Teropavimab / 7n28

A4DAB261_7n28_C_D | Source PDB: 7n28 | Chains: C, D | Done
99.55
Yes
10 Å
Yes
Avg A4D Score
-0.7832
Max Score
1.4127
Min Score
-3.6694
Total Score
-328.93
Score CDR
-0.6675
Score non-CDR
-0.795

Calculation Parameters

Chain Sequence(s) QVQLLQSGAAVTKPGASVRVSCEASGYNIRDYFIHWWRQAPGQGLQWVGWINPKTGQPNNPRQFQGRVSLTRHASWDFDTYSFYMDLKALRSDDTAVYFCARQRSDYWDFDVWGSGTQVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPDIQMTQSPSSLSASVGDTVTITCQANGYLNWYQQRRGKAPKLLIYDGSKLERGVPSRFSGRRWGQEYNLTINNLQPEDIATYFCQVYEFVVPGTRLDLKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) C (Heavy), D (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6694
Maximum Score 1.4127
Average Score -0.7832
Total Score -328.9269

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q C -1.4869 Soluble
2 V C -1.0110 Soluble
3 Q C -1.3872 Soluble
4 L C 0.0000 Buried
5 L C -0.0552 Soluble
6 Q C -0.3769 Soluble
7 S C -0.7107 Soluble
8 G C -0.6668 Soluble
9 A C -0.2965 Soluble
11 A C -0.0159 Soluble
12 V C 0.4466 Aggregation-prone
13 T C -0.5570 Soluble
14 K C -2.0648 Soluble
15 P C -1.9485 Soluble
16 G C -1.6682 Soluble
17 A C -1.1791 Soluble
18 S C -1.2466 Soluble
19 V C 0.0000 Buried
20 R C -1.8596 Soluble
21 V C 0.0000 Buried
22 S C -0.6399 Soluble
23 C C 0.0000 Buried
24 E C -1.0340 Soluble
25 A C 0.0000 Buried
26 S C -1.1015 Soluble
27 G C -1.2821 Soluble
28 Y C -1.3000 Soluble
29 N C -2.1920 Soluble
30 I C 0.0000 Buried
35 R C -3.0592 Soluble
36 D C -2.8437 Soluble
37 Y C -1.3741 Soluble
38 F C -0.3369 Soluble
39 I C 0.0000 Buried
40 H C 0.0000 Buried
41 W C 0.0000 Buried
42 W C 0.0000 Buried
43 R C -0.5046 Soluble
44 Q C -0.8414 Soluble
45 A C -1.0741 Soluble
46 P C -0.9539 Soluble
47 G C -1.2485 Soluble
48 Q C -1.7284 Soluble
49 G C -1.1537 Soluble
50 L C 0.0000 Buried
51 Q C -0.6811 Soluble
52 W C -0.1799 Soluble
53 V C 0.0000 Buried
54 G C 0.0000 Buried
55 W C -0.2399 Soluble
56 I C 0.0000 Buried
57 N C -1.2647 Soluble
58 P C 0.0000 Buried
59 K C -1.8205 Soluble
62 T C -1.1714 Soluble
63 G C -1.2705 Soluble
64 Q C -1.7499 Soluble
65 P C -1.3729 Soluble
66 N C -1.7046 Soluble
67 N C -1.6589 Soluble
68 P C -1.9037 Soluble
69 R C -3.0392 Soluble
70 Q C -2.5272 Soluble
71 F C -1.8773 Soluble
72 Q C -2.6649 Soluble
74 G C -1.8021 Soluble
75 R C -1.4391 Soluble
76 V C 0.0000 Buried
77 S C -1.0472 Soluble
78 L C 0.0000 Buried
79 T C -0.7729 Soluble
80 R C -1.3012 Soluble
81 H C -0.9810 Soluble
82 A C -0.4659 Soluble
83 S C -0.0603 Soluble
84 W C 0.4670 Aggregation-prone
85 D C -0.8129 Soluble
85A F C -0.0286 Soluble
85B D C -1.7481 Soluble
85C T C -1.0414 Soluble
85D Y C 0.0000 Buried
86 S C -0.8496 Soluble
87 F C 0.0000 Buried
88 Y C -0.7364 Soluble
89 M C 0.0000 Buried
90 D C -1.2709 Soluble
91 L C 0.0000 Buried
92 K C -2.0350 Soluble
93 A C -1.5877 Soluble
94 L C 0.0000 Buried
95 R C -2.9730 Soluble
96 S C -2.2980 Soluble
97 D C -2.4312 Soluble
98 D C 0.0000 Buried
99 T C -0.8933 Soluble
100 A C 0.0000 Buried
101 V C -0.4786 Soluble
102 Y C 0.0000 Buried
103 F C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C 0.0000 Buried
107 Q C 0.0000 Buried
108 R C -1.0390 Soluble
109 S C -1.3036 Soluble
110 D C -1.4569 Soluble
112 Y C -0.2747 Soluble
113 W C 0.0000 Buried
114 D C 0.0000 Buried
115 F C 0.0000 Buried
116 D C -0.6540 Soluble
117 V C -0.3198 Soluble
118 W C -0.2180 Soluble
119 G C 0.0000 Buried
120 S C -0.5514 Soluble
121 G C -0.7849 Soluble
122 T C 0.0000 Buried
123 Q C -0.7343 Soluble
124 V C 0.0000 Buried
125 T C 0.0000 Buried
126 V C 0.0000 Buried
127 S C -1.1176 Soluble
128 S C -0.8380 Soluble
129 A C -0.7750 Soluble
130 S C -0.8289 Soluble
131 T C -1.2010 Soluble
132 K C -1.9835 Soluble
133 G C -1.7791 Soluble
134 P C -0.7133 Soluble
135 S C -0.4906 Soluble
136 V C -0.1427 Soluble
137 F C 0.0000 Buried
138 P C -0.9717 Soluble
139 L C 0.0000 Buried
140 A C -0.6129 Soluble
141 P C -0.4574 Soluble
142 S C -1.1294 Soluble
143 T C -0.1829 Soluble
144 A C 0.0000 Buried
145 A C 0.0000 Buried
146 L C 0.0000 Buried
147 G C 0.0000 Buried
148 C C 0.0000 Buried
149 L C 0.0000 Buried
150 V C 0.0000 Buried
151 K C -0.3775 Soluble
152 D C -0.8212 Soluble
153 Y C 0.0000 Buried
154 F C 0.0000 Buried
155 P C -0.7862 Soluble
156 E C -0.7637 Soluble
157 P C -0.7271 Soluble
158 V C -0.4525 Soluble
159 T C -0.2899 Soluble
160 V C -0.1067 Soluble
161 S C -0.3199 Soluble
162 W C 0.0000 Buried
163 N C -0.7529 Soluble
164 S C -0.8258 Soluble
165 G C -0.6430 Soluble
166 A C -0.3544 Soluble
167 L C -0.0027 Soluble
168 T C 0.0039 Aggregation-prone
169 S C 0.0396 Aggregation-prone
170 G C 0.1894 Aggregation-prone
171 V C 0.6517 Aggregation-prone
172 H C -0.1192 Soluble
173 T C 0.0800 Aggregation-prone
174 F C 0.1318 Aggregation-prone
175 P C 0.1220 Aggregation-prone
176 A C 0.5122 Aggregation-prone
177 V C 0.7300 Aggregation-prone
178 L C 1.4127 Aggregation-prone
179 Q C 0.0439 Aggregation-prone
180 S C -0.0996 Soluble
181 S C -0.3454 Soluble
182 G C -0.2171 Soluble
183 L C 0.0000 Buried
184 Y C 0.0000 Buried
185 S C 0.1991 Aggregation-prone
186 L C 0.3555 Aggregation-prone
187 S C 0.0000 Buried
188 S C 0.0000 Buried
189 V C 0.0000 Buried
190 V C 0.0000 Buried
191 T C 0.0339 Aggregation-prone
192 V C -0.0360 Soluble
193 P C -0.3172 Soluble
194 S C -0.4469 Soluble
195 S C -0.5664 Soluble
196 S C -0.5974 Soluble
197 L C -0.8424 Soluble
198 G C -1.2155 Soluble
199 T C -0.8760 Soluble
200 Q C -1.5366 Soluble
201 T C -1.2331 Soluble
202 Y C -0.6325 Soluble
203 I C -0.9020 Soluble
204 C C 0.0000 Buried
205 N C 0.0000 Buried
206 V C 0.0000 Buried
207 N C -1.5468 Soluble
208 H C 0.0000 Buried
209 K C -2.6817 Soluble
210 P C -1.7286 Soluble
211 S C -1.9715 Soluble
212 N C -2.3273 Soluble
213 T C -1.8691 Soluble
214 K C -2.0727 Soluble
215 V C -0.3537 Soluble
216 D C -1.9066 Soluble
217 K C -1.6004 Soluble
218 K C -2.4121 Soluble
219 V C 0.0000 Buried
220 E C -2.5373 Soluble
221 P C -1.2725 Soluble
1 D D -1.5592 Soluble
2 I D -0.5230 Soluble
3 Q D -1.2723 Soluble
4 M D -0.4724 Soluble
5 T D -0.5428 Soluble
6 Q D -0.4770 Soluble
7 S D -0.3457 Soluble
8 P D -0.5321 Soluble
9 S D -0.7270 Soluble
10 S D -0.8769 Soluble
11 L D -0.2364 Soluble
12 S D -0.7121 Soluble
13 A D -0.5883 Soluble
14 S D -0.8302 Soluble
15 V D 0.0199 Aggregation-prone
16 G D -1.2876 Soluble
17 D D -1.8260 Soluble
18 T D -1.2921 Soluble
19 V D -0.5281 Soluble
20 T D -0.1441 Soluble
21 I D 0.0000 Buried
22 T D -0.3828 Soluble
23 C D 0.0000 Buried
24 Q D -1.3358 Soluble
25 A D 0.0000 Buried
27 N D -1.7129 Soluble
28 G D -0.1628 Soluble
38 Y D 0.9193 Aggregation-prone
39 L D 0.0000 Buried
40 N D 0.0000 Buried
41 W D 0.0000 Buried
42 Y D 0.0000 Buried
43 Q D -1.1083 Soluble
44 Q D -1.9683 Soluble
45 R D -2.8069 Soluble
46 R D -3.2825 Soluble
47 G D -2.4874 Soluble
48 K D -3.1028 Soluble
49 A D -1.8400 Soluble
50 P D 0.0000 Buried
51 K D -2.0913 Soluble
52 L D 0.0000 Buried
53 L D 0.0000 Buried
54 I D 0.0000 Buried
55 Y D 0.0000 Buried
56 D D 0.0000 Buried
57 G D 0.0000 Buried
65 S D -1.4660 Soluble
66 K D -1.1329 Soluble
67 L D -0.6607 Soluble
68 E D -1.5934 Soluble
69 R D -2.2184 Soluble
70 G D -1.3501 Soluble
71 V D -0.7344 Soluble
72 P D -0.6293 Soluble
74 S D -0.7927 Soluble
75 R D -1.3968 Soluble
76 F D 0.0000 Buried
77 S D -1.0291 Soluble
78 G D -1.5890 Soluble
79 R D -2.6861 Soluble
80 R D -2.4690 Soluble
83 W D -0.7527 Soluble
84 G D -1.2094 Soluble
85 Q D -2.1332 Soluble
86 E D -1.8583 Soluble
87 Y D 0.0000 Buried
88 N D -1.1301 Soluble
89 L D 0.0000 Buried
90 T D -0.7892 Soluble
91 I D 0.0000 Buried
92 N D -2.4181 Soluble
93 N D -2.4530 Soluble
94 L D 0.0000 Buried
95 Q D -1.5102 Soluble
96 P D -1.0402 Soluble
97 E D -1.9243 Soluble
98 D D 0.0000 Buried
99 I D -0.7398 Soluble
100 A D -1.0976 Soluble
101 T D -1.0664 Soluble
102 Y D 0.0000 Buried
103 F D 0.0000 Buried
104 C D 0.0000 Buried
105 Q D 0.0000 Buried
106 V D 0.0000 Buried
107 Y D 1.2805 Aggregation-prone
116 E D 0.0854 Aggregation-prone
117 F D 1.1112 Aggregation-prone
118 V D 0.0000 Buried
119 V D 0.0000 Buried
120 P D -0.7672 Soluble
121 G D -0.8196 Soluble
122 T D 0.0000 Buried
123 R D -1.4882 Soluble
124 L D -0.4876 Soluble
125 D D 0.0000 Buried
126 L D -0.8208 Soluble
127 K D -1.5435 Soluble
128 R D -2.1057 Soluble
129 T D -0.8055 Soluble
130 V D 0.8014 Aggregation-prone
131 A D 0.3703 Aggregation-prone
132 A D 0.0659 Aggregation-prone
133 P D 0.0000 Buried
134 S D -0.0425 Soluble
135 V D 0.2042 Aggregation-prone
136 F D 0.4594 Aggregation-prone
137 I D 0.2948 Aggregation-prone
138 F D 0.0000 Buried
139 P D 0.0000 Buried
140 P D 0.0000 Buried
141 S D 0.0000 Buried
142 D D -2.7606 Soluble
143 E D -2.6050 Soluble
144 Q D 0.0000 Buried
145 L D -1.9494 Soluble
146 K D -2.7093 Soluble
147 S D -1.7980 Soluble
148 G D -1.4080 Soluble
149 T D -1.3194 Soluble
150 A D 0.0000 Buried
151 S D 0.0000 Buried
152 V D 0.0000 Buried
153 V D 0.0000 Buried
154 C D 0.0000 Buried
155 L D 0.0000 Buried
156 L D 0.0000 Buried
157 N D -0.2855 Soluble
158 N D -0.9324 Soluble
159 F D 0.0000 Buried
160 Y D 0.0000 Buried
161 P D -1.1320 Soluble
162 R D -1.5846 Soluble
163 E D -2.7342 Soluble
164 A D -2.0989 Soluble
165 K D -2.6600 Soluble
166 V D -1.4205 Soluble
167 Q D -1.0604 Soluble
168 W D 0.0000 Buried
169 K D -1.2584 Soluble
170 V D 0.0000 Buried
171 D D -2.5317 Soluble
172 N D -1.9265 Soluble
173 A D -0.6899 Soluble
174 L D 0.6229 Aggregation-prone
175 Q D 0.0460 Aggregation-prone
176 S D -0.5090 Soluble
177 G D -1.0246 Soluble
178 N D -1.0052 Soluble
179 S D -1.5325 Soluble
180 Q D -2.2223 Soluble
181 E D -2.4283 Soluble
182 S D 0.0000 Buried
183 V D -0.1730 Soluble
184 T D -0.8441 Soluble
185 E D -2.2047 Soluble
186 Q D -1.9075 Soluble
187 D D -2.3648 Soluble
188 S D -2.1621 Soluble
189 K D -2.8888 Soluble
190 D D -3.1398 Soluble
191 S D 0.0000 Buried
192 T D 0.0000 Buried
193 Y D 0.0000 Buried
194 S D 0.0000 Buried
195 L D 0.0000 Buried
196 S D -0.3849 Soluble
197 S D 0.0000 Buried
198 T D -0.8004 Soluble
199 L D 0.0000 Buried
200 T D -0.6449 Soluble
201 L D -0.6227 Soluble
202 S D -1.1925 Soluble
203 K D -2.1152 Soluble
204 A D -2.0087 Soluble
205 D D -2.8459 Soluble
206 Y D 0.0000 Buried
207 E D -3.6694 Soluble
208 K D -3.5552 Soluble
209 H D -2.9367 Soluble
210 K D -3.0369 Soluble
211 V D -1.6957 Soluble
212 Y D 0.0000 Buried
213 A D -1.3206 Soluble
214 C D 0.0000 Buried
215 E D -1.0263 Soluble
216 V D 0.0000 Buried
217 T D -1.2748 Soluble
218 H D -1.4183 Soluble
219 Q D -1.5587 Soluble
220 G D -0.3201 Soluble
221 L D -0.1605 Soluble
222 S D -0.4052 Soluble
223 S D -0.3521 Soluble
224 P D -0.2436 Soluble
225 V D 0.1930 Aggregation-prone
226 T D -0.5590 Soluble
227 K D -0.7594 Soluble
228 S D -0.6435 Soluble
229 F D -0.9670 Soluble
230 N D -2.0685 Soluble
231 R D -2.1803 Soluble
232 G D -1.5483 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6989 4.1457 CSV PDB
4.5 -0.7448 3.9269 CSV PDB
5.0 -0.7989 3.7701 CSV PDB
5.5 -0.8509 3.578 CSV PDB
6.0 -0.8894 3.3752 CSV PDB
6.5 -0.9066 3.1853 CSV PDB
7.0 -0.9038 3.0322 CSV PDB
7.5 -0.888 2.9272 CSV PDB
8.0 -0.8645 2.8596 CSV PDB
8.5 -0.8346 2.8167 CSV PDB
9.0 -0.7971 2.7925 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH