Ginisortamab / 8b7h

A4DAB130_8b7h_H_L | Source PDB: 8b7h | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7251
Max Score
1.368
Min Score
-3.6067
Total Score
-319.02
Score CDR
—
Score non-CDR
—

Calculation Parameters

Chain Sequence(s) QVQLVESGAEVKKPGATVKISCKVSGYTFTDYYMHWVQQAPGKGLEWMGLVDPEDGETIYAEKFQGRVTITADTSTDTAYMELSSLRSEDTAVYYCATDARGSGSYYPNHFDYWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTINSLQAEDVAVYFCQQYYDTPTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6067
Maximum Score 1.368
Average Score -0.7251
Total Score -319.025

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.2857 Soluble
2 V H -0.5708 Soluble
3 Q H -1.4731 Soluble
4 L H 0.0000 Buried
5 V H -0.6752 Soluble
6 E H 0.0000 Buried
7 S H -0.7583 Soluble
8 G H -0.4537 Soluble
9 A H -0.1001 Soluble
11 E H -0.4547 Soluble
12 V H -0.0494 Soluble
13 K H -1.3766 Soluble
14 K H -2.3372 Soluble
15 P H -2.2714 Soluble
16 G H -1.6439 Soluble
17 A H -1.2476 Soluble
18 T H -1.2821 Soluble
19 V H 0.0000 Buried
20 K H -1.9738 Soluble
21 I H 0.0000 Buried
22 S H -0.9428 Soluble
23 C H 0.0000 Buried
24 K H -2.2863 Soluble
25 V H -1.3716 Soluble
26 S H -1.1145 Soluble
27 G H -0.4516 Soluble
28 Y H -0.1387 Soluble
29 T H -0.5338 Soluble
30 F H 0.0000 Buried
35 T H -2.0125 Soluble
36 D H -2.0760 Soluble
37 Y H 0.0000 Buried
38 Y H -0.2150 Soluble
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 Q H 0.0000 Buried
44 Q H -0.6553 Soluble
45 A H 0.0000 Buried
46 P H -1.2024 Soluble
47 G H -1.5681 Soluble
48 K H -2.5080 Soluble
49 G H -1.5183 Soluble
50 L H 0.0000 Buried
51 E H -1.1936 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 L H 0.0000 Buried
56 V H 0.0000 Buried
57 D H -2.3610 Soluble
58 P H -2.6403 Soluble
59 E H -3.6067 Soluble
62 D H -3.5133 Soluble
63 G H -2.8386 Soluble
64 E H -2.7576 Soluble
65 T H -0.9002 Soluble
66 I H 0.0256 Aggregation-prone
67 Y H -0.5476 Soluble
68 A H 0.0000 Buried
69 E H -2.9768 Soluble
70 K H -3.0619 Soluble
71 F H 0.0000 Buried
72 Q H -2.4783 Soluble
74 G H -1.7319 Soluble
75 R H -1.3676 Soluble
76 V H 0.0000 Buried
77 T H -0.6619 Soluble
78 I H 0.0000 Buried
79 T H -0.6194 Soluble
80 A H -1.4914 Soluble
81 D H -2.1811 Soluble
82 T H -1.9479 Soluble
83 S H -1.1292 Soluble
84 T H -1.5989 Soluble
85 D H -2.3513 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.8768 Soluble
89 M H 0.0000 Buried
90 E H -1.2957 Soluble
91 L H 0.0000 Buried
92 S H -1.1233 Soluble
93 S H -1.2722 Soluble
94 L H 0.0000 Buried
95 R H -3.0814 Soluble
96 S H -2.3483 Soluble
97 E H -2.7449 Soluble
98 D H 0.0000 Buried
99 T H -0.8655 Soluble
100 A H 0.0000 Buried
101 V H 0.4548 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 T H 0.0000 Buried
107 D H 0.0000 Buried
108 A H 0.0000 Buried
109 R H -1.0321 Soluble
110 G H -0.7891 Soluble
111 S H -0.4372 Soluble
111A G H -0.5182 Soluble
111B S H 0.0345 Aggregation-prone
112B Y H 1.3680 Aggregation-prone
112A Y H 0.8234 Aggregation-prone
112 P H 0.1810 Aggregation-prone
113 N H 0.3488 Aggregation-prone
114 H H 0.0000 Buried
115 F H 0.0000 Buried
116 D H 0.0000 Buried
117 Y H -0.1731 Soluble
118 W H -0.3715 Soluble
119 G H 0.0000 Buried
120 Q H -1.1152 Soluble
121 G H -0.4835 Soluble
122 T H 0.0000 Buried
123 L H 0.7025 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.5514 Soluble
126 V H 0.0000 Buried
127 S H -1.3192 Soluble
128 S H -0.9630 Soluble
129 A H -0.6305 Soluble
130 S H -0.6687 Soluble
131 T H -0.6454 Soluble
132 K H -1.2691 Soluble
133 G H -1.3734 Soluble
134 P H 0.0000 Buried
135 S H -0.3904 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1508 Soluble
139 L H 0.0000 Buried
140 A H -1.0428 Soluble
141 P H 0.0000 Buried
142 S H -0.4195 Soluble
143 G H -0.6346 Soluble
144 T H -0.4565 Soluble
145 A H -0.2360 Soluble
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.3808 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H 0.0000 Buried
157 E H -0.6977 Soluble
158 P H -0.9380 Soluble
159 V H -0.8110 Soluble
160 T H -0.7134 Soluble
161 V H -0.4309 Soluble
162 S H -0.4304 Soluble
163 W H 0.0000 Buried
164 N H -0.7454 Soluble
165 S H -0.6720 Soluble
166 G H -0.5772 Soluble
167 A H -0.2558 Soluble
168 L H -0.0103 Soluble
169 T H -0.1699 Soluble
170 S H -0.1679 Soluble
171 G H -0.1784 Soluble
172 V H 0.1700 Aggregation-prone
173 H H -0.2680 Soluble
174 T H 0.0249 Aggregation-prone
175 F H 0.0000 Buried
176 P H -0.3697 Soluble
177 A H 0.0157 Aggregation-prone
178 V H 0.2547 Aggregation-prone
179 L H 1.0956 Aggregation-prone
180 Q H 0.2746 Aggregation-prone
181 S H -0.0520 Soluble
182 S H -0.1633 Soluble
183 G H 0.0499 Aggregation-prone
184 L H 0.0622 Aggregation-prone
185 Y H 0.3263 Aggregation-prone
186 S H 0.0000 Buried
187 L H 0.0000 Buried
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.1235 Soluble
193 V H 0.0000 Buried
194 P H -0.5720 Soluble
195 S H -0.5051 Soluble
196 S H -0.5766 Soluble
197 S H -0.5759 Soluble
198 L H -0.8079 Soluble
199 G H -1.0961 Soluble
200 T H -0.8856 Soluble
201 Q H -1.2213 Soluble
202 T H -1.1200 Soluble
203 Y H 0.0000 Buried
204 I H -1.2045 Soluble
205 C H 0.0000 Buried
206 N H -1.4742 Soluble
207 V H 0.0000 Buried
208 N H -2.2219 Soluble
209 H H 0.0000 Buried
210 K H -2.8824 Soluble
211 P H -1.6934 Soluble
212 S H -1.9165 Soluble
213 N H -2.6460 Soluble
214 T H -2.1345 Soluble
215 K H -2.7770 Soluble
216 V H -1.6846 Soluble
217 D H -2.4667 Soluble
218 K H -2.0444 Soluble
219 K H -2.3864 Soluble
220 V H 0.0000 Buried
221 E H -2.6810 Soluble
222 P H -1.5205 Soluble
223 K H -1.7829 Soluble
224 S H -0.6398 Soluble
225 C H 0.0993 Aggregation-prone
1 D L -1.8264 Soluble
2 I L 0.0000 Buried
3 V L 0.8648 Aggregation-prone
4 M L 0.0000 Buried
5 T L -0.7025 Soluble
6 Q L 0.0000 Buried
7 S L -1.3332 Soluble
8 P L -1.2136 Soluble
9 D L -2.0815 Soluble
10 S L -0.9347 Soluble
11 L L -0.3995 Soluble
12 A L -0.3448 Soluble
13 V L 0.0000 Buried
14 S L -1.1173 Soluble
15 L L -0.1991 Soluble
16 G L -1.3064 Soluble
17 E L -2.8198 Soluble
18 R L -2.9277 Soluble
19 A L 0.0000 Buried
20 T L -0.6905 Soluble
21 I L 0.0000 Buried
22 N L -1.5721 Soluble
23 C L 0.0000 Buried
24 K L -2.0929 Soluble
25 S L 0.0000 Buried
26 S L -0.8667 Soluble
27 Q L -1.3259 Soluble
28 S L -0.4668 Soluble
29 V L 0.0000 Buried
30 L L 0.3123 Aggregation-prone
31 Y L 0.2810 Aggregation-prone
32 S L -0.8098 Soluble
33 S L -0.9996 Soluble
34 N L -1.8425 Soluble
35 N L -1.7558 Soluble
36 K L -1.0182 Soluble
37 N L 0.0000 Buried
38 Y L 0.4315 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -0.9996 Soluble
45 K L -1.5127 Soluble
46 P L -1.3490 Soluble
47 G L -1.4348 Soluble
48 Q L -2.0945 Soluble
49 P L -1.3820 Soluble
50 P L 0.0000 Buried
51 K L -1.4897 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.1635 Aggregation-prone
56 W L 0.3256 Aggregation-prone
57 A L 0.0000 Buried
65 S L -0.4430 Soluble
66 T L -0.4243 Soluble
67 R L -1.2953 Soluble
68 E L -1.0452 Soluble
69 S L -0.7300 Soluble
70 G L -0.9862 Soluble
71 V L 0.0000 Buried
72 P L -1.4092 Soluble
74 D L -2.2998 Soluble
75 R L -1.7777 Soluble
76 F L 0.0000 Buried
77 S L -0.9764 Soluble
78 G L -0.4700 Soluble
79 S L -0.7201 Soluble
80 G L -1.1917 Soluble
83 S L -1.0414 Soluble
84 G L -0.9246 Soluble
85 T L -1.5532 Soluble
86 D L -2.4501 Soluble
87 F L 0.0000 Buried
88 T L -1.0457 Soluble
89 L L 0.0000 Buried
90 T L -0.7575 Soluble
91 I L 0.0000 Buried
92 N L -2.1752 Soluble
93 S L -1.7489 Soluble
94 L L 0.0000 Buried
95 Q L -1.2385 Soluble
96 A L -0.9381 Soluble
97 E L -1.9165 Soluble
98 D L 0.0000 Buried
99 V L -0.2879 Soluble
100 A L 0.0000 Buried
101 V L -0.0242 Soluble
102 Y L 0.0000 Buried
103 F L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 Y L -0.0970 Soluble
114 D L -1.7038 Soluble
115 T L -1.2463 Soluble
116 P L 0.0000 Buried
117 T L -0.3167 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.3476 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 R L -0.5832 Soluble
124 L L 0.0000 Buried
125 E L 0.0000 Buried
126 I L 0.0000 Buried
127 K L -1.3516 Soluble
128 R L -0.7493 Soluble
129 T L 0.1513 Aggregation-prone
130 V L 0.9715 Aggregation-prone
131 A L 0.3230 Aggregation-prone
132 A L 0.0240 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.0547 Soluble
135 V L 0.0736 Aggregation-prone
136 F L 0.1796 Aggregation-prone
137 I L 0.1409 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.3944 Soluble
140 P L 0.0000 Buried
141 S L 0.0000 Buried
142 D L -2.9180 Soluble
143 E L -2.6743 Soluble
144 Q L 0.0000 Buried
145 L L -2.1413 Soluble
146 K L -2.7047 Soluble
147 S L -1.6433 Soluble
148 G L -1.2162 Soluble
149 T L -0.7858 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.6979 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.2412 Soluble
162 R L -2.1916 Soluble
163 E L -2.8119 Soluble
164 A L -2.1235 Soluble
165 K L -2.3098 Soluble
166 V L -1.0186 Soluble
167 Q L -0.6319 Soluble
168 W L 0.0000 Buried
169 K L -0.4133 Soluble
170 V L 0.0000 Buried
171 D L -1.6693 Soluble
172 N L -1.3735 Soluble
173 A L -0.1863 Soluble
174 L L 0.7904 Aggregation-prone
175 Q L -0.0599 Soluble
176 S L -0.4023 Soluble
177 G L -0.9557 Soluble
178 N L -0.9370 Soluble
179 S L -1.2191 Soluble
180 Q L -1.5139 Soluble
181 E L -1.9631 Soluble
182 S L -0.9785 Soluble
183 V L -0.7530 Soluble
184 T L -1.0182 Soluble
185 E L -2.1389 Soluble
186 Q L -1.7379 Soluble
187 D L -1.9564 Soluble
188 S L -1.8826 Soluble
189 K L -2.2103 Soluble
190 D L -1.6525 Soluble
191 S L -1.7160 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.6958 Soluble
199 L L 0.0000 Buried
200 T L -0.4752 Soluble
201 L L -0.6716 Soluble
202 S L -1.2000 Soluble
203 K L -2.0162 Soluble
204 A L -1.8913 Soluble
205 D L -2.5780 Soluble
206 Y L 0.0000 Buried
207 E L -3.3012 Soluble
208 K L -3.4717 Soluble
209 H L -2.6167 Soluble
210 K L -2.5164 Soluble
211 V L -0.7643 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.8919 Soluble
216 V L 0.0000 Buried
217 T L -1.2120 Soluble
218 H L 0.0000 Buried
219 Q L -1.5813 Soluble
220 G L -0.3076 Soluble
221 L L -0.1935 Soluble
222 S L -0.4729 Soluble
223 S L -0.4200 Soluble
224 P L -0.5576 Soluble
225 V L 0.0573 Aggregation-prone
226 T L -0.4542 Soluble
227 K L -0.7271 Soluble
228 S L -0.5821 Soluble
229 F L -0.5781 Soluble
230 N L -1.3291 Soluble
231 R L -1.9548 Soluble
232 G L -1.7076 Soluble
233 E L -1.8909 Soluble
234 C L -0.4383 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6467 1.4601 CSV PDB
4.5 -0.7015 1.4094 CSV PDB
5.0 -0.7686 1.4094 CSV PDB
5.5 -0.8353 1.4094 CSV PDB
6.0 -0.8877 1.4094 CSV PDB
6.5 -0.915 1.4093 CSV PDB
7.0 -0.9161 1.4093 CSV PDB
7.5 -0.899 1.4093 CSV PDB
8.0 -0.8714 1.409 CSV PDB
8.5 -0.8364 1.4083 CSV PDB
9.0 -0.7936 1.406 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH