Lanadelumab / 4ogy

A4DAB151_4ogy_M_N | Source PDB: 4ogy | Chains: M, N | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6595
Max Score
1.9173
Min Score
-3.3504
Total Score
-271.7
Score CDR
-0.2975
Score non-CDR
-0.7027

Calculation Parameters

Chain Sequence(s) VQLLESGGGLVQPGGSLRLSCAASGHYIMMWVRQAPGKGLEWVSGIYSSGGITVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAYRRIGVPRRDEFDIWGQGTMVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVYICNVNHKPSNTKVDKRVEPDIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNTYWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) M (Heavy), N (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3504
Maximum Score 1.9173
Average Score -0.6595
Total Score -271.6988

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V M 1.0866 Aggregation-prone
3 Q M -0.0590 Soluble
4 L M 0.0000 Buried
5 L M 0.1972 Aggregation-prone
6 E M 0.0000 Buried
7 S M -0.4374 Soluble
8 G M -0.5874 Soluble
9 G M -0.1598 Soluble
11 G M 0.2432 Aggregation-prone
12 L M 0.7347 Aggregation-prone
13 V M -0.2411 Soluble
14 Q M -1.3686 Soluble
15 P M -1.6257 Soluble
16 G M -1.3257 Soluble
17 G M 0.0000 Buried
18 S M -1.2209 Soluble
19 L M -0.8803 Soluble
20 R M -1.5507 Soluble
21 L M 0.0000 Buried
22 S M -0.3744 Soluble
23 C M 0.0000 Buried
24 A M -0.5951 Soluble
25 A M -0.4825 Soluble
26 S M -0.4132 Soluble
27 G M -0.1696 Soluble
28 H M -0.6594 Soluble
37 Y M 0.2024 Aggregation-prone
38 I M 0.6955 Aggregation-prone
39 M M 0.2465 Aggregation-prone
40 M M 0.0000 Buried
41 W M 0.0000 Buried
42 V M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M -0.7666 Soluble
45 A M -1.1538 Soluble
46 P M -1.0049 Soluble
47 G M -1.5012 Soluble
48 K M -2.3861 Soluble
49 G M -1.6729 Soluble
50 L M 0.0000 Buried
51 E M -1.0676 Soluble
52 W M 0.0000 Buried
53 V M 0.0000 Buried
54 S M 0.0000 Buried
55 G M 0.0000 Buried
56 I M 0.0000 Buried
57 Y M 1.0128 Aggregation-prone
58 S M 0.2781 Aggregation-prone
59 S M -0.5252 Soluble
62 G M -0.4849 Soluble
63 G M 0.5582 Aggregation-prone
64 I M 1.9173 Aggregation-prone
65 T M 0.9770 Aggregation-prone
66 V M 0.4423 Aggregation-prone
67 Y M -0.7426 Soluble
68 A M -1.4614 Soluble
69 D M -2.6926 Soluble
70 S M -1.5697 Soluble
71 V M 0.0000 Buried
72 K M -2.6267 Soluble
74 G M -1.9274 Soluble
75 R M -1.8761 Soluble
76 F M 0.0000 Buried
77 T M -0.8890 Soluble
78 I M 0.0000 Buried
79 S M -0.6481 Soluble
80 R M -1.5736 Soluble
81 D M -2.3330 Soluble
82 N M -2.8735 Soluble
83 S M -2.2633 Soluble
84 K M -3.0529 Soluble
85 N M -2.9404 Soluble
86 T M -1.7137 Soluble
87 L M 0.0000 Buried
88 Y M -0.5019 Soluble
89 L M 0.0000 Buried
90 Q M -1.2100 Soluble
91 M M 0.0000 Buried
92 N M -2.0286 Soluble
93 S M -1.5056 Soluble
94 L M 0.0000 Buried
95 R M -2.4941 Soluble
96 A M -1.7922 Soluble
97 E M -2.2904 Soluble
98 D M 0.0000 Buried
99 T M -0.6419 Soluble
100 A M 0.0000 Buried
101 V M 0.3277 Aggregation-prone
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 Y M 0.0000 Buried
107 R M 0.0000 Buried
108 R M 0.0000 Buried
109 I M 0.6658 Aggregation-prone
110 G M 0.3062 Aggregation-prone
111 V M 0.7968 Aggregation-prone
111A P M -1.1750 Soluble
112A R M -2.8439 Soluble
112 R M -3.1317 Soluble
113 D M -2.6009 Soluble
114 E M -1.8977 Soluble
115 F M 0.0000 Buried
116 D M 0.0000 Buried
117 I M 0.0815 Aggregation-prone
118 W M -0.1168 Soluble
119 G M 0.0000 Buried
120 Q M -1.5153 Soluble
121 G M -0.6462 Soluble
122 T M 0.0238 Aggregation-prone
123 M M 0.6802 Aggregation-prone
124 V M 0.0000 Buried
125 T M -0.1894 Soluble
126 V M 0.0000 Buried
127 S M -0.8664 Soluble
128 S M -0.7834 Soluble
129 A M -0.5407 Soluble
130 S M -0.6350 Soluble
131 T M -0.7296 Soluble
132 K M -1.1783 Soluble
133 G M -1.3987 Soluble
134 P M 0.0000 Buried
135 S M -0.2247 Soluble
136 V M 0.0000 Buried
137 F M 0.0000 Buried
138 P M -1.1634 Soluble
139 L M 0.0000 Buried
140 A M -0.8874 Soluble
141 P M -0.4998 Soluble
142 T M 0.2243 Aggregation-prone
143 A M 0.2845 Aggregation-prone
144 A M 0.0000 Buried
145 L M 0.0000 Buried
146 G M 0.0000 Buried
147 C M 0.0000 Buried
148 L M 0.0000 Buried
149 V M 0.0000 Buried
150 K M 0.0000 Buried
151 D M -0.3334 Soluble
152 Y M 0.0000 Buried
153 F M 0.0000 Buried
154 P M -0.8168 Soluble
155 E M -1.1117 Soluble
156 P M -1.1659 Soluble
157 V M -0.9267 Soluble
158 T M -0.7430 Soluble
159 V M -0.4370 Soluble
160 S M -0.4258 Soluble
161 W M 0.0000 Buried
162 N M -0.6028 Soluble
163 S M -0.5758 Soluble
164 G M -0.4976 Soluble
165 A M -0.2400 Soluble
166 L M 0.1461 Aggregation-prone
167 T M -0.1631 Soluble
168 S M -0.0632 Soluble
169 G M -0.0498 Soluble
170 V M 0.2636 Aggregation-prone
171 H M -0.1095 Soluble
172 T M -0.0057 Soluble
173 F M 0.0000 Buried
174 P M -0.3702 Soluble
175 A M 0.1137 Aggregation-prone
176 V M 0.5368 Aggregation-prone
177 L M 1.1743 Aggregation-prone
178 Q M 0.3648 Aggregation-prone
179 S M -0.0259 Soluble
180 S M -0.1641 Soluble
181 G M 0.0741 Aggregation-prone
182 L M 0.1030 Aggregation-prone
183 Y M 0.3325 Aggregation-prone
184 S M 0.0000 Buried
185 L M 0.0000 Buried
186 S M 0.0000 Buried
187 S M 0.0000 Buried
188 V M 0.0000 Buried
189 V M 0.0000 Buried
190 T M 0.3895 Aggregation-prone
191 V M 1.0485 Aggregation-prone
192 Y M 0.3855 Aggregation-prone
193 I M -0.6470 Soluble
194 C M 0.0000 Buried
195 N M -1.5591 Soluble
196 V M 0.0000 Buried
197 N M -2.2634 Soluble
198 H M 0.0000 Buried
199 K M -2.8773 Soluble
200 P M -1.7715 Soluble
201 S M -1.8645 Soluble
202 N M -2.6386 Soluble
203 T M -2.1387 Soluble
204 K M -2.7700 Soluble
205 V M -1.4938 Soluble
206 D M -2.5834 Soluble
207 K M -1.8768 Soluble
208 R M -2.3609 Soluble
209 V M 0.0000 Buried
210 E M -2.1902 Soluble
211 P M -1.1976 Soluble
1 D N -2.4290 Soluble
2 I N 0.0000 Buried
3 Q N -2.2519 Soluble
4 M N 0.0000 Buried
5 T N -1.2362 Soluble
6 Q N 0.0000 Buried
7 S N -0.6928 Soluble
8 P N -0.5776 Soluble
9 S N -0.8194 Soluble
10 T N -0.7585 Soluble
11 L N -0.3683 Soluble
12 S N -0.6612 Soluble
13 A N 0.0000 Buried
14 S N -0.2965 Soluble
15 V N 0.5642 Aggregation-prone
16 G N -0.5188 Soluble
17 D N -1.3305 Soluble
18 R N -2.1368 Soluble
19 V N 0.0000 Buried
20 T N -0.5965 Soluble
21 I N 0.0000 Buried
22 T N -0.7603 Soluble
23 C N 0.0000 Buried
24 R N -2.1659 Soluble
25 A N 0.0000 Buried
26 S N -1.9239 Soluble
27 Q N -2.1133 Soluble
28 S N -1.3342 Soluble
29 I N 0.0000 Buried
36 S N -0.8313 Soluble
37 S N -0.7545 Soluble
38 W N -0.1246 Soluble
39 L N 0.0000 Buried
40 A N 0.0000 Buried
41 W N 0.0000 Buried
42 Y N 0.0000 Buried
43 Q N 0.0000 Buried
44 Q N 0.0000 Buried
45 K N -1.8696 Soluble
46 P N -1.5891 Soluble
47 G N -1.6904 Soluble
48 K N -2.6550 Soluble
49 A N -1.7188 Soluble
50 P N 0.0000 Buried
51 K N -1.5353 Soluble
52 L N 0.0000 Buried
53 L N 0.0000 Buried
54 I N 0.0000 Buried
55 Y N 0.0000 Buried
56 K N -1.0400 Soluble
57 A N 0.0000 Buried
65 S N -0.5803 Soluble
66 T N -0.2894 Soluble
67 L N 0.1441 Aggregation-prone
68 E N 0.0000 Buried
69 S N -1.0292 Soluble
70 G N -0.6183 Soluble
71 V N -0.2590 Soluble
72 P N -0.2984 Soluble
74 S N -0.4072 Soluble
75 R N -0.8134 Soluble
76 F N 0.0000 Buried
77 S N -0.3122 Soluble
78 G N -0.4538 Soluble
79 S N -0.9029 Soluble
80 G N -1.2997 Soluble
83 S N -1.1747 Soluble
84 G N -1.1956 Soluble
85 T N -1.8211 Soluble
86 E N -2.5821 Soluble
87 F N 0.0000 Buried
88 T N -0.7854 Soluble
89 L N 0.0000 Buried
90 T N -0.6175 Soluble
91 I N 0.0000 Buried
92 S N -1.2884 Soluble
93 S N -1.0193 Soluble
94 L N 0.0000 Buried
95 Q N -0.7734 Soluble
96 P N -0.8025 Soluble
97 D N -1.8524 Soluble
98 D N 0.0000 Buried
99 F N -0.3789 Soluble
100 A N 0.0000 Buried
101 T N -0.8489 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 Q N 0.0000 Buried
106 Q N 0.0000 Buried
107 Y N 0.1236 Aggregation-prone
108 N N -0.2311 Soluble
114 T N -0.0784 Soluble
115 Y N 0.5278 Aggregation-prone
116 W N 0.0000 Buried
117 T N -0.6559 Soluble
118 F N 0.0000 Buried
119 G N 0.0000 Buried
120 Q N -1.9020 Soluble
121 G N 0.0000 Buried
122 T N 0.0000 Buried
123 K N -1.3553 Soluble
124 V N 0.0000 Buried
125 E N 0.0000 Buried
126 I N -0.2392 Soluble
127 K N -1.2507 Soluble
128 R N -1.0812 Soluble
129 T N 0.0117 Aggregation-prone
130 V N 0.7848 Aggregation-prone
131 A N 0.3682 Aggregation-prone
132 A N -0.0074 Soluble
133 P N 0.0000 Buried
134 S N -0.1477 Soluble
135 V N 0.0000 Buried
136 F N 0.1425 Aggregation-prone
137 I N 0.1134 Aggregation-prone
138 F N 0.0000 Buried
139 P N -0.5067 Soluble
140 P N -0.7869 Soluble
141 S N -1.5674 Soluble
142 D N -2.8714 Soluble
143 E N -2.7654 Soluble
144 Q N 0.0000 Buried
145 L N -2.1416 Soluble
146 K N -2.7565 Soluble
147 S N -1.7316 Soluble
148 G N -1.2150 Soluble
149 T N -0.9391 Soluble
150 A N 0.0000 Buried
151 S N 0.0000 Buried
152 V N 0.0000 Buried
153 V N 0.0000 Buried
154 C N 0.0000 Buried
155 L N 0.0000 Buried
156 L N 0.0000 Buried
157 N N 0.0000 Buried
158 N N -0.8161 Soluble
159 F N 0.0000 Buried
160 Y N 0.0000 Buried
161 P N -1.5467 Soluble
162 R N -2.8183 Soluble
163 E N -3.1209 Soluble
164 A N -2.2175 Soluble
165 K N -2.1063 Soluble
166 V N -0.8987 Soluble
167 Q N -0.3919 Soluble
168 W N 0.0000 Buried
169 K N -0.4664 Soluble
170 V N 0.0000 Buried
171 D N -1.8075 Soluble
172 N N -1.4538 Soluble
173 A N -0.2203 Soluble
174 L N 0.7710 Aggregation-prone
175 Q N -0.2500 Soluble
176 S N -0.6111 Soluble
177 G N -1.2370 Soluble
178 N N -1.5150 Soluble
179 S N -1.4328 Soluble
180 Q N -1.5177 Soluble
181 E N -1.9466 Soluble
182 S N -0.8550 Soluble
183 V N -0.8241 Soluble
184 T N -1.1746 Soluble
185 E N -2.2406 Soluble
186 Q N -1.8091 Soluble
187 D N -1.8982 Soluble
188 S N -1.6613 Soluble
189 K N -2.2238 Soluble
190 D N -1.6983 Soluble
191 S N -1.6538 Soluble
192 T N 0.0000 Buried
193 Y N 0.0000 Buried
194 S N 0.0000 Buried
195 L N 0.0000 Buried
196 S N 0.0000 Buried
197 S N 0.0000 Buried
198 T N -0.7650 Soluble
199 L N 0.0000 Buried
200 T N -0.5912 Soluble
201 L N -0.6953 Soluble
202 S N -0.9165 Soluble
203 K N -1.8775 Soluble
204 A N -1.6639 Soluble
205 D N -2.2828 Soluble
206 Y N 0.0000 Buried
207 E N -3.0037 Soluble
208 K N -3.3504 Soluble
209 H N -2.6999 Soluble
210 K N -2.6835 Soluble
211 V N -1.2072 Soluble
212 Y N 0.0000 Buried
213 A N -0.6683 Soluble
214 C N 0.0000 Buried
215 E N -0.6706 Soluble
216 V N 0.0000 Buried
217 T N -1.1067 Soluble
218 H N 0.0000 Buried
219 Q N -1.4352 Soluble
220 G N -0.2726 Soluble
221 L N -0.1938 Soluble
222 S N -0.4807 Soluble
223 S N -0.4370 Soluble
224 P N -0.4875 Soluble
225 V N 0.0536 Aggregation-prone
226 T N -0.3793 Soluble
227 K N -0.5950 Soluble
228 S N -0.4782 Soluble
229 F N -0.8732 Soluble
230 N N -1.7676 Soluble
231 R N -2.2258 Soluble
232 G N -1.8842 Soluble
233 E N -2.2502 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6991 2.919 CSV PDB
4.5 -0.7405 2.919 CSV PDB
5.0 -0.7878 2.919 CSV PDB
5.5 -0.832 2.919 CSV PDB
6.0 -0.8626 2.919 CSV PDB
6.5 -0.8717 2.919 CSV PDB
7.0 -0.8596 2.919 CSV PDB
7.5 -0.8327 2.919 CSV PDB
8.0 -0.797 2.9189 CSV PDB
8.5 -0.754 2.9189 CSV PDB
9.0 -0.7045 2.9188 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH