Aducanumab / 6co3

A4DAB007_6co3_H_L | Source PDB: 6co3 | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7373
Max Score
1.2439
Min Score
-3.7347
Total Score
-316.28
Score CDR
-0.5792
Score non-CDR
-0.7586

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWFDGTKKYYTDSVKGRFTISRDNSKNTLYLQMNTLRAEDTAVYYCARDRGIGARRGPYYMDVWGKGTTVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKDIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7347
Maximum Score 1.2439
Average Score -0.7373
Total Score -316.2849

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.1713 Soluble
2 V H -0.3459 Soluble
3 Q H -0.9619 Soluble
4 L H 0.0000 Buried
5 V H -0.1588 Soluble
6 E H 0.0000 Buried
7 S H -0.6648 Soluble
8 G H -0.8241 Soluble
9 G H -0.3084 Soluble
11 G H 0.4149 Aggregation-prone
12 V H 1.0501 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.6340 Soluble
15 P H -1.8460 Soluble
16 G H -1.9894 Soluble
17 R H -2.7025 Soluble
18 S H -1.9311 Soluble
19 L H -1.1132 Soluble
20 R H -1.4891 Soluble
21 L H 0.0000 Buried
22 S H -0.3926 Soluble
23 C H 0.0000 Buried
24 A H -0.3978 Soluble
25 A H 0.0000 Buried
26 S H -0.7301 Soluble
27 G H -0.6897 Soluble
28 F H -0.0966 Soluble
29 A H 0.0627 Aggregation-prone
30 F H 0.0000 Buried
35 S H -0.8896 Soluble
36 S H -0.5105 Soluble
37 Y H -0.5619 Soluble
38 G H -0.8166 Soluble
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.8905 Soluble
45 A H -1.2711 Soluble
46 P H -0.9508 Soluble
47 G H -1.5147 Soluble
48 K H -2.2955 Soluble
49 G H -1.4654 Soluble
50 L H 0.0000 Buried
51 E H -1.2578 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 A H 0.0000 Buried
55 V H 0.0000 Buried
56 I H 0.0000 Buried
57 W H -1.2831 Soluble
58 F H -0.7905 Soluble
59 D H -1.4601 Soluble
62 G H -1.3744 Soluble
63 T H -1.2938 Soluble
64 K H -1.9314 Soluble
65 K H -1.2529 Soluble
66 Y H -0.5536 Soluble
67 Y H -0.8046 Soluble
68 T H -1.4696 Soluble
69 D H -2.5877 Soluble
70 S H -1.8255 Soluble
71 V H 0.0000 Buried
72 K H -2.5327 Soluble
74 G H -1.7767 Soluble
75 R H -1.3886 Soluble
76 F H 0.0000 Buried
77 T H -0.8117 Soluble
78 I H 0.0000 Buried
79 S H -0.5005 Soluble
80 R H 0.0000 Buried
81 D H -2.2992 Soluble
82 N H -2.0846 Soluble
83 S H -1.8442 Soluble
84 K H -2.6067 Soluble
85 N H -1.9457 Soluble
86 T H -1.2891 Soluble
87 L H 0.0000 Buried
88 Y H -0.4462 Soluble
89 L H 0.0000 Buried
90 Q H -0.9413 Soluble
91 M H 0.0000 Buried
92 N H -1.8349 Soluble
93 T H -1.6481 Soluble
94 L H 0.0000 Buried
95 R H -2.1584 Soluble
96 A H -1.5308 Soluble
97 E H -2.1295 Soluble
98 D H 0.0000 Buried
99 T H -0.5859 Soluble
100 A H 0.0000 Buried
101 V H 0.0392 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.5297 Soluble
107 D H 0.0000 Buried
108 R H -1.4537 Soluble
109 G H -1.1289 Soluble
110 I H -0.5940 Soluble
111 G H -1.0288 Soluble
111A A H -1.2360 Soluble
111B R H -2.2971 Soluble
112B R H -1.9158 Soluble
112A G H -1.1878 Soluble
112 P H -0.4521 Soluble
113 Y H -0.0355 Soluble
114 Y H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.7278 Soluble
117 V H -0.2880 Soluble
118 W H -0.4880 Soluble
119 G H 0.0000 Buried
120 K H -2.0702 Soluble
121 G H -1.0236 Soluble
122 T H -0.4300 Soluble
123 T H 0.1067 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.1128 Soluble
126 V H 0.0000 Buried
127 S H -0.5901 Soluble
128 S H -0.5394 Soluble
129 A H -0.3660 Soluble
130 S H -0.4602 Soluble
131 T H -0.7160 Soluble
132 K H -1.1946 Soluble
133 G H -1.4076 Soluble
134 P H -0.6616 Soluble
135 S H -0.3806 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H 0.0000 Buried
139 L H 0.0000 Buried
140 A H -1.1896 Soluble
141 P H 0.0000 Buried
142 S H -0.6844 Soluble
143 T H -0.3267 Soluble
144 A H 0.0000 Buried
145 A H 0.0000 Buried
146 L H 0.0000 Buried
147 G H 0.0000 Buried
148 C H 0.0000 Buried
149 L H 0.0000 Buried
150 V H 0.0000 Buried
151 K H 0.0000 Buried
152 D H -0.3869 Soluble
153 Y H 0.0000 Buried
154 F H 0.0000 Buried
155 P H -0.8363 Soluble
156 E H -1.1243 Soluble
157 P H -1.3068 Soluble
158 V H -1.0845 Soluble
159 T H -0.8626 Soluble
160 V H -0.3041 Soluble
161 S H -0.4243 Soluble
162 W H 0.0000 Buried
163 N H -0.7068 Soluble
164 S H -0.6072 Soluble
165 G H -0.4386 Soluble
166 A H -0.2081 Soluble
167 L H 0.0289 Aggregation-prone
168 T H -0.1470 Soluble
169 S H -0.1547 Soluble
170 G H -0.0887 Soluble
171 V H 0.2005 Aggregation-prone
172 H H -0.3593 Soluble
173 T H 0.0406 Aggregation-prone
174 F H 0.0000 Buried
175 P H -0.3538 Soluble
176 A H 0.0637 Aggregation-prone
177 V H 0.4638 Aggregation-prone
178 L H 1.2439 Aggregation-prone
179 Q H 0.2737 Aggregation-prone
180 S H -0.0504 Soluble
181 S H -0.1827 Soluble
182 G H 0.0671 Aggregation-prone
183 L H 0.0031 Aggregation-prone
184 Y H 0.0000 Buried
185 S H 0.0000 Buried
186 L H 0.0000 Buried
187 S H 0.0000 Buried
188 S H 0.0000 Buried
189 V H 0.0000 Buried
190 V H 0.0000 Buried
191 T H -0.1201 Soluble
192 V H 0.0000 Buried
193 P H -0.4292 Soluble
194 S H -0.5188 Soluble
195 S H -0.5968 Soluble
196 S H -0.6455 Soluble
197 L H -0.8840 Soluble
198 G H -0.9742 Soluble
199 T H -0.7609 Soluble
200 Q H -1.2756 Soluble
201 T H -1.2264 Soluble
202 Y H 0.0000 Buried
203 I H -1.2727 Soluble
204 C H 0.0000 Buried
205 N H -1.4789 Soluble
206 V H 0.0000 Buried
207 N H -2.4428 Soluble
208 H H 0.0000 Buried
209 K H -2.9666 Soluble
210 P H -1.8381 Soluble
211 S H -1.9003 Soluble
212 N H -2.6656 Soluble
213 T H -2.2255 Soluble
214 K H -2.8054 Soluble
215 V H -1.5809 Soluble
216 D H -2.3345 Soluble
217 K H -1.8653 Soluble
218 R H -2.5752 Soluble
219 V H 0.0000 Buried
220 E H -2.9348 Soluble
221 P H -1.9284 Soluble
222 K H -2.2928 Soluble
1 D L -2.4515 Soluble
2 I L 0.0000 Buried
3 Q L -2.2240 Soluble
4 M L 0.0000 Buried
5 T L -1.3776 Soluble
6 Q L -1.0243 Soluble
7 S L -0.8804 Soluble
8 P L -0.6173 Soluble
9 S L -0.8180 Soluble
10 S L -0.8674 Soluble
11 L L -0.5364 Soluble
12 S L -0.8001 Soluble
13 A L 0.0000 Buried
14 S L -0.3455 Soluble
15 V L 0.5421 Aggregation-prone
16 G L -0.5100 Soluble
17 D L -1.3761 Soluble
18 R L -2.2039 Soluble
19 V L 0.0000 Buried
20 T L -0.5162 Soluble
21 I L 0.0000 Buried
22 T L -0.8664 Soluble
23 C L 0.0000 Buried
24 R L -2.7536 Soluble
25 A L 0.0000 Buried
26 S L -1.9533 Soluble
27 Q L -2.0244 Soluble
28 S L -1.0556 Soluble
29 I L 0.0000 Buried
36 S L -0.3708 Soluble
37 S L -0.1461 Soluble
38 Y L 0.5851 Aggregation-prone
39 L L 0.0000 Buried
40 N L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.7652 Soluble
46 P L -1.5257 Soluble
47 G L -1.7141 Soluble
48 K L -2.6923 Soluble
49 A L -1.7732 Soluble
50 P L 0.0000 Buried
51 K L -1.4829 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.2887 Aggregation-prone
56 A L 0.1242 Aggregation-prone
57 A L 0.0000 Buried
65 S L -0.2162 Soluble
66 S L 0.0359 Aggregation-prone
67 L L 0.2572 Aggregation-prone
68 Q L -0.3120 Soluble
69 S L -0.4161 Soluble
70 G L -0.5052 Soluble
71 V L -0.3300 Soluble
72 P L -0.3183 Soluble
74 S L -0.3724 Soluble
75 R L -0.7514 Soluble
76 F L 0.0000 Buried
77 S L -0.2853 Soluble
78 G L 0.0000 Buried
79 S L -0.6143 Soluble
80 G L -0.9885 Soluble
83 S L -0.9353 Soluble
84 G L -1.0745 Soluble
85 T L -1.6379 Soluble
86 D L -2.0282 Soluble
87 F L 0.0000 Buried
88 T L -0.7005 Soluble
89 L L 0.0000 Buried
90 T L -0.5755 Soluble
91 I L 0.0000 Buried
92 S L -1.2069 Soluble
93 S L -1.0405 Soluble
94 L L 0.0000 Buried
95 Q L -1.0059 Soluble
96 P L -0.8059 Soluble
97 E L -1.8660 Soluble
98 D L 0.0000 Buried
99 F L -0.5494 Soluble
100 A L 0.0000 Buried
101 T L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 S L 0.0000 Buried
108 Y L 0.9139 Aggregation-prone
109 S L 0.0682 Aggregation-prone
114 T L -0.2994 Soluble
115 P L -0.6990 Soluble
116 L L 0.0000 Buried
117 T L -0.6549 Soluble
118 F L -0.4136 Soluble
119 G L 0.0000 Buried
120 G L -1.2347 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.6612 Soluble
124 V L 0.0000 Buried
125 E L -1.0573 Soluble
126 I L -0.5675 Soluble
127 K L -1.3027 Soluble
128 R L -0.9883 Soluble
129 T L 0.0366 Aggregation-prone
130 V L 0.7222 Aggregation-prone
131 A L 0.2623 Aggregation-prone
132 A L -0.1036 Soluble
133 P L 0.0000 Buried
134 S L -0.1950 Soluble
135 V L 0.0000 Buried
136 F L 0.1549 Aggregation-prone
137 I L 0.1596 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.7717 Soluble
140 P L -0.9664 Soluble
141 S L -1.7999 Soluble
142 D L -2.9043 Soluble
143 E L -2.8446 Soluble
144 Q L 0.0000 Buried
145 L L -2.3186 Soluble
146 K L -2.7665 Soluble
147 S L -1.7170 Soluble
148 G L -1.2202 Soluble
149 T L -0.9698 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -1.1587 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.2783 Soluble
162 R L -2.2151 Soluble
163 E L -2.8060 Soluble
164 A L -2.1364 Soluble
165 K L -2.3216 Soluble
166 V L -1.0508 Soluble
167 Q L -0.6011 Soluble
168 W L 0.0000 Buried
169 K L -0.5044 Soluble
170 V L 0.0000 Buried
171 D L -1.2856 Soluble
172 N L -1.0999 Soluble
173 A L -0.1191 Soluble
174 L L 0.7506 Aggregation-prone
175 Q L -0.3409 Soluble
176 S L -0.7155 Soluble
177 G L -1.3740 Soluble
178 N L -1.7552 Soluble
179 S L -1.6396 Soluble
180 Q L -1.7272 Soluble
181 E L -1.9908 Soluble
182 S L -0.9898 Soluble
183 V L -0.5703 Soluble
184 T L -1.1454 Soluble
185 E L -2.3086 Soluble
186 Q L -2.1722 Soluble
187 D L -2.7241 Soluble
188 S L -2.1354 Soluble
189 K L -2.6830 Soluble
190 D L -2.3386 Soluble
191 S L -2.2219 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.8274 Soluble
199 L L 0.0000 Buried
200 T L -0.6984 Soluble
201 L L -0.8130 Soluble
202 S L -1.2073 Soluble
203 K L -1.9958 Soluble
204 A L -1.9577 Soluble
205 D L -2.5817 Soluble
206 Y L 0.0000 Buried
207 E L -3.7198 Soluble
208 K L -3.7347 Soluble
209 H L -3.2286 Soluble
210 K L -3.3323 Soluble
211 V L -1.5834 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.8709 Soluble
216 V L 0.0000 Buried
217 T L -1.1946 Soluble
218 H L 0.0000 Buried
219 Q L -1.6130 Soluble
220 G L -0.3338 Soluble
221 L L -0.2794 Soluble
222 S L -0.5059 Soluble
223 S L -0.4717 Soluble
224 P L -0.6946 Soluble
225 V L -0.1199 Soluble
226 T L -0.5043 Soluble
227 K L -0.6795 Soluble
228 S L -0.5906 Soluble
229 F L -1.1110 Soluble
230 N L -2.5561 Soluble
231 R L -3.4290 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.8409 1.7216 CSV PDB
4.5 -0.8835 1.5597 CSV PDB
5.0 -0.9323 1.5271 CSV PDB
5.5 -0.9786 1.4896 CSV PDB
6.0 -1.0115 1.4519 CSV PDB
6.5 -1.0218 1.4181 CSV PDB
7.0 -1.0082 1.3923 CSV PDB
7.5 -0.9784 1.3746 CSV PDB
8.0 -0.9389 1.3726 CSV PDB
8.5 -0.8919 1.5273 CSV PDB
9.0 -0.8379 1.682 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH