Lanadelumab

A4DAB151 | Cardiovascular / hemostasis disorders | Approved
KLKB1
G1 / IgG1
Dyax Shire Takeda
Approved
Whole mAb
DX-2930 DX2390 DX 2930 OHB-401 OHB401 OHB 401 SHP 643 SHP-643 SHP643 TAK-743 TAK743 TAK 743 Takhzyro
6
IMGT PubChem (312468039) PubChem (315661179) PubChem (381127378) PubChem (404772049) PubChem (471144008) PubChem (471146751) PubChem (472406758) PubChem (483928547) Thera-SAbDab YAbS
Avg A4D Score
-0.6578
Score Range
-0.67 to -0.63
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB151_4pub_H_L 4pub 100% -0.6746 6.5 4.0 -0.3266 -0.7635
A4DAB151_4ogy_H_L 4ogy 100% -0.6713 6.5 9.0 -0.1501 -0.7366
A4DAB151_4ogy_M_N 4ogy 100% -0.6595 6.5 4.0 -0.2975 -0.7027
A4DAB151_4ogx_H_L 4ogx 100% -0.6259 6.5 9.0 -0.0869 -0.694