Cinpanemab / 6ct7

A4DAB065_6ct7_H_L | Source PDB: 6ct7 | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7444
Max Score
1.2574
Min Score
-3.4363
Total Score
-316.38
Score CDR
-0.6612
Score non-CDR
-0.7536

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVEPGGSLRLSCAVSGFDFEKAWMSWVRQAPGQGLQWVARIKSTADGGTTSYAAPVEGRFIISRDDSRNMLYLQMNSLKTEDTAVYYCTSAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSYELTQPPSVSVSPGQTARITCSGEALPMQFAHWYQQRPGKAPVIVVYKDSERPSGVPERFSGSSSGTTATLTITGVQAEDEADYYCQSPDSTNTYEVFGGGTKLTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4363
Maximum Score 1.2574
Average Score -0.7444
Total Score -316.3796

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -1.9852 Soluble
2 V H -1.2462 Soluble
3 Q H -1.5125 Soluble
4 L H 0.0000 Buried
5 V H 0.2256 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.5194 Soluble
8 G H -0.8787 Soluble
9 G H -0.4186 Soluble
11 G H -0.2862 Soluble
12 L H -0.2169 Soluble
13 V H -0.8920 Soluble
14 E H -2.1255 Soluble
15 P H -1.8033 Soluble
16 G H -1.3941 Soluble
17 G H -1.1400 Soluble
18 S H -1.2741 Soluble
19 L H -1.2712 Soluble
20 R H -2.1207 Soluble
21 L H 0.0000 Buried
22 S H -0.5662 Soluble
23 C H 0.0000 Buried
24 A H -0.3364 Soluble
25 V H 0.0000 Buried
26 S H -1.0857 Soluble
27 G H -1.3953 Soluble
28 F H -1.5374 Soluble
29 D H -2.8551 Soluble
30 F H 0.0000 Buried
35 E H -3.4363 Soluble
36 K H -3.2769 Soluble
37 A H -1.8157 Soluble
38 W H -0.6650 Soluble
39 M H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.6436 Soluble
45 A H -0.9521 Soluble
46 P H -0.8577 Soluble
47 G H -1.2426 Soluble
48 Q H -1.7936 Soluble
49 G H -1.2324 Soluble
50 L H 0.0000 Buried
51 Q H -0.8794 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 A H 0.0000 Buried
55 R H 0.0000 Buried
56 I H 0.0000 Buried
57 K H -1.2731 Soluble
58 S H 0.0000 Buried
59 T H -1.6850 Soluble
60 A H -1.6068 Soluble
61 D H -2.2088 Soluble
62 G H -1.4223 Soluble
63 G H -0.9887 Soluble
64 T H -0.6789 Soluble
65 T H 0.0129 Aggregation-prone
66 S H -0.1609 Soluble
67 Y H -0.3719 Soluble
68 A H -0.5742 Soluble
69 A H -0.7586 Soluble
70 P H -0.9917 Soluble
71 V H 0.0000 Buried
72 E H -1.9657 Soluble
74 G H -1.3754 Soluble
75 R H -1.1426 Soluble
76 F H 0.0000 Buried
77 I H 0.0094 Aggregation-prone
78 I H 0.0000 Buried
79 S H -0.3163 Soluble
80 R H -1.2948 Soluble
81 D H -2.0010 Soluble
82 D H -2.6675 Soluble
83 S H -1.9693 Soluble
84 R H -2.5190 Soluble
85 N H -2.2519 Soluble
86 M H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H -0.5712 Soluble
89 L H 0.0000 Buried
90 Q H -1.2085 Soluble
91 M H 0.0000 Buried
92 N H -1.0783 Soluble
93 S H -1.0983 Soluble
94 L H 0.0000 Buried
95 K H -1.9021 Soluble
96 T H -1.6830 Soluble
97 E H -2.1373 Soluble
98 D H 0.0000 Buried
99 T H -0.5977 Soluble
100 A H 0.0000 Buried
101 V H 0.3422 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 T H 0.0000 Buried
106 S H -0.0274 Soluble
116 A H 0.0776 Aggregation-prone
117 H H -0.1054 Soluble
118 W H -0.0451 Soluble
119 G H 0.0000 Buried
120 Q H -1.3651 Soluble
121 G H -0.5151 Soluble
122 T H -0.0080 Soluble
123 L H 0.2422 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.1629 Soluble
128 S H -0.9503 Soluble
129 A H -0.6252 Soluble
130 S H -0.7313 Soluble
131 T H -0.7207 Soluble
132 K H -1.3100 Soluble
133 G H -1.4968 Soluble
134 P H -0.7241 Soluble
135 S H -0.3704 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.0657 Soluble
139 L H 0.0000 Buried
140 A H -1.3296 Soluble
141 P H 0.0000 Buried
142 S H -1.6532 Soluble
143 S H -1.3795 Soluble
144 K H -1.9991 Soluble
145 S H -1.0368 Soluble
146 T H -1.0542 Soluble
147 S H -0.9873 Soluble
148 G H -0.8525 Soluble
149 G H -0.9092 Soluble
150 T H -0.6328 Soluble
151 A H 0.0000 Buried
152 A H -0.3531 Soluble
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.7195 Soluble
160 Y H 0.0000 Buried
161 F H 0.0000 Buried
162 P H 0.0000 Buried
163 E H -0.6583 Soluble
164 P H -0.8425 Soluble
165 V H -0.6740 Soluble
166 T H -0.5277 Soluble
167 V H -0.2948 Soluble
168 S H -0.3238 Soluble
169 W H 0.0000 Buried
170 N H -0.7397 Soluble
171 S H -0.6540 Soluble
172 G H -0.4482 Soluble
173 A H -0.1757 Soluble
174 L H 0.0646 Aggregation-prone
175 T H -0.1562 Soluble
176 S H -0.2565 Soluble
177 G H -0.2852 Soluble
178 V H 0.2131 Aggregation-prone
179 H H -0.1409 Soluble
180 T H -0.0630 Soluble
181 F H 0.0000 Buried
182 P H 0.0332 Aggregation-prone
183 A H 0.2835 Aggregation-prone
184 V H 0.0000 Buried
185 L H 1.2448 Aggregation-prone
186 Q H 0.2906 Aggregation-prone
187 S H -0.1079 Soluble
188 S H -0.1985 Soluble
189 G H 0.0325 Aggregation-prone
190 L H -0.0310 Soluble
191 Y H 0.2192 Aggregation-prone
192 S H 0.0000 Buried
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.2067 Soluble
199 V H 0.0000 Buried
200 P H -0.6477 Soluble
201 S H -0.6191 Soluble
202 S H -0.5918 Soluble
203 S H -0.5926 Soluble
204 L H -0.7971 Soluble
205 G H -0.9640 Soluble
206 T H -0.6980 Soluble
207 Q H -1.1803 Soluble
208 T H -1.1018 Soluble
209 Y H 0.0000 Buried
210 I H -1.3299 Soluble
211 C H 0.0000 Buried
212 N H -1.5273 Soluble
213 V H 0.0000 Buried
214 N H -1.7058 Soluble
215 H H 0.0000 Buried
216 K H -2.7417 Soluble
217 P H -1.6529 Soluble
218 S H -1.8478 Soluble
219 N H -2.4448 Soluble
220 T H -2.0357 Soluble
221 K H -2.6067 Soluble
222 V H -1.5596 Soluble
223 D H -2.5349 Soluble
224 K H -2.1748 Soluble
225 R H -2.5521 Soluble
226 V H 0.0000 Buried
227 E H -2.8736 Soluble
228 P H -1.9795 Soluble
229 K H -2.5136 Soluble
1 S L -0.5510 Soluble
2 Y L -1.1157 Soluble
3 E L -2.1315 Soluble
4 L L 0.0000 Buried
5 T L -0.8835 Soluble
6 Q L 0.0000 Buried
7 P L -0.5768 Soluble
8 P L -0.8932 Soluble
9 S L -0.9031 Soluble
11 V L -0.7228 Soluble
12 S L -0.3079 Soluble
13 V L 0.0000 Buried
14 S L -0.3801 Soluble
15 P L -0.9882 Soluble
16 G L -1.2938 Soluble
17 Q L -1.4698 Soluble
18 T L -1.3030 Soluble
19 A L 0.0000 Buried
20 R L -1.8697 Soluble
21 I L 0.0000 Buried
22 T L -0.5667 Soluble
23 C L 0.0000 Buried
24 S L -0.8791 Soluble
25 G L 0.0000 Buried
26 E L -2.1624 Soluble
27 A L 0.0000 Buried
28 L L 0.0000 Buried
29 P L -0.1340 Soluble
36 M L 0.7547 Aggregation-prone
37 Q L 0.5139 Aggregation-prone
38 F L 1.2574 Aggregation-prone
39 A L 0.0000 Buried
40 H L -0.2298 Soluble
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -0.7299 Soluble
45 R L -1.4446 Soluble
46 P L -1.4291 Soluble
47 G L -1.6712 Soluble
48 K L -2.2134 Soluble
49 A L -1.0484 Soluble
50 P L 0.0000 Buried
51 V L 1.2379 Aggregation-prone
52 I L 0.0000 Buried
53 V L 0.0000 Buried
54 V L 0.0000 Buried
55 Y L -0.8720 Soluble
56 K L -1.0349 Soluble
57 D L -0.9619 Soluble
65 S L -1.5760 Soluble
66 E L -2.6838 Soluble
67 R L -2.4422 Soluble
68 P L -1.1115 Soluble
69 S L -1.0576 Soluble
70 G L -0.9159 Soluble
71 V L -0.7377 Soluble
72 P L -1.3680 Soluble
74 E L -2.3126 Soluble
75 R L -1.3753 Soluble
76 F L 0.0000 Buried
77 S L -1.4744 Soluble
78 G L -1.2390 Soluble
79 S L -0.8878 Soluble
80 S L -0.4536 Soluble
83 S L -0.5245 Soluble
84 G L -0.8426 Soluble
85 T L -0.9048 Soluble
86 T L -0.6491 Soluble
87 A L 0.0000 Buried
88 T L -0.7148 Soluble
89 L L 0.0000 Buried
90 T L -0.9599 Soluble
91 I L 0.0000 Buried
92 T L -1.2755 Soluble
93 G L -1.0551 Soluble
94 V L 0.0000 Buried
95 Q L -1.5317 Soluble
96 A L -1.3118 Soluble
97 E L -2.2888 Soluble
98 D L 0.0000 Buried
99 E L 0.0000 Buried
100 A L 0.0000 Buried
101 D L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 S L 0.0000 Buried
107 P L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.4446 Soluble
110 T L -0.1885 Soluble
113 N L -0.3417 Soluble
114 T L -0.2033 Soluble
115 Y L 0.0714 Aggregation-prone
116 E L -0.2551 Soluble
117 V L -0.3387 Soluble
118 F L -0.3858 Soluble
119 G L 0.0000 Buried
120 G L -1.1759 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.8848 Soluble
124 L L 0.0000 Buried
125 T L -0.5007 Soluble
126 V L 0.0000 Buried
127 L L 0.8076 Aggregation-prone
128 S L -0.1285 Soluble
129 Q L -0.5487 Soluble
130 P L -1.1035 Soluble
131 K L -2.2907 Soluble
132 A L -1.3896 Soluble
133 A L -0.9382 Soluble
134 P L -0.5811 Soluble
135 S L -0.4437 Soluble
136 V L 0.0000 Buried
137 T L -0.6745 Soluble
138 L L 0.0000 Buried
139 F L 0.0000 Buried
140 P L -0.3441 Soluble
141 P L 0.0000 Buried
142 S L -1.2378 Soluble
143 S L -1.8451 Soluble
144 E L -2.6175 Soluble
145 E L 0.0000 Buried
146 L L -2.1963 Soluble
147 Q L -2.4840 Soluble
148 A L -2.0679 Soluble
149 N L -2.8696 Soluble
150 K L -2.8973 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.7104 Soluble
159 D L -1.7146 Soluble
160 F L 0.0000 Buried
161 Y L -1.2045 Soluble
162 P L -1.0381 Soluble
163 G L -0.6772 Soluble
164 A L -0.2010 Soluble
165 V L -0.0283 Soluble
166 T L -0.0358 Soluble
167 V L 0.0545 Aggregation-prone
168 A L -0.5035 Soluble
169 W L 0.0000 Buried
170 K L -1.2049 Soluble
171 A L -1.0457 Soluble
172 D L -1.2691 Soluble
173 S L -0.8919 Soluble
174 S L -0.8047 Soluble
175 P L -0.9067 Soluble
176 V L -0.8797 Soluble
177 K L -1.7004 Soluble
178 A L -0.8301 Soluble
179 G L -0.6747 Soluble
180 V L -0.5095 Soluble
181 E L -0.3232 Soluble
182 T L 0.0641 Aggregation-prone
183 T L 0.1062 Aggregation-prone
184 T L -0.1300 Soluble
185 P L -0.2367 Soluble
186 S L -0.5220 Soluble
187 K L -1.1798 Soluble
188 Q L -1.3616 Soluble
189 S L -1.3533 Soluble
190 N L -2.0965 Soluble
191 N L -1.6922 Soluble
192 K L -1.6251 Soluble
193 Y L -0.8675 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.6336 Soluble
201 L L -1.2516 Soluble
202 T L -1.9743 Soluble
203 P L -2.5799 Soluble
204 E L -3.2558 Soluble
205 Q L -2.4604 Soluble
206 W L 0.0000 Buried
207 K L -3.1537 Soluble
208 S L -2.4367 Soluble
209 H L -2.3985 Soluble
210 R L -2.5172 Soluble
211 S L -1.7486 Soluble
212 Y L 0.0000 Buried
213 S L -1.0483 Soluble
214 C L 0.0000 Buried
215 Q L -1.0738 Soluble
216 V L 0.0000 Buried
217 T L -0.6695 Soluble
218 H L 0.0000 Buried
219 E L -2.3025 Soluble
220 G L -1.4291 Soluble
221 S L -0.8495 Soluble
222 T L -0.7425 Soluble
223 V L -0.7620 Soluble
224 E L -2.0777 Soluble
225 K L -1.7389 Soluble
226 T L -1.1236 Soluble
227 V L 0.0000 Buried
228 A L -1.4951 Soluble
229 P L -1.7463 Soluble
230 T L -1.5969 Soluble
231 E L -2.0705 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6462 3.0459 CSV PDB
4.5 -0.695 3.036 CSV PDB
5.0 -0.7555 3.0327 CSV PDB
5.5 -0.8153 3.0427 CSV PDB
6.0 -0.8607 3.075 CSV PDB
6.5 -0.8806 3.1292 CSV PDB
7.0 -0.8731 3.1962 CSV PDB
7.5 -0.8467 3.2697 CSV PDB
8.0 -0.8107 3.3485 CSV PDB
8.5 -0.7694 3.4327 CSV PDB
9.0 -0.7237 3.5197 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH