Galegenimab / 7sjm

A4DAB122_7sjm_H_L | Source PDB: 7sjm | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.766
Max Score
1.3674
Min Score
-3.7333
Total Score
-328.62
Score CDR
-0.8578
Score non-CDR
-0.7552

Calculation Parameters

Chain Sequence(s) EVQLVQSGAEVKKPGASVKVSCKASGYKFTDSEMHWVRQAPGQGLEWIGGVDPETEGAAYNQKFKGRATITRDTSTTAYLELSSLRSEDTAVYYCTRGYDYDYALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYLSSVVTVPSSLGTQTYICNVNHKPSNTKVDKKVEPKSDIQMTQSPSSLSASVGDRVTITCRASSSVEFIHWYQQKPGKAPKPLISATSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSAPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7333
Maximum Score 1.3674
Average Score -0.766
Total Score -328.616

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.1243 Soluble
2 V H -1.3122 Soluble
3 Q H -1.5001 Soluble
4 L H 0.0000 Buried
5 V H -0.3339 Soluble
6 Q H 0.0000 Buried
7 S H -0.8601 Soluble
8 G H -1.0445 Soluble
9 A H -0.8898 Soluble
11 E H -1.4795 Soluble
12 V H -0.9739 Soluble
13 K H -1.7312 Soluble
14 K H -2.4860 Soluble
15 P H -2.2232 Soluble
16 G H -1.6002 Soluble
17 A H -1.2676 Soluble
18 S H -1.4025 Soluble
19 V H 0.0000 Buried
20 K H -2.1232 Soluble
21 V H 0.0000 Buried
22 S H -0.8026 Soluble
23 C H 0.0000 Buried
24 K H -1.6068 Soluble
25 A H -1.0723 Soluble
26 S H -1.4310 Soluble
27 G H -1.5408 Soluble
28 Y H -1.4518 Soluble
29 K H -2.1322 Soluble
30 F H -1.9768 Soluble
35 T H -2.5004 Soluble
36 D H -2.8480 Soluble
37 S H 0.0000 Buried
38 E H -1.9797 Soluble
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.5699 Soluble
44 Q H 0.0000 Buried
45 A H -0.9994 Soluble
46 P H -0.9203 Soluble
47 G H -1.3254 Soluble
48 Q H -1.8507 Soluble
49 G H -1.3634 Soluble
50 L H 0.0000 Buried
51 E H -1.3989 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 G H 0.0000 Buried
56 V H 0.0000 Buried
57 D H -2.4692 Soluble
58 P H 0.0000 Buried
59 E H -3.1027 Soluble
62 T H -2.0934 Soluble
63 E H -2.9325 Soluble
64 G H -1.8141 Soluble
65 A H -0.7250 Soluble
66 A H 0.1204 Aggregation-prone
67 Y H -0.1672 Soluble
68 N H 0.0000 Buried
69 Q H -1.9184 Soluble
70 K H -2.6768 Soluble
71 F H 0.0000 Buried
72 K H -2.7118 Soluble
74 G H -1.7618 Soluble
75 R H -1.5445 Soluble
76 A H 0.0000 Buried
77 T H -0.5942 Soluble
78 I H 0.0000 Buried
79 T H -0.8500 Soluble
80 R H -1.3925 Soluble
81 D H -1.3021 Soluble
82 T H -1.2191 Soluble
83 S H -0.5091 Soluble
84 T H -0.7320 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.7947 Soluble
89 L H 0.0000 Buried
90 E H -1.6071 Soluble
91 L H 0.0000 Buried
92 S H -1.1582 Soluble
93 S H -1.1791 Soluble
94 L H 0.0000 Buried
95 R H -2.9985 Soluble
96 S H -2.3324 Soluble
97 E H -2.5169 Soluble
98 D H 0.0000 Buried
99 T H -0.9460 Soluble
100 A H 0.0000 Buried
101 V H 0.0879 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 T H 0.0000 Buried
106 R H 0.0000 Buried
107 G H -0.3212 Soluble
108 Y H 0.0491 Aggregation-prone
109 D H -1.0447 Soluble
110 Y H 0.0364 Aggregation-prone
112 D H -1.3650 Soluble
113 Y H 0.0692 Aggregation-prone
114 A H 0.0000 Buried
115 L H 0.0000 Buried
116 D H 0.0755 Aggregation-prone
117 Y H 0.2717 Aggregation-prone
118 W H -0.3190 Soluble
119 G H 0.0000 Buried
120 Q H -1.4325 Soluble
121 G H -0.7699 Soluble
122 T H 0.0000 Buried
123 L H -0.1388 Soluble
124 V H 0.0000 Buried
125 T H -0.9846 Soluble
126 V H 0.0000 Buried
127 S H -1.4121 Soluble
128 S H -0.9666 Soluble
129 A H -0.5500 Soluble
130 S H -0.5903 Soluble
131 T H -0.6839 Soluble
132 K H -1.1315 Soluble
133 G H -1.3278 Soluble
134 P H -0.6133 Soluble
135 S H -0.5110 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.3211 Soluble
139 L H 0.0000 Buried
140 A H -1.4155 Soluble
141 P H 0.0000 Buried
142 S H -1.1825 Soluble
143 S H -0.8350 Soluble
144 K H -1.1062 Soluble
145 S H 0.0000 Buried
146 T H -0.6147 Soluble
147 S H -0.6344 Soluble
148 G H -0.7929 Soluble
149 G H -0.8718 Soluble
150 T H -0.6037 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H -0.2575 Soluble
159 D H -0.3991 Soluble
160 Y H 0.0000 Buried
161 F H -0.2120 Soluble
162 P H 0.0000 Buried
163 E H -0.8044 Soluble
164 P H -0.8040 Soluble
165 V H 0.0000 Buried
166 T H -0.5394 Soluble
167 V H -0.3670 Soluble
168 S H -0.3993 Soluble
169 W H 0.0000 Buried
170 N H -0.8349 Soluble
171 S H -0.7097 Soluble
172 G H -0.6138 Soluble
173 A H -0.2863 Soluble
174 L H -0.0348 Soluble
175 T H -0.2017 Soluble
176 S H -0.1942 Soluble
177 G H -0.2423 Soluble
178 V H 0.1505 Aggregation-prone
179 H H -0.2776 Soluble
180 T H -0.0618 Soluble
181 F H 0.0000 Buried
182 P H -0.2161 Soluble
183 A H 0.2199 Aggregation-prone
184 V H 0.6145 Aggregation-prone
185 L H 1.3674 Aggregation-prone
186 Q H 0.3741 Aggregation-prone
187 S H -0.0112 Soluble
188 S H -0.1645 Soluble
189 G H 0.2021 Aggregation-prone
190 L H 0.1967 Aggregation-prone
191 Y H 0.5221 Aggregation-prone
193 L H 0.1610 Aggregation-prone
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.1433 Soluble
199 V H 0.0000 Buried
200 P H -0.6322 Soluble
201 S H -0.5485 Soluble
202 S H -0.5769 Soluble
204 L H -0.8076 Soluble
205 G H -1.0142 Soluble
206 T H -0.8372 Soluble
207 Q H -1.5518 Soluble
208 T H -1.2393 Soluble
209 Y H 0.0000 Buried
210 I H -1.1398 Soluble
211 C H 0.0000 Buried
212 N H -1.4647 Soluble
213 V H 0.0000 Buried
214 N H -1.6828 Soluble
215 H H 0.0000 Buried
216 K H -2.6077 Soluble
217 P H -1.6579 Soluble
218 S H -1.6978 Soluble
219 N H -2.5180 Soluble
220 T H -1.9336 Soluble
221 K H -2.5671 Soluble
222 V H -1.5122 Soluble
223 D H -2.5217 Soluble
224 K H -2.2490 Soluble
225 K H -2.5063 Soluble
226 V H 0.0000 Buried
227 E H -2.8997 Soluble
228 P H -1.9341 Soluble
229 K H -2.4437 Soluble
230 S H -1.5142 Soluble
1 D L -2.1369 Soluble
2 I L 0.0000 Buried
3 Q L -2.0084 Soluble
4 M L 0.0000 Buried
5 T L -1.1224 Soluble
6 Q L 0.0000 Buried
7 S L -0.5919 Soluble
8 P L -0.5253 Soluble
9 S L -0.8420 Soluble
10 S L -0.8186 Soluble
11 L L -0.5072 Soluble
12 S L -0.8774 Soluble
13 A L -0.9523 Soluble
14 S L -0.9400 Soluble
15 V L -0.2862 Soluble
16 G L -0.9372 Soluble
17 D L -1.8215 Soluble
18 R L -2.3471 Soluble
19 V L 0.0000 Buried
20 T L -0.6292 Soluble
21 I L 0.0000 Buried
22 T L -0.6722 Soluble
23 C L 0.0000 Buried
24 R L -1.8111 Soluble
25 A L 0.0000 Buried
26 S L -1.4102 Soluble
27 S L -1.1435 Soluble
28 S L -1.1661 Soluble
29 V L 0.0000 Buried
37 E L -2.1573 Soluble
38 F L 0.0000 Buried
39 I L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.7776 Soluble
46 P L -1.3617 Soluble
47 G L -1.7203 Soluble
48 K L -2.5066 Soluble
49 A L -1.4951 Soluble
50 P L 0.0000 Buried
51 K L -1.2202 Soluble
52 P L -0.3357 Soluble
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 S L 0.0000 Buried
56 A L -0.7632 Soluble
57 T L 0.0000 Buried
65 S L -0.8575 Soluble
66 N L -1.2607 Soluble
67 L L -0.2995 Soluble
68 A L -0.3226 Soluble
69 S L -0.4805 Soluble
70 G L -0.4639 Soluble
71 V L -0.3872 Soluble
72 P L -0.2961 Soluble
74 S L -0.3844 Soluble
75 R L -0.7279 Soluble
76 F L 0.0000 Buried
77 S L -0.5077 Soluble
78 G L -0.5390 Soluble
79 S L -0.7971 Soluble
80 G L -0.9772 Soluble
83 S L -1.2773 Soluble
84 G L -1.3584 Soluble
85 T L -1.4870 Soluble
86 D L -1.8183 Soluble
87 F L 0.0000 Buried
88 T L -0.6546 Soluble
89 L L 0.0000 Buried
90 T L -0.6196 Soluble
91 I L 0.0000 Buried
92 S L -1.3847 Soluble
93 S L -1.2419 Soluble
94 L L 0.0000 Buried
95 Q L -1.1553 Soluble
96 P L -1.7957 Soluble
97 E L -2.2859 Soluble
98 D L 0.0000 Buried
99 F L 0.0000 Buried
100 A L 0.0000 Buried
101 T L -0.8489 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 W L 0.0000 Buried
108 S L -0.4916 Soluble
109 S L -0.6887 Soluble
114 A L -0.3356 Soluble
115 P L 0.0000 Buried
116 W L -0.3685 Soluble
117 T L -0.8353 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.5908 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.4943 Soluble
124 V L 0.0000 Buried
125 E L -1.2816 Soluble
126 I L 0.0000 Buried
127 K L -1.2372 Soluble
128 R L -0.9861 Soluble
129 T L -0.1891 Soluble
130 V L 0.3051 Aggregation-prone
131 A L -0.0472 Soluble
132 A L -0.1319 Soluble
133 P L 0.0000 Buried
134 S L -0.2218 Soluble
135 V L 0.0000 Buried
136 F L 0.0000 Buried
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -1.0073 Soluble
140 P L 0.0000 Buried
141 S L -1.8323 Soluble
142 D L -2.9686 Soluble
143 E L -3.0755 Soluble
144 Q L 0.0000 Buried
145 L L -2.2069 Soluble
146 K L -2.8356 Soluble
147 S L -1.7422 Soluble
148 G L -1.1519 Soluble
149 T L -1.1178 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.9437 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.4027 Soluble
162 R L -2.1864 Soluble
163 E L -2.8095 Soluble
164 A L -2.0762 Soluble
165 K L -2.3302 Soluble
166 V L -1.1085 Soluble
167 Q L -0.6243 Soluble
168 W L 0.0000 Buried
169 K L -0.6466 Soluble
170 V L 0.0000 Buried
171 D L -2.2206 Soluble
172 N L -1.6898 Soluble
173 A L -0.4311 Soluble
174 L L 0.4565 Aggregation-prone
175 Q L -0.1903 Soluble
176 S L -0.4414 Soluble
177 G L -0.8612 Soluble
178 N L -0.7448 Soluble
179 S L -1.0895 Soluble
180 Q L -1.2543 Soluble
181 E L -1.7106 Soluble
182 S L -0.8383 Soluble
183 V L -0.6311 Soluble
184 T L 0.0000 Buried
185 E L -1.5398 Soluble
186 Q L 0.0000 Buried
187 D L -2.1216 Soluble
189 K L -2.6728 Soluble
190 D L -1.9427 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.6350 Soluble
199 L L 0.0000 Buried
200 T L -0.3883 Soluble
201 L L -0.6279 Soluble
202 S L -0.9695 Soluble
203 K L -1.9538 Soluble
204 A L -1.8387 Soluble
205 D L -2.5306 Soluble
206 Y L 0.0000 Buried
207 E L -3.6935 Soluble
208 K L -3.7333 Soluble
209 H L -3.1529 Soluble
210 K L -3.5017 Soluble
211 V L -1.6852 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.5747 Soluble
216 V L 0.0000 Buried
217 T L -1.2144 Soluble
218 H L 0.0000 Buried
219 Q L -1.6487 Soluble
220 G L -0.4255 Soluble
221 L L -0.2233 Soluble
222 S L -0.4506 Soluble
223 S L -0.4323 Soluble
224 P L -0.5822 Soluble
225 V L 0.0248 Aggregation-prone
226 T L -0.3657 Soluble
227 K L -0.6723 Soluble
228 S L -0.6394 Soluble
229 F L 0.0000 Buried
230 N L -2.2290 Soluble
231 R L -2.8091 Soluble
232 G L -2.3091 Soluble
233 E L -2.6303 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.804 1.8792 CSV PDB
4.5 -0.8555 1.733 CSV PDB
5.0 -0.9178 1.6812 CSV PDB
5.5 -0.9781 1.6242 CSV PDB
6.0 -1.0218 1.5692 CSV PDB
6.5 -1.0381 1.5252 CSV PDB
7.0 -1.0264 1.5252 CSV PDB
7.5 -0.995 1.5252 CSV PDB
8.0 -0.9523 1.5252 CSV PDB
8.5 -0.9017 1.5252 CSV PDB
9.0 -0.8439 1.5252 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH