Ogalvibart / 7k8r

A4DAB189_7k8r_H_L | Source PDB: 7k8r | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7268
Max Score
1.0369
Min Score
-3.6294
Total Score
-314.68
Score CDR
-0.5653
Score non-CDR
-0.7459

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVIPFDGRNKYYADSVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASSSGYLFHSDYWGQGTLVTVSSASTKGPSVFPLAPSSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDIQMTQSPSTLSASVGDRVTITCRASQSISNWLAWFQQKPGKAPKLLIYEASSLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNSYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6294
Maximum Score 1.0369
Average Score -0.7268
Total Score -314.6835

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.6722 Soluble
2 V H -1.3230 Soluble
3 Q H -1.6772 Soluble
4 L H 0.0000 Buried
5 V H 0.1772 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.5814 Soluble
8 G H -0.8954 Soluble
9 G H -0.4946 Soluble
11 G H -0.1613 Soluble
12 V H 0.2144 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -2.0106 Soluble
15 P H -2.0781 Soluble
16 G H -2.1525 Soluble
17 R H -2.8018 Soluble
18 S H -1.9972 Soluble
19 L H -1.4263 Soluble
20 R H -2.0783 Soluble
21 L H 0.0000 Buried
22 S H -0.5556 Soluble
23 C H 0.0000 Buried
24 A H -0.4196 Soluble
25 A H 0.0000 Buried
26 S H -0.8053 Soluble
27 G H -1.0348 Soluble
28 F H -0.4193 Soluble
29 T H -0.1985 Soluble
30 F H 0.0000 Buried
35 S H -0.5102 Soluble
36 S H 0.0451 Aggregation-prone
37 Y H 0.4260 Aggregation-prone
38 A H 0.4365 Aggregation-prone
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.7326 Soluble
45 A H -1.1121 Soluble
46 P H -1.0179 Soluble
47 G H -1.5141 Soluble
48 K H -2.3569 Soluble
49 G H -1.5898 Soluble
50 L H 0.0000 Buried
51 E H -1.0674 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 A H 0.0000 Buried
55 V H 0.0000 Buried
56 I H 0.0000 Buried
57 P H -0.5820 Soluble
58 F H 0.0464 Aggregation-prone
59 D H -1.5842 Soluble
62 G H -1.8820 Soluble
63 R H -2.6591 Soluble
64 N H -2.0341 Soluble
65 K H -1.4270 Soluble
66 Y H -0.0128 Soluble
67 Y H -0.2256 Soluble
68 A H 0.0000 Buried
69 D H -2.1955 Soluble
70 S H -1.5052 Soluble
71 V H 0.0000 Buried
72 T H -0.8737 Soluble
74 G H -0.9711 Soluble
75 R H -0.8511 Soluble
76 F H 0.0000 Buried
77 T H -0.6534 Soluble
78 I H 0.0000 Buried
79 S H -0.7603 Soluble
80 R H -1.0680 Soluble
81 D H -1.7400 Soluble
82 N H -1.5756 Soluble
83 S H -1.6136 Soluble
84 K H -2.3332 Soluble
85 N H -1.6181 Soluble
86 T H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H 0.0000 Buried
89 L H 0.0000 Buried
90 Q H -1.1903 Soluble
91 M H 0.0000 Buried
92 N H -1.8621 Soluble
93 S H -1.8010 Soluble
94 L H 0.0000 Buried
95 R H -2.4523 Soluble
96 A H -1.6593 Soluble
97 E H -2.2010 Soluble
98 D H 0.0000 Buried
99 T H -0.6323 Soluble
100 A H 0.0000 Buried
101 V H 0.3569 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0797 Aggregation-prone
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 S H 0.0000 Buried
107 S H 0.0000 Buried
108 S H -0.3525 Soluble
109 G H 0.0536 Aggregation-prone
110 Y H 1.0314 Aggregation-prone
112 L H 0.0000 Buried
113 F H 0.0000 Buried
114 H H -1.1449 Soluble
115 S H -1.7369 Soluble
116 D H -2.3109 Soluble
117 Y H -1.1782 Soluble
118 W H 0.0000 Buried
119 G H -0.7752 Soluble
120 Q H -1.3762 Soluble
121 G H -0.2839 Soluble
122 T H -0.0534 Soluble
123 L H 0.3253 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -0.9113 Soluble
128 S H -0.6993 Soluble
129 A H -0.5158 Soluble
130 S H -0.6027 Soluble
131 T H -0.5972 Soluble
132 K H -1.2841 Soluble
133 G H -1.4656 Soluble
134 P H 0.0000 Buried
135 S H -0.3921 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2788 Soluble
139 L H 0.0000 Buried
140 A H -1.2165 Soluble
141 P H 0.0000 Buried
142 S H -0.7376 Soluble
143 S H -0.5530 Soluble
144 T H -0.6608 Soluble
145 S H -0.7141 Soluble
146 G H -0.8934 Soluble
147 G H -0.8803 Soluble
148 T H -0.5943 Soluble
149 A H 0.0000 Buried
150 A H 0.0000 Buried
151 L H 0.0000 Buried
152 G H 0.0000 Buried
153 C H 0.0000 Buried
154 L H 0.0000 Buried
155 V H 0.0000 Buried
156 K H 0.0000 Buried
157 D H -0.4614 Soluble
158 Y H 0.0000 Buried
159 F H 0.0000 Buried
160 P H 0.0000 Buried
161 E H -0.4301 Soluble
162 P H -0.7435 Soluble
163 V H -0.7868 Soluble
164 T H -0.6863 Soluble
165 V H -0.2800 Soluble
166 S H -0.4298 Soluble
167 W H 0.0000 Buried
168 N H -0.7510 Soluble
169 S H -0.6566 Soluble
170 G H -0.5647 Soluble
171 A H -0.2404 Soluble
172 L H 0.0065 Aggregation-prone
173 T H -0.1641 Soluble
174 S H -0.1688 Soluble
175 G H -0.2515 Soluble
176 V H 0.2041 Aggregation-prone
177 H H -0.2886 Soluble
178 T H 0.0295 Aggregation-prone
179 F H 0.0000 Buried
180 P H -0.4419 Soluble
181 A H 0.0098 Aggregation-prone
182 V H 0.2997 Aggregation-prone
183 L H 1.0369 Aggregation-prone
184 Q H 0.1446 Aggregation-prone
185 S H -0.0804 Soluble
186 S H -0.2387 Soluble
187 G H -0.0072 Soluble
188 L H -0.0042 Soluble
189 Y H 0.0000 Buried
190 S H 0.0000 Buried
191 L H 0.0000 Buried
192 S H 0.0000 Buried
193 S H 0.0000 Buried
194 V H 0.0000 Buried
195 V H 0.0000 Buried
196 T H -0.1119 Soluble
197 V H 0.0000 Buried
198 P H -0.5623 Soluble
199 S H 0.0000 Buried
200 S H -0.8170 Soluble
201 S H -0.6701 Soluble
202 L H -0.8323 Soluble
203 G H -0.9450 Soluble
204 T H -0.7510 Soluble
205 Q H -1.2343 Soluble
206 T H -1.1180 Soluble
207 Y H 0.0000 Buried
208 I H -1.2961 Soluble
209 C H 0.0000 Buried
210 N H -1.5608 Soluble
211 V H 0.0000 Buried
212 N H -2.2979 Soluble
213 H H 0.0000 Buried
214 K H -2.8163 Soluble
215 P H -1.6168 Soluble
216 S H -1.9078 Soluble
217 N H -2.6557 Soluble
218 T H -2.1795 Soluble
219 K H -2.8456 Soluble
220 V H -1.7196 Soluble
221 D H -2.5977 Soluble
222 K H -2.1981 Soluble
223 R H -2.6312 Soluble
224 V H 0.0000 Buried
225 E H -2.8939 Soluble
226 P H -1.8413 Soluble
227 K H -2.5713 Soluble
228 S H -1.1704 Soluble
229 C H -0.2017 Soluble
1 D L -2.6436 Soluble
2 I L 0.0000 Buried
3 Q L -2.3097 Soluble
4 M L 0.0000 Buried
5 T L -1.4609 Soluble
6 Q L 0.0000 Buried
7 S L -0.8380 Soluble
8 P L -0.5624 Soluble
9 S L -0.7882 Soluble
10 T L -0.6277 Soluble
11 L L -0.4489 Soluble
12 S L -0.8762 Soluble
13 A L 0.0000 Buried
14 S L -0.4606 Soluble
15 V L 0.4850 Aggregation-prone
16 G L -0.5517 Soluble
17 D L -1.4674 Soluble
18 R L -2.2421 Soluble
19 V L 0.0000 Buried
20 T L -0.6000 Soluble
21 I L 0.0000 Buried
22 T L -0.9055 Soluble
23 C L 0.0000 Buried
24 R L -2.9425 Soluble
25 A L -2.1855 Soluble
26 S L -2.0763 Soluble
27 Q L -2.2134 Soluble
28 S L -1.4377 Soluble
29 I L 0.0000 Buried
36 S L -0.8750 Soluble
37 N L -0.6833 Soluble
38 W L -0.1581 Soluble
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 F L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -1.3491 Soluble
45 K L -1.8339 Soluble
46 P L -1.5783 Soluble
47 G L -1.7209 Soluble
48 K L -2.5309 Soluble
49 A L -1.9077 Soluble
50 P L 0.0000 Buried
51 K L -1.7913 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.1293 Aggregation-prone
56 E L -0.6437 Soluble
57 A L 0.0000 Buried
65 S L -0.4384 Soluble
66 S L -0.1086 Soluble
67 L L 0.1149 Aggregation-prone
68 E L -0.2161 Soluble
69 S L -0.3827 Soluble
70 G L -0.5157 Soluble
71 V L -0.3616 Soluble
72 P L -0.3816 Soluble
74 S L -0.4509 Soluble
75 R L -0.8062 Soluble
76 F L 0.0000 Buried
77 S L -0.3466 Soluble
78 G L -0.3472 Soluble
79 S L -0.8372 Soluble
80 G L -1.2601 Soluble
83 S L -1.2235 Soluble
84 G L -1.2955 Soluble
85 T L -1.9720 Soluble
86 E L -2.5334 Soluble
87 F L 0.0000 Buried
88 T L -0.8175 Soluble
89 L L 0.0000 Buried
90 T L -0.6113 Soluble
91 I L 0.0000 Buried
92 S L -1.3161 Soluble
93 S L -1.0843 Soluble
94 L L 0.0000 Buried
95 Q L -0.9808 Soluble
96 P L -0.8133 Soluble
97 D L -1.8420 Soluble
98 D L 0.0000 Buried
99 F L -0.5104 Soluble
100 A L 0.0000 Buried
101 T L -0.8475 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 N L -0.5572 Soluble
109 S L -0.3959 Soluble
114 Y L -0.1302 Soluble
115 P L -0.4821 Soluble
116 W L 0.0000 Buried
117 T L -0.9751 Soluble
118 F L -0.4677 Soluble
119 G L 0.0000 Buried
120 Q L -1.7121 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.3985 Soluble
124 V L 0.0000 Buried
125 E L -0.9211 Soluble
126 I L -0.4983 Soluble
127 K L -1.5056 Soluble
128 R L -1.2639 Soluble
129 T L -0.2541 Soluble
130 V L 0.3126 Aggregation-prone
131 A L 0.0914 Aggregation-prone
132 A L -0.1534 Soluble
133 P L 0.0000 Buried
134 S L -0.1785 Soluble
135 V L 0.0000 Buried
136 F L 0.1195 Aggregation-prone
137 I L 0.1515 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.5917 Soluble
140 P L 0.0000 Buried
141 S L -1.7501 Soluble
142 D L -3.0164 Soluble
143 E L -2.7923 Soluble
144 Q L 0.0000 Buried
145 L L -2.2693 Soluble
146 K L -2.8004 Soluble
147 S L -1.7563 Soluble
148 G L -1.2816 Soluble
149 T L -1.0729 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7709 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.3810 Soluble
162 R L -2.0764 Soluble
163 E L -2.7536 Soluble
164 A L -2.0701 Soluble
165 K L -2.2812 Soluble
166 V L -1.0811 Soluble
167 Q L -0.4507 Soluble
168 W L 0.0000 Buried
169 K L -0.4733 Soluble
170 V L 0.0000 Buried
171 D L -1.5758 Soluble
172 N L -1.3725 Soluble
173 A L -0.1925 Soluble
174 L L 0.8148 Aggregation-prone
175 Q L -0.0427 Soluble
176 S L -0.4705 Soluble
177 G L -0.9414 Soluble
178 N L -0.8695 Soluble
179 S L -1.2645 Soluble
180 Q L -1.7304 Soluble
181 E L -2.0820 Soluble
182 S L -0.8507 Soluble
183 V L -0.5518 Soluble
184 T L -1.0351 Soluble
185 E L -2.1687 Soluble
186 Q L -1.7966 Soluble
187 D L -2.1092 Soluble
188 S L -1.7866 Soluble
189 K L -2.2419 Soluble
190 D L -1.6317 Soluble
191 S L -1.7181 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7168 Soluble
199 L L 0.0000 Buried
200 T L -0.5084 Soluble
201 L L -0.8008 Soluble
202 S L -1.2115 Soluble
203 K L -2.2985 Soluble
204 A L -2.0874 Soluble
205 D L -2.7786 Soluble
206 Y L 0.0000 Buried
207 E L -3.6294 Soluble
208 K L -3.6055 Soluble
209 H L -2.6068 Soluble
210 K L -1.9696 Soluble
211 V L -0.6580 Soluble
212 Y L 0.0000 Buried
213 A L -0.5726 Soluble
215 E L -1.0272 Soluble
216 V L 0.0000 Buried
217 T L -1.2652 Soluble
218 H L 0.0000 Buried
219 Q L -1.6508 Soluble
220 G L -0.4815 Soluble
221 L L -0.2719 Soluble
222 S L -0.4854 Soluble
223 S L -0.4772 Soluble
224 P L -0.6645 Soluble
225 V L -0.2138 Soluble
226 T L -0.6137 Soluble
227 K L -0.8132 Soluble
228 S L -0.4864 Soluble
229 F L -0.4968 Soluble
230 N L -1.0548 Soluble
231 R L -1.8317 Soluble
232 G L -1.5848 Soluble
233 E L -1.9380 Soluble
234 C L -0.4426 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.767 2.2507 CSV PDB
4.5 -0.8134 2.0971 CSV PDB
5.0 -0.8673 1.9081 CSV PDB
5.5 -0.9188 1.704 CSV PDB
6.0 -0.9572 1.4945 CSV PDB
6.5 -0.9736 1.4602 CSV PDB
7.0 -0.968 1.5087 CSV PDB
7.5 -0.9474 1.5745 CSV PDB
8.0 -0.9182 1.6512 CSV PDB
8.5 -0.8819 1.732 CSV PDB
9.0 -0.8386 1.8118 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH