W | A | 0.0000 | Buried |
| 53 | V | A | 0.0000 | Buried |
| 54 | A | A | 0.0000 | Buried |
| 55 | A | A | 0.0000 | Buried |
| 56 | I | A | 0.0000 | Buried |
| 57 | N | A | 0.0000 | Buried |
| 58 | Q | A | -1.5405 | Soluble |
| 59 | D | A | -2.4363 | Soluble |
| 62 | G | A | -1.9019 | Soluble |
| 63 | S | A | -1.5967 | Soluble |
| 64 | E | A | -1.8854 | Soluble |
| 65 | K | A | -1.4096 | Soluble |
| 66 | Y | A | -0.2127 | Soluble |
| 67 | Y | A | -0.1113 | Soluble |
| 68 | V | A | -0.2225 | Soluble |
| 69 | G | A | -0.8421 | Soluble |
| 70 | S | A | -1.0001 | Soluble |
| 71 | V | A | 0.0000 | Buried |
| 72 | K | A | -1.9173 | Soluble |
| 74 | G | A | -1.4283 | Soluble |
| 75 | R | A | 0.0000 | Buried |
| 76 | F | A | 0.0000 | Buried |
| 77 | T | A | -0.8473 | Soluble |
| 78 | I | A | 0.0000 | Buried |
| 79 | S | A | -0.8859 | Soluble |
| 80 | R | A | -1.2423 | Soluble |
| 81 | D | A | -1.7105 | Soluble |
| 82 | N | A | -1.9592 | Soluble |
| 83 | A | A | -1.3344 | Soluble |
| 84 | K | A | -2.2589 | Soluble |
| 85 | N | A | -1.7341 | Soluble |
| 86 | S | A | 0.0000 | Buried |
| 87 | L | A | 0.0000 | Buried |
| 88 | Y | A | -0.5526 | Soluble |
| 89 | L | A | 0.0000 | Buried |
| 90 | Q | A | -1.2502 | Soluble |
| 91 | M | A | 0.0000 | Buried |
| 92 | N | A | -1.3625 | Soluble |
| 93 | S | A | -1.1909 | Soluble |
| 94 | L | A | 0.0000 | Buried |
| 95 | R | A | -1.4015 | Soluble |
| 96 | V | A | 0.0315 | Aggregation-prone |
| 97 | E | A | -1.3967 | Soluble |
| 98 | D | A | 0.0000 | Buried |
| 99 | T | A | -0.1783 | Soluble |
| 100 | A | A | 0.0000 | Buried |
| 101 | V | A | 0.1687 | Aggregation-prone |
| 102 | Y | A | 0.0000 | Buried |
| 103 | Y | A | 0.0000 | Buried |
| 104 | C | A | 0.0000 | Buried |
| 105 | V | A | 0.0000 | Buried |
| 106 | R | A | -0.1790 | Soluble |
| 107 | D | A | 0.0000 | Buried |
| 108 | Y | A | 0.3355 | Aggregation-prone |
| 109 | Y | A | 0.7199 | Aggregation-prone |
| 110 | D | A | 1.1467 | Aggregation-prone |
| 111 | I | A | 2.3886 | Aggregation-prone |
| 111A | L | A | 2.2549 | Aggregation-prone |
| 111B | T | A | 0.6306 | Aggregation-prone |
| 111C | D | A | -0.2658 | Soluble |
| 112D | Y | A | 1.6057 | Aggregation-prone |
| 112C | Y | A | 1.4739 | Aggregation-prone |
| 112B | I | A | 1.3085 | Aggregation-prone |
| 112A | H | A | 0.6376 | Aggregation-prone |
| 112 | Y | A | 0.4877 | Aggregation-prone |
| 113 | W | A | 0.2548 | Aggregation-prone |
| 114 | Y | A | 0.0000 | Buried |
| 115 | F | A | 0.0000 | Buried |
| 116 | D | A | -0.5699 | Soluble |
| 117 | L | A | -0.3338 | Soluble |
| 118 | W | A | 0.0000 | Buried |
| 119 | G | A | 0.0000 | Buried |
| 120 | R | A | -1.9318 | Soluble |
| 121 | G | A | 0.0000 | Buried |
| 122 | T | A | 0.0000 | Buried |
| 123 | L | A | 0.3012 | Aggregation-prone |
| 124 | V | A | 0.0000 | Buried |
| 125 | T | A | 0.0000 | Buried |
| 126 | V | A | 0.0000 | Buried |
| 127 | S | A | -0.4542 | Soluble |
| 128 | S | A | -0.4829 | Soluble |
| 129 | A | A | -0.4734 | Soluble |
| 130 | S | A | -0.5776 | Soluble |
| 131 | T | A | -0.5500 | Soluble |
| 132 | K | A | -1.1185 | Soluble |
| 133 | G | A | -1.3888 | Soluble |
| 134 | P | A | 0.0000 | Buried |
| 135 | S | A | -0.1700 | Soluble |
| 136 | V | A | 0.0000 | Buried |
| 137 | F | A | -0.6041 | Soluble |
| 138 | P | A | -1.1546 | Soluble |
| 139 | L | A | 0.0000 | Buried |
| 140 | A | A | -1.2298 | Soluble |
| 141 | P | A | 0.0000 | Buried |
| 142 | S | A | -1.5234 | Soluble |
| 143 | S | A | -1.8440 | Soluble |
| 144 | K | A | -2.0525 | Soluble |
| 145 | S | A | -1.3389 | Soluble |
| 146 | T | A | -0.7850 | Soluble |
| 147 | S | A | -0.7541 | Soluble |
| 148 | G | A | -1.0420 | Soluble |
| 149 | G | A | -0.9097 | Soluble |
| 150 | T | A | -0.6397 | Soluble |
| 151 | A | A | 0.0000 | Buried |
| 152 | A | A | 0.0000 | Buried |
| 153 | L | A | 0.0000 | Buried |
| 154 | G | A | 0.0000 | Buried |
| 155 | C | A | 0.0000 | Buried |
| 156 | L | A | 0.0000 | Buried |
| 157 | V | A | 0.0000 | Buried |
| 158 | K | A | 0.0000 | Buried |
| 159 | D | A | -0.3599 | Soluble |
| 160 | Y | A | 0.0000 | Buried |
| 161 | F | A | 0.0000 | Buried |
| 162 | P | A | 0.0000 | Buried |
| 163 | E | A | -0.4947 | Soluble |
| 164 | P | A | -0.8182 | Soluble |
| 165 | V | A | -0.8472 | Soluble |
| 166 | T | A | -0.7393 | Soluble |
| 167 | V | A | -0.4005 | Soluble |
| 168 | S | A | -0.3709 | Soluble |
| 169 | W | A | 0.0000 | Buried |
| 170 | N | A | -0.6475 | Soluble |
| 171 | S | A | -0.5482 | Soluble |
| 172 | G | A | -0.3865 | Soluble |
| 173 | A | A | -0.1755 | Soluble |
| 174 | L | A | 0.0538 | Aggregation-prone |
| 175 | T | A | -0.1514 | Soluble |
| 176 | S | A | -0.2086 | Soluble |
| 177 | G | A | -0.2681 | Soluble |
| 178 | V | A | 0.1435 | Aggregation-prone |
| 179 | H | A | -0.2738 | Soluble |
| 180 | T | A | -0.0066 | Soluble |
| 181 | F | A | 0.0000 | Buried |
| 182 | P | A | -0.2815 | Soluble |
| 183 | A | A | 0.2318 | Aggregation-prone |
| 184 | V | A | 0.5855 | Aggregation-prone |
| 185 | L | A | 1.0883 | Aggregation-prone |
| 186 | Q | A | 0.2688 | Aggregation-prone |
| 187 | S | A | -0.0660 | Soluble |
| 188 | S | A | -0.1894 | Soluble |
| 189 | G | A | 0.0413 | Aggregation-prone |
| 190 | L | A | 0.1490 | Aggregation-prone |
| 191 | Y | A | 0.3994 | Aggregation-prone |
| 192 | S | A | 0.0000 | Buried |
| 193 | L | A | 0.0000 | Buried |
| 194 | S | A | 0.0000 | Buried |
| 195 | S | A | 0.0000 | Buried |
| 196 | V | A | 0.0000 | Buried |
| 197 | V | A | 0.0000 | Buried |
| 198 | T | A | -0.1355 | Soluble |
| 199 | V | A | 0.0000 | Buried |
| 200 | P | A | -0.5710 | Soluble |
| 201 | S | A | -0.9617 | Soluble |
| 202 | S | A | -0.8698 | Soluble |
| 203 | S | A | -0.7056 | Soluble |
| 204 | L | A | 0.0000 | Buried |
| 205 | G | A | -1.0446 | Soluble |
| 206 | T | A | -0.7422 | Soluble |
| 207 | Q | A | -1.1641 | Soluble |
| 208 | T | A | -1.0883 | Soluble |
| 209 | Y | A | 0.0000 | Buried |
| 210 | I | A | -1.1205 | Soluble |
| 211 | C | A | 0.0000 | Buried |
| 212 | N | A | -1.4661 | Soluble |
| 213 | V | A | 0.0000 | Buried |
| 214 | N | A | -2.4022 | Soluble |
| 215 | H | A | 0.0000 | Buried |
| 216 | K | A | -2.8781 | Soluble |
| 217 | P | A | -1.6256 | Soluble |
| 218 | S | A | -1.8633 | Soluble |
| 219 | N | A | -2.6790 | Soluble |
| 220 | T | A | -2.1807 | Soluble |
| 221 | K | A | -2.8570 | Soluble |
| 222 | V | A | -1.6105 | Soluble |
| 223 | D | A | -2.2838 | Soluble |
| 224 | K | A | -2.0163 | Soluble |
| 225 | K | A | -2.3520 | Soluble |
| 226 | V | A | 0.0000 | Buried |
| 227 | E | A | -2.8660 | Soluble |
| 228 | P | A | -2.2691 | Soluble |
| 229 | K | A | -2.3260 | Soluble |
| 230 | S | A | -1.2519 | Soluble |
| 231 | C | A | -0.1019 | Soluble |
| 1 | E | B | -1.6218 | Soluble |
| 2 | I | B | 0.0000 | Buried |
| 3 | V | B | 0.7376 | Aggregation-prone |
| 4 | L | B | 0.0000 | Buried |
| 5 | T | B | -0.5826 | Soluble |
| 6 | Q | B | 0.0000 | Buried |
| 7 | S | B | -0.6680 | Soluble |
| 8 | P | B | -0.4306 | Soluble |
| 9 | G | B | -0.7780 | Soluble |
| 10 | T | B | -0.3397 | Soluble |
| 11 | L | B | -0.1378 | Soluble |
| 12 | S | B | -0.4310 | Soluble |
| 13 | L | B | -0.9516 | Soluble |
| 14 | S | B | -1.5878 | Soluble |
| 15 | P | B | -2.1020 | Soluble |
| 16 | G | B | -2.3765 | Soluble |
| 17 | E | B | -2.8719 | Soluble |
| 18 | R | B | -3.2500 | Soluble |
| 19 | A | B | 0.0000 | Buried |
| 20 | T | B | -0.5292 | Soluble |
| 21 | L | B | 0.0000 | Buried |
| 22 | S | B | -0.8658 | Soluble |
| 23 | C | B | 0.0000 | Buried |
| 24 | R | B | -1.9576 | Soluble |
| 25 | A | B | 0.0000 | Buried |
| 26 | S | B | -0.9796 | Soluble |
| 27 | Q | B | -1.7399 | Soluble |
| 28 | S | B | -1.4282 | Soluble |
| 29 | V | B | 0.0000 | Buried |
| 30 | S | B | -0.4835 | Soluble |
| 36 | S | B | -0.3139 | Soluble |
| 37 | S | B | -0.4178 | Soluble |
| 38 | Y | B | 0.2891 | Aggregation-prone |
| 39 | L | B | 0.0000 | Buried |
| 40 | A | B | 0.0000 | Buried |
| 41 | W | B | 0.0000 | Buried |
| 42 | Y | B | 0.0000 | Buried |
| 43 | Q | B | 0.0000 | Buried |
| 44 | Q | B | 0.0000 | Buried |
| 45 | K | B | -1.2479 | Soluble |
| 46 | P | B | -1.2645 | Soluble |
| 47 | G | B | -1.4418 | Soluble |
| 48 | Q | B | -2.0309 | Soluble |
| 49 | A | B | -1.4845 | Soluble |
| 50 | P | B | 0.0000 | Buried |
| 51 | R | B | -1.2353 | Soluble |
| 52 | L | B | -0.5368 | Soluble |
| 53 | L | B | 0.0000 | Buried |
| 54 | I | B | 0.0000 | Buried |
| 55 | Y | B | 0.1330 | Aggregation-prone |
| 56 | G | B | -0.1189 | Soluble |
| 57 | A | B | 0.0000 | Buried |
| 65 | S | B | -0.5567 | Soluble |
| 66 | S | B | -0.5987 | Soluble |
| 67 | R | B | -1.3092 | Soluble |
| 68 | A | B | -0.6991 | Soluble |
| 69 | T | B | -0.5397 | Soluble |
| 70 | G | B | -0.7765 | Soluble |
| 71 | I | B | -0.7823 | Soluble |
| 72 | P | B | -1.2065 | Soluble |
| 74 | D | B | -2.3202 | Soluble |
| 75 | R | B | -1.9503 | Soluble |
| 76 | F | B | 0.0000 | Buried |
| 77 | S | B | -0.8810 | Soluble |
| 78 | G | B | -0.4916 | Soluble |
| 79 | S | B | -0.7906 | Soluble |
| 80 | G | B | -1.2334 | Soluble |
| 83 | S | B | -1.1660 | Soluble |
| 84 | G | B | -1.3041 | Soluble |
| 85 | T | B | -1.9114 | Soluble |
| 86 | D | B | -2.6652 | Soluble |
| 87 | F | B | 0.0000 | Buried |
| 88 | T | B | -0.8393 | Soluble |
| 89 | L | B | 0.0000 | Buried |
| 90 | T | B | -0.7989 | Soluble |
| 91 | I | B | 0.0000 | Buried |
| 92 | S | B | -2.4084 | Soluble |
| 93 | R | B | -3.5560 | Soluble |
| 94 | L | B | 0.0000 | Buried |
| 95 | E | B | -2.5026 | Soluble |
| 96 | P | B | -1.5786 | Soluble |
| 97 | E | B | -2.2458 | Soluble |
| 98 | D | B | 0.0000 | Buried |
| 99 | F | B | -0.5542 | Soluble |
| 100 | A | B | 0.0000 | Buried |
| 101 | V | B | -0.0761 | Soluble |
| 102 | Y | B | 0.0000 | Buried |
| 103 | Y | B | 0.0000 | Buried |
| 104 | C | B | 0.0000 | Buried |
| 105 | Q | B | 0.0000 | Buried |
| 106 | Q | B | 0.0000 | Buried |
| 107 | Y | B | 0.0000 | Buried |
| 108 | G | B | -0.1630 | Soluble |
| 109 | S | B | -0.7366 | Soluble |
| 114 | S | B | -0.6660 | Soluble |
| 115 | P | B | -0.5227 | Soluble |
| 116 | C | B | 0.0000 | Buried |
| 117 | T | B | -0.2194 | Soluble |
| 118 | F | B | 0.0181 | Aggregation-prone |
| 119 | G | B | 0.0000 | Buried |
| 120 | Q | B | -1.4868 | Soluble |
| 121 | G | B | 0.0000 | Buried |
| 122 | T | B | 0.0000 | Buried |
| 123 | R | B | -0.5035 | Soluble |
| 124 | L | B | 0.0000 | Buried |
| 125 | E | B | 0.0000 | Buried |
| 126 | I | B | -0.7782 | Soluble |
| 127 | K | B | -1.2683 | Soluble |
| 128 | R | B | -0.9083 | Soluble |
| 129 | T | B | 0.2537 | Aggregation-prone |
| 130 | V | B | 1.2380 | Aggregation-prone |
| 131 | A | B | 0.6739 | Aggregation-prone |
| 132 | A | B | 0.3683 | Aggregation-prone |
| 133 | P | B | 0.0974 | Aggregation-prone |
| 134 | S | B | -0.1887 | Soluble |
| 135 | V | B | 0.0022 | Aggregation-prone |
| 136 | F | B | 0.0878 | Aggregation-prone |
| 137 | I | B | 0.1472 | Aggregation-prone |
| 138 | F | B | 0.0000 | Buried |
| 139 | P | B | -0.4552 | Soluble |
| 140 | P | B | 0.0000 | Buried |
| 141 | S | B | -1.6884 | Soluble |
| 142 | D | B | -2.7886 | Soluble |
| 143 | E | B | -2.6984 | Soluble |
| 144 | Q | B | 0.0000 | Buried |
| 145 | L | B | -2.2354 | Soluble |
| 146 | K | B | -2.7031 | Soluble |
| 147 | S | B | -1.6611 | Soluble |
| 148 | G | B | -1.3264 | Soluble |
| 149 | T | B | -0.9609 | Soluble |
| 150 | A | B | 0.0000 | Buried |
| 151 | S | B | 0.0000 | Buried |
| 152 | V | B | 0.0000 | Buried |
| 153 | V | B | 0.0000 | Buried |
| 154 | C | B | 0.0000 | Buried |
| 155 | L | B | 0.0000 | Buried |
| 156 | L | B | 0.0000 | Buried |
| 157 | N | B | 0.0000 | Buried |
| 158 | N | B | -0.8355 | Soluble |
| 159 | F | B | 0.0000 | Buried |
| 160 | Y | B | 0.0000 | Buried |
| 161 | P | B | -1.3487 | Soluble |
| 162 | R | B | -2.7912 | Soluble |
| 163 | E | B | -3.0823 | Soluble |
| 164 | A | B | -2.2406 | Soluble |
| 165 | K | B | -2.3479 | Soluble |
| 166 | V | B | -1.1637 | Soluble |
| 167 | Q | B | -0.6561 | Soluble |
| 168 | W | B | 0.0000 | Buried |
| 169 | K | B | -0.6092 | Soluble |
| 170 | V | B | 0.0000 | Buried |
| 171 | D | B | -1.4847 | Soluble |
| 172 | N | B | -1.3850 | Soluble |
| 173 | A | B | -0.3180 | Soluble |
| 174 | L | B | 0.3257 | Aggregation-prone |
| 175 | Q | B | -0.3045 | Soluble |
| 176 | S | B | -0.4951 | Soluble |
| 177 | G | B | -0.8610 | Soluble |
| 178 | N | B | -0.7521 | Soluble |
| 179 | S | B | -0.9674 | Soluble |
| 180 | Q | B | -1.1066 | Soluble |
| 181 | E | B | -1.4088 | Soluble |
| 182 | S | B | -0.5734 | Soluble |
| 183 | V | B | -0.6755 | Soluble |
| 184 | T | B | -1.0074 | Soluble |
| 185 | E | B | -1.9435 | Soluble |
| 186 | Q | B | -1.6983 | Soluble |
| 187 | D | B | -1.8828 | Soluble |
| 188 | S | B | -1.9448 | Soluble |
| 189 | K | B | -2.3916 | Soluble |
| 190 | D | B | -2.0026 | Soluble |
| 191 | S | B | -1.7509 | Soluble |
| 192 | T | B | 0.0000 | Buried |
| 193 | Y | B | 0.0000 | Buried |
| 194 | S | B | 0.0000 | Buried |
| 195 | L | B | 0.0000 | Buried |
| 196 | S | B | 0.0000 | Buried |
| 197 | S | B | 0.0000 | Buried |
| 198 | T | B | -0.5275 | Soluble |
| 199 | L | B | 0.0000 | Buried |
| 200 | T | B | -0.3974 | Soluble |
| 201 | L | B | -0.6247 | Soluble |
| 202 | S | B | -0.9985 | Soluble |
| 203 | K | B | -2.0129 | Soluble |
| 204 | A | B | -1.8305 | Soluble |
| 205 | D | B | -2.4726 | Soluble |
| 206 | Y | B | 0.0000 | Buried |
| 207 | E | B | -3.3792 | Soluble |
| 208 | K | B | -3.4734 | Soluble |
| 209 | H | B | -2.7383 | Soluble |
| 210 | K | B | -2.9429 | Soluble |
| 211 | V | B | -0.9722 | Soluble |
| 212 | Y | B | 0.0000 | Buried |
| 213 | A | B | 0.0000 | Buried |
| 214 | C | B | 0.0000 | Buried |
| 215 | E | B | -0.7614 | Soluble |
| 216 | V | B | 0.0000 | Buried |
| 217 | T | B | -1.0780 | Soluble |
| 218 | Q | B | -1.0988 | Soluble |
| 219 | G | B | -1.0622 | Soluble |
| 220 | T | B | -0.4254 | Soluble |
| 221 | T | B | -0.2927 | Soluble |
| 222 | S | B | -0.4914 | Soluble |
| 223 | V | B | 0.0591 | Aggregation-prone |
| 224 | T | B | -0.4132 | Soluble |
| 225 | K | B | -0.7572 | Soluble |
| 226 | S | B | -0.4835 | Soluble |
| 227 | F | B | -0.7708 | Soluble |
| 228 | N | B | -1.7587 | Soluble |
| 229 | R | B | -2.3132 | Soluble |
| 230 | G | B | -1.9942 | Soluble |
| 231 | E | B | -2.0999 | Soluble |
| 232 | C | B | -0.6809 | Soluble |
3D Structure — colored by A4D score
pH-Dependent Aggregation Profiles
A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.
| pH | Avg A4D Score | Max A4D Score | Downloads |
|---|---|---|---|
| 4.0 | -0.6954 | 4.0659 | CSV PDB |
| 4.5 | -0.7408 | 3.9214 | CSV PDB |
| 5.0 | -0.7941 | 3.7607 | CSV PDB |
| 5.5 | -0.8454 | 3.5951 | CSV PDB |
| 6.0 | -0.8837 | 3.43 | CSV PDB |
| 6.5 | -0.8994 | 3.2672 | CSV PDB |
| 7.0 | -0.8915 | 3.1052 | CSV PDB |
| 7.5 | -0.867 | 2.9437 | CSV PDB |
| 8.0 | -0.8329 | 2.7884 | CSV PDB |
| 8.5 | -0.7915 | 2.6539 | CSV PDB |
| 9.0 | -0.7434 | 2.5593 | CSV PDB |