Masavibart / 6xdg

A4DAB166_6xdg_C_A | Source PDB: 6xdg | Chains: C, A | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6143
Max Score
1.7974
Min Score
-2.937
Total Score
-259.87
Score CDR
-0.3863
Score non-CDR
-0.6456

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYAMYWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRTEDTAVYYCASGSDYGDYLLVYWGQGTLVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSKRPSGVSNRFSGSKSGNTASLTISGLQSEDEADYYCNSLTSISTWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT input.pdb
Selected Chain(s) C (Heavy), A (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.937
Maximum Score 1.7974
Average Score -0.6143
Total Score -259.8653

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q C -1.1425 Soluble
2 V C -0.0616 Soluble
3 Q C -0.6722 Soluble
4 L C 0.2197 Aggregation-prone
5 V C 1.1323 Aggregation-prone
6 E C 0.2305 Aggregation-prone
7 S C -0.2511 Soluble
8 G C -0.4325 Soluble
9 G C -0.3356 Soluble
11 G C 0.5964 Aggregation-prone
12 V C 1.0841 Aggregation-prone
13 V C -0.3353 Soluble
14 Q C -1.7149 Soluble
15 P C -2.0958 Soluble
16 G C -2.1456 Soluble
17 R C -2.7192 Soluble
18 S C -2.0333 Soluble
19 L C -1.5349 Soluble
20 R C -2.1046 Soluble
21 L C 0.0000 Buried
22 S C -0.3728 Soluble
23 C C 0.0000 Buried
24 A C 0.1550 Aggregation-prone
25 A C -0.2409 Soluble
26 S C -0.4518 Soluble
27 G C -0.6909 Soluble
28 F C -0.4328 Soluble
29 T C -0.5740 Soluble
30 F C 0.0000 Buried
35 S C -1.3111 Soluble
36 N C -1.4001 Soluble
37 Y C -0.6103 Soluble
38 A C -0.1929 Soluble
39 M C 0.0000 Buried
40 Y C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 R C -0.1924 Soluble
44 Q C -0.6653 Soluble
45 A C -1.0433 Soluble
46 P C -0.8416 Soluble
47 G C -1.5607 Soluble
48 K C -2.2148 Soluble
49 G C -1.4090 Soluble
50 L C -0.7903 Soluble
51 E C -0.8194 Soluble
52 W C 0.0000 Buried
53 V C 0.0000 Buried
54 A C 0.0000 Buried
55 V C 0.0000 Buried
56 I C 0.0000 Buried
57 S C -0.8166 Soluble
58 Y C -0.3106 Soluble
59 D C -2.0911 Soluble
62 G C -1.8367 Soluble
63 S C -1.6012 Soluble
64 N C -1.9112 Soluble
65 K C -1.3408 Soluble
66 Y C -0.5544 Soluble
67 Y C -0.9159 Soluble
68 A C 0.0000 Buried
69 D C -2.3687 Soluble
70 S C -1.5247 Soluble
71 V C 0.0000 Buried
72 K C -2.4107 Soluble
74 G C -1.6380 Soluble
75 R C 0.0000 Buried
76 F C 0.0000 Buried
77 T C -0.8342 Soluble
78 I C 0.0000 Buried
79 S C -0.7580 Soluble
80 R C -1.1822 Soluble
81 D C -1.9976 Soluble
82 N C -2.1153 Soluble
83 S C -1.7139 Soluble
84 K C -2.4270 Soluble
85 N C -1.8521 Soluble
86 T C -1.2192 Soluble
87 L C 0.0000 Buried
88 Y C -0.3736 Soluble
89 L C 0.0000 Buried
90 Q C -1.4385 Soluble
91 M C 0.0000 Buried
92 N C -1.7956 Soluble
93 S C -1.7919 Soluble
94 L C 0.0000 Buried
95 R C -2.4284 Soluble
96 T C -1.7800 Soluble
97 E C -2.2143 Soluble
98 D C 0.0000 Buried
99 T C -0.4163 Soluble
100 A C 0.0000 Buried
101 V C 0.7071 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 S C 0.0000 Buried
107 G C 0.0000 Buried
108 S C 0.0000 Buried
109 D C -1.5348 Soluble
110 Y C -0.0418 Soluble
111 G C -0.7026 Soluble
112 D C -0.7942 Soluble
113 Y C 0.2083 Aggregation-prone
114 L C 0.0000 Buried
115 L C 0.0000 Buried
116 V C -0.1220 Soluble
117 Y C -0.0098 Soluble
118 W C 0.0000 Buried
119 G C 0.0000 Buried
120 Q C -1.1027 Soluble
121 G C 0.0000 Buried
122 T C 0.0000 Buried
123 L C 1.3370 Aggregation-prone
124 V C 0.0000 Buried
125 T C 0.1123 Aggregation-prone
126 V C 0.0000 Buried
127 S C -0.6407 Soluble
128 S C -0.4930 Soluble
129 A C -0.3315 Soluble
130 S C -0.5617 Soluble
131 T C -0.7506 Soluble
132 K C -0.9711 Soluble
133 G C -1.2735 Soluble
134 P C 0.0000 Buried
135 S C -0.3390 Soluble
136 V C 0.0000 Buried
137 F C -0.3202 Soluble
138 P C -0.9922 Soluble
139 L C 0.0000 Buried
140 A C -0.9178 Soluble
141 P C -0.6452 Soluble
142 T C -0.2340 Soluble
143 A C -0.2051 Soluble
144 A C 0.0000 Buried
145 L C 0.0000 Buried
146 G C 0.0000 Buried
147 C C 0.0000 Buried
148 L C 0.0000 Buried
149 V C 0.0000 Buried
150 K C 0.0000 Buried
151 D C -0.4400 Soluble
152 Y C 0.0000 Buried
153 F C 0.0000 Buried
154 P C -0.6518 Soluble
155 E C -0.9563 Soluble
156 P C -1.0496 Soluble
157 V C 0.0000 Buried
158 T C -0.4077 Soluble
159 V C 0.1360 Aggregation-prone
160 S C -0.0416 Soluble
161 W C 0.0000 Buried
162 N C -0.2897 Soluble
163 S C -0.4522 Soluble
164 G C -0.5684 Soluble
165 A C -0.2539 Soluble
166 L C 0.1087 Aggregation-prone
167 T C 0.0500 Aggregation-prone
168 S C 0.0363 Aggregation-prone
169 G C 0.0568 Aggregation-prone
170 V C 0.7755 Aggregation-prone
171 H C -0.0863 Soluble
172 T C 0.0312 Aggregation-prone
173 F C 0.1538 Aggregation-prone
174 P C 0.2488 Aggregation-prone
175 A C 0.5511 Aggregation-prone
176 V C 1.1696 Aggregation-prone
177 L C 1.0103 Aggregation-prone
178 Q C 0.2729 Aggregation-prone
179 S C -0.0434 Soluble
180 S C -0.2515 Soluble
181 G C -0.0858 Soluble
182 L C -0.0334 Soluble
183 Y C 0.2390 Aggregation-prone
184 S C 0.0000 Buried
185 L C 0.1601 Aggregation-prone
186 S C 0.1638 Aggregation-prone
187 S C 0.0000 Buried
188 V C 0.0000 Buried
189 V C 0.0000 Buried
190 T C 0.0462 Aggregation-prone
191 V C -0.0938 Soluble
192 P C -0.3676 Soluble
193 S C -0.4965 Soluble
194 S C -0.4825 Soluble
195 S C -0.6867 Soluble
196 L C -0.9283 Soluble
197 G C -1.2415 Soluble
198 T C -0.9141 Soluble
199 Q C -1.3731 Soluble
200 T C -1.1845 Soluble
201 Y C 0.0000 Buried
202 I C -0.5259 Soluble
203 C C 0.0000 Buried
204 N C -0.8887 Soluble
205 V C 0.0000 Buried
206 N C -1.7657 Soluble
207 H C 0.0000 Buried
208 K C -2.8721 Soluble
209 P C -1.8073 Soluble
210 S C -1.8606 Soluble
211 N C -2.5828 Soluble
212 T C -2.0612 Soluble
213 K C -2.4565 Soluble
214 V C -1.3600 Soluble
215 D C -1.8867 Soluble
216 K C -1.7423 Soluble
217 K C -2.3965 Soluble
218 V C 0.0000 Buried
219 E C -2.4885 Soluble
220 P C -1.2762 Soluble
3 A A 0.0633 Aggregation-prone
4 L A 0.0169 Aggregation-prone
5 T A -0.2009 Soluble
6 Q A -0.5395 Soluble
7 P A -0.5032 Soluble
8 A A -0.5219 Soluble
9 S A -0.7527 Soluble
11 V A -0.3179 Soluble
12 S A -0.2042 Soluble
13 G A -0.4182 Soluble
14 S A -0.7346 Soluble
15 P A -1.1107 Soluble
16 G A -1.3706 Soluble
17 Q A -1.5170 Soluble
18 S A -0.8495 Soluble
19 I A -0.2647 Soluble
20 T A -0.0753 Soluble
21 I A 0.0000 Buried
22 S A -0.3872 Soluble
23 C A 0.0000 Buried
24 T A -0.5087 Soluble
25 G A -0.4489 Soluble
26 T A -0.6046 Soluble
27 S A -0.8369 Soluble
28 S A -0.3433 Soluble
29 D A -0.2798 Soluble
30 V A 0.0000 Buried
31 G A -1.2348 Soluble
35 G A -0.8707 Soluble
36 Y A -0.3925 Soluble
37 N A -0.8611 Soluble
38 Y A -0.0720 Soluble
39 V A 0.0000 Buried
40 S A 0.0000 Buried
41 W A 0.0000 Buried
42 Y A 0.0000 Buried
43 Q A 0.0000 Buried
44 Q A 0.0000 Buried
45 H A -1.8103 Soluble
46 P A -1.3316 Soluble
47 G A -1.7027 Soluble
48 K A -2.5685 Soluble
49 A A -1.7531 Soluble
50 P A 0.0000 Buried
51 K A -1.7876 Soluble
52 L A 0.0000 Buried
53 M A 0.0000 Buried
54 I A 0.0000 Buried
55 Y A 0.0000 Buried
56 D A -0.5588 Soluble
57 V A -0.0858 Soluble
65 S A -0.9702 Soluble
66 K A -2.1846 Soluble
67 R A -2.1528 Soluble
68 P A -1.1630 Soluble
69 S A -0.8733 Soluble
70 G A -0.8159 Soluble
71 V A -0.9290 Soluble
72 S A -1.1727 Soluble
74 N A -2.0339 Soluble
75 R A -1.3386 Soluble
76 F A 0.0000 Buried
77 S A -0.9040 Soluble
78 G A -0.5129 Soluble
79 S A -0.3391 Soluble
80 K A -1.0445 Soluble
83 S A -0.9608 Soluble
84 G A -1.1203 Soluble
85 N A -1.1346 Soluble
86 T A -0.8244 Soluble
87 A A 0.0000 Buried
88 S A -0.4878 Soluble
89 L A 0.0000 Buried
90 T A -0.2686 Soluble
91 I A 0.0000 Buried
92 S A -1.0570 Soluble
93 G A -1.1278 Soluble
94 L A 0.0000 Buried
95 Q A -1.8155 Soluble
96 S A -1.6606 Soluble
97 E A -2.3530 Soluble
98 D A 0.0000 Buried
99 E A -1.6307 Soluble
100 A A 0.0000 Buried
101 D A -1.2947 Soluble
102 Y A 0.0000 Buried
103 Y A 0.0000 Buried
104 C A 0.0000 Buried
105 N A 0.0000 Buried
106 S A 0.0000 Buried
107 L A 0.4845 Aggregation-prone
108 T A 0.0000 Buried
109 S A 0.7119 Aggregation-prone
113 I A 1.7974 Aggregation-prone
114 S A 0.8613 Aggregation-prone
115 T A 0.4112 Aggregation-prone
116 W A 0.3872 Aggregation-prone
117 V A 0.2663 Aggregation-prone
118 F A 0.0000 Buried
119 G A 0.0000 Buried
120 G A -0.6050 Soluble
121 G A -1.2738 Soluble
122 T A 0.0000 Buried
123 K A -1.8386 Soluble
124 L A 0.0000 Buried
125 T A -0.7961 Soluble
126 V A 0.0000 Buried
127 L A -0.1674 Soluble
128 G A -0.7412 Soluble
129 Q A -1.0842 Soluble
130 P A -1.2151 Soluble
131 K A -2.1110 Soluble
132 A A -1.3901 Soluble
133 A A -0.6045 Soluble
134 P A 0.0000 Buried
135 S A -0.0223 Soluble
136 V A 0.0000 Buried
137 T A -0.3086 Soluble
138 L A 0.0000 Buried
139 F A 0.0000 Buried
140 P A -0.1797 Soluble
141 P A -0.2113 Soluble
142 S A 0.0000 Buried
143 S A -0.7587 Soluble
144 E A -1.3879 Soluble
145 E A 0.0000 Buried
146 L A -1.1708 Soluble
147 Q A -1.8295 Soluble
148 A A -1.3766 Soluble
149 N A -1.8302 Soluble
150 K A -1.2930 Soluble
151 A A 0.0000 Buried
152 T A 0.0000 Buried
153 L A 0.0000 Buried
154 V A 0.0000 Buried
155 C A 0.0000 Buried
156 L A 0.0000 Buried
157 I A 0.0000 Buried
158 S A 0.0000 Buried
159 D A -1.1403 Soluble
160 F A 0.0000 Buried
161 Y A 0.0000 Buried
162 P A -1.2418 Soluble
163 G A -0.8414 Soluble
164 A A -0.4747 Soluble
165 V A -0.2066 Soluble
166 T A -0.1204 Soluble
167 V A -0.2186 Soluble
168 A A -0.5587 Soluble
169 W A 0.0000 Buried
170 K A -1.4733 Soluble
171 A A 0.0000 Buried
172 D A -1.6157 Soluble
173 S A -1.0451 Soluble
174 S A -0.7015 Soluble
175 P A -0.9900 Soluble
176 V A -1.0082 Soluble
177 K A -1.7099 Soluble
178 A A -0.8954 Soluble
179 G A -0.7587 Soluble
180 V A -0.4189 Soluble
181 E A -0.1535 Soluble
182 T A -0.1396 Soluble
183 T A 0.1378 Aggregation-prone
184 T A -0.1598 Soluble
185 P A -0.5309 Soluble
186 S A -0.9013 Soluble
187 K A -2.0965 Soluble
188 Q A 0.0000 Buried
189 S A -1.4757 Soluble
190 N A -2.2618 Soluble
191 N A -2.2380 Soluble
192 K A -2.2234 Soluble
193 Y A 0.0000 Buried
194 A A 0.0000 Buried
195 A A 0.0000 Buried
196 S A 0.0000 Buried
197 S A 0.0000 Buried
198 Y A 0.0000 Buried
199 L A 0.0000 Buried
200 S A -0.5424 Soluble
201 L A -0.6648 Soluble
202 T A -1.2684 Soluble
203 P A -1.9013 Soluble
204 E A -2.6479 Soluble
205 Q A -1.9195 Soluble
206 W A 0.0000 Buried
207 K A -2.9370 Soluble
208 S A -2.2609 Soluble
209 H A -2.3829 Soluble
210 R A -2.5818 Soluble
211 S A -1.6173 Soluble
212 Y A 0.0000 Buried
213 S A 0.0000 Buried
214 C A 0.0000 Buried
215 Q A -1.1216 Soluble
216 V A 0.0000 Buried
217 T A -0.3488 Soluble
218 H A 0.0000 Buried
219 E A -1.6307 Soluble
220 G A -1.0435 Soluble
221 S A -0.4723 Soluble
222 T A -0.5430 Soluble
223 V A -0.3263 Soluble
224 E A -1.9434 Soluble
225 K A -1.5323 Soluble
226 T A -1.0940 Soluble
227 V A 0.0000 Buried
228 A A -0.8035 Soluble
229 P A -0.9275 Soluble
230 T A -0.3125 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6086 2.529 CSV PDB
4.5 -0.6395 2.4845 CSV PDB
5.0 -0.6739 2.4224 CSV PDB
5.5 -0.7037 2.353 CSV PDB
6.0 -0.7196 2.2872 CSV PDB
6.5 -0.7149 2.2358 CSV PDB
7.0 -0.6911 2.2055 CSV PDB
7.5 -0.6559 2.1923 CSV PDB
8.0 -0.6148 2.1875 CSV PDB
8.5 -0.5695 2.1859 CSV PDB
9.0 -0.52 2.1854 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH