Masavibart / 7zjl

A4DAB166_7zjl_j_i | Source PDB: 7zjl | Chains: j, i | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6528
Max Score
1.9067
Min Score
-3.5781
Total Score
-287.88
Score CDR
-0.3615
Score non-CDR
-0.6909

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYAMYWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRTEDTAVYYCASGSDYGDYLLVYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCQSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSKRPSGVSNRFSGSKSGNTASLTISGLQSEDEADYYCNSLTSISTWVFGGGTKLTVLGRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) j (Heavy), i (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5781
Maximum Score 1.9067
Average Score -0.6528
Total Score -287.8779

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q j -1.4353 Soluble
2 V j -0.8510 Soluble
3 Q j -0.8950 Soluble
4 L j 0.0000 Buried
5 V j 1.1559 Aggregation-prone
6 E j 0.0000 Buried
7 S j -0.1976 Soluble
8 G j -0.6292 Soluble
9 G j 0.2079 Aggregation-prone
11 G j 0.8952 Aggregation-prone
12 V j 1.7156 Aggregation-prone
13 V j -0.0627 Soluble
14 Q j -1.4720 Soluble
15 P j -2.0621 Soluble
16 G j -2.1271 Soluble
17 R j -2.6872 Soluble
18 S j -1.8588 Soluble
19 L j -0.9788 Soluble
20 R j -1.4213 Soluble
21 L j 0.0000 Buried
22 S j -0.2401 Soluble
23 C j 0.0000 Buried
24 A j -0.1408 Soluble
25 A j 0.0000 Buried
26 S j -0.6408 Soluble
27 G j -0.9261 Soluble
28 F j -0.4976 Soluble
29 T j -0.4083 Soluble
30 F j 0.0000 Buried
35 S j -1.1975 Soluble
36 N j -1.4891 Soluble
37 Y j -0.7407 Soluble
38 A j 0.0000 Buried
39 M j 0.0000 Buried
40 Y j 0.0000 Buried
41 W j 0.0000 Buried
42 V j 0.0000 Buried
43 R j 0.0000 Buried
44 Q j -0.6193 Soluble
45 A j -0.9656 Soluble
46 P j -0.9098 Soluble
47 G j -1.5463 Soluble
48 K j -2.2363 Soluble
49 G j -1.3909 Soluble
50 L j 0.0000 Buried
51 E j -0.8133 Soluble
52 W j 0.0000 Buried
53 V j 0.0000 Buried
54 A j 0.0000 Buried
55 V j 0.0000 Buried
56 I j 0.0000 Buried
57 S j -0.7533 Soluble
58 Y j -0.4003 Soluble
59 D j -1.6793 Soluble
62 G j -1.2854 Soluble
63 S j -1.2299 Soluble
64 N j -1.5661 Soluble
65 K j -0.7612 Soluble
66 Y j -0.2713 Soluble
67 Y j -0.9325 Soluble
68 A j 0.0000 Buried
69 D j -2.4662 Soluble
70 S j -1.7550 Soluble
71 V j 0.0000 Buried
72 K j -2.4924 Soluble
74 G j -1.7484 Soluble
75 R j -1.7037 Soluble
76 F j 0.0000 Buried
77 T j -0.8282 Soluble
78 I j 0.0000 Buried
79 S j -0.6128 Soluble
80 R j -1.1177 Soluble
81 D j -1.9982 Soluble
82 N j -1.9939 Soluble
83 S j -1.6787 Soluble
84 K j -2.4516 Soluble
85 N j -1.8360 Soluble
86 T j 0.0000 Buried
87 L j 0.0000 Buried
88 Y j -0.3807 Soluble
89 L j 0.0000 Buried
90 Q j -0.8488 Soluble
91 M j 0.0000 Buried
92 N j -1.7309 Soluble
93 S j -1.7114 Soluble
94 L j 0.0000 Buried
95 R j -2.5131 Soluble
96 T j -1.7563 Soluble
97 E j -2.2639 Soluble
98 D j 0.0000 Buried
99 T j -0.4148 Soluble
100 A j 0.0000 Buried
101 V j 0.3324 Aggregation-prone
102 Y j 0.0000 Buried
103 Y j 0.0000 Buried
104 C j 0.0000 Buried
105 A j 0.0000 Buried
106 S j 0.0000 Buried
107 G j 0.0000 Buried
108 S j 0.0000 Buried
109 D j -1.9514 Soluble
110 Y j -0.8866 Soluble
111 G j -0.8310 Soluble
112 D j -1.2455 Soluble
113 Y j -0.0181 Soluble
114 L j 0.0000 Buried
115 L j 0.0000 Buried
116 V j -0.0932 Soluble
117 Y j 0.2095 Aggregation-prone
118 W j -0.0454 Soluble
119 G j 0.0000 Buried
120 Q j -1.1936 Soluble
121 G j -0.4051 Soluble
122 T j 0.4134 Aggregation-prone
123 L j 1.3966 Aggregation-prone
124 V j 0.0000 Buried
125 T j 0.4732 Aggregation-prone
126 V j 0.0000 Buried
127 S j -0.5135 Soluble
128 S j -0.5681 Soluble
129 A j -0.3157 Soluble
130 S j -0.6255 Soluble
131 T j -0.7201 Soluble
132 K j -1.1680 Soluble
133 G j -1.4044 Soluble
134 P j -0.6468 Soluble
135 S j -0.3108 Soluble
136 V j 0.0000 Buried
137 F j 0.0000 Buried
138 P j -1.1342 Soluble
139 L j 0.0000 Buried
140 A j -1.0534 Soluble
141 P j 0.0000 Buried
142 S j 0.0000 Buried
143 S j -0.5198 Soluble
144 K j -0.5928 Soluble
145 S j 0.0000 Buried
146 T j -0.5237 Soluble
147 S j -0.6035 Soluble
148 G j -0.7920 Soluble
149 G j -0.8591 Soluble
150 T j -0.5704 Soluble
151 A j 0.0000 Buried
152 A j 0.0000 Buried
153 L j 0.0000 Buried
154 G j 0.0000 Buried
155 C j 0.0000 Buried
156 L j 0.0000 Buried
157 V j 0.0000 Buried
158 K j -0.1594 Soluble
159 D j -0.4472 Soluble
160 Y j 0.0000 Buried
161 F j 0.0000 Buried
162 P j -0.5929 Soluble
163 E j -1.1292 Soluble
164 P j -1.0558 Soluble
165 V j -0.8180 Soluble
166 T j -0.6535 Soluble
167 V j -0.3873 Soluble
168 S j -0.4148 Soluble
169 W j 0.0000 Buried
170 N j -0.7306 Soluble
171 S j -0.6651 Soluble
172 G j -0.4695 Soluble
173 A j -0.2317 Soluble
174 L j 0.0053 Aggregation-prone
175 T j -0.1748 Soluble
176 S j -0.2136 Soluble
177 G j -0.2640 Soluble
178 V j 0.1289 Aggregation-prone
179 H j -0.1113 Soluble
180 T j 0.0399 Aggregation-prone
181 F j 0.0000 Buried
182 P j -0.3696 Soluble
183 A j 0.1820 Aggregation-prone
184 V j 0.5314 Aggregation-prone
185 L j 0.7748 Aggregation-prone
186 Q j 0.0971 Aggregation-prone
187 S j -0.2623 Soluble
188 S j -0.2759 Soluble
189 G j -0.0788 Soluble
190 L j -0.0377 Soluble
191 Y j 0.2707 Aggregation-prone
192 S j 0.0000 Buried
193 L j 0.2048 Aggregation-prone
194 S j 0.0000 Buried
195 S j 0.0000 Buried
196 V j 0.0000 Buried
197 V j 0.0000 Buried
198 T j -0.1707 Soluble
199 V j 0.0000 Buried
200 P j -0.5146 Soluble
201 S j -0.5243 Soluble
202 S j -0.5235 Soluble
203 S j -0.4983 Soluble
204 L j -0.6796 Soluble
205 G j -1.0884 Soluble
206 T j -0.6555 Soluble
207 Q j -1.1930 Soluble
208 T j -1.0210 Soluble
209 Y j 0.0000 Buried
210 I j -1.0815 Soluble
211 C j 0.0000 Buried
212 N j -1.5932 Soluble
213 V j 0.0000 Buried
214 N j -2.0346 Soluble
215 H j 0.0000 Buried
216 K j -2.7715 Soluble
217 P j -1.6811 Soluble
218 S j -1.8039 Soluble
219 N j -2.5616 Soluble
220 T j -2.0882 Soluble
221 K j -2.7019 Soluble
222 V j -1.6861 Soluble
223 D j -2.6074 Soluble
224 K j -2.0332 Soluble
225 K j -2.2731 Soluble
226 V j 0.0000 Buried
227 E j -2.4479 Soluble
228 P j -1.3273 Soluble
229 K j -1.2282 Soluble
230 S j -0.6696 Soluble
231 C j -0.8621 Soluble
1 Q i -1.0227 Soluble
2 S i -0.4322 Soluble
3 A i -0.4356 Soluble
4 L i 0.0000 Buried
5 T i -0.3502 Soluble
6 Q i -0.4350 Soluble
7 P i -0.4913 Soluble
8 A i -0.5348 Soluble
9 S i -0.8324 Soluble
11 V i -0.2196 Soluble
12 S i -0.3304 Soluble
13 G i 0.0000 Buried
14 S i -0.6765 Soluble
15 P i -1.1042 Soluble
16 G i -1.3987 Soluble
17 Q i -1.6891 Soluble
18 S i -0.9567 Soluble
19 I i -0.2344 Soluble
20 T i -0.0285 Soluble
21 I i 0.0000 Buried
22 S i -0.3110 Soluble
23 C i 0.0000 Buried
24 T i -0.5256 Soluble
25 G i -0.5750 Soluble
26 T i -0.6112 Soluble
27 S i -0.6446 Soluble
28 S i -0.3820 Soluble
29 D i 0.0000 Buried
30 V i 0.0000 Buried
31 G i -0.8866 Soluble
35 G i -0.4274 Soluble
36 Y i 0.4273 Aggregation-prone
37 N i -0.6560 Soluble
38 Y i -0.0204 Soluble
39 V i 0.0000 Buried
40 S i 0.0000 Buried
41 W i 0.0000 Buried
42 Y i 0.0000 Buried
43 Q i 0.0000 Buried
44 Q i 0.0000 Buried
45 H i -1.6103 Soluble
46 P i -1.4114 Soluble
47 G i -1.5281 Soluble
48 K i -2.4283 Soluble
49 A i -1.5349 Soluble
50 P i 0.0000 Buried
51 K i -1.4781 Soluble
52 L i 0.0000 Buried
53 M i 0.0000 Buried
54 I i 0.0000 Buried
55 Y i -0.3836 Soluble
56 D i -0.5163 Soluble
57 V i -0.6355 Soluble
65 S i -1.0887 Soluble
66 K i -1.4923 Soluble
67 R i -1.4741 Soluble
68 P i -0.6523 Soluble
69 S i -0.6262 Soluble
70 G i -0.7371 Soluble
71 V i -0.7790 Soluble
72 S i -1.0032 Soluble
74 N i -1.6509 Soluble
75 R i -1.1493 Soluble
76 F i 0.0000 Buried
77 S i -0.9529 Soluble
78 G i -0.6425 Soluble
79 S i -0.8165 Soluble
80 K i -1.0597 Soluble
83 S i -0.8710 Soluble
84 G i -1.1449 Soluble
85 N i -1.1752 Soluble
86 T i -0.8440 Soluble
87 A i 0.0000 Buried
88 S i -0.3570 Soluble
89 L i 0.0000 Buried
90 T i -0.2466 Soluble
91 I i 0.0000 Buried
92 S i -1.0470 Soluble
93 G i -1.2732 Soluble
94 L i 0.0000 Buried
95 Q i -1.9216 Soluble
96 S i -1.6255 Soluble
97 E i -2.3708 Soluble
98 D i 0.0000 Buried
99 E i -1.6686 Soluble
100 A i 0.0000 Buried
101 D i 0.0000 Buried
102 Y i 0.0000 Buried
103 Y i 0.0000 Buried
104 C i 0.0000 Buried
105 N i 0.0000 Buried
106 S i 0.0000 Buried
107 L i 0.0000 Buried
108 T i 0.2661 Aggregation-prone
109 S i 0.8787 Aggregation-prone
113 I i 1.9067 Aggregation-prone
114 S i 0.8080 Aggregation-prone
115 T i 0.2841 Aggregation-prone
116 W i 0.0000 Buried
117 V i 0.0000 Buried
118 F i 0.0000 Buried
119 G i 0.0000 Buried
120 G i -1.0768 Soluble
121 G i -1.0457 Soluble
122 T i 0.0000 Buried
123 K i -1.8856 Soluble
124 L i 0.0000 Buried
125 T i -0.7120 Soluble
126 V i 0.0000 Buried
127 L i 0.2542 Aggregation-prone
128 G i -0.4605 Soluble
129 R i -0.5058 Soluble
130 T i 0.1745 Aggregation-prone
131 V i 0.5714 Aggregation-prone
132 A i 0.0309 Aggregation-prone
133 A i -0.0820 Soluble
134 P i 0.0000 Buried
135 S i -0.2659 Soluble
136 V i 0.0000 Buried
137 F i 0.0000 Buried
138 I i 0.0000 Buried
139 F i 0.0000 Buried
140 P i 0.0000 Buried
141 P i 0.0000 Buried
142 S i -1.4573 Soluble
143 D i -2.7194 Soluble
144 E i -2.8338 Soluble
145 Q i 0.0000 Buried
146 L i -2.0388 Soluble
147 K i -2.8156 Soluble
148 S i -1.7268 Soluble
149 G i -1.5003 Soluble
150 T i -1.2451 Soluble
151 A i 0.0000 Buried
152 S i 0.0000 Buried
153 V i 0.0000 Buried
154 V i 0.0000 Buried
155 C i 0.0000 Buried
156 L i 0.0000 Buried
157 L i 0.0000 Buried
158 N i -0.3304 Soluble
159 N i -0.7673 Soluble
160 F i 0.0000 Buried
161 Y i 0.0000 Buried
162 P i -0.8847 Soluble
163 R i -2.1341 Soluble
164 E i -2.1206 Soluble
165 A i -1.7056 Soluble
166 K i -2.3186 Soluble
167 V i 0.0000 Buried
168 Q i -1.0402 Soluble
169 W i 0.0000 Buried
170 K i -0.7617 Soluble
171 V i 0.0000 Buried
172 D i -1.7521 Soluble
173 N i -1.5479 Soluble
174 A i -0.3420 Soluble
175 L i 0.3474 Aggregation-prone
176 Q i -0.3970 Soluble
177 S i -0.6805 Soluble
178 G i -1.0502 Soluble
179 N i -1.1423 Soluble
180 S i -1.1818 Soluble
181 Q i -1.1677 Soluble
182 E i -1.3655 Soluble
183 S i -0.6530 Soluble
184 V i -0.7338 Soluble
185 T i -1.1962 Soluble
186 E i -2.3286 Soluble
187 Q i -2.2013 Soluble
188 D i -2.0025 Soluble
189 S i -1.8276 Soluble
190 K i -2.3598 Soluble
191 D i -1.9404 Soluble
192 S i -1.8447 Soluble
193 T i 0.0000 Buried
194 Y i -1.2606 Soluble
195 S i 0.0000 Buried
196 L i 0.0000 Buried
197 S i 0.0000 Buried
198 S i 0.0000 Buried
199 T i -0.6237 Soluble
200 L i 0.0000 Buried
201 T i -0.5925 Soluble
202 L i 0.0000 Buried
203 S i -1.2468 Soluble
204 K i -2.0998 Soluble
205 A i -1.9342 Soluble
206 D i -2.3919 Soluble
207 Y i 0.0000 Buried
208 E i -3.5781 Soluble
209 K i -3.4348 Soluble
210 H i -2.8861 Soluble
211 K i -3.1235 Soluble
212 V i -1.7441 Soluble
213 Y i 0.0000 Buried
214 A i 0.0000 Buried
215 C i 0.0000 Buried
216 E i -0.7555 Soluble
217 V i 0.0000 Buried
218 T i -1.1067 Soluble
219 H i 0.0000 Buried
220 Q i -1.5305 Soluble
221 G i -0.4104 Soluble
222 L i -0.2232 Soluble
223 S i -0.4335 Soluble
224 S i -0.4125 Soluble
225 P i -0.5757 Soluble
226 V i 0.1291 Aggregation-prone
227 T i -0.3744 Soluble
228 K i -0.4976 Soluble
229 S i -0.5823 Soluble
230 F i 0.0000 Buried
231 N i -1.7311 Soluble
232 R i -2.0522 Soluble
233 G i -1.6713 Soluble
234 E i -1.8983 Soluble
235 C i -1.1828 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6839 2.2182 CSV PDB
4.5 -0.7216 2.2184 CSV PDB
5.0 -0.7649 2.2189 CSV PDB
5.5 -0.8055 2.2205 CSV PDB
6.0 -0.8338 2.2248 CSV PDB
6.5 -0.8414 2.2341 CSV PDB
7.0 -0.8279 2.2491 CSV PDB
7.5 -0.7998 2.2677 CSV PDB
8.0 -0.7636 2.288 CSV PDB
8.5 -0.7215 2.3087 CSV PDB
9.0 -0.6739 2.3293 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH