Ogalvibart

A4DAB189 | Phase-II/III
SARS-CoV-2 Spike RBD
G1 / None
National Institute of Allergy and Infectious Diseases Rockefeller University Xencor
Phase-II/III
Whole mAb
C-135-LS BMS-986414 BMS 986414 BMS986414
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IMGT PubChem (461453495) PubChem (472423988) PubChem (476000809) PubChem (476262116) PubChem (476269252) PubChem (513907261) Thera-SAbDab YAbS
Avg A4D Score
-0.6391
Score Range
-0.73 to -0.59
Structures
3
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB189_7k8z_M_N 7k8z 100% -0.5978 7.5 4.0 -0.5897 -0.5999
A4DAB189_7k8z_H_L 7k8z 100% -0.5927 7.5 4.0 -0.5669 -0.5994
A4DAB189_7k8r_H_L 7k8r 100% -0.7268 6.5 4.0 -0.5653 -0.7459