Secukinumab

A4DAB237 | Immune-mediated / inflammatory disorders | Approved
IL17A
G1 / IgG1
Beth Israel Deaconess Medical Center GWT-TUD GmbH Icahn School of Medicine at Mount Sinai Novartis Alcon
Approved
Whole mAb
AIN-457 AIN457 AIN 547 Cosentyx KB-03303A KB03303A KB 03303A KB3303A KB-3303A KB 3303A Kosentikusu NVP-AIN-457 Scapho
5.8
IMGT PubChem (135288104) PubChem (160677295) PubChem (249565758) PubChem (347910391) PubChem (348644151) PubChem (354355044) PubChem (387060192) PubChem (461629171) PubChem (463561821) PubChem (469690928) PubChem (472264664) PubChem (472402212) PubChem (475546923) PubChem (481101848) PubChem (481155328) PubChem (488421038) PubChem (496156071) PubChem (498154447) PubChem (507720775) PubChem (513686597) Thera-SAbDab YAbS
Avg A4D Score
-0.6758
Score Range
-0.69 to -0.66
Structures
2
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB237_6wio_A_B 6wio 100% -0.6603 6.5 4.0 -0.1894 -0.7271
A4DAB237_6wir_A_B 6wir 100% -0.6913 7.0 4.0 -0.2126 -0.7598