Aducanumab

A4DAB007 | Neurological disorders | Approved

Target APP

Isotype / Subclass G1 / IgG1

Company

Biogen Neurimmune

Clinical Status Approved

Format Whole mAb

Synonyms

ADUHELM BIIB 037 BIIB-037 NI-10 NI10

pH Formulation 5.5

IMGT PubChem (174505063) PubChem (252166537) PubChem (347911309) PubChem (381127201) PubChem (459143277) PubChem (464013616) PubChem (468569299) PubChem (472408372) PubChem (481155595) PubChem (483928245) PubChem (500131943) PubChem (518314162) Thera-SAbDab YAbS

Avg A4D Score

-0.7206

Score Range

-0.74 to -0.7

Structures

2

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB007_6co3_H_L	6co3	100%	-0.7373	6.5	9.0	-0.5792	-0.7586
A4DAB007_6cnr_H_L	6cnr	100%	-0.7038	6.5	9.0	-0.5018	-0.731

Aducanumab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2