Lanadelumab / 4ogy

A4DAB151_4ogy_H_L | Source PDB: 4ogy | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6713
Max Score
2.088
Min Score
-3.5222
Total Score
-289.33
Score CDR
-0.1501
Score non-CDR
-0.7366

Calculation Parameters

Chain Sequence(s) EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYIMMWVRQAPGKGLEWVSGIYSSGGITVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAYRRIGVPRRDEFDIWGQGTMVTVSSASTKGPSVFPLAPSSKGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKDIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNTYWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5222
Maximum Score 2.088
Average Score -0.6713
Total Score -289.3315

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -1.7647 Soluble
2 V H -0.9388 Soluble
3 Q H -1.1669 Soluble
4 L H 0.0000 Buried
5 L H 0.3872 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.5126 Soluble
8 G H -0.9253 Soluble
9 G H -0.2999 Soluble
11 G H 0.1513 Aggregation-prone
12 L H 0.7615 Aggregation-prone
13 V H -0.2854 Soluble
14 Q H -1.4226 Soluble
15 P H -1.6660 Soluble
16 G H -1.4139 Soluble
17 G H -1.0103 Soluble
18 S H -1.2729 Soluble
19 L H -1.1035 Soluble
20 R H -2.1691 Soluble
21 L H 0.0000 Buried
22 S H -0.5902 Soluble
23 C H 0.0000 Buried
24 A H -0.3603 Soluble
25 A H -0.4353 Soluble
26 S H -0.3790 Soluble
27 G H -0.2504 Soluble
28 F H 1.6782 Aggregation-prone
29 T H 1.3278 Aggregation-prone
30 F H 2.0880 Aggregation-prone
35 S H 0.4882 Aggregation-prone
36 H H -0.2965 Soluble
37 Y H 0.1995 Aggregation-prone
38 I H 0.4022 Aggregation-prone
39 M H 0.0942 Aggregation-prone
40 M H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.7478 Soluble
45 A H -1.1489 Soluble
46 P H -0.9720 Soluble
47 G H -1.5276 Soluble
48 K H -2.3525 Soluble
49 G H -1.6002 Soluble
50 L H 0.0000 Buried
51 E H -1.0546 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 G H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H 0.8683 Aggregation-prone
58 S H 0.1130 Aggregation-prone
59 S H -0.6494 Soluble
62 G H -0.3612 Soluble
63 G H 0.4690 Aggregation-prone
64 I H 1.8608 Aggregation-prone
65 T H 0.9447 Aggregation-prone
66 V H 0.4715 Aggregation-prone
67 Y H -0.5306 Soluble
68 A H -1.4812 Soluble
69 D H -2.6892 Soluble
70 S H -1.7453 Soluble
71 V H 0.0000 Buried
72 K H -2.5594 Soluble
74 G H -1.7332 Soluble
75 R H -1.4276 Soluble
76 F H 0.0000 Buried
77 T H -0.8196 Soluble
78 I H 0.0000 Buried
79 S H -0.7391 Soluble
80 R H -1.6077 Soluble
81 D H -2.2320 Soluble
82 N H -2.6010 Soluble
83 S H -2.0713 Soluble
84 K H -2.7227 Soluble
85 N H -2.2379 Soluble
86 T H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H 0.0000 Buried
89 L H 0.0000 Buried
90 Q H -1.2824 Soluble
91 M H 0.0000 Buried
92 N H -1.4438 Soluble
93 S H -1.2543 Soluble
94 L H 0.0000 Buried
95 R H -2.3320 Soluble
96 A H -1.7406 Soluble
97 E H -2.2529 Soluble
98 D H 0.0000 Buried
99 T H -0.5969 Soluble
100 A H 0.0000 Buried
101 V H 0.3707 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 Y H 0.0000 Buried
107 R H 0.0000 Buried
108 R H -0.0461 Soluble
109 I H 0.8306 Aggregation-prone
110 G H 0.3946 Aggregation-prone
111 V H 0.8661 Aggregation-prone
111A P H -1.0521 Soluble
112A R H -2.7488 Soluble
112 R H -3.0051 Soluble
113 D H -2.3486 Soluble
114 E H -1.6144 Soluble
115 F H -0.3595 Soluble
116 D H 0.0000 Buried
117 I H 0.0000 Buried
118 W H -0.3574 Soluble
119 G H 0.0000 Buried
120 Q H -1.3856 Soluble
121 G H 0.0000 Buried
122 T H 0.0702 Aggregation-prone
123 M H 0.6899 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.1636 Soluble
126 V H 0.0000 Buried
127 S H -0.8654 Soluble
128 S H -0.7868 Soluble
129 A H -0.6424 Soluble
130 S H -0.7271 Soluble
131 T H -1.1280 Soluble
132 K H -2.0596 Soluble
133 G H 0.0000 Buried
134 P H 0.0000 Buried
135 S H -0.4181 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2985 Soluble
139 L H 0.0000 Buried
140 A H -1.3315 Soluble
141 P H 0.0000 Buried
142 S H -1.3637 Soluble
143 S H -1.4955 Soluble
144 K H -1.8639 Soluble
145 G H -0.6407 Soluble
146 T H -0.4727 Soluble
147 A H -0.4828 Soluble
148 A H 0.0000 Buried
149 L H 0.0000 Buried
150 G H 0.0000 Buried
151 C H 0.0000 Buried
152 L H 0.0000 Buried
153 V H 0.0000 Buried
154 K H 0.0000 Buried
155 D H -0.6530 Soluble
156 Y H 0.0000 Buried
157 F H 0.0000 Buried
158 P H -0.8189 Soluble
159 E H -1.0489 Soluble
160 P H -1.1681 Soluble
161 V H -0.9403 Soluble
162 T H -0.7799 Soluble
163 V H -0.3983 Soluble
164 S H -0.4233 Soluble
165 W H 0.0000 Buried
166 N H -0.7852 Soluble
167 S H -0.6389 Soluble
168 G H -0.5866 Soluble
169 A H -0.2598 Soluble
170 L H -0.0160 Soluble
171 T H -0.1939 Soluble
172 S H -0.2110 Soluble
173 G H -0.2788 Soluble
174 V H 0.1375 Aggregation-prone
175 H H -0.2896 Soluble
176 T H 0.0167 Aggregation-prone
177 F H 0.0000 Buried
178 P H -0.3328 Soluble
179 A H 0.2315 Aggregation-prone
180 V H 0.7004 Aggregation-prone
181 L H 1.3783 Aggregation-prone
182 Q H 0.4562 Aggregation-prone
183 S H 0.0410 Aggregation-prone
184 S H -0.1367 Soluble
185 G H 0.1323 Aggregation-prone
186 L H 0.0528 Aggregation-prone
187 Y H 0.4641 Aggregation-prone
188 S H 0.0000 Buried
189 L H 0.0000 Buried
190 S H 0.0000 Buried
191 S H 0.0000 Buried
192 V H 0.0000 Buried
193 V H 0.0000 Buried
194 T H -0.1489 Soluble
195 V H 0.0000 Buried
196 P H -0.6174 Soluble
197 S H -0.7325 Soluble
198 S H -0.6482 Soluble
199 S H -0.6886 Soluble
200 L H -0.9501 Soluble
201 G H -1.0744 Soluble
202 T H -0.8584 Soluble
203 Q H -1.5618 Soluble
204 T H -1.2925 Soluble
205 Y H 0.0000 Buried
206 I H -1.1391 Soluble
207 C H 0.0000 Buried
208 N H -1.4376 Soluble
209 V H 0.0000 Buried
210 N H -2.3017 Soluble
211 H H 0.0000 Buried
212 K H -2.8942 Soluble
213 P H -1.9136 Soluble
214 S H -2.1104 Soluble
215 N H -2.7569 Soluble
216 T H -2.2824 Soluble
217 K H -2.6879 Soluble
218 V H -1.3085 Soluble
219 D H -2.1489 Soluble
220 K H -1.8958 Soluble
221 R H -2.6411 Soluble
222 V H 0.0000 Buried
223 E H -2.9882 Soluble
224 P H -2.0009 Soluble
225 K H -2.3471 Soluble
1 D L -2.4304 Soluble
2 I L 0.0000 Buried
3 Q L -2.2872 Soluble
4 M L 0.0000 Buried
5 T L -1.3926 Soluble
6 Q L 0.0000 Buried
7 S L -0.7256 Soluble
8 P L -0.3781 Soluble
9 S L -0.5906 Soluble
10 T L -0.4191 Soluble
11 L L -0.1662 Soluble
12 S L -0.5619 Soluble
13 A L 0.0000 Buried
14 S L -0.1757 Soluble
15 V L 0.6296 Aggregation-prone
16 G L -0.5106 Soluble
17 D L -1.3193 Soluble
18 R L -2.1231 Soluble
19 V L 0.0000 Buried
20 T L -0.5868 Soluble
21 I L 0.0000 Buried
22 T L -0.9271 Soluble
23 C L 0.0000 Buried
24 R L -2.7601 Soluble
25 A L 0.0000 Buried
26 S L -2.0128 Soluble
27 Q L -2.1856 Soluble
28 S L -1.3924 Soluble
29 I L 0.0000 Buried
36 S L -0.8004 Soluble
37 S L -0.7105 Soluble
38 W L -0.0876 Soluble
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.7449 Soluble
46 P L -1.5581 Soluble
47 G L -1.6461 Soluble
48 K L -2.5853 Soluble
49 A L -1.6293 Soluble
50 P L 0.0000 Buried
51 K L -1.4690 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.0000 Buried
56 K L -0.9300 Soluble
57 A L 0.0000 Buried
65 S L -0.5264 Soluble
66 T L -0.1975 Soluble
67 L L 0.2464 Aggregation-prone
68 E L 0.0000 Buried
69 S L -0.9488 Soluble
70 G L -0.6665 Soluble
71 V L 0.0000 Buried
72 P L -0.3753 Soluble
74 S L -0.4205 Soluble
75 R L -0.7868 Soluble
76 F L 0.0000 Buried
77 S L -0.3266 Soluble
78 G L -0.4306 Soluble
79 S L -0.8899 Soluble
80 G L -1.3279 Soluble
83 S L -1.2103 Soluble
84 G L -1.2644 Soluble
85 T L -2.0073 Soluble
86 E L -2.8027 Soluble
87 F L 0.0000 Buried
88 T L -0.8580 Soluble
89 L L 0.0000 Buried
90 T L -0.6193 Soluble
91 I L 0.0000 Buried
92 S L -1.2625 Soluble
93 S L -0.9951 Soluble
94 L L 0.0000 Buried
95 Q L -0.7541 Soluble
96 P L -0.7731 Soluble
97 D L -1.8375 Soluble
98 D L 0.0000 Buried
99 F L -0.2034 Soluble
100 A L 0.0000 Buried
101 T L -0.5345 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.1316 Aggregation-prone
108 N L -0.2403 Soluble
114 T L -0.1104 Soluble
115 Y L 0.4937 Aggregation-prone
116 W L 0.0000 Buried
117 T L -0.6456 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.5930 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -0.6454 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.0489 Soluble
127 K L -1.1291 Soluble
128 R L -1.1397 Soluble
129 T L -0.2815 Soluble
130 V L 0.1933 Aggregation-prone
131 A L -0.0683 Soluble
132 A L -0.1418 Soluble
133 P L 0.0000 Buried
134 S L -0.0727 Soluble
135 V L 0.0311 Aggregation-prone
136 F L 0.0937 Aggregation-prone
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.5657 Soluble
140 P L 0.0000 Buried
141 S L -1.6964 Soluble
142 D L -2.7857 Soluble
143 E L -2.6042 Soluble
144 Q L 0.0000 Buried
145 L L -2.1574 Soluble
146 K L -2.7361 Soluble
147 S L -1.7282 Soluble
148 G L -1.2755 Soluble
149 T L -0.9754 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7785 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.3786 Soluble
162 R L -2.1738 Soluble
163 E L -2.8159 Soluble
164 A L -2.1201 Soluble
165 K L -2.2234 Soluble
166 V L -1.0364 Soluble
167 Q L -0.5262 Soluble
168 W L 0.0000 Buried
169 K L -0.5058 Soluble
170 V L 0.0000 Buried
171 D L -1.9268 Soluble
172 N L -1.4993 Soluble
173 A L -0.2167 Soluble
174 L L 0.7912 Aggregation-prone
175 Q L -0.2022 Soluble
176 S L -0.5943 Soluble
177 G L -1.2522 Soluble
178 N L -1.5519 Soluble
179 S L -1.4075 Soluble
180 Q L -1.4342 Soluble
181 E L -1.6182 Soluble
182 S L -0.5838 Soluble
183 V L -0.3459 Soluble
184 T L -0.9496 Soluble
185 E L -2.0936 Soluble
186 Q L -1.6464 Soluble
187 D L -1.8706 Soluble
188 S L -1.6339 Soluble
189 K L -2.2049 Soluble
190 D L -1.6031 Soluble
191 S L -1.5870 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7409 Soluble
199 L L 0.0000 Buried
200 T L -0.6157 Soluble
201 L L -0.7405 Soluble
202 S L -0.9855 Soluble
203 K L -2.0414 Soluble
204 A L -1.7600 Soluble
205 D L -2.3316 Soluble
206 Y L 0.0000 Buried
207 E L -3.3372 Soluble
208 K L -3.5222 Soluble
209 H L -2.9456 Soluble
210 K L -3.2343 Soluble
211 V L -1.4197 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.9140 Soluble
216 V L 0.0000 Buried
217 T L -1.2248 Soluble
218 H L 0.0000 Buried
219 Q L -1.4899 Soluble
220 G L -0.4646 Soluble
221 L L -0.2483 Soluble
222 S L -0.4553 Soluble
223 S L -0.4464 Soluble
224 P L -0.5834 Soluble
225 V L -0.0605 Soluble
226 T L -0.4989 Soluble
227 K L -0.7123 Soluble
228 S L -0.5947 Soluble
229 F L -1.1612 Soluble
230 N L -1.8651 Soluble
231 R L -2.6301 Soluble
232 G L -2.2062 Soluble
233 E L -2.4791 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7258 4.828 CSV PDB
4.5 -0.7663 4.7741 CSV PDB
5.0 -0.8129 4.7008 CSV PDB
5.5 -0.8557 4.6205 CSV PDB
6.0 -0.8835 4.5455 CSV PDB
6.5 -0.888 4.5442 CSV PDB
7.0 -0.8701 4.5943 CSV PDB
7.5 -0.8378 4.622 CSV PDB
8.0 -0.7978 4.6332 CSV PDB
8.5 -0.752 4.6371 CSV PDB
9.0 -0.7006 4.6383 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH