Vesencumab / 2qqn

A4DAB292_2qqn_H_L | Source PDB: 2qqn | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6685
Max Score
1.8752
Min Score
-3.7635
Total Score
-294.15
Score CDR
-0.0364
Score non-CDR
-0.7496

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSQISPAGGYTNYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARGELPYYRMSKVMDVWGQGTLVTVSSASTKGPSVFPLAPSSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHDIQMTQSPSSLSASVGDRVTITCRASQYFSSYLAWYQQKPGKAPKLLIYGASSRASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLGSPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7635
Maximum Score 1.8752
Average Score -0.6685
Total Score -294.1533

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -1.9293 Soluble
2 V H -0.8957 Soluble
3 Q H -0.9461 Soluble
4 L H 0.0000 Buried
5 V H 1.2197 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.4171 Soluble
8 G H -1.0300 Soluble
9 G H -0.4403 Soluble
11 G H -0.1473 Soluble
12 L H 0.1639 Aggregation-prone
13 V H -0.4512 Soluble
14 Q H -1.4954 Soluble
15 P H -1.6620 Soluble
16 G H -1.3888 Soluble
17 G H 0.0000 Buried
18 S H -1.1905 Soluble
19 L H -1.0809 Soluble
20 R H -2.1330 Soluble
21 L H 0.0000 Buried
22 S H -0.3529 Soluble
23 C H 0.0000 Buried
24 A H 0.0105 Aggregation-prone
25 A H 0.0000 Buried
26 S H -0.4177 Soluble
27 G H -1.0258 Soluble
28 F H -0.3668 Soluble
29 T H -0.2857 Soluble
30 F H 0.0000 Buried
35 S H -0.3671 Soluble
36 S H -0.3044 Soluble
37 Y H -0.1978 Soluble
38 A H 0.0000 Buried
39 M H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.8559 Soluble
45 A H -1.2035 Soluble
46 P H -0.9304 Soluble
47 G H -1.4818 Soluble
48 K H -2.4037 Soluble
49 G H -1.6441 Soluble
50 L H 0.0000 Buried
51 E H -1.4969 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 Q H 0.0000 Buried
56 I H 0.0000 Buried
57 S H 0.0808 Aggregation-prone
58 P H -0.1598 Soluble
59 A H -0.2880 Soluble
62 G H -0.3397 Soluble
63 G H 0.1616 Aggregation-prone
64 Y H 1.0214 Aggregation-prone
65 T H 0.3841 Aggregation-prone
66 N H -0.4022 Soluble
67 Y H -1.0934 Soluble
68 A H -1.5818 Soluble
69 D H -2.5522 Soluble
70 S H -1.6172 Soluble
71 V H 0.0000 Buried
72 K H -2.6369 Soluble
74 G H -1.7704 Soluble
75 R H -1.5177 Soluble
76 F H 0.0000 Buried
77 T H -0.8684 Soluble
78 I H 0.0000 Buried
79 S H -0.2289 Soluble
80 A H -0.8792 Soluble
81 D H -1.5742 Soluble
82 T H -1.3052 Soluble
83 S H -1.4026 Soluble
84 K H -2.1975 Soluble
85 N H -1.3848 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.5488 Soluble
89 L H 0.0000 Buried
90 Q H -1.1527 Soluble
91 M H 0.0000 Buried
92 N H -1.5503 Soluble
93 S H -1.3196 Soluble
94 L H 0.0000 Buried
95 R H -2.2752 Soluble
96 A H -1.7045 Soluble
97 E H -2.2128 Soluble
98 D H 0.0000 Buried
99 T H -0.6101 Soluble
100 A H 0.0000 Buried
101 V H 0.4866 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.5258 Soluble
107 G H 0.0000 Buried
108 E H -0.8361 Soluble
109 L H 0.2396 Aggregation-prone
110 P H 0.8399 Aggregation-prone
111 Y H 1.8752 Aggregation-prone
111A Y H 1.7225 Aggregation-prone
112B R H 0.4426 Aggregation-prone
112A M H 0.6466 Aggregation-prone
112 S H 0.0000 Buried
113 K H -0.7343 Soluble
114 V H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.9605 Soluble
117 V H -0.5582 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.3483 Soluble
121 G H 0.0000 Buried
122 T H 0.1858 Aggregation-prone
123 L H 0.7012 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -0.9281 Soluble
128 S H -0.6721 Soluble
129 A H -0.4602 Soluble
130 S H -0.5576 Soluble
131 T H -0.5811 Soluble
132 K H -1.1774 Soluble
133 G H -1.2997 Soluble
134 P H -0.6396 Soluble
135 S H -0.2966 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1978 Soluble
139 L H 0.0000 Buried
140 A H -1.1249 Soluble
141 P H 0.0000 Buried
142 S H -0.5979 Soluble
143 S H -0.1986 Soluble
144 G H -0.8133 Soluble
145 G H -0.8663 Soluble
146 T H -0.5928 Soluble
147 A H 0.0000 Buried
148 A H 0.0000 Buried
149 L H 0.0000 Buried
150 G H 0.0000 Buried
151 C H 0.0000 Buried
152 L H 0.0000 Buried
153 V H 0.0000 Buried
154 K H 0.0000 Buried
155 D H -0.6482 Soluble
156 Y H 0.0000 Buried
157 F H 0.0000 Buried
158 P H 0.0000 Buried
159 E H -0.6060 Soluble
160 P H -0.8802 Soluble
161 V H -0.7042 Soluble
162 T H -0.5269 Soluble
163 V H -0.3454 Soluble
164 S H -0.3832 Soluble
165 W H 0.0000 Buried
166 N H -0.7717 Soluble
167 S H -0.6730 Soluble
168 G H -0.5720 Soluble
169 A H -0.2604 Soluble
170 L H -0.0060 Soluble
171 T H -0.1811 Soluble
172 S H -0.3918 Soluble
173 G H -0.4590 Soluble
174 V H 0.1295 Aggregation-prone
175 H H 0.0000 Buried
176 T H 0.0894 Aggregation-prone
177 F H 0.0000 Buried
178 P H -0.3642 Soluble
179 A H 0.1206 Aggregation-prone
180 V H 0.3965 Aggregation-prone
181 L H 0.9643 Aggregation-prone
182 Q H 0.1495 Aggregation-prone
183 S H -0.1071 Soluble
184 S H -0.2599 Soluble
185 G H -0.0494 Soluble
186 L H -0.0704 Soluble
187 Y H 0.0000 Buried
188 S H 0.0000 Buried
189 L H 0.0000 Buried
190 S H 0.0000 Buried
191 S H 0.0000 Buried
192 V H 0.0000 Buried
193 V H 0.0000 Buried
194 T H -0.1354 Soluble
195 V H 0.0000 Buried
196 P H -0.6647 Soluble
197 S H -0.6221 Soluble
198 S H -0.6771 Soluble
199 S H -0.6600 Soluble
200 L H -0.8845 Soluble
201 G H -1.0828 Soluble
202 T H -0.8383 Soluble
203 Q H -1.5615 Soluble
204 T H -1.2495 Soluble
205 Y H 0.0000 Buried
206 I H -1.0023 Soluble
207 C H 0.0000 Buried
208 N H -1.4188 Soluble
209 V H 0.0000 Buried
210 N H -1.7969 Soluble
211 H H 0.0000 Buried
212 K H -2.7519 Soluble
213 P H -1.6171 Soluble
214 S H -1.8452 Soluble
215 N H -2.5716 Soluble
216 T H -2.0096 Soluble
217 K H -2.5357 Soluble
218 V H -1.3392 Soluble
219 D H -2.4370 Soluble
220 K H -1.9155 Soluble
221 K H -2.4412 Soluble
222 V H 0.0000 Buried
223 E H -2.7756 Soluble
224 P H -1.7038 Soluble
225 K H -2.0893 Soluble
226 S H -1.6193 Soluble
227 C H -1.6011 Soluble
228 D H -2.7862 Soluble
229 K H -2.7850 Soluble
230 T H -1.7816 Soluble
231 H H -1.5904 Soluble
1 D L -2.3465 Soluble
2 I L 0.0000 Buried
3 Q L -2.2575 Soluble
4 M L 0.0000 Buried
5 T L -1.3234 Soluble
6 Q L 0.0000 Buried
7 S L -0.6529 Soluble
8 P L -0.5599 Soluble
9 S L -0.7663 Soluble
10 S L -0.6317 Soluble
11 L L -0.3854 Soluble
12 S L -0.6672 Soluble
13 A L 0.0000 Buried
14 S L -0.3640 Soluble
15 V L 0.5457 Aggregation-prone
16 G L -0.5644 Soluble
17 D L -1.4369 Soluble
18 R L -2.1812 Soluble
19 V L 0.0000 Buried
20 T L -0.6059 Soluble
21 I L 0.0000 Buried
22 T L -0.9622 Soluble
23 C L 0.0000 Buried
24 R L -2.6941 Soluble
25 A L 0.0000 Buried
26 S L -1.7150 Soluble
27 Q L -1.4252 Soluble
28 Y L 0.3077 Aggregation-prone
29 F L 0.0000 Buried
36 S L 0.1093 Aggregation-prone
37 S L -0.1133 Soluble
38 Y L 0.6554 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.9056 Soluble
46 P L -1.5681 Soluble
47 G L -1.7403 Soluble
48 K L -2.6880 Soluble
49 A L -1.7420 Soluble
50 P L 0.0000 Buried
51 K L -1.7561 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.0000 Buried
56 G L 0.0000 Buried
57 A L 0.0000 Buried
65 S L -0.5834 Soluble
66 S L -0.7184 Soluble
67 R L -1.3751 Soluble
68 A L 0.0000 Buried
69 S L -0.8241 Soluble
70 G L -0.8022 Soluble
71 V L 0.0000 Buried
72 P L -0.6444 Soluble
74 S L -0.7094 Soluble
75 R L -0.8974 Soluble
76 F L 0.0000 Buried
77 S L -0.6081 Soluble
78 G L 0.0000 Buried
79 S L -0.8036 Soluble
80 G L -1.4603 Soluble
83 S L -1.1412 Soluble
84 G L -0.9784 Soluble
85 T L -1.5983 Soluble
86 D L -2.6983 Soluble
87 F L 0.0000 Buried
88 T L -0.9285 Soluble
89 L L 0.0000 Buried
90 T L -0.6172 Soluble
91 I L 0.0000 Buried
92 S L -1.2886 Soluble
93 S L -1.0208 Soluble
94 L L 0.0000 Buried
95 Q L -0.7408 Soluble
96 P L -0.7778 Soluble
97 E L -1.8670 Soluble
98 D L 0.0000 Buried
99 F L -0.3971 Soluble
100 A L 0.0000 Buried
101 T L -0.7669 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 L L 1.2081 Aggregation-prone
109 G L -0.0453 Soluble
114 S L -0.6753 Soluble
115 P L -0.8850 Soluble
116 P L 0.0000 Buried
117 T L -0.8361 Soluble
118 F L -0.5266 Soluble
119 G L 0.0000 Buried
120 Q L -1.5610 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.1506 Soluble
124 V L 0.0000 Buried
125 E L -0.7405 Soluble
126 I L -0.3114 Soluble
127 K L -1.3982 Soluble
128 R L -1.2107 Soluble
129 T L -0.1740 Soluble
130 V L 0.5362 Aggregation-prone
131 A L 0.1357 Aggregation-prone
132 A L -0.0881 Soluble
133 P L 0.0000 Buried
134 S L -0.1204 Soluble
135 V L 0.0000 Buried
136 F L 0.0681 Aggregation-prone
137 I L 0.0435 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.6696 Soluble
140 P L -0.7555 Soluble
141 S L -1.6764 Soluble
142 D L -2.9149 Soluble
143 E L -2.6541 Soluble
144 Q L 0.0000 Buried
145 L L -2.0783 Soluble
146 K L -2.6834 Soluble
147 S L -1.6392 Soluble
148 G L -1.0957 Soluble
149 T L -0.9823 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7006 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.1697 Soluble
162 R L -1.9131 Soluble
163 E L -2.7361 Soluble
164 A L -2.0465 Soluble
165 K L -2.4402 Soluble
166 V L -1.1535 Soluble
167 Q L -0.5775 Soluble
168 W L 0.0000 Buried
169 K L -0.6024 Soluble
170 V L 0.0000 Buried
171 D L -1.9351 Soluble
172 N L -1.5638 Soluble
173 A L -0.2786 Soluble
174 L L 0.7453 Aggregation-prone
175 Q L -0.3248 Soluble
176 S L -0.7123 Soluble
177 G L -1.3550 Soluble
178 N L -1.7602 Soluble
179 S L -1.6454 Soluble
180 Q L -1.6479 Soluble
181 E L -2.1293 Soluble
182 S L -0.7958 Soluble
183 V L -0.5208 Soluble
184 T L 0.0000 Buried
185 E L -2.0763 Soluble
186 Q L -1.6276 Soluble
187 D L -1.7634 Soluble
188 S L -1.6889 Soluble
189 K L -2.2811 Soluble
190 D L -1.6745 Soluble
191 S L -1.6588 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.8436 Soluble
199 L L 0.0000 Buried
200 T L -0.7452 Soluble
201 L L -1.0147 Soluble
202 S L -1.2126 Soluble
203 K L -2.1795 Soluble
204 A L -2.0821 Soluble
205 D L -3.0803 Soluble
206 Y L 0.0000 Buried
207 E L -3.7042 Soluble
208 K L -3.7635 Soluble
209 H L -2.9720 Soluble
210 K L -3.1638 Soluble
211 V L -1.3594 Soluble
212 Y L 0.0000 Buried
213 A L -0.8382 Soluble
214 C L 0.0000 Buried
215 E L -0.9562 Soluble
216 V L 0.0000 Buried
217 T L -1.1877 Soluble
218 H L 0.0000 Buried
219 Q L -1.4534 Soluble
220 G L -0.4183 Soluble
221 L L -0.2399 Soluble
222 S L -0.4618 Soluble
223 S L -0.4238 Soluble
224 P L -0.4812 Soluble
225 V L -0.0519 Soluble
226 T L -0.5251 Soluble
227 K L -0.7698 Soluble
228 S L -0.5136 Soluble
229 F L -0.7754 Soluble
230 N L -1.6889 Soluble
231 R L -2.3804 Soluble
232 G L -1.9638 Soluble
233 E L -2.0534 Soluble
234 C L -0.5505 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6891 2.0348 CSV PDB
4.5 -0.7352 2.0054 CSV PDB
5.0 -0.7885 1.9647 CSV PDB
5.5 -0.8385 1.9209 CSV PDB
6.0 -0.8736 1.883 CSV PDB
6.5 -0.8847 1.8592 CSV PDB
7.0 -0.8724 1.8529 CSV PDB
7.5 -0.8447 1.8594 CSV PDB
8.0 -0.8084 1.8714 CSV PDB
8.5 -0.7652 1.883 CSV PDB
9.0 -0.7148 1.8867 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH