Sipavibart / 7zff

A4DAB241_7zff_H_L | Source PDB: 7zff | Chains: H, L | Done
98.29
Yes
10 Å
Yes
Avg A4D Score
-0.6968
Max Score
1.7098
Min Score
-3.2276
Total Score
-302.4
Score CDR
-0.4343
Score non-CDR
-0.7349

Calculation Parameters

Chain Sequence(s) EVQLLETGGGLVQPGRSLRLSCAASGFPFDDYAIHWVRLAPGKGLEWVSSISWDSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKGAFPGYSSGWYYGLDVWGQGATVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCSVVTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIFEVSKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYAGNKGVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.2276
Maximum Score 1.7098
Average Score -0.6968
Total Score -302.4012

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -1.9503 Soluble
2 V H -0.9611 Soluble
3 Q H -1.0538 Soluble
4 L H 0.0000 Buried
5 L H 0.3780 Aggregation-prone
6 E H 0.0000 Buried
7 T H -0.3276 Soluble
8 G H -0.6395 Soluble
9 G H -0.4929 Soluble
11 G H -0.2990 Soluble
12 L H -0.2459 Soluble
13 V H -0.8906 Soluble
14 Q H -1.9527 Soluble
15 P H -2.4206 Soluble
16 G H -2.5043 Soluble
17 R H -3.0162 Soluble
18 S H -2.1856 Soluble
19 L H -1.4011 Soluble
20 R H -1.7297 Soluble
21 L H 0.0000 Buried
22 S H -0.4163 Soluble
23 C H 0.0000 Buried
24 A H -0.2307 Soluble
25 A H 0.0000 Buried
26 S H -0.9823 Soluble
27 G H -1.1520 Soluble
28 F H -0.9077 Soluble
29 P H -1.2428 Soluble
30 F H 0.0000 Buried
35 D H -3.0293 Soluble
36 D H -2.1194 Soluble
37 Y H -0.6375 Soluble
38 A H 0.0000 Buried
39 I H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 L H -0.3529 Soluble
45 A H -1.0844 Soluble
46 P H -1.1238 Soluble
47 G H -1.3982 Soluble
48 K H -2.2055 Soluble
49 G H -1.3289 Soluble
50 L H 0.0000 Buried
51 E H -0.8163 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 S H 0.0000 Buried
56 I H 0.0000 Buried
57 S H 0.0000 Buried
58 W H -1.4163 Soluble
59 D H -2.3140 Soluble
62 S H -0.9558 Soluble
63 G H -0.7539 Soluble
64 S H -0.1278 Soluble
65 I H 0.6315 Aggregation-prone
66 G H -0.3247 Soluble
67 Y H -0.9901 Soluble
68 A H -1.6647 Soluble
69 D H -2.5032 Soluble
70 S H -1.6843 Soluble
71 V H 0.0000 Buried
72 K H -2.6050 Soluble
74 G H -1.8003 Soluble
75 R H -1.7486 Soluble
76 F H 0.0000 Buried
77 T H -0.9137 Soluble
78 I H 0.0000 Buried
79 S H -0.5930 Soluble
80 R H -1.2186 Soluble
81 D H -2.0083 Soluble
82 N H -2.3878 Soluble
83 A H -1.6039 Soluble
84 K H -2.4109 Soluble
85 N H -1.9140 Soluble
86 S H -1.0617 Soluble
87 L H 0.0000 Buried
88 Y H 0.0000 Buried
89 L H 0.0000 Buried
90 Q H -1.6361 Soluble
91 M H 0.0000 Buried
92 N H -2.6929 Soluble
93 S H -2.2629 Soluble
94 L H 0.0000 Buried
95 R H -3.0461 Soluble
96 A H -1.9306 Soluble
97 E H -2.4132 Soluble
98 D H 0.0000 Buried
99 T H -0.8258 Soluble
100 A H 0.0000 Buried
101 L H 0.0906 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 K H 0.0000 Buried
107 G H 0.0000 Buried
108 A H 0.8826 Aggregation-prone
109 F H 1.7098 Aggregation-prone
110 P H 0.3510 Aggregation-prone
111 G H 0.4366 Aggregation-prone
111A Y H 0.2098 Aggregation-prone
111B S H -0.2361 Soluble
112C S H 0.0000 Buried
112B G H 0.0000 Buried
112A W H 0.0000 Buried
112 Y H 0.7544 Aggregation-prone
113 Y H 0.5532 Aggregation-prone
114 G H 0.0000 Buried
115 L H 0.0000 Buried
116 D H -0.7058 Soluble
117 V H -0.3852 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.3857 Soluble
121 G H 0.0000 Buried
122 A H 0.0000 Buried
123 T H -0.1082 Soluble
124 V H 0.0000 Buried
125 T H -0.5750 Soluble
126 V H 0.0000 Buried
127 S H -1.0178 Soluble
128 S H -0.8052 Soluble
129 A H -0.2706 Soluble
130 S H -0.4404 Soluble
131 T H -0.9585 Soluble
132 K H -1.1604 Soluble
133 G H -1.4147 Soluble
134 P H 0.0000 Buried
135 S H -0.3364 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H 0.0000 Buried
139 L H 0.0000 Buried
140 A H -1.2538 Soluble
141 P H 0.0000 Buried
142 S H -0.8956 Soluble
143 S H -0.9783 Soluble
144 G H -0.6297 Soluble
145 T H -0.4607 Soluble
146 A H -0.3122 Soluble
147 A H -0.1067 Soluble
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H -0.2189 Soluble
154 D H -0.2669 Soluble
155 Y H 0.0000 Buried
156 F H -0.0540 Soluble
157 P H -0.3416 Soluble
158 E H -0.5150 Soluble
159 P H -0.6761 Soluble
160 V H -0.6438 Soluble
161 T H -0.5920 Soluble
162 V H -0.1349 Soluble
163 S H -0.3804 Soluble
164 W H 0.0000 Buried
165 N H -0.9675 Soluble
166 S H -0.7020 Soluble
167 G H -0.4688 Soluble
168 A H -0.2729 Soluble
169 L H -0.0376 Soluble
170 T H -0.2129 Soluble
171 S H -0.2241 Soluble
172 G H -0.2707 Soluble
173 V H 0.0143 Aggregation-prone
174 H H -0.4088 Soluble
175 T H -0.1115 Soluble
176 F H 0.0526 Aggregation-prone
177 P H 0.1687 Aggregation-prone
178 A H 0.4108 Aggregation-prone
179 V H 0.0000 Buried
180 L H 1.3832 Aggregation-prone
181 Q H 0.4781 Aggregation-prone
182 S H 0.0120 Aggregation-prone
183 S H -0.1505 Soluble
184 G H 0.1399 Aggregation-prone
185 L H 0.3207 Aggregation-prone
186 Y H 0.5824 Aggregation-prone
187 S H 0.0000 Buried
188 L H 0.3989 Aggregation-prone
190 S H 0.0862 Aggregation-prone
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.1782 Soluble
194 V H 0.0000 Buried
195 P H -0.5082 Soluble
196 S H -0.6093 Soluble
197 S H -0.6771 Soluble
198 S H 0.0000 Buried
199 L H 0.0000 Buried
200 G H -1.1514 Soluble
201 T H -0.9204 Soluble
202 Q H -1.4935 Soluble
203 T H -1.3238 Soluble
204 Y H 0.0000 Buried
205 I H -1.3915 Soluble
206 C H 0.0000 Buried
207 N H -1.5524 Soluble
208 V H 0.0000 Buried
209 N H -2.2311 Soluble
210 H H 0.0000 Buried
211 K H -2.7260 Soluble
212 P H -1.4945 Soluble
213 S H -1.8571 Soluble
214 N H -2.6182 Soluble
215 T H -2.1736 Soluble
216 K H -2.8877 Soluble
217 V H -1.8856 Soluble
218 D H -2.6970 Soluble
219 K H -2.3523 Soluble
220 R H -2.6843 Soluble
221 V H 0.0000 Buried
222 E H -2.7463 Soluble
223 P H -1.8216 Soluble
224 K H -2.1328 Soluble
225 S H -0.9489 Soluble
226 C H -0.1893 Soluble
2 S L 0.4305 Aggregation-prone
3 V L 1.5934 Aggregation-prone
4 V L 0.0000 Buried
5 T L 0.1560 Aggregation-prone
6 Q L 0.0000 Buried
7 P L -0.6682 Soluble
8 P L -1.1611 Soluble
9 S L -1.1191 Soluble
11 A L -0.8033 Soluble
12 S L -0.4572 Soluble
13 G L -0.4195 Soluble
14 S L -0.3544 Soluble
15 L L -0.4019 Soluble
16 G L -1.0276 Soluble
17 Q L -1.4649 Soluble
18 S L -1.0965 Soluble
19 V L 0.0000 Buried
20 T L -0.2268 Soluble
21 I L 0.0000 Buried
22 S L -0.2166 Soluble
23 C L 0.0000 Buried
24 T L -0.2906 Soluble
25 G L 0.0000 Buried
26 T L -0.4586 Soluble
27 S L -0.7567 Soluble
28 S L -0.5476 Soluble
29 D L 0.0000 Buried
30 V L 0.0000 Buried
31 G L -1.1761 Soluble
35 G L -0.7859 Soluble
36 Y L -0.4428 Soluble
37 N L -1.1258 Soluble
38 Y L -0.3030 Soluble
39 V L 0.0000 Buried
40 S L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 H L -1.4351 Soluble
46 P L -1.3037 Soluble
47 G L -1.6452 Soluble
48 K L -2.1807 Soluble
49 A L -1.3517 Soluble
50 P L 0.0000 Buried
51 K L -1.5306 Soluble
52 L L 0.0000 Buried
53 M L 0.0000 Buried
54 I L 0.0000 Buried
55 F L -0.6870 Soluble
56 E L -0.9325 Soluble
57 V L 0.0000 Buried
65 S L -1.4464 Soluble
66 K L -2.0312 Soluble
67 R L -2.1087 Soluble
68 P L -1.0783 Soluble
69 S L -0.8116 Soluble
70 G L -0.8740 Soluble
71 V L -1.1877 Soluble
72 P L -1.3343 Soluble
74 D L -2.2356 Soluble
75 R L -1.4275 Soluble
76 F L 0.0000 Buried
77 S L -1.1739 Soluble
78 G L -0.8326 Soluble
79 S L -0.8825 Soluble
80 K L -1.1268 Soluble
83 S L -0.8909 Soluble
84 G L -1.1759 Soluble
85 N L -1.2847 Soluble
86 T L -0.8306 Soluble
87 A L 0.0000 Buried
88 S L -0.3465 Soluble
89 L L 0.0000 Buried
90 T L -0.3156 Soluble
91 V L 0.0000 Buried
92 S L -1.1703 Soluble
93 G L -1.2003 Soluble
94 L L 0.0000 Buried
95 Q L -1.3257 Soluble
96 A L -1.1096 Soluble
97 E L -2.1746 Soluble
98 D L 0.0000 Buried
99 E L 0.0000 Buried
100 A L 0.0000 Buried
101 D L -0.9804 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 S L 0.0000 Buried
106 S L 0.0000 Buried
107 Y L -0.4804 Soluble
108 A L -0.8030 Soluble
109 G L -1.2001 Soluble
114 N L -1.7647 Soluble
115 K L -1.6956 Soluble
116 G L 0.0000 Buried
117 V L 0.0310 Aggregation-prone
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.7391 Soluble
121 G L -1.2115 Soluble
122 T L 0.0000 Buried
123 K L -1.9834 Soluble
124 L L 0.0000 Buried
125 T L -0.3416 Soluble
126 V L 0.0000 Buried
127 L L 0.4264 Aggregation-prone
128 G L -0.3222 Soluble
129 Q L -0.6511 Soluble
130 P L -1.1991 Soluble
131 K L -2.4632 Soluble
132 A L -2.0011 Soluble
133 N L -2.1333 Soluble
134 P L 0.0000 Buried
135 T L -0.5849 Soluble
136 V L 0.0000 Buried
137 T L -0.4390 Soluble
138 L L 0.0000 Buried
139 F L 0.0000 Buried
140 P L -0.0697 Soluble
141 P L 0.0000 Buried
142 S L -0.8195 Soluble
143 S L -1.2628 Soluble
144 E L -1.4908 Soluble
145 E L 0.0000 Buried
146 L L -1.6582 Soluble
147 Q L -2.0065 Soluble
148 A L -1.6586 Soluble
149 N L -2.4870 Soluble
150 K L -2.3275 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.8899 Soluble
159 D L -1.7820 Soluble
160 F L 0.0000 Buried
161 Y L -1.4290 Soluble
162 P L -1.0527 Soluble
163 G L -0.6055 Soluble
164 A L -0.1829 Soluble
165 V L -0.0915 Soluble
166 T L -0.0535 Soluble
167 V L 0.1291 Aggregation-prone
168 A L -0.1374 Soluble
169 W L 0.0000 Buried
170 K L -1.1190 Soluble
171 A L 0.0000 Buried
172 D L -1.4596 Soluble
173 S L -0.9713 Soluble
174 S L -0.8564 Soluble
175 P L -0.9073 Soluble
176 V L -0.8054 Soluble
177 K L -1.5753 Soluble
178 A L -0.6042 Soluble
179 G L -0.1777 Soluble
180 V L 0.4606 Aggregation-prone
181 E L 0.2866 Aggregation-prone
182 T L 0.2518 Aggregation-prone
183 T L 0.0000 Buried
184 T L 0.0442 Aggregation-prone
185 P L -0.2131 Soluble
186 S L -0.4282 Soluble
187 K L -1.2034 Soluble
188 Q L -1.5181 Soluble
189 S L -1.6421 Soluble
190 N L -2.2886 Soluble
191 N L -1.8696 Soluble
192 K L -1.6850 Soluble
193 Y L -0.8981 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.3283 Soluble
201 L L -1.0610 Soluble
202 T L -1.8173 Soluble
203 P L -2.4420 Soluble
204 E L -3.2276 Soluble
205 Q L -2.5654 Soluble
206 W L 0.0000 Buried
207 K L -3.1881 Soluble
208 S L -2.5269 Soluble
209 H L -2.5843 Soluble
210 R L -2.8295 Soluble
211 S L 0.0000 Buried
212 Y L 0.0000 Buried
213 S L -1.0340 Soluble
214 C L 0.0000 Buried
215 Q L -1.0362 Soluble
216 V L 0.0000 Buried
217 T L -0.6838 Soluble
218 H L 0.0000 Buried
219 E L -2.4638 Soluble
220 G L -1.3963 Soluble
221 S L -1.0136 Soluble
222 T L -0.8853 Soluble
223 V L -0.9560 Soluble
224 E L -2.1596 Soluble
225 K L -1.6560 Soluble
226 T L -0.9669 Soluble
227 V L -0.7191 Soluble
228 A L -1.4974 Soluble
229 P L -1.5726 Soluble
230 T L -1.5019 Soluble
231 E L -1.9285 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6591 4.4534 CSV PDB
4.5 -0.6976 4.4037 CSV PDB
5.0 -0.7429 4.3456 CSV PDB
5.5 -0.7862 4.2836 CSV PDB
6.0 -0.8171 4.2202 CSV PDB
6.5 -0.8271 4.1567 CSV PDB
7.0 -0.8151 4.0946 CSV PDB
7.5 -0.7878 4.036 CSV PDB
8.0 -0.7513 3.9841 CSV PDB
8.5 -0.7081 3.9408 CSV PDB
9.0 -0.6591 3.9064 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH