Sovipostobart

A4DAB246 | Phase-II
CTLA4/CD152
G1 / None
CytomX Therapeutics Bristol-Myers Squibb
Phase-II
Whole mAb
BMS-986249 BMS 986249 BMS986249
—
Avg A4D Score
-0.66
Score Range
-0.71 to -0.6
Structures
11
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB246_5xj3_G_H 5xj3 100% -0.6227 7.0 4.0 -0.1722 -0.7384
A4DAB246_6jc2_H_L 6jc2 100% -0.6931 6.5 4.0 -0.1845 -0.7546
A4DAB246_7elx_H_L 7elx 100% -0.6754 7.0 4.0 -0.1751 -0.7364
A4DAB246_5tru_h_l 5tru 100% -0.6806 6.5 4.0 -0.1955 -0.7398
A4DAB246_5xj3_J_K 5xj3 100% -0.6031 7.0 4.0 -0.1936 -0.7084
A4DAB246_7elx_h_l 7elx 100% -0.6896 6.5 4.0 -0.1849 -0.751
A4DAB246_6rp8_H_L 6rp8 100% -0.6732 6.5 4.0 -0.134 -0.7388
A4DAB246_5xj3_A_B 5xj3 100% -0.5972 7.0 4.0 -0.154 -0.7111
A4DAB246_5xj3_D_E 5xj3 100% -0.6282 7.0 4.0 -0.1827 -0.7427
A4DAB246_6rp8_h_l 6rp8 100% -0.692 6.5 4.0 -0.1115 -0.7629
A4DAB246_5tru_H_L 5tru 100% -0.7054 6.5 4.0 -0.1892 -0.7676