Elipovimab / 7uoj

A4DAB100_7uoj_k_m | Source PDB: 7uoj | Chains: k, m | Done
96.61
Yes
10 Å
Yes
Avg A4D Score
-0.6455
Max Score
3.064
Min Score
-2.766
Total Score
-152.98
Score CDR
-0.3255
Score non-CDR
-0.7589

Calculation Parameters

Chain Sequence(s) QMQLQESGPGLVKPSETLSLTCSVSGASISDSYWSWIRRSPGKGLEWIGYVHKSGDTNYSPSLKSRVNLSLDTSKNQVSLSLVAATAADSGKYYCARTLHGRRIYGIVAFNEWFTYFYMDVWGNGTQVTVSSADISVAPGETARISCGEKSLGSRAVQWYQHRAGQAPSLIIYNNQDRPSGIPERFSGSPDSPFGTTATLTITSVEAGDEADYYCHIWDSRVPTKWVFGGGTTLTVL input.pdb
Selected Chain(s) k (Heavy), m (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.766
Maximum Score 3.064
Average Score -0.6455
Total Score -152.9823

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q k -1.4726 Soluble
2 M k -1.3338 Soluble
3 Q k -2.0457 Soluble
4 L k 0.0000 Buried
5 Q k -2.0629 Soluble
6 E k -1.5511 Soluble
7 S k -0.8564 Soluble
8 G k -0.6150 Soluble
9 P k -0.0993 Soluble
11 G k 0.0997 Aggregation-prone
12 L k 0.8769 Aggregation-prone
13 V k -0.4651 Soluble
14 K k -1.8733 Soluble
15 P k -1.3034 Soluble
16 S k -1.1493 Soluble
17 E k -1.6914 Soluble
18 T k -0.7895 Soluble
19 L k 0.0000 Buried
20 S k -0.2828 Soluble
21 L k 0.0000 Buried
22 T k -0.5680 Soluble
23 C k 0.0000 Buried
24 S k -1.4873 Soluble
25 V k 0.0000 Buried
26 S k -1.3301 Soluble
27 G k -1.3921 Soluble
28 A k -1.1357 Soluble
29 S k -1.1861 Soluble
30 I k 0.0000 Buried
35 S k -1.6722 Soluble
36 D k -2.1343 Soluble
37 S k -1.3746 Soluble
38 Y k 0.0000 Buried
39 W k 0.0000 Buried
40 S k 0.0000 Buried
41 W k 0.0000 Buried
42 I k 0.0000 Buried
43 R k 0.0000 Buried
44 R k -1.6176 Soluble
45 S k -1.3411 Soluble
46 P k -1.2720 Soluble
47 G k -1.5438 Soluble
48 K k -2.3537 Soluble
49 G k -1.6137 Soluble
50 L k 0.0000 Buried
51 E k -0.7433 Soluble
52 W k 0.0000 Buried
53 I k 0.0000 Buried
54 G k 0.0000 Buried
55 Y k -0.4316 Soluble
56 V k 0.0000 Buried
57 H k -2.1363 Soluble
58 K k -2.7660 Soluble
59 S k -1.9121 Soluble
63 G k -2.2024 Soluble
64 D k -2.6858 Soluble
65 T k -1.8383 Soluble
66 N k -1.6193 Soluble
67 Y k -1.0353 Soluble
68 S k -0.6374 Soluble
69 P k -0.9611 Soluble
70 S k -0.7287 Soluble
71 L k -0.9416 Soluble
72 K k -2.1991 Soluble
74 S k -1.2435 Soluble
75 R k -0.8869 Soluble
76 V k 0.0000 Buried
77 N k -1.4952 Soluble
78 L k 0.0000 Buried
79 S k -0.8245 Soluble
80 L k -1.1491 Soluble
81 D k -1.6543 Soluble
82 T k -1.3773 Soluble
83 S k -1.5107 Soluble
84 K k -2.4953 Soluble
85 N k -2.0703 Soluble
86 Q k -1.6656 Soluble
87 V k 0.0000 Buried
88 S k -0.5273 Soluble
89 L k 0.0000 Buried
90 S k -0.5104 Soluble
91 L k 0.0000 Buried
92 V k 0.1870 Aggregation-prone
93 A k -0.4554 Soluble
94 A k 0.0000 Buried
95 T k -0.5011 Soluble
96 A k -0.3335 Soluble
97 A k -0.1066 Soluble
98 D k -0.3870 Soluble
99 S k -0.4388 Soluble
100 G k -0.9755 Soluble
101 K k -1.3155 Soluble
102 Y k 0.0000 Buried
103 Y k 0.0000 Buried
104 C k 0.0000 Buried
105 A k 0.0000 Buried
106 R k 0.0000 Buried
107 T k 0.0000 Buried
108 L k -0.1971 Soluble
109 H k -1.1269 Soluble
110 G k 0.0000 Buried
111 R k -1.9668 Soluble
111A R k -1.0002 Soluble
111B I k 1.0612 Aggregation-prone
111C Y k 1.4241 Aggregation-prone
111D G k 1.5038 Aggregation-prone
111E I k 3.0640 Aggregation-prone
111F V k 2.9597 Aggregation-prone
112G A k 1.8394 Aggregation-prone
112F F k 2.1191 Aggregation-prone
112E N k 0.3969 Aggregation-prone
112D E k 0.0030 Aggregation-prone
112C W k 0.3771 Aggregation-prone
112B F k -0.3736 Soluble
112A T k -0.6862 Soluble
112 Y k 0.0000 Buried
113 F k 0.0000 Buried
114 Y k 0.0421 Aggregation-prone
115 M k 0.0000 Buried
116 D k -0.5132 Soluble
117 V k -0.3402 Soluble
118 W k 0.0000 Buried
119 G k 0.0000 Buried
120 N k -1.9769 Soluble
121 G k -1.4831 Soluble
122 T k -1.4035 Soluble
123 Q k -1.4630 Soluble
124 V k 0.0000 Buried
125 T k -0.0997 Soluble
126 V k 0.0000 Buried
127 S k -0.3261 Soluble
128 S k -0.5047 Soluble
129 A k -0.1360 Soluble
10 D m -1.6728 Soluble
11 I m -0.5728 Soluble
12 S m -0.0107 Soluble
13 V m 0.0000 Buried
14 A m -0.2716 Soluble
15 P m -0.9722 Soluble
16 G m -1.7373 Soluble
17 E m -2.2109 Soluble
18 T m -1.4968 Soluble
19 A m 0.0000 Buried
20 R m -1.8917 Soluble
21 I m 0.0000 Buried
22 S m -1.1396 Soluble
23 C m 0.0000 Buried
24 G m -1.7521 Soluble
25 E m -2.2938 Soluble
26 K m -1.4093 Soluble
27 S m 0.0000 Buried
28 L m 0.3601 Aggregation-prone
29 G m -0.0162 Soluble
36 S m 0.0573 Aggregation-prone
37 R m 0.0000 Buried
38 A m 0.0000 Buried
39 V m 0.0000 Buried
40 Q m 0.0000 Buried
41 W m 0.0000 Buried
42 Y m 0.0000 Buried
43 Q m -1.0010 Soluble
44 H m -1.5944 Soluble
45 R m -2.5179 Soluble
46 A m -1.5239 Soluble
47 G m -1.5993 Soluble
48 Q m -2.1618 Soluble
49 A m -1.4512 Soluble
50 P m 0.0000 Buried
51 S m -0.6618 Soluble
52 L m 0.0000 Buried
53 I m 0.0000 Buried
54 I m 0.0000 Buried
55 Y m -0.5221 Soluble
56 N m 0.0000 Buried
57 N m -1.3602 Soluble
65 Q m -2.1960 Soluble
66 D m -2.4013 Soluble
67 R m -1.8035 Soluble
68 P m -1.0229 Soluble
69 S m -0.8896 Soluble
70 G m -0.7725 Soluble
71 I m -0.6785 Soluble
72 P m -1.2701 Soluble
74 E m -2.2417 Soluble
75 R m -1.5882 Soluble
76 F m 0.0000 Buried
77 S m -1.3207 Soluble
78 G m -0.9757 Soluble
79 S m -0.5161 Soluble
80 P m -0.7396 Soluble
81 D m -0.3611 Soluble
82 S m -0.1481 Soluble
82A P m 0.3541 Aggregation-prone
83 F m 1.5460 Aggregation-prone
84 G m 0.3791 Aggregation-prone
85 T m 0.0775 Aggregation-prone
86 T m -0.3451 Soluble
87 A m 0.0000 Buried
88 T m -0.7353 Soluble
89 L m 0.0000 Buried
90 T m -0.9223 Soluble
91 I m 0.0000 Buried
92 T m -1.4360 Soluble
93 S m -1.5278 Soluble
94 V m -1.6491 Soluble
95 E m -2.3620 Soluble
96 A m -0.9874 Soluble
97 G m -1.3516 Soluble
98 D m 0.0000 Buried
99 E m -1.5668 Soluble
100 A m -1.4064 Soluble
101 D m -1.3854 Soluble
102 Y m 0.0000 Buried
103 Y m 0.0000 Buried
104 C m 0.0000 Buried
105 H m 0.0000 Buried
106 I m 0.0000 Buried
107 W m 0.0000 Buried
108 D m 0.0000 Buried
109 S m -0.7134 Soluble
110 R m -1.5051 Soluble
112 V m -0.4629 Soluble
113 P m -0.6567 Soluble
114 T m -0.4173 Soluble
115 K m -0.3010 Soluble
116 W m 0.2360 Aggregation-prone
117 V m 0.6429 Aggregation-prone
118 F m 0.0000 Buried
119 G m -0.9712 Soluble
120 G m -1.2880 Soluble
121 G m -1.3904 Soluble
122 T m -0.8783 Soluble
123 T m -1.0337 Soluble
124 L m 0.0000 Buried
125 T m -0.3267 Soluble
126 V m 0.2753 Aggregation-prone
127 L m 1.4955 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4 5.3986 CSV PDB
4.5 -0.4384 5.3602 CSV PDB
5.0 -0.4885 5.2941 CSV PDB
5.5 -0.5414 5.2087 CSV PDB
6.0 -0.5865 5.1181 CSV PDB
6.5 -0.6165 5.0363 CSV PDB
7.0 -0.6293 4.9772 CSV PDB
7.5 -0.6284 4.9455 CSV PDB
8.0 -0.6186 4.9326 CSV PDB
8.5 -0.6028 4.928 CSV PDB
9.0 -0.5816 4.9266 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH