Ogalvibart / 7k8z

A4DAB189_7k8z_H_L | Source PDB: 7k8z | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5927
Max Score
2.007
Min Score
-3.045
Total Score
-132.77
Score CDR
-0.5669
Score non-CDR
-0.5994

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVIPFDGRNKYYADSVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASSSGYLFHSDYWGQGTLVTVSDIQMTQSPSTLSASVGDRVTITCRASQSISNWLAWFQQKPGKAPKLLIYEASSLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNSYPWTFGQGTKVEI input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.045
Maximum Score 2.007
Average Score -0.5927
Total Score -132.7677

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.8958 Soluble
2 V H 0.0000 Buried
3 Q H -1.8086 Soluble
4 L H 0.0000 Buried
5 V H 0.4642 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.3131 Soluble
8 G H -0.6206 Soluble
9 G H 0.0515 Aggregation-prone
11 G H 0.7944 Aggregation-prone
12 V H 1.4726 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.8056 Soluble
15 P H -2.1302 Soluble
16 G H -2.2727 Soluble
17 R H -2.8729 Soluble
18 S H -2.1126 Soluble
19 L H -1.2393 Soluble
20 R H -1.6469 Soluble
21 L H 0.0000 Buried
22 S H -0.2353 Soluble
23 C H 0.0000 Buried
24 A H -0.1339 Soluble
25 A H 0.0000 Buried
26 S H -0.9039 Soluble
27 G H -1.1680 Soluble
28 F H -0.5004 Soluble
29 T H -0.0679 Soluble
30 F H 0.0000 Buried
35 S H -0.5540 Soluble
36 S H 0.0897 Aggregation-prone
37 Y H 0.4651 Aggregation-prone
38 A H 0.4892 Aggregation-prone
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.7317 Soluble
45 A H -1.0782 Soluble
46 P H -0.9956 Soluble
47 G H -1.6332 Soluble
48 K H -2.4912 Soluble
49 G H -1.8602 Soluble
50 L H 0.0000 Buried
51 E H -0.9780 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 A H 0.0000 Buried
55 V H 0.0000 Buried
56 I H 0.0000 Buried
57 P H -0.7315 Soluble
58 F H 0.0199 Aggregation-prone
59 D H -2.0976 Soluble
62 G H -2.2126 Soluble
63 R H -3.0450 Soluble
64 N H -2.6517 Soluble
65 K H -1.8808 Soluble
66 Y H -0.2150 Soluble
67 Y H -0.2770 Soluble
68 A H 0.0000 Buried
69 D H -1.8529 Soluble
70 S H -1.3396 Soluble
71 V H 0.0000 Buried
72 T H -0.9034 Soluble
74 G H -0.9864 Soluble
75 R H -1.0282 Soluble
76 F H 0.0000 Buried
77 T H -0.5080 Soluble
78 I H 0.0000 Buried
79 S H -0.3410 Soluble
80 R H -0.8797 Soluble
81 D H -1.5978 Soluble
82 N H -1.5827 Soluble
83 S H -1.6044 Soluble
84 K H -2.3383 Soluble
85 N H -1.6584 Soluble
86 T H -0.8884 Soluble
87 L H 0.0000 Buried
88 Y H -0.0879 Soluble
89 L H 0.0000 Buried
90 Q H -0.8227 Soluble
91 M H 0.0000 Buried
92 N H -1.9309 Soluble
93 S H -1.8584 Soluble
94 L H 0.0000 Buried
95 R H -2.7125 Soluble
96 A H -1.8428 Soluble
97 E H -2.2837 Soluble
98 D H 0.0000 Buried
99 T H -0.4172 Soluble
100 A H 0.0000 Buried
101 V H 0.6151 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 S H 0.0000 Buried
107 S H 0.0000 Buried
108 S H -0.3008 Soluble
109 G H 0.0972 Aggregation-prone
110 Y H 1.0953 Aggregation-prone
112 L H 0.0000 Buried
113 F H 0.0000 Buried
114 H H -0.8575 Soluble
115 S H -1.4638 Soluble
116 D H -2.3375 Soluble
117 Y H 0.0000 Buried
118 W H -0.9778 Soluble
119 G H 0.0000 Buried
120 Q H -1.3753 Soluble
121 G H -0.2608 Soluble
122 T H 0.3659 Aggregation-prone
123 L H 1.4538 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.3168 Aggregation-prone
126 V H 0.0000 Buried
127 S H -0.8370 Soluble
1 D L -2.1928 Soluble
2 I L 0.0000 Buried
3 Q L -2.1708 Soluble
4 M L 0.0000 Buried
5 T L -1.5730 Soluble
6 Q L 0.0000 Buried
7 S L -0.6224 Soluble
8 P L -0.3482 Soluble
9 S L -0.5773 Soluble
10 T L -0.3272 Soluble
11 L L 0.2487 Aggregation-prone
12 S L 0.3524 Aggregation-prone
13 A L 0.3897 Aggregation-prone
14 S L 0.5698 Aggregation-prone
15 V L 0.9546 Aggregation-prone
16 G L -0.5456 Soluble
17 D L -1.4529 Soluble
18 R L -2.0741 Soluble
19 V L 0.0000 Buried
20 T L -0.4103 Soluble
21 I L 0.0000 Buried
22 T L -0.9306 Soluble
23 C L 0.0000 Buried
24 R L -2.8454 Soluble
25 A L -2.1846 Soluble
26 S L -2.0330 Soluble
27 Q L -2.1637 Soluble
28 S L -1.1440 Soluble
29 I L 0.0000 Buried
36 S L -0.8900 Soluble
37 N L -0.8305 Soluble
38 W L -0.0512 Soluble
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 F L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.8111 Soluble
46 P L -1.4303 Soluble
47 G L -1.7533 Soluble
48 K L -2.5849 Soluble
49 A L -1.7040 Soluble
50 P L 0.0000 Buried
51 K L -2.0662 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.3600 Aggregation-prone
56 E L -0.5207 Soluble
57 A L 0.0000 Buried
65 S L -0.2945 Soluble
66 S L 0.1265 Aggregation-prone
67 L L 0.6527 Aggregation-prone
68 E L 0.0364 Aggregation-prone
69 S L -0.2957 Soluble
70 G L -0.4461 Soluble
71 V L -0.0868 Soluble
72 P L -0.2495 Soluble
74 S L -0.3087 Soluble
75 R L -0.7516 Soluble
76 F L 0.0000 Buried
77 S L -0.1302 Soluble
78 G L -0.2746 Soluble
79 S L -0.8520 Soluble
80 G L -1.0990 Soluble
83 S L -1.0877 Soluble
84 G L -1.2667 Soluble
85 T L -1.9437 Soluble
86 E L -2.7978 Soluble
87 F L 0.0000 Buried
88 T L -0.8443 Soluble
89 L L 0.0000 Buried
90 T L -0.5631 Soluble
91 I L 0.0000 Buried
92 S L -1.2311 Soluble
93 S L -1.0185 Soluble
94 L L 0.0000 Buried
95 Q L -0.9530 Soluble
96 P L -0.6701 Soluble
97 D L -1.8482 Soluble
98 D L 0.0000 Buried
99 F L -0.1692 Soluble
100 A L 0.0000 Buried
101 T L -0.6294 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 N L -0.9644 Soluble
109 S L -0.5980 Soluble
114 Y L 0.0208 Aggregation-prone
115 P L -0.3269 Soluble
116 W L 0.0000 Buried
117 T L -0.7031 Soluble
118 F L -0.4602 Soluble
119 G L -1.0899 Soluble
120 Q L -1.5916 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -0.8287 Soluble
124 V L 0.0000 Buried
125 E L 0.3722 Aggregation-prone
126 I L 2.0070 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5772 2.8583 CSV PDB
4.5 -0.6165 2.8128 CSV PDB
5.0 -0.6616 2.7516 CSV PDB
5.5 -0.7065 2.685 CSV PDB
6.0 -0.7448 2.6232 CSV PDB
6.5 -0.7712 2.5765 CSV PDB
7.0 -0.7847 2.5502 CSV PDB
7.5 -0.7883 2.5391 CSV PDB
8.0 -0.785 2.5351 CSV PDB
8.5 -0.775 2.5338 CSV PDB
9.0 -0.7578 2.5334 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH