Clesrovimab / 6ous

A4DAB067_6ous_U_V | Source PDB: 6ous | Chains: U, V | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7334
Max Score
1.1457
Min Score
-3.5325
Total Score
-310.98
Score CDR
-0.7354
Score non-CDR
-0.7331

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVRPGRSLRLSCTVSGFSFDDSAMSWVRQAPGKGLEWISFIKSKTYGGTKEYAASVKGRFTISRDDSKNIAYLQMNSLKTEDTAVYYCTRGAPYGGNSDYYYGLDVWGQGTTVTVSSASKGPSVFPLAPGTAALGCLVKDYFPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNHKPSNTKVDKKVEPDIQMTQSPSSLSASVGDRVTITCRTSQDVRGALAWYQQKPGKAPKLLIFDASSLETGVPSRFSGSGSGTVFTLTISSLQPEDFAAYYCQQFLDFPFTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF input.pdb
Selected Chain(s) U (Heavy), V (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5325
Maximum Score 1.1457
Average Score -0.7334
Total Score -310.9771

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E U -1.6976 Soluble
2 V U -0.4670 Soluble
3 Q U -0.9960 Soluble
4 L U 0.0000 Buried
5 V U 0.2485 Aggregation-prone
6 E U 0.0000 Buried
7 S U -0.5584 Soluble
8 G U -0.8985 Soluble
9 G U -0.4985 Soluble
11 G U 0.2516 Aggregation-prone
12 L U 0.9347 Aggregation-prone
13 V U -0.4413 Soluble
14 R U -2.1637 Soluble
15 P U -2.1318 Soluble
16 G U -2.1649 Soluble
17 R U -3.0558 Soluble
18 S U -2.1090 Soluble
19 L U -1.7908 Soluble
20 R U -2.1999 Soluble
21 L U 0.0000 Buried
22 S U -0.5223 Soluble
23 C U 0.0000 Buried
24 T U -0.2393 Soluble
25 V U 0.0000 Buried
26 S U -0.5594 Soluble
27 G U -0.7287 Soluble
28 F U -0.4844 Soluble
29 S U -0.8171 Soluble
30 F U 0.0000 Buried
35 D U -2.9757 Soluble
36 D U -2.2484 Soluble
37 S U -1.7211 Soluble
38 A U 0.0000 Buried
39 M U 0.0000 Buried
40 S U 0.0000 Buried
41 W U 0.0000 Buried
42 V U 0.0000 Buried
43 R U 0.0000 Buried
44 Q U -0.7800 Soluble
45 A U -1.2117 Soluble
46 P U -0.9931 Soluble
47 G U -1.4695 Soluble
48 K U -2.3744 Soluble
49 G U -1.6437 Soluble
50 L U 0.0000 Buried
51 E U -1.0370 Soluble
52 W U 0.0000 Buried
53 I U 0.0000 Buried
54 S U 0.0000 Buried
55 F U 0.0000 Buried
56 I U 0.0000 Buried
57 K U -1.4326 Soluble
58 S U 0.0000 Buried
59 K U -2.4106 Soluble
60 T U -1.2775 Soluble
61 Y U 0.2413 Aggregation-prone
62 G U -1.1680 Soluble
63 G U -1.0985 Soluble
64 T U -0.9733 Soluble
65 K U -1.4066 Soluble
66 E U -1.0953 Soluble
67 Y U -0.8658 Soluble
68 A U 0.0000 Buried
69 A U -0.9072 Soluble
70 S U -0.7308 Soluble
71 V U 0.0000 Buried
72 K U -2.0359 Soluble
74 G U -1.5407 Soluble
75 R U -1.7024 Soluble
76 F U 0.0000 Buried
77 T U -1.1689 Soluble
78 I U 0.0000 Buried
79 S U -0.5749 Soluble
80 R U -1.2419 Soluble
81 D U -1.6321 Soluble
82 D U -2.1861 Soluble
83 S U -1.6573 Soluble
84 K U -2.3648 Soluble
85 N U -1.8278 Soluble
86 I U -0.8946 Soluble
87 A U 0.0000 Buried
88 Y U -0.6136 Soluble
89 L U 0.0000 Buried
90 Q U -1.6529 Soluble
91 M U 0.0000 Buried
92 N U -2.4127 Soluble
93 S U -1.9926 Soluble
94 L U 0.0000 Buried
95 K U -3.0174 Soluble
96 T U -2.0500 Soluble
97 E U -2.4051 Soluble
98 D U 0.0000 Buried
99 T U -0.7084 Soluble
100 A U 0.0000 Buried
101 V U 0.0598 Aggregation-prone
102 Y U 0.0000 Buried
103 Y U 0.0000 Buried
104 C U 0.0000 Buried
105 T U 0.0000 Buried
106 R U -0.2982 Soluble
107 G U 0.0000 Buried
108 A U 0.0000 Buried
109 P U -0.3145 Soluble
110 Y U 0.6703 Aggregation-prone
111 G U -0.5432 Soluble
111A G U -1.1099 Soluble
111B N U -1.8209 Soluble
112C S U -1.2395 Soluble
112B D U -1.3162 Soluble
112A Y U -0.1682 Soluble
112 Y U 0.0000 Buried
113 Y U 0.6731 Aggregation-prone
114 G U 0.0000 Buried
115 L U 0.0000 Buried
116 D U -0.3953 Soluble
117 V U -0.1741 Soluble
118 W U -0.4975 Soluble
119 G U 0.0000 Buried
120 Q U -1.4456 Soluble
121 G U 0.0000 Buried
122 T U -0.3159 Soluble
123 T U 0.0334 Aggregation-prone
124 V U 0.0000 Buried
125 T U -0.2253 Soluble
126 V U 0.0000 Buried
127 S U -0.7893 Soluble
128 S U -0.9501 Soluble
129 A U -0.6008 Soluble
130 S U -0.4762 Soluble
131 K U -1.5219 Soluble
132 G U -1.4972 Soluble
133 P U -0.6700 Soluble
134 S U -0.6982 Soluble
135 V U 0.0000 Buried
136 F U 0.0000 Buried
137 P U -1.2532 Soluble
138 L U 0.0000 Buried
139 A U -0.8227 Soluble
140 P U -0.4563 Soluble
141 G U -0.6338 Soluble
142 T U -0.4766 Soluble
143 A U -0.2390 Soluble
144 A U 0.0000 Buried
145 L U 0.0000 Buried
146 G U 0.0000 Buried
147 C U 0.0000 Buried
148 L U 0.0000 Buried
149 V U 0.0000 Buried
150 K U 0.0000 Buried
151 D U -0.2692 Soluble
152 Y U 0.0000 Buried
153 F U -0.1534 Soluble
154 P U -0.4290 Soluble
155 V U -0.2396 Soluble
156 T U -0.3338 Soluble
157 V U -0.2129 Soluble
158 S U -0.3323 Soluble
159 W U 0.0000 Buried
160 N U -0.6912 Soluble
161 S U -0.6837 Soluble
162 G U -0.5953 Soluble
163 A U -0.2480 Soluble
164 L U 0.0425 Aggregation-prone
165 T U -0.1026 Soluble
166 S U -0.1300 Soluble
167 G U -0.0596 Soluble
168 V U 0.2641 Aggregation-prone
169 H U -0.3410 Soluble
170 T U -0.1745 Soluble
171 F U 0.0000 Buried
172 P U -0.4648 Soluble
173 A U 0.2919 Aggregation-prone
174 V U 0.4113 Aggregation-prone
175 L U 1.1457 Aggregation-prone
176 Q U 0.0668 Aggregation-prone
177 S U -0.2003 Soluble
178 S U -0.1804 Soluble
179 G U 0.0180 Aggregation-prone
180 L U 0.2821 Aggregation-prone
181 Y U 0.7206 Aggregation-prone
182 S U 0.0000 Buried
183 L U 0.0000 Buried
184 S U 0.0000 Buried
185 S U 0.0000 Buried
186 V U 0.0000 Buried
187 V U 0.0000 Buried
188 T U -0.1342 Soluble
189 V U 0.0000 Buried
190 P U -0.4846 Soluble
191 S U -0.5526 Soluble
192 S U -0.6327 Soluble
193 S U -0.6590 Soluble
194 L U -0.8755 Soluble
195 G U -1.0720 Soluble
196 T U -0.8269 Soluble
197 Q U -1.3899 Soluble
198 T U -1.1373 Soluble
199 Y U 0.0000 Buried
200 I U -1.1754 Soluble
201 C U 0.0000 Buried
202 N U -1.5669 Soluble
203 H U -1.6563 Soluble
204 K U -2.7196 Soluble
205 P U -1.6766 Soluble
206 S U -1.9851 Soluble
207 N U -2.7333 Soluble
208 T U -2.0264 Soluble
209 K U -2.5422 Soluble
210 V U -1.5309 Soluble
211 D U -2.4879 Soluble
212 K U -2.1329 Soluble
213 K U -2.2120 Soluble
214 V U 0.0000 Buried
215 E U -2.3697 Soluble
216 P U -1.1720 Soluble
1 D V -2.2557 Soluble
2 I V -1.7857 Soluble
3 Q V -1.9193 Soluble
4 M V 0.0000 Buried
5 T V -0.9864 Soluble
6 Q V 0.0000 Buried
7 S V -0.6194 Soluble
8 P V -0.6504 Soluble
9 S V -1.0078 Soluble
10 S V -1.1664 Soluble
11 L V -0.5508 Soluble
12 S V -0.9670 Soluble
13 A V 0.0000 Buried
14 S V -0.3142 Soluble
15 V V 0.7657 Aggregation-prone
16 G V -0.5415 Soluble
17 D V -1.3475 Soluble
18 R V -2.1397 Soluble
19 V V 0.0000 Buried
20 T V -0.4758 Soluble
21 I V 0.0000 Buried
22 T V -0.1773 Soluble
23 C V 0.0000 Buried
24 R V -1.2825 Soluble
25 T V 0.0000 Buried
26 S V -1.7320 Soluble
27 Q V -2.7254 Soluble
28 D V -2.5601 Soluble
29 V V 0.0000 Buried
36 R V -2.5611 Soluble
37 G V -1.2633 Soluble
38 A V 0.0000 Buried
39 L V 0.0000 Buried
40 A V 0.0000 Buried
41 W V 0.0000 Buried
42 Y V 0.0000 Buried
43 Q V 0.0000 Buried
44 Q V -1.3297 Soluble
45 K V -1.5903 Soluble
46 P V -1.3861 Soluble
47 G V -1.6385 Soluble
48 K V -2.5516 Soluble
49 A V -1.6039 Soluble
50 P V 0.0000 Buried
51 K V -1.5146 Soluble
52 L V 0.0000 Buried
53 L V 0.0000 Buried
54 I V 0.0000 Buried
55 F V 0.2325 Aggregation-prone
56 D V -0.2978 Soluble
57 A V -0.5575 Soluble
65 S V -0.3619 Soluble
66 S V -0.1004 Soluble
67 L V 0.1387 Aggregation-prone
68 E V -0.4331 Soluble
69 T V -0.3255 Soluble
70 G V -0.4823 Soluble
71 V V -0.3471 Soluble
72 P V -0.3570 Soluble
74 S V -0.4373 Soluble
75 R V -0.8565 Soluble
76 F V 0.0000 Buried
77 S V -0.3445 Soluble
78 G V -0.3273 Soluble
79 S V -0.2966 Soluble
80 G V -0.1591 Soluble
83 S V -0.7830 Soluble
84 G V -1.3581 Soluble
85 T V -0.9508 Soluble
86 V V 0.3974 Aggregation-prone
87 F V 0.0000 Buried
88 T V -0.1226 Soluble
89 L V 0.0000 Buried
90 T V -0.5941 Soluble
91 I V 0.0000 Buried
92 S V -1.3259 Soluble
93 S V -1.0091 Soluble
94 L V 0.0000 Buried
95 Q V -0.9516 Soluble
96 P V -0.9462 Soluble
97 E V -2.0908 Soluble
98 D V 0.0000 Buried
99 F V -0.6069 Soluble
100 A V -1.0659 Soluble
101 A V 0.0000 Buried
102 Y V 0.0000 Buried
103 Y V 0.0000 Buried
104 C V 0.0000 Buried
105 Q V 0.0000 Buried
106 Q V 0.0000 Buried
107 F V 0.0000 Buried
108 L V -1.0904 Soluble
109 D V -1.5659 Soluble
114 F V -0.7836 Soluble
115 P V -0.6475 Soluble
116 F V 0.0000 Buried
117 T V -0.7602 Soluble
118 F V -0.4315 Soluble
119 G V 0.0000 Buried
120 Q V -1.6196 Soluble
121 G V -1.4068 Soluble
122 T V 0.0000 Buried
123 R V -1.9063 Soluble
124 L V 0.0000 Buried
125 E V 0.0000 Buried
126 I V -0.5579 Soluble
127 K V -1.5197 Soluble
128 R V -1.7068 Soluble
129 T V -0.5016 Soluble
130 V V 0.4618 Aggregation-prone
131 A V 0.0867 Aggregation-prone
132 A V -0.0828 Soluble
133 P V 0.0000 Buried
134 S V -0.1427 Soluble
135 V V 0.0000 Buried
136 F V 0.1727 Aggregation-prone
137 I V 0.2752 Aggregation-prone
138 F V 0.0000 Buried
139 P V -0.1187 Soluble
140 P V -0.7639 Soluble
141 S V -1.7121 Soluble
142 D V -3.0688 Soluble
143 E V -3.2408 Soluble
144 Q V 0.0000 Buried
145 L V -2.3561 Soluble
146 K V -2.8786 Soluble
147 S V -1.8717 Soluble
148 G V -1.3806 Soluble
149 T V -0.9832 Soluble
150 A V 0.0000 Buried
151 S V 0.0000 Buried
152 V V 0.0000 Buried
153 V V 0.0000 Buried
154 C V 0.0000 Buried
155 L V 0.0000 Buried
156 L V 0.0000 Buried
157 N V -0.3539 Soluble
158 N V -0.9042 Soluble
159 F V 0.0000 Buried
160 Y V 0.0000 Buried
161 P V -1.3939 Soluble
162 R V -2.1250 Soluble
163 E V -2.8056 Soluble
164 A V -2.0794 Soluble
165 K V -2.1939 Soluble
166 V V -0.9851 Soluble
167 Q V -0.4534 Soluble
168 W V 0.0000 Buried
169 K V -0.6222 Soluble
170 V V 0.0000 Buried
171 D V -1.8350 Soluble
172 N V -1.4054 Soluble
173 A V -0.3500 Soluble
174 L V 0.7060 Aggregation-prone
175 Q V -0.2469 Soluble
176 S V -0.6920 Soluble
177 G V -1.2518 Soluble
178 N V -1.5590 Soluble
179 S V -1.5826 Soluble
180 Q V -1.8504 Soluble
181 E V -2.0589 Soluble
182 S V -0.8917 Soluble
183 V V -0.7006 Soluble
184 T V -1.0217 Soluble
185 E V -2.1241 Soluble
186 Q V -2.0114 Soluble
187 D V -2.3916 Soluble
188 S V -2.0449 Soluble
189 K V -2.8591 Soluble
190 D V -3.1873 Soluble
191 S V 0.0000 Buried
192 T V -1.8295 Soluble
193 Y V 0.0000 Buried
194 S V 0.0000 Buried
195 L V 0.0000 Buried
196 S V 0.0000 Buried
197 S V 0.0000 Buried
198 T V -0.8615 Soluble
199 L V 0.0000 Buried
200 T V -0.5001 Soluble
201 L V -0.6303 Soluble
202 S V -1.0857 Soluble
203 K V -1.9735 Soluble
204 A V -1.7809 Soluble
205 D V -2.3919 Soluble
206 Y V -2.2561 Soluble
207 E V -3.5054 Soluble
208 K V -3.5325 Soluble
209 H V -2.8393 Soluble
210 K V -2.5078 Soluble
211 V V -0.8848 Soluble
212 Y V 0.0000 Buried
213 A V 0.0000 Buried
214 C V 0.0000 Buried
215 E V -0.5996 Soluble
216 V V 0.0000 Buried
217 T V -1.1332 Soluble
218 H V 0.0000 Buried
219 Q V -1.6581 Soluble
220 G V -0.4643 Soluble
221 L V -0.2664 Soluble
222 S V -0.4964 Soluble
223 S V -0.4042 Soluble
224 P V -0.5512 Soluble
225 V V 0.0434 Aggregation-prone
226 T V -0.4398 Soluble
227 K V -0.6222 Soluble
228 S V -0.0665 Soluble
229 F V 0.4484 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7228 1.8926 CSV PDB
4.5 -0.7726 1.8382 CSV PDB
5.0 -0.8299 1.7659 CSV PDB
5.5 -0.8843 1.7143 CSV PDB
6.0 -0.9239 1.7821 CSV PDB
6.5 -0.9388 1.8663 CSV PDB
7.0 -0.9293 1.9582 CSV PDB
7.5 -0.9044 2.0528 CSV PDB
8.0 -0.8709 2.148 CSV PDB
8.5 -0.83 2.2424 CSV PDB
9.0 -0.7807 2.3337 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH