Aducanumab / 6cnr

A4DAB007_6cnr_H_L | Source PDB: 6cnr | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7038
Max Score
1.2023
Min Score
-3.7095
Total Score
-302.64
Score CDR
-0.5018
Score non-CDR
-0.731

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWFDGTKKYYTDSVKGRFTISRDNSKNTLYLQMNTLRAEDTAVYYCARDRGIGARRGPYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKDIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7095
Maximum Score 1.2023
Average Score -0.7038
Total Score -302.6379

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.2288 Soluble
2 V H -0.4406 Soluble
3 Q H -0.6167 Soluble
4 L H 0.0000 Buried
5 V H 1.0727 Aggregation-prone
6 E H 0.0574 Aggregation-prone
7 S H -0.4584 Soluble
8 G H -0.8286 Soluble
9 G H -0.3778 Soluble
11 G H 0.2097 Aggregation-prone
12 V H 0.8835 Aggregation-prone
13 V H -0.2544 Soluble
14 Q H -1.2856 Soluble
15 P H -1.6935 Soluble
16 G H -1.8619 Soluble
17 R H -2.3073 Soluble
18 S H -1.6325 Soluble
19 L H -0.9318 Soluble
20 R H -1.4786 Soluble
21 L H 0.0000 Buried
22 S H -0.2489 Soluble
23 C H 0.0000 Buried
24 A H -0.0704 Soluble
25 A H 0.0000 Buried
26 S H -0.5568 Soluble
27 G H -0.7640 Soluble
28 F H -0.1497 Soluble
29 A H 0.0507 Aggregation-prone
30 F H 0.0000 Buried
35 S H -0.8828 Soluble
36 S H -0.5396 Soluble
37 Y H -0.5928 Soluble
38 G H -0.7758 Soluble
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.8514 Soluble
45 A H -1.2219 Soluble
46 P H -1.0232 Soluble
47 G H -1.5087 Soluble
48 K H -2.2730 Soluble
49 G H -1.4216 Soluble
50 L H 0.0000 Buried
51 E H -0.9666 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 A H 0.0000 Buried
55 V H 0.0000 Buried
56 I H 0.0000 Buried
57 W H 0.0000 Buried
58 F H -0.9451 Soluble
59 D H -1.8078 Soluble
62 G H -1.4194 Soluble
63 T H -1.2184 Soluble
64 K H -1.5277 Soluble
65 K H -0.8807 Soluble
66 Y H -0.4021 Soluble
67 Y H -0.6895 Soluble
68 T H -1.2133 Soluble
69 D H -2.3445 Soluble
70 S H -1.6955 Soluble
71 V H 0.0000 Buried
72 K H -2.4178 Soluble
74 G H -1.5902 Soluble
75 R H 0.0000 Buried
76 F H 0.0000 Buried
77 T H -0.6908 Soluble
78 I H 0.0000 Buried
79 S H -0.4461 Soluble
80 R H -1.1366 Soluble
81 D H -1.7949 Soluble
82 N H -1.8985 Soluble
83 S H -1.6211 Soluble
84 K H -2.3960 Soluble
85 N H -1.7405 Soluble
86 T H -0.9587 Soluble
87 L H 0.0000 Buried
88 Y H -0.3983 Soluble
89 L H 0.0000 Buried
90 Q H -0.8656 Soluble
91 M H 0.0000 Buried
92 N H -1.4841 Soluble
93 T H -1.3948 Soluble
94 L H 0.0000 Buried
95 R H -2.1519 Soluble
96 A H -1.5237 Soluble
97 E H -2.1481 Soluble
98 D H 0.0000 Buried
99 T H -0.6462 Soluble
100 A H 0.0000 Buried
101 V H -0.1143 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.4102 Soluble
107 D H 0.0000 Buried
108 R H -1.3089 Soluble
109 G H -0.8179 Soluble
110 I H -0.3863 Soluble
111 G H -1.0424 Soluble
111A A H -1.0781 Soluble
111B R H -2.0619 Soluble
112B R H -1.3576 Soluble
112A G H -0.8639 Soluble
112 P H -0.2829 Soluble
113 Y H 0.1102 Aggregation-prone
114 Y H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.6598 Soluble
117 V H -0.3495 Soluble
118 W H -0.4018 Soluble
119 G H 0.0000 Buried
120 K H -1.8611 Soluble
121 G H 0.0000 Buried
122 T H -0.3466 Soluble
123 T H 0.0309 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.1352 Soluble
126 V H 0.0000 Buried
127 S H -0.5794 Soluble
128 S H -0.5882 Soluble
129 A H -0.3513 Soluble
130 S H -0.4424 Soluble
131 T H -0.6329 Soluble
132 K H -1.2309 Soluble
133 G H -1.4205 Soluble
134 P H 0.0000 Buried
135 S H -0.4486 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2559 Soluble
139 L H 0.0000 Buried
140 A H -1.1699 Soluble
141 P H 0.0000 Buried
142 S H -0.8317 Soluble
143 S H -0.5464 Soluble
144 T H -0.3037 Soluble
145 A H -0.2313 Soluble
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.3951 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H -0.8513 Soluble
157 E H -1.1263 Soluble
158 P H -1.2751 Soluble
159 V H -1.0556 Soluble
160 T H -0.8509 Soluble
161 V H -0.3303 Soluble
162 S H -0.4569 Soluble
163 W H 0.0000 Buried
164 N H -0.7738 Soluble
165 S H -0.6817 Soluble
166 G H -0.5783 Soluble
167 A H -0.2352 Soluble
168 L H 0.0647 Aggregation-prone
169 T H -0.1195 Soluble
170 S H -0.1240 Soluble
171 G H -0.1235 Soluble
172 V H 0.2398 Aggregation-prone
173 H H 0.0000 Buried
174 T H 0.1450 Aggregation-prone
175 F H 0.0000 Buried
176 P H -0.2220 Soluble
177 A H 0.1401 Aggregation-prone
178 V H 0.4974 Aggregation-prone
179 L H 1.2023 Aggregation-prone
180 Q H 0.3242 Aggregation-prone
181 S H -0.1501 Soluble
182 S H -0.1870 Soluble
183 G H 0.0525 Aggregation-prone
184 L H -0.0012 Soluble
185 Y H 0.0000 Buried
186 S H 0.0000 Buried
187 L H 0.1586 Aggregation-prone
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.1140 Soluble
193 V H 0.0000 Buried
194 P H -0.4308 Soluble
195 S H -0.5479 Soluble
196 S H -0.6299 Soluble
197 S H -0.7312 Soluble
198 L H -0.9749 Soluble
199 G H -1.0648 Soluble
200 T H -0.8736 Soluble
201 Q H -1.5411 Soluble
202 T H -1.1959 Soluble
203 Y H 0.0000 Buried
204 I H -1.1136 Soluble
205 C H 0.0000 Buried
206 N H -1.5943 Soluble
207 V H 0.0000 Buried
208 N H -2.5228 Soluble
209 H H 0.0000 Buried
210 K H -2.9768 Soluble
211 P H -1.7935 Soluble
212 S H -1.8914 Soluble
213 N H -2.6454 Soluble
214 T H -2.2169 Soluble
215 K H -2.9497 Soluble
216 V H -1.8692 Soluble
217 D H -2.6203 Soluble
218 K H -2.2034 Soluble
219 R H -2.4490 Soluble
220 V H 0.0000 Buried
221 E H -2.8250 Soluble
222 P H -1.9862 Soluble
223 K H -2.4843 Soluble
1 D L -2.2725 Soluble
2 I L 0.0000 Buried
3 Q L -2.2169 Soluble
4 M L 0.0000 Buried
5 T L -1.4004 Soluble
6 Q L -1.0641 Soluble
7 S L -0.8915 Soluble
8 P L -0.5949 Soluble
9 S L -0.7566 Soluble
10 S L -0.6408 Soluble
11 L L -0.3685 Soluble
12 S L -0.6942 Soluble
13 A L 0.0000 Buried
14 S L -0.2585 Soluble
15 V L 0.6563 Aggregation-prone
16 G L -0.3781 Soluble
17 D L -1.2147 Soluble
18 R L -2.1183 Soluble
19 V L 0.0000 Buried
20 T L -0.5969 Soluble
21 I L 0.0000 Buried
22 T L -0.8740 Soluble
23 C L 0.0000 Buried
24 R L -2.7341 Soluble
25 A L -1.9862 Soluble
26 S L -1.9175 Soluble
27 Q L -1.9086 Soluble
28 S L -1.0279 Soluble
29 I L 0.0000 Buried
36 S L -0.3679 Soluble
37 S L -0.1591 Soluble
38 Y L 0.5158 Aggregation-prone
39 L L 0.0000 Buried
40 N L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.6841 Soluble
46 P L -1.4843 Soluble
47 G L -1.7239 Soluble
48 K L -2.7248 Soluble
49 A L -1.8635 Soluble
50 P L 0.0000 Buried
51 K L -1.6339 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.2956 Aggregation-prone
56 A L 0.1254 Aggregation-prone
57 A L 0.0000 Buried
65 S L -0.2356 Soluble
66 S L 0.0627 Aggregation-prone
67 L L 0.2956 Aggregation-prone
68 Q L -0.2966 Soluble
69 S L -0.4024 Soluble
70 G L -0.4936 Soluble
71 V L -0.3357 Soluble
72 P L -0.3394 Soluble
74 S L -0.4265 Soluble
75 R L -0.7823 Soluble
76 F L 0.0000 Buried
77 S L -0.3203 Soluble
78 G L -0.2740 Soluble
79 S L -0.6606 Soluble
80 G L -1.0306 Soluble
83 S L -0.9539 Soluble
84 G L -1.0772 Soluble
85 T L -1.6226 Soluble
86 D L -1.9754 Soluble
87 F L 0.0000 Buried
88 T L -0.7486 Soluble
89 L L 0.0000 Buried
90 T L -0.6091 Soluble
91 I L 0.0000 Buried
92 S L -1.2315 Soluble
93 S L -0.9662 Soluble
94 L L 0.0000 Buried
95 Q L -0.8345 Soluble
96 P L -0.7456 Soluble
97 E L -1.8175 Soluble
98 D L 0.0000 Buried
99 F L -0.3389 Soluble
100 A L 0.0000 Buried
101 T L -0.7216 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 S L 0.0000 Buried
108 Y L 0.8460 Aggregation-prone
109 S L 0.0408 Aggregation-prone
114 T L -0.1681 Soluble
115 P L -0.6615 Soluble
116 L L 0.0000 Buried
117 T L -0.6294 Soluble
118 F L -0.3503 Soluble
119 G L 0.0000 Buried
120 G L -1.1897 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.2848 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.0919 Soluble
127 K L -1.1949 Soluble
128 R L -0.9750 Soluble
129 T L 0.1384 Aggregation-prone
130 V L 1.0972 Aggregation-prone
131 A L 0.3911 Aggregation-prone
132 A L 0.0199 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.1611 Soluble
135 V L 0.0000 Buried
136 F L 0.1272 Aggregation-prone
137 I L 0.1380 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.7096 Soluble
140 P L 0.0000 Buried
141 S L -1.7780 Soluble
142 D L -2.9330 Soluble
143 E L -2.9204 Soluble
144 Q L 0.0000 Buried
145 L L -2.1823 Soluble
146 K L -2.7419 Soluble
147 S L -1.7164 Soluble
148 G L -1.2167 Soluble
149 T L -0.9982 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7886 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -0.9718 Soluble
162 R L -1.7621 Soluble
163 E L -2.6412 Soluble
164 A L -2.0320 Soluble
165 K L -2.2495 Soluble
166 V L -1.2341 Soluble
167 Q L -0.9017 Soluble
168 W L 0.0000 Buried
169 K L -1.0106 Soluble
170 V L 0.0000 Buried
171 D L -2.1918 Soluble
172 N L -1.6017 Soluble
173 A L -0.6560 Soluble
174 L L -0.0434 Soluble
175 Q L -0.7203 Soluble
176 S L -0.8557 Soluble
177 G L -1.3572 Soluble
178 N L -1.7739 Soluble
179 S L -1.6315 Soluble
180 Q L -1.6114 Soluble
181 E L -1.8952 Soluble
182 S L -0.8464 Soluble
183 V L -0.3107 Soluble
184 T L -0.8739 Soluble
185 E L -2.0243 Soluble
186 Q L -1.6124 Soluble
187 D L -1.8965 Soluble
188 S L -1.6926 Soluble
189 K L -2.1552 Soluble
190 D L -1.5310 Soluble
191 S L -1.6158 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7903 Soluble
199 L L 0.0000 Buried
200 T L -0.7088 Soluble
201 L L -0.8399 Soluble
202 S L -1.0243 Soluble
203 K L -1.9799 Soluble
204 A L -1.8818 Soluble
205 D L -2.5854 Soluble
206 Y L 0.0000 Buried
207 E L -3.4896 Soluble
208 K L -3.7095 Soluble
209 H L -3.3027 Soluble
210 K L -3.4607 Soluble
211 V L -1.9275 Soluble
212 Y L 0.0000 Buried
213 A L -1.0235 Soluble
214 C L 0.0000 Buried
215 E L -1.0305 Soluble
216 V L 0.0000 Buried
217 T L -1.2886 Soluble
218 H L 0.0000 Buried
219 Q L -1.3081 Soluble
220 G L -0.2579 Soluble
221 L L -0.2025 Soluble
222 S L -0.4944 Soluble
223 S L -0.4585 Soluble
224 P L -0.5946 Soluble
225 V L -0.0358 Soluble
226 T L -0.5245 Soluble
227 K L -0.6597 Soluble
228 S L -0.8288 Soluble
229 F L -1.1638 Soluble
230 N L -2.5901 Soluble
231 R L -3.2905 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.82 1.7649 CSV PDB
4.5 -0.8607 1.5736 CSV PDB
5.0 -0.907 1.4323 CSV PDB
5.5 -0.9505 1.394 CSV PDB
6.0 -0.9807 1.3569 CSV PDB
6.5 -0.9884 1.3254 CSV PDB
7.0 -0.973 1.3021 CSV PDB
7.5 -0.9416 1.2858 CSV PDB
8.0 -0.9008 1.2797 CSV PDB
8.5 -0.8529 1.4382 CSV PDB
9.0 -0.7986 1.5975 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH