Galegenimab / 7sjp

A4DAB122_7sjp_H_L | Source PDB: 7sjp | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.741
Max Score
1.3273
Min Score
-3.6788
Total Score
-319.35
Score CDR
-0.741
Score non-CDR
-0.7409

Calculation Parameters

Chain Sequence(s) EVQLVQSGAEVKKPGASVKVSCKASGYKFTDSEMHWVRQAPGQGLEWIGGVDPETEGAAYNQKFKGRATITRDTSTSTAYLELSSLRSEDTAVYYCTRGYDYDYALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSDIQMTQSPSSLSASVGDRVTITCRASSSVEFIHWYQQKPGKAPKPLISATSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSAPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6788
Maximum Score 1.3273
Average Score -0.741
Total Score -319.3498

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.1223 Soluble
2 V H -1.4068 Soluble
3 Q H -1.1912 Soluble
4 L H 0.0000 Buried
5 V H 0.6689 Aggregation-prone
7 S H -0.5710 Soluble
8 G H -0.9588 Soluble
9 A H 0.0000 Buried
11 E H -1.3164 Soluble
12 V H -0.9500 Soluble
13 K H -1.6317 Soluble
14 K H -2.3891 Soluble
15 P H -1.8417 Soluble
16 G H -1.4571 Soluble
17 A H -1.1469 Soluble
18 S H -1.2747 Soluble
19 V H 0.0000 Buried
20 K H -1.8529 Soluble
21 V H 0.0000 Buried
22 S H -0.4224 Soluble
23 C H 0.0000 Buried
24 K H -0.5442 Soluble
25 A H 0.0000 Buried
26 S H -1.1218 Soluble
27 G H -1.5779 Soluble
28 Y H -1.5195 Soluble
29 K H -2.2570 Soluble
30 F H 0.0000 Buried
35 T H -2.2044 Soluble
36 D H -2.6559 Soluble
37 S H 0.0000 Buried
38 E H -1.3130 Soluble
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.4083 Soluble
44 Q H -0.6088 Soluble
45 A H -1.0463 Soluble
46 P H -1.1112 Soluble
47 G H -1.5717 Soluble
48 Q H -1.8023 Soluble
49 G H 0.0000 Buried
50 L H 0.0000 Buried
51 E H -0.8454 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 G H 0.0000 Buried
56 V H 0.0000 Buried
57 D H -2.1971 Soluble
58 P H 0.0000 Buried
59 E H -2.9791 Soluble
62 T H -2.0794 Soluble
63 E H -2.6400 Soluble
64 G H -1.6362 Soluble
65 A H -0.6748 Soluble
66 A H -0.3266 Soluble
67 Y H -0.8735 Soluble
68 N H 0.0000 Buried
69 Q H -2.8070 Soluble
70 K H -2.8632 Soluble
71 F H 0.0000 Buried
72 K H -2.8878 Soluble
74 G H -1.8873 Soluble
75 R H -1.6789 Soluble
76 A H 0.0000 Buried
77 T H -0.8896 Soluble
78 I H 0.0000 Buried
79 T H -0.7578 Soluble
80 R H -1.1328 Soluble
81 D H -1.0940 Soluble
82 T H -1.0036 Soluble
83 S H -0.5432 Soluble
84 T H -0.5979 Soluble
85 S H -0.8765 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.6358 Soluble
89 L H 0.0000 Buried
90 E H -1.3702 Soluble
91 L H 0.0000 Buried
92 S H -1.0248 Soluble
93 S H -1.0842 Soluble
94 L H 0.0000 Buried
95 R H -2.4108 Soluble
96 S H -1.9793 Soluble
97 E H -2.4182 Soluble
98 D H 0.0000 Buried
99 T H -0.9530 Soluble
100 A H 0.0000 Buried
101 V H 0.1951 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 T H 0.0000 Buried
106 R H 0.0000 Buried
107 G H 0.1666 Aggregation-prone
108 Y H 0.6075 Aggregation-prone
109 D H -0.1419 Soluble
110 Y H 0.3210 Aggregation-prone
112 D H -0.9516 Soluble
113 Y H 0.4354 Aggregation-prone
114 A H 0.0000 Buried
115 L H 0.0000 Buried
116 D H 0.0905 Aggregation-prone
117 Y H 0.1510 Aggregation-prone
118 W H -0.3343 Soluble
119 G H 0.0000 Buried
120 Q H -1.3133 Soluble
121 G H -0.6806 Soluble
122 T H 0.0000 Buried
123 L H -0.0993 Soluble
124 V H 0.0000 Buried
125 T H -0.9002 Soluble
126 V H 0.0000 Buried
127 S H -1.1125 Soluble
128 S H -0.9948 Soluble
129 A H -0.5445 Soluble
130 S H -0.6216 Soluble
131 T H -0.7476 Soluble
132 K H -0.9854 Soluble
133 G H -1.1864 Soluble
134 P H 0.0000 Buried
135 S H -0.2509 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2583 Soluble
139 L H 0.0000 Buried
140 A H -1.2954 Soluble
141 P H 0.0000 Buried
142 S H -1.1064 Soluble
143 S H -0.8046 Soluble
144 K H -0.9153 Soluble
145 S H 0.0000 Buried
146 T H -0.5993 Soluble
147 S H -0.6186 Soluble
148 G H -0.7784 Soluble
149 G H -0.8519 Soluble
150 T H -0.5913 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.2806 Soluble
160 Y H 0.0000 Buried
161 F H -0.1717 Soluble
162 P H 0.0000 Buried
163 E H -0.8898 Soluble
164 P H -0.8641 Soluble
165 V H 0.0000 Buried
166 T H -0.6136 Soluble
167 V H -0.4101 Soluble
168 S H -0.3752 Soluble
169 W H 0.0000 Buried
170 N H -0.7886 Soluble
171 S H -0.6759 Soluble
172 G H -0.5165 Soluble
173 A H -0.2184 Soluble
174 L H 0.0425 Aggregation-prone
175 T H -0.1244 Soluble
177 G H -0.3938 Soluble
178 V H 0.1143 Aggregation-prone
179 H H -0.2617 Soluble
180 T H -0.0069 Soluble
181 F H 0.0000 Buried
182 P H -0.2754 Soluble
183 A H 0.1952 Aggregation-prone
184 V H 0.5827 Aggregation-prone
185 L H 1.3273 Aggregation-prone
186 Q H 0.4023 Aggregation-prone
187 S H -0.0119 Soluble
188 S H -0.1710 Soluble
189 G H 0.1436 Aggregation-prone
190 L H 0.2454 Aggregation-prone
191 Y H 0.4775 Aggregation-prone
192 S H 0.0000 Buried
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.1734 Soluble
199 V H 0.0000 Buried
200 P H -0.6029 Soluble
201 S H -0.5433 Soluble
202 S H -0.5732 Soluble
203 S H -0.5857 Soluble
204 L H -0.8175 Soluble
205 G H -1.0209 Soluble
206 T H -0.7704 Soluble
207 Q H -1.3332 Soluble
208 T H -1.1113 Soluble
209 Y H 0.0000 Buried
210 I H -1.1421 Soluble
211 C H 0.0000 Buried
212 N H -1.3732 Soluble
213 V H 0.0000 Buried
214 N H -1.7322 Soluble
215 H H 0.0000 Buried
216 K H -2.6841 Soluble
217 P H -1.6766 Soluble
218 S H -1.7080 Soluble
219 N H -2.4770 Soluble
220 T H -1.9692 Soluble
221 K H -2.5917 Soluble
222 V H -1.4899 Soluble
223 D H -2.3198 Soluble
224 K H -2.0558 Soluble
225 K H -2.1539 Soluble
226 V H 0.0000 Buried
227 E H -2.7936 Soluble
228 P H -1.8897 Soluble
229 K H -2.2443 Soluble
230 S H -1.4422 Soluble
1 D L -2.2746 Soluble
2 I L 0.0000 Buried
3 Q L -2.0064 Soluble
4 M L 0.0000 Buried
5 T L -1.1087 Soluble
6 Q L 0.0000 Buried
7 S L -0.5601 Soluble
8 P L -0.4274 Soluble
9 S L -0.6492 Soluble
10 S L -0.6086 Soluble
11 L L -0.3572 Soluble
12 S L -0.9102 Soluble
13 A L -1.2476 Soluble
14 S L -1.2954 Soluble
15 V L -0.6431 Soluble
16 G L -1.1661 Soluble
17 D L -2.2088 Soluble
18 R L -2.4680 Soluble
19 V L 0.0000 Buried
20 T L -0.6120 Soluble
21 I L 0.0000 Buried
22 T L -0.7034 Soluble
23 C L 0.0000 Buried
24 R L -1.8618 Soluble
25 A L 0.0000 Buried
26 S L -1.4232 Soluble
27 S L -1.1409 Soluble
28 S L -1.1557 Soluble
29 V L 0.0000 Buried
37 E L -2.0414 Soluble
38 F L -1.2643 Soluble
39 I L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.9052 Soluble
44 Q L 0.0000 Buried
45 K L -1.7166 Soluble
46 P L -1.3668 Soluble
47 G L -1.7554 Soluble
48 K L -2.5493 Soluble
49 A L -1.6052 Soluble
50 P L 0.0000 Buried
51 K L -1.5393 Soluble
52 P L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 S L 0.0000 Buried
56 A L -0.5713 Soluble
57 T L 0.0000 Buried
65 S L -0.7437 Soluble
66 N L -1.0163 Soluble
67 L L -0.0564 Soluble
68 A L -0.2112 Soluble
69 S L -0.4118 Soluble
70 G L -0.4138 Soluble
71 V L -0.1789 Soluble
72 P L -0.2560 Soluble
74 S L -0.3412 Soluble
75 R L -0.6570 Soluble
76 F L 0.0000 Buried
77 S L -0.4559 Soluble
78 G L -0.5044 Soluble
79 S L -0.8069 Soluble
80 G L -1.0327 Soluble
83 S L -1.3275 Soluble
84 G L -1.3880 Soluble
85 T L -1.5520 Soluble
86 D L -2.0322 Soluble
87 F L 0.0000 Buried
88 T L -0.6934 Soluble
89 L L 0.0000 Buried
90 T L -0.5851 Soluble
91 I L 0.0000 Buried
92 S L -1.3831 Soluble
93 S L -1.3109 Soluble
94 L L 0.0000 Buried
95 Q L -1.0543 Soluble
96 P L -1.6618 Soluble
97 E L -1.8527 Soluble
98 D L 0.0000 Buried
99 F L 0.0000 Buried
100 A L 0.0000 Buried
101 T L -0.6426 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 W L 0.0000 Buried
108 S L -0.4385 Soluble
109 S L -0.6529 Soluble
114 A L -0.4445 Soluble
115 P L -0.8304 Soluble
116 W L -0.3142 Soluble
117 T L -0.6896 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.3833 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.0130 Soluble
124 V L 0.0000 Buried
125 E L -1.3630 Soluble
126 I L 0.0000 Buried
127 K L -1.6851 Soluble
128 R L -1.0745 Soluble
129 T L -0.2059 Soluble
130 V L 0.1814 Aggregation-prone
131 A L 0.0376 Aggregation-prone
132 A L -0.1438 Soluble
133 P L 0.0000 Buried
134 S L -0.1712 Soluble
135 V L 0.0000 Buried
136 F L 0.0000 Buried
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.7726 Soluble
140 P L 0.0000 Buried
141 S L -1.8819 Soluble
142 D L -3.0853 Soluble
143 E L -3.2890 Soluble
144 Q L 0.0000 Buried
145 L L -2.3794 Soluble
146 K L -2.9855 Soluble
147 S L -1.8686 Soluble
148 G L -1.4467 Soluble
149 T L -1.2820 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.8574 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.8063 Soluble
162 R L -2.9745 Soluble
163 E L -3.1686 Soluble
164 A L -2.1560 Soluble
165 K L -2.0172 Soluble
166 V L -0.9035 Soluble
167 Q L -0.6367 Soluble
168 W L 0.0000 Buried
169 K L -0.7875 Soluble
170 V L 0.0000 Buried
171 D L -2.1099 Soluble
172 N L -1.6844 Soluble
173 A L -0.5114 Soluble
174 L L 0.1903 Aggregation-prone
175 Q L -0.6008 Soluble
176 S L -0.7148 Soluble
177 G L -1.1680 Soluble
178 N L -1.3694 Soluble
179 S L -1.3471 Soluble
180 Q L -1.3082 Soluble
181 E L -1.5772 Soluble
182 S L -0.8276 Soluble
183 V L -0.5248 Soluble
184 T L 0.0000 Buried
185 E L -1.7384 Soluble
186 Q L 0.0000 Buried
187 D L -1.7717 Soluble
188 S L -2.0456 Soluble
189 K L -2.4744 Soluble
190 D L -1.7461 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L -1.1319 Soluble
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7166 Soluble
199 L L 0.0000 Buried
200 T L -0.6090 Soluble
201 L L -0.8519 Soluble
202 S L -1.0996 Soluble
203 K L -2.1236 Soluble
204 A L -1.9496 Soluble
205 D L -2.6956 Soluble
206 Y L 0.0000 Buried
207 E L -3.5406 Soluble
208 K L -3.6788 Soluble
209 H L -3.0751 Soluble
210 K L -3.3350 Soluble
211 V L -1.5486 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.5140 Soluble
216 V L 0.0000 Buried
217 T L -1.0395 Soluble
218 H L 0.0000 Buried
219 Q L -1.7228 Soluble
220 G L -0.4544 Soluble
221 L L -0.2206 Soluble
222 S L -0.4398 Soluble
223 S L -0.3880 Soluble
224 P L -0.3951 Soluble
225 V L 0.3279 Aggregation-prone
226 T L -0.1618 Soluble
227 K L -0.4026 Soluble
228 S L -0.4550 Soluble
229 F L 0.0000 Buried
230 N L -2.0259 Soluble
231 R L -2.5880 Soluble
232 G L -2.1477 Soluble
233 E L -2.5689 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.769 1.8438 CSV PDB
4.5 -0.8198 1.7114 CSV PDB
5.0 -0.8804 1.6671 CSV PDB
5.5 -0.9387 1.6161 CSV PDB
6.0 -0.9814 1.565 CSV PDB
6.5 -0.9984 1.5201 CSV PDB
7.0 -0.9886 1.4871 CSV PDB
7.5 -0.9605 1.4658 CSV PDB
8.0 -0.9222 1.4521 CSV PDB
8.5 -0.8766 1.4429 CSV PDB
9.0 -0.8239 1.4378 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH