Sovipostobart / 7elx

A4DAB246_7elx_h_l | Source PDB: 7elx | Chains: h, l | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6896
Max Score
2.1193
Min Score
-3.4765
Total Score
-292.38
Score CDR
-0.1849
Score non-CDR
-0.751

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) h (Heavy), l (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4765
Maximum Score 2.1193
Average Score -0.6896
Total Score -292.3807

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q h -1.3565 Soluble
2 V h -0.6129 Soluble
3 Q h -0.5894 Soluble
4 L h 0.0000 Buried
5 V h 0.8741 Aggregation-prone
6 E h 0.0000 Buried
7 S h -0.4050 Soluble
8 G h -0.8189 Soluble
9 G h -0.4292 Soluble
11 G h -0.0028 Soluble
12 V h 0.2417 Aggregation-prone
13 V h 0.0000 Buried
14 Q h -1.6727 Soluble
15 P h -2.1986 Soluble
16 G h -2.3022 Soluble
17 R h -2.7965 Soluble
18 S h -2.1020 Soluble
19 L h -1.4194 Soluble
20 R h -2.0005 Soluble
21 L h 0.0000 Buried
22 S h -0.3553 Soluble
23 C h 0.0000 Buried
24 A h -0.1315 Soluble
25 A h 0.0000 Buried
26 S h -0.6323 Soluble
27 G h -0.8870 Soluble
28 F h -0.3337 Soluble
29 T h -0.2095 Soluble
30 F h 0.0000 Buried
35 S h -0.5512 Soluble
36 S h 0.0417 Aggregation-prone
37 Y h 0.0000 Buried
38 T h 0.0000 Buried
39 M h 0.0000 Buried
40 H h 0.0000 Buried
41 W h 0.0000 Buried
42 V h 0.0000 Buried
43 R h 0.0000 Buried
44 Q h 0.0000 Buried
45 A h -1.0227 Soluble
46 P h -0.8688 Soluble
47 G h -1.4699 Soluble
48 K h -2.3605 Soluble
49 G h -1.5774 Soluble
50 L h 0.0000 Buried
51 E h -1.0713 Soluble
52 W h 0.0000 Buried
53 V h 0.0000 Buried
54 T h 0.0000 Buried
55 F h 0.2222 Aggregation-prone
56 I h 0.0000 Buried
57 S h -0.8218 Soluble
58 Y h -0.4076 Soluble
59 D h -2.0760 Soluble
62 G h -1.9193 Soluble
63 N h -2.3347 Soluble
64 N h -1.9583 Soluble
65 K h -0.9539 Soluble
66 Y h -0.0360 Soluble
67 Y h -0.5913 Soluble
68 A h -1.1652 Soluble
69 D h -2.3380 Soluble
70 S h -1.7998 Soluble
71 V h 0.0000 Buried
72 K h -2.4686 Soluble
74 G h -1.7685 Soluble
75 R h -1.3492 Soluble
76 F h 0.0000 Buried
77 T h -0.7305 Soluble
78 I h 0.0000 Buried
79 S h -0.8054 Soluble
80 R h -1.0508 Soluble
81 D h -1.7195 Soluble
82 N h -1.7585 Soluble
83 S h -1.5638 Soluble
84 K h -2.3704 Soluble
85 N h -1.8131 Soluble
86 T h -1.0136 Soluble
87 L h 0.0000 Buried
88 Y h -0.3760 Soluble
89 L h 0.0000 Buried
90 Q h -1.0613 Soluble
91 M h 0.0000 Buried
92 N h -1.9445 Soluble
93 S h -1.9381 Soluble
94 L h 0.0000 Buried
95 R h -3.1068 Soluble
96 A h -1.9602 Soluble
97 E h -2.4278 Soluble
98 D h 0.0000 Buried
99 T h -0.7245 Soluble
100 A h 0.0000 Buried
101 I h 0.4862 Aggregation-prone
102 Y h 0.0000 Buried
103 Y h 0.0000 Buried
104 C h 0.0000 Buried
105 A h 0.0000 Buried
106 R h 0.0000 Buried
107 T h 0.5910 Aggregation-prone
108 G h 0.0000 Buried
109 W h 1.8443 Aggregation-prone
110 L h 2.1193 Aggregation-prone
113 G h 1.0875 Aggregation-prone
114 P h 0.0000 Buried
115 F h 0.0000 Buried
116 D h 0.0845 Aggregation-prone
117 Y h 0.1858 Aggregation-prone
118 W h -0.1416 Soluble
119 G h 0.0000 Buried
120 Q h -1.1726 Soluble
121 G h -0.4328 Soluble
122 T h 0.0788 Aggregation-prone
123 L h 0.5023 Aggregation-prone
124 V h 0.0000 Buried
125 T h 0.0000 Buried
126 V h 0.0000 Buried
127 S h -0.9079 Soluble
128 S h -0.7396 Soluble
129 A h -0.4887 Soluble
130 S h -0.6410 Soluble
131 T h -0.7997 Soluble
132 K h -1.6084 Soluble
133 G h -1.5582 Soluble
134 P h -0.7073 Soluble
135 S h -0.4119 Soluble
136 V h 0.0000 Buried
137 F h 0.0000 Buried
138 P h -1.1848 Soluble
139 L h 0.0000 Buried
140 A h -0.8064 Soluble
141 P h -0.5705 Soluble
142 S h -0.1649 Soluble
143 S h -0.2799 Soluble
144 T h -0.3022 Soluble
145 A h 0.0000 Buried
146 A h 0.0000 Buried
147 L h 0.0000 Buried
148 G h 0.0000 Buried
149 C h 0.0000 Buried
150 L h 0.0000 Buried
151 V h 0.0000 Buried
152 K h 0.0000 Buried
153 D h -0.5214 Soluble
154 Y h 0.0000 Buried
155 F h 0.0000 Buried
156 P h 0.0000 Buried
157 E h -0.4996 Soluble
158 P h -0.7566 Soluble
159 V h -0.6793 Soluble
160 T h -0.5056 Soluble
161 V h -0.2614 Soluble
162 S h -0.3420 Soluble
163 W h 0.0000 Buried
164 N h -0.7646 Soluble
165 S h -0.6624 Soluble
166 G h -0.5601 Soluble
167 A h -0.2559 Soluble
168 L h 0.0048 Aggregation-prone
169 T h -0.1644 Soluble
170 S h -0.1697 Soluble
171 G h -0.2115 Soluble
172 V h 0.2031 Aggregation-prone
173 H h -0.3050 Soluble
174 T h 0.0304 Aggregation-prone
175 F h 0.0000 Buried
176 P h -0.3959 Soluble
177 A h 0.0021 Aggregation-prone
178 V h 0.2702 Aggregation-prone
179 L h 1.1430 Aggregation-prone
180 Q h 0.1621 Aggregation-prone
181 S h -0.0654 Soluble
182 S h -0.2010 Soluble
183 G h 0.0138 Aggregation-prone
184 L h -0.0079 Soluble
185 Y h 0.3112 Aggregation-prone
186 S h 0.0000 Buried
187 L h 0.0000 Buried
188 S h 0.0000 Buried
189 S h 0.0000 Buried
190 V h 0.0000 Buried
191 V h 0.0000 Buried
192 T h -0.1420 Soluble
193 V h 0.0000 Buried
194 P h -0.5249 Soluble
195 S h -0.4804 Soluble
196 S h -0.5682 Soluble
197 S h 0.0000 Buried
198 L h -0.9529 Soluble
199 G h -1.2685 Soluble
200 T h -1.0549 Soluble
201 Q h -1.5881 Soluble
202 T h -1.2564 Soluble
203 Y h 0.0000 Buried
204 I h -1.2013 Soluble
205 C h 0.0000 Buried
206 N h -1.4819 Soluble
207 V h 0.0000 Buried
208 N h -1.7598 Soluble
209 H h 0.0000 Buried
210 K h -2.7455 Soluble
211 P h -1.6744 Soluble
212 S h -1.9100 Soluble
213 N h -2.6228 Soluble
214 T h -2.0978 Soluble
215 K h -2.5788 Soluble
216 V h -1.5733 Soluble
217 D h -2.6002 Soluble
218 K h -2.3332 Soluble
219 R h -2.5920 Soluble
220 V h 0.0000 Buried
221 E h -2.5436 Soluble
222 P h -1.2453 Soluble
1 E l -1.4623 Soluble
2 I l -0.3670 Soluble
3 V l 0.8030 Aggregation-prone
4 L l 0.0000 Buried
5 T l -0.5909 Soluble
6 Q l 0.0000 Buried
7 S l -0.8267 Soluble
8 P l -0.5253 Soluble
9 G l -0.8635 Soluble
10 T l -0.4450 Soluble
11 L l -0.1945 Soluble
12 S l -0.4363 Soluble
13 L l -1.1415 Soluble
14 S l -1.5829 Soluble
15 P l -2.0483 Soluble
16 G l -2.3779 Soluble
17 E l -2.9601 Soluble
18 R l -3.3177 Soluble
19 A l 0.0000 Buried
20 T l -0.5487 Soluble
21 L l 0.0000 Buried
22 S l -0.7520 Soluble
23 C l 0.0000 Buried
24 R l -1.8358 Soluble
25 A l 0.0000 Buried
26 S l -0.9092 Soluble
27 Q l -1.6149 Soluble
28 S l -1.3410 Soluble
29 V l 0.0000 Buried
30 G l -0.5018 Soluble
36 S l -0.0930 Soluble
37 S l 0.4844 Aggregation-prone
38 Y l 0.6093 Aggregation-prone
39 L l 0.0000 Buried
40 A l 0.0000 Buried
41 W l 0.0000 Buried
42 Y l 0.0000 Buried
43 Q l 0.0000 Buried
44 Q l 0.0000 Buried
45 K l -1.5306 Soluble
46 P l -1.4396 Soluble
47 G l -1.4844 Soluble
48 Q l -2.1196 Soluble
49 A l -1.3206 Soluble
50 P l 0.0000 Buried
51 R l -1.3493 Soluble
52 L l 0.0000 Buried
53 L l 0.0000 Buried
54 I l 0.0000 Buried
55 Y l 0.6887 Aggregation-prone
56 G l 0.7080 Aggregation-prone
57 A l 0.0000 Buried
65 F l 1.4728 Aggregation-prone
66 S l 0.2771 Aggregation-prone
67 R l -1.0678 Soluble
68 A l -0.6481 Soluble
69 T l -0.6247 Soluble
70 G l -0.9110 Soluble
71 I l 0.0000 Buried
72 P l -1.3706 Soluble
74 D l -2.2562 Soluble
75 R l -2.0094 Soluble
76 F l 0.0000 Buried
77 S l -0.4791 Soluble
78 G l 0.3639 Aggregation-prone
79 S l 0.0180 Aggregation-prone
80 G l -0.5817 Soluble
83 S l -0.7670 Soluble
84 G l -1.2332 Soluble
85 T l -1.6571 Soluble
86 D l -2.0401 Soluble
87 F l 0.0000 Buried
88 T l -0.4621 Soluble
89 L l 0.0000 Buried
90 T l -0.8355 Soluble
91 I l 0.0000 Buried
92 S l -2.4265 Soluble
93 R l -3.4765 Soluble
94 L l 0.0000 Buried
95 E l -2.5950 Soluble
96 P l -1.8105 Soluble
97 E l -2.2970 Soluble
98 D l 0.0000 Buried
99 F l -0.6408 Soluble
100 A l 0.0000 Buried
101 V l -0.2266 Soluble
102 Y l 0.0000 Buried
103 Y l 0.0000 Buried
104 C l 0.0000 Buried
105 Q l 0.0000 Buried
106 Q l 0.0000 Buried
107 Y l 0.0000 Buried
108 G l -0.0845 Soluble
109 S l -0.5538 Soluble
114 S l -0.4153 Soluble
115 P l -0.6289 Soluble
116 W l -0.0472 Soluble
117 T l 0.0000 Buried
118 F l 0.0869 Aggregation-prone
119 G l 0.0000 Buried
120 Q l -1.5143 Soluble
121 G l 0.0000 Buried
122 T l 0.0000 Buried
123 K l -0.7353 Soluble
124 V l 0.0000 Buried
125 E l 0.0000 Buried
126 I l -0.6924 Soluble
127 K l -1.3142 Soluble
128 R l -1.0175 Soluble
129 T l -0.0910 Soluble
130 V l 0.3860 Aggregation-prone
131 A l -0.0302 Soluble
132 A l -0.1373 Soluble
133 P l 0.0000 Buried
134 S l -0.0561 Soluble
135 V l 0.1293 Aggregation-prone
136 F l 0.2067 Aggregation-prone
137 I l 0.1911 Aggregation-prone
138 F l 0.0000 Buried
139 P l -0.7357 Soluble
140 P l -0.9111 Soluble
141 S l -1.5544 Soluble
142 D l -2.8590 Soluble
143 E l -2.7470 Soluble
144 Q l 0.0000 Buried
145 L l -2.1441 Soluble
146 K l -2.8653 Soluble
147 S l -1.8383 Soluble
148 G l -1.5364 Soluble
149 T l -1.1411 Soluble
150 A l 0.0000 Buried
151 S l 0.0000 Buried
152 V l 0.0000 Buried
153 V l 0.0000 Buried
154 C l 0.0000 Buried
155 L l 0.0000 Buried
156 L l 0.0000 Buried
157 N l 0.0000 Buried
158 N l -0.9792 Soluble
159 F l 0.0000 Buried
160 Y l 0.0000 Buried
161 P l -1.6023 Soluble
162 R l -2.7356 Soluble
163 E l -3.0285 Soluble
164 A l -2.2706 Soluble
165 K l -2.3898 Soluble
166 V l -1.0976 Soluble
167 Q l -0.5286 Soluble
168 W l 0.0000 Buried
169 K l -0.3901 Soluble
170 V l 0.0000 Buried
171 D l -1.1923 Soluble
172 N l -1.0940 Soluble
173 A l -0.2096 Soluble
174 L l 0.5863 Aggregation-prone
175 Q l -0.4123 Soluble
176 S l -0.6993 Soluble
177 G l -1.3649 Soluble
178 N l -1.6664 Soluble
179 S l -1.7576 Soluble
180 Q l -2.1261 Soluble
181 E l -2.2840 Soluble
182 S l -1.0330 Soluble
183 V l -1.0608 Soluble
184 T l 0.0000 Buried
185 E l -2.2443 Soluble
186 Q l -1.8314 Soluble
187 D l -1.8629 Soluble
188 S l -1.8566 Soluble
189 K l -2.1509 Soluble
190 D l -1.5652 Soluble
191 S l -1.6219 Soluble
192 T l 0.0000 Buried
193 Y l 0.0000 Buried
194 S l 0.0000 Buried
195 L l 0.0000 Buried
196 S l 0.0000 Buried
197 S l 0.0000 Buried
198 T l -0.9142 Soluble
199 L l 0.0000 Buried
200 T l -0.5192 Soluble
201 L l -0.7482 Soluble
202 S l -1.1453 Soluble
203 K l -2.1087 Soluble
204 A l -1.9444 Soluble
205 D l -2.8962 Soluble
206 Y l 0.0000 Buried
207 E l -3.0924 Soluble
208 K l -3.2593 Soluble
209 H l -2.8707 Soluble
210 K l -3.0259 Soluble
211 V l -1.4501 Soluble
212 Y l 0.0000 Buried
213 A l 0.0000 Buried
214 C l 0.0000 Buried
215 E l -0.6883 Soluble
216 V l 0.0000 Buried
217 T l -1.1455 Soluble
218 H l 0.0000 Buried
219 Q l -1.6802 Soluble
220 G l -0.4326 Soluble
221 L l -0.2318 Soluble
222 S l -0.4617 Soluble
223 S l -0.4052 Soluble
224 P l -0.4916 Soluble
225 V l 0.1413 Aggregation-prone
226 T l -0.3108 Soluble
227 K l -0.5209 Soluble
228 S l -0.5022 Soluble
229 F l -1.0586 Soluble
230 N l -2.4838 Soluble
231 R l -2.9677 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7024 4.2942 CSV PDB
4.5 -0.7443 4.2805 CSV PDB
5.0 -0.7932 4.2665 CSV PDB
5.5 -0.8406 4.2524 CSV PDB
6.0 -0.8767 4.2383 CSV PDB
6.5 -0.8929 4.2244 CSV PDB
7.0 -0.8882 4.2109 CSV PDB
7.5 -0.8688 4.1987 CSV PDB
8.0 -0.841 4.1892 CSV PDB
8.5 -0.8066 4.1835 CSV PDB
9.0 -0.7656 4.181 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH