Galegenimab / 7sjn

A4DAB122_7sjn_H_L | Source PDB: 7sjn | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7679
Max Score
1.2683
Min Score
-3.1112
Total Score
-171.24
Score CDR
-0.8291
Score non-CDR
-0.7524

Calculation Parameters

Chain Sequence(s) EVQLVQSGAEVKKPGASVKVSCKASGYKFTDSEMHWVRQAPGQGLEWIGGVDPETEGAAYNQKFKGRATITRDTSTSTAYLELSSLRSEDTAVYYCTRGYDYDYALDYWGQGTLVTVDIQMTQSPSSLSASVGDRVTITCRASSSVEFIHWYQQKPGKAPKPLISATSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSAPWTFGQGTKVEIK input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1112
Maximum Score 1.2683
Average Score -0.7679
Total Score -171.2372

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.0363 Soluble
2 V H -1.2942 Soluble
3 Q H -1.5435 Soluble
4 L H 0.0000 Buried
5 V H -0.6581 Soluble
6 Q H 0.0000 Buried
7 S H -0.7303 Soluble
8 G H -0.3300 Soluble
9 A H 0.0697 Aggregation-prone
11 E H -0.6083 Soluble
12 V H 0.7526 Aggregation-prone
13 K H -0.9121 Soluble
14 K H -1.8481 Soluble
15 P H -1.4180 Soluble
16 G H -1.2548 Soluble
17 A H -0.9797 Soluble
18 S H -1.3470 Soluble
19 V H 0.0000 Buried
20 K H -2.1386 Soluble
21 V H 0.0000 Buried
22 S H -0.6606 Soluble
23 C H 0.0000 Buried
24 K H -1.6115 Soluble
25 A H 0.0000 Buried
26 S H -1.5149 Soluble
27 G H -1.5466 Soluble
28 Y H -1.5362 Soluble
29 K H -2.1881 Soluble
30 F H 0.0000 Buried
35 T H -2.2819 Soluble
36 D H -2.6327 Soluble
37 S H 0.0000 Buried
38 E H -1.4883 Soluble
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.3532 Soluble
44 Q H -0.6457 Soluble
45 A H -1.1804 Soluble
46 P H -0.9313 Soluble
47 G H -1.2111 Soluble
48 Q H -1.8345 Soluble
49 G H -1.3566 Soluble
50 L H 0.0000 Buried
51 E H -1.0295 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 G H 0.0000 Buried
56 V H 0.0000 Buried
57 D H -2.0787 Soluble
58 P H 0.0000 Buried
59 E H -3.1112 Soluble
62 T H -2.0365 Soluble
63 E H -2.7034 Soluble
64 G H -1.5907 Soluble
65 A H -0.6123 Soluble
66 A H -0.3086 Soluble
67 Y H -1.0184 Soluble
68 N H -1.8142 Soluble
69 Q H -2.9671 Soluble
70 K H -2.9665 Soluble
71 F H 0.0000 Buried
72 K H -3.0796 Soluble
74 G H -2.0776 Soluble
75 R H -2.0789 Soluble
76 A H 0.0000 Buried
77 T H -0.8350 Soluble
78 I H -0.2658 Soluble
79 T H -0.6702 Soluble
80 R H -1.4721 Soluble
81 D H -1.2525 Soluble
82 T H -1.1624 Soluble
83 S H -0.5898 Soluble
84 T H -0.7950 Soluble
85 S H -1.2273 Soluble
86 T H -0.9418 Soluble
87 A H 0.0000 Buried
88 Y H -0.4906 Soluble
89 L H 0.0000 Buried
90 E H -1.5666 Soluble
91 L H 0.0000 Buried
92 S H -1.1899 Soluble
93 S H -0.8874 Soluble
94 L H 0.0000 Buried
95 R H -1.6983 Soluble
96 S H -1.3685 Soluble
97 E H -2.0705 Soluble
98 D H 0.0000 Buried
99 T H -0.2517 Soluble
100 A H 0.0000 Buried
101 V H 0.0000 Buried
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 T H 0.0000 Buried
106 R H -0.1385 Soluble
107 G H -0.2725 Soluble
108 Y H 0.2219 Aggregation-prone
109 D H -0.7588 Soluble
110 Y H 0.1177 Aggregation-prone
112 D H -1.1152 Soluble
113 Y H -0.5536 Soluble
114 A H 0.0000 Buried
115 L H 0.0000 Buried
116 D H -0.3138 Soluble
117 Y H -0.0409 Soluble
118 W H -0.6003 Soluble
119 G H 0.0000 Buried
120 Q H -1.2814 Soluble
121 G H -0.5679 Soluble
122 T H 0.0000 Buried
123 L H 1.2683 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.1940 Aggregation-prone
126 V H -0.5531 Soluble
1 D L -2.1795 Soluble
2 I L -1.3177 Soluble
3 Q L -1.8482 Soluble
4 M L -1.1669 Soluble
5 T L -0.9245 Soluble
6 Q L 0.0000 Buried
7 S L -0.6419 Soluble
8 P L -0.5653 Soluble
9 S L -0.8518 Soluble
10 S L -1.1295 Soluble
11 L L -0.6780 Soluble
12 S L -1.2275 Soluble
13 A L 0.0000 Buried
14 S L -0.7032 Soluble
15 V L 0.5625 Aggregation-prone
16 G L -0.8044 Soluble
17 D L -1.8730 Soluble
18 R L -2.3877 Soluble
19 V L 0.0000 Buried
20 T L -0.5635 Soluble
21 I L 0.0000 Buried
22 T L -0.7691 Soluble
23 C L 0.0000 Buried
24 R L -1.8638 Soluble
25 A L 0.0000 Buried
26 S L -1.2003 Soluble
27 S L -1.0288 Soluble
28 S L -1.1843 Soluble
29 V L 0.0000 Buried
37 E L -1.9145 Soluble
38 F L -1.0963 Soluble
39 I L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -2.6025 Soluble
46 P L -1.7607 Soluble
47 G L -1.9362 Soluble
48 K L -2.8298 Soluble
49 A L -1.7820 Soluble
50 P L 0.0000 Buried
51 K L -1.6514 Soluble
52 P L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 S L 0.0000 Buried
56 A L -0.7941 Soluble
57 T L 0.0000 Buried
65 S L -0.8252 Soluble
66 N L -1.1667 Soluble
67 L L -0.2573 Soluble
68 A L -0.3665 Soluble
69 S L -0.3812 Soluble
70 G L -0.3691 Soluble
71 V L 0.0149 Aggregation-prone
72 P L -0.3186 Soluble
74 S L -0.5193 Soluble
75 R L -0.5347 Soluble
76 F L 0.0000 Buried
77 S L -0.6092 Soluble
78 G L -0.5420 Soluble
79 S L -0.8557 Soluble
80 G L -1.3186 Soluble
83 S L -1.3511 Soluble
84 G L -1.4893 Soluble
85 T L -1.7026 Soluble
86 D L -2.3304 Soluble
87 F L 0.0000 Buried
88 T L -0.8058 Soluble
89 L L 0.0000 Buried
90 T L -0.6348 Soluble
91 I L 0.0000 Buried
92 S L -1.5299 Soluble
93 S L -1.2669 Soluble
94 L L 0.0000 Buried
95 Q L -1.0535 Soluble
96 P L -0.9506 Soluble
97 E L -2.1174 Soluble
98 D L 0.0000 Buried
99 F L -0.9265 Soluble
100 A L 0.0000 Buried
101 T L -1.2362 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 W L 0.0000 Buried
108 S L -0.5448 Soluble
109 S L -0.5969 Soluble
114 A L -0.4679 Soluble
115 P L -0.9106 Soluble
116 W L -0.4737 Soluble
117 T L -0.8121 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.4173 Soluble
121 G L -1.1345 Soluble
122 T L 0.0000 Buried
123 K L -2.1406 Soluble
124 V L 0.0000 Buried
125 E L -2.1589 Soluble
126 I L -0.9471 Soluble
127 K L -1.6217 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7067 2.0376 CSV PDB
4.5 -0.7625 1.9953 CSV PDB
5.0 -0.8314 1.9354 CSV PDB
5.5 -0.8998 1.8682 CSV PDB
6.0 -0.9531 1.8039 CSV PDB
6.5 -0.9807 1.7532 CSV PDB
7.0 -0.9817 1.723 CSV PDB
7.5 -0.9637 1.7097 CSV PDB
8.0 -0.9348 1.7048 CSV PDB
8.5 -0.8985 1.7032 CSV PDB
9.0 -0.8546 1.7027 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH