Galegenimab / 7sjn

A4DAB122_7sjn_F_G | Source PDB: 7sjn | Chains: F, G | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7272
Max Score
1.1482
Min Score
-3.1642
Total Score
-162.17
Score CDR
-0.7588
Score non-CDR
-0.7192

Calculation Parameters

Chain Sequence(s) EVQLVQSGAEVKKPGASVKVSCKASGYKFTDSEMHWVRQAPGQGLEWIGGVDPETEGAAYNQKFKGRATITRDTSTSTAYLELSSLRSEDTAVYYCTRGYDYDYALDYWGQGTLVTVDIQMTQSPSSLSASVGDRVTITCRASSSVEFIHWYQQKPGKAPKPLISATSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSAPWTFGQGTKVEIK input.pdb
Selected Chain(s) F (Heavy), G (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1642
Maximum Score 1.1482
Average Score -0.7272
Total Score -162.1713

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E F -2.1058 Soluble
2 V F -1.1529 Soluble
3 Q F -1.3755 Soluble
4 L F -0.4967 Soluble
5 V F 0.1490 Aggregation-prone
6 Q F 0.0000 Buried
7 S F -0.4592 Soluble
8 G F -0.2686 Soluble
9 A F 0.2587 Aggregation-prone
11 E F 0.1041 Aggregation-prone
12 V F 0.9877 Aggregation-prone
13 K F -0.7663 Soluble
14 K F -1.8573 Soluble
15 P F -1.4315 Soluble
16 G F -1.3392 Soluble
17 A F -1.0312 Soluble
18 S F -1.3277 Soluble
19 V F 0.0000 Buried
20 K F -1.7141 Soluble
21 V F 0.0000 Buried
22 S F -0.6389 Soluble
23 C F 0.0000 Buried
24 K F -0.9598 Soluble
25 A F 0.0000 Buried
26 S F -1.3931 Soluble
27 G F -1.6407 Soluble
28 Y F -1.4668 Soluble
29 K F -2.1710 Soluble
30 F F 0.0000 Buried
35 T F -2.2692 Soluble
36 D F -2.6665 Soluble
37 S F 0.0000 Buried
38 E F -1.4897 Soluble
39 M F 0.0000 Buried
40 H F 0.0000 Buried
41 W F 0.0000 Buried
42 V F 0.0000 Buried
43 R F -0.2175 Soluble
44 Q F -0.5555 Soluble
45 A F -1.1285 Soluble
46 P F -0.8697 Soluble
47 G F -1.2084 Soluble
48 Q F -1.8463 Soluble
49 G F -1.3666 Soluble
50 L F 0.0000 Buried
51 E F -0.6756 Soluble
52 W F -0.2607 Soluble
53 I F 0.0000 Buried
54 G F 0.0000 Buried
55 G F 0.0000 Buried
56 V F 0.0000 Buried
57 D F -2.1697 Soluble
58 P F 0.0000 Buried
59 E F -3.1642 Soluble
62 T F -2.3212 Soluble
63 E F -2.7658 Soluble
64 G F -1.6774 Soluble
65 A F -0.6047 Soluble
66 A F -0.2604 Soluble
67 Y F -0.7960 Soluble
68 N F -1.4987 Soluble
69 Q F -2.8273 Soluble
70 K F -2.8725 Soluble
71 F F 0.0000 Buried
72 K F -2.9071 Soluble
74 G F -1.8947 Soluble
75 R F -1.7227 Soluble
76 A F 0.0000 Buried
77 T F -0.9843 Soluble
78 I F 0.0000 Buried
79 T F -1.0241 Soluble
80 R F -1.7833 Soluble
81 D F -1.1620 Soluble
82 T F -1.0974 Soluble
83 S F -0.5453 Soluble
84 T F -0.6810 Soluble
85 S F -1.0373 Soluble
86 T F 0.0000 Buried
87 A F 0.0000 Buried
88 Y F -0.7630 Soluble
89 L F 0.0000 Buried
90 E F -1.8988 Soluble
91 L F 0.0000 Buried
92 S F -1.2161 Soluble
93 S F -1.0746 Soluble
94 L F 0.0000 Buried
95 R F -1.8035 Soluble
96 S F -1.4862 Soluble
97 E F -2.1112 Soluble
98 D F 0.0000 Buried
99 T F -0.4920 Soluble
100 A F 0.0000 Buried
101 V F 0.4499 Aggregation-prone
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 T F 0.0000 Buried
106 R F 0.0000 Buried
107 G F -0.0686 Soluble
108 Y F 0.5265 Aggregation-prone
109 D F -0.4089 Soluble
110 Y F 0.4048 Aggregation-prone
112 D F -0.5403 Soluble
113 Y F 0.3324 Aggregation-prone
114 A F 0.0000 Buried
115 L F 0.0000 Buried
116 D F -0.0827 Soluble
117 Y F 0.1661 Aggregation-prone
118 W F -0.4389 Soluble
119 G F 0.0000 Buried
120 Q F -1.2579 Soluble
121 G F -0.6065 Soluble
122 T F 0.0000 Buried
123 L F 1.1482 Aggregation-prone
124 V F 0.0000 Buried
125 T F 0.4564 Aggregation-prone
126 V F -0.4976 Soluble
1 D G -2.0743 Soluble
2 I G -1.1902 Soluble
3 Q G -1.8765 Soluble
4 M G 0.0000 Buried
5 T G -1.3654 Soluble
6 Q G 0.0000 Buried
7 S G -0.7469 Soluble
8 P G -0.3924 Soluble
9 S G -0.6962 Soluble
10 S G -0.6877 Soluble
11 L G -0.4490 Soluble
12 S G -0.7522 Soluble
13 A G -0.7669 Soluble
14 S G -0.7368 Soluble
15 V G -0.1322 Soluble
16 G G -0.6828 Soluble
17 D G -1.5092 Soluble
18 R G -2.1691 Soluble
19 V G 0.0000 Buried
20 T G -0.6285 Soluble
21 I G 0.0000 Buried
22 T G -0.8293 Soluble
23 C G 0.0000 Buried
24 R G -2.5256 Soluble
25 A G -1.6405 Soluble
26 S G -1.2527 Soluble
27 S G -0.8362 Soluble
28 S G -1.1470 Soluble
29 V G 0.0000 Buried
37 E G -1.8973 Soluble
38 F G -1.1484 Soluble
39 I G 0.0000 Buried
40 H G 0.0000 Buried
41 W G 0.0000 Buried
42 Y G 0.0000 Buried
43 Q G 0.0000 Buried
44 Q G 0.0000 Buried
45 K G -2.4975 Soluble
46 P G -1.5626 Soluble
47 G G -1.8575 Soluble
48 K G -2.8350 Soluble
49 A G -1.8084 Soluble
50 P G 0.0000 Buried
51 K G -1.8040 Soluble
52 P G -0.5803 Soluble
53 L G 0.0000 Buried
54 I G 0.0000 Buried
55 S G 0.0000 Buried
56 A G -0.5383 Soluble
57 T G -0.8381 Soluble
65 S G -0.8261 Soluble
66 N G -1.2664 Soluble
67 L G -0.3745 Soluble
68 A G -0.3760 Soluble
69 S G -0.5091 Soluble
70 G G -0.4817 Soluble
71 V G -0.2275 Soluble
72 P G -0.4570 Soluble
74 S G -0.6953 Soluble
75 R G -0.7478 Soluble
76 F G 0.0000 Buried
77 S G -0.6059 Soluble
78 G G -0.4702 Soluble
79 S G -0.7205 Soluble
80 G G -0.9979 Soluble
83 S G -1.3504 Soluble
84 G G -1.4825 Soluble
85 T G -1.7623 Soluble
86 D G -2.2858 Soluble
87 F G 0.0000 Buried
88 T G -0.7479 Soluble
89 L G 0.0000 Buried
90 T G -0.6061 Soluble
91 I G 0.0000 Buried
92 S G -1.1518 Soluble
93 S G -0.9269 Soluble
94 L G 0.0000 Buried
95 Q G -0.8056 Soluble
96 P G -0.9840 Soluble
97 E G -1.9472 Soluble
98 D G -1.2278 Soluble
99 F G -0.7191 Soluble
100 A G 0.0000 Buried
101 T G -0.9361 Soluble
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 Q G 0.0000 Buried
106 Q G 0.0000 Buried
107 W G 0.0000 Buried
108 S G -0.6575 Soluble
109 S G -0.4612 Soluble
114 A G -0.5577 Soluble
115 P G -0.8855 Soluble
116 W G -0.2741 Soluble
117 T G 0.0000 Buried
118 F G 0.0000 Buried
119 G G 0.0000 Buried
120 Q G -1.6588 Soluble
121 G G -1.1149 Soluble
122 T G 0.0000 Buried
123 K G -1.4193 Soluble
124 V G 0.0000 Buried
125 E G -1.1459 Soluble
126 I G -0.6466 Soluble
127 K G -1.4948 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6741 1.9971 CSV PDB
4.5 -0.7237 1.7739 CSV PDB
5.0 -0.7861 1.7146 CSV PDB
5.5 -0.8481 1.6791 CSV PDB
6.0 -0.8959 1.644 CSV PDB
6.5 -0.9201 1.6149 CSV PDB
7.0 -0.9193 1.5964 CSV PDB
7.5 -0.9003 1.5877 CSV PDB
8.0 -0.8711 1.5844 CSV PDB
8.5 -0.8353 1.5833 CSV PDB
9.0 -0.7936 1.5829 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH