Lanadelumab / 4ogx

A4DAB151_4ogx_H_L | Source PDB: 4ogx | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6259
Max Score
1.9187
Min Score
-3.2882
Total Score
-267.89
Score CDR
-0.0869
Score non-CDR
-0.694

Calculation Parameters

Chain Sequence(s) EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYIMMWVRQAPGKGLEWVSGIYSSGGITVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAYRRIGVPRRDEFDIWGQGTMVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPDIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNTYWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.2882
Maximum Score 1.9187
Average Score -0.6259
Total Score -267.8931

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -1.9751 Soluble
2 V H 0.0000 Buried
3 Q H -1.2944 Soluble
4 L H 0.0000 Buried
5 L H 0.8634 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.3943 Soluble
8 G H -0.9553 Soluble
9 G H -0.2747 Soluble
11 G H 0.2407 Aggregation-prone
12 L H 0.8611 Aggregation-prone
13 V H -0.2553 Soluble
14 Q H -1.4586 Soluble
15 P H -1.7061 Soluble
16 G H -1.4794 Soluble
17 G H -1.0631 Soluble
18 S H -1.3176 Soluble
19 L H -0.9532 Soluble
20 R H -2.0095 Soluble
21 L H 0.0000 Buried
22 S H -0.4149 Soluble
23 C H 0.0000 Buried
24 A H -0.5985 Soluble
25 A H 0.0000 Buried
26 S H -0.8769 Soluble
27 G H -0.4933 Soluble
28 F H 1.5317 Aggregation-prone
29 T H 1.2309 Aggregation-prone
30 F H 1.8518 Aggregation-prone
35 S H 0.8458 Aggregation-prone
36 H H 0.1973 Aggregation-prone
37 Y H 0.0000 Buried
38 I H 0.7512 Aggregation-prone
39 M H 0.0000 Buried
40 M H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.7854 Soluble
45 A H -1.1469 Soluble
46 P H -1.0278 Soluble
47 G H -1.5169 Soluble
48 K H -2.3954 Soluble
49 G H -1.7025 Soluble
50 L H 0.0000 Buried
51 E H -1.1261 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 G H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H 1.0020 Aggregation-prone
58 S H 0.2737 Aggregation-prone
59 S H -0.6223 Soluble
62 G H -0.3629 Soluble
63 G H 0.5434 Aggregation-prone
64 I H 1.9187 Aggregation-prone
65 T H 0.9922 Aggregation-prone
66 V H 0.4600 Aggregation-prone
67 Y H -0.7143 Soluble
68 A H -1.2292 Soluble
69 D H -2.4327 Soluble
70 S H -1.6070 Soluble
71 V H 0.0000 Buried
72 K H -2.5801 Soluble
74 G H -1.8186 Soluble
75 R H -1.4532 Soluble
76 F H 0.0000 Buried
77 T H -0.8461 Soluble
78 I H 0.0000 Buried
79 S H -0.6602 Soluble
80 R H -1.5962 Soluble
81 D H -2.4302 Soluble
82 N H -2.8950 Soluble
83 S H -2.2678 Soluble
84 K H -3.0961 Soluble
85 N H -2.9032 Soluble
86 T H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H -0.6408 Soluble
89 L H 0.0000 Buried
90 Q H -1.2446 Soluble
91 M H 0.0000 Buried
92 N H -1.6811 Soluble
93 S H -1.3806 Soluble
94 L H 0.0000 Buried
95 R H -2.5042 Soluble
96 A H -1.8302 Soluble
97 E H -2.2942 Soluble
98 D H 0.0000 Buried
99 T H -0.6087 Soluble
100 A H 0.0000 Buried
101 V H 0.1872 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 Y H 0.0000 Buried
107 R H 0.0000 Buried
108 R H 0.0000 Buried
109 I H 1.1255 Aggregation-prone
110 G H 0.5267 Aggregation-prone
111 V H 0.9091 Aggregation-prone
111A P H -1.0382 Soluble
112A R H -2.4069 Soluble
112 R H -2.9832 Soluble
113 D H -2.2091 Soluble
114 E H -1.9360 Soluble
115 F H 0.0000 Buried
116 D H 0.0000 Buried
117 I H -0.5390 Soluble
118 W H -0.2639 Soluble
119 G H 0.0000 Buried
120 Q H -1.3182 Soluble
121 G H 0.0000 Buried
122 T H 0.1228 Aggregation-prone
123 M H 0.6791 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.1572 Soluble
126 V H 0.0000 Buried
127 S H -0.8613 Soluble
128 S H -0.7920 Soluble
129 A H -0.5357 Soluble
130 S H -0.6304 Soluble
131 T H -0.6951 Soluble
132 K H -1.1347 Soluble
133 G H -1.3349 Soluble
134 P H 0.0000 Buried
135 S H -0.4208 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1061 Soluble
139 L H 0.0000 Buried
140 A H -0.7857 Soluble
141 P H 0.0000 Buried
142 S H -0.1693 Soluble
143 G H -0.6552 Soluble
144 T H -0.5129 Soluble
145 A H 0.0000 Buried
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.4378 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H -0.6367 Soluble
157 E H -1.1005 Soluble
158 P H -1.1455 Soluble
159 V H -0.9109 Soluble
160 T H -0.7076 Soluble
161 V H -0.1641 Soluble
162 S H -0.3120 Soluble
163 W H 0.0000 Buried
164 N H -0.6228 Soluble
165 S H -0.5433 Soluble
166 G H -0.5499 Soluble
167 A H -0.2287 Soluble
168 L H 0.0255 Aggregation-prone
169 T H -0.1655 Soluble
170 S H -0.1901 Soluble
171 G H -0.2811 Soluble
172 V H 0.1820 Aggregation-prone
173 H H -0.2455 Soluble
174 T H 0.0522 Aggregation-prone
175 F H 0.0000 Buried
176 P H -0.2061 Soluble
177 A H 0.3746 Aggregation-prone
178 V H 0.6556 Aggregation-prone
179 L H 1.3876 Aggregation-prone
180 Q H 0.2687 Aggregation-prone
181 S H -0.0161 Soluble
182 S H -0.1638 Soluble
183 G H 0.0936 Aggregation-prone
184 L H 0.0947 Aggregation-prone
185 Y H 0.3580 Aggregation-prone
186 S H 0.0000 Buried
187 L H 0.0000 Buried
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.1500 Soluble
193 V H 0.0000 Buried
194 P H -0.5253 Soluble
195 S H -0.5591 Soluble
196 S H -0.6041 Soluble
197 S H -0.5678 Soluble
198 L H -0.8209 Soluble
199 G H -0.9911 Soluble
200 T H -0.6837 Soluble
201 Q H -1.1231 Soluble
202 T H -1.1149 Soluble
203 Y H 0.0000 Buried
204 I H -1.1517 Soluble
205 C H 0.0000 Buried
206 N H -1.2932 Soluble
207 V H 0.0000 Buried
208 N H -2.1914 Soluble
209 H H 0.0000 Buried
210 K H -2.8812 Soluble
211 P H -1.7257 Soluble
212 S H -1.8368 Soluble
213 N H -2.6154 Soluble
214 T H -2.2491 Soluble
215 K H -2.7425 Soluble
216 V H -1.5322 Soluble
217 D H -2.0255 Soluble
218 K H -1.8157 Soluble
219 R H -2.5254 Soluble
220 V H 0.0000 Buried
221 E H -2.5005 Soluble
222 P H -1.2119 Soluble
1 D L -2.2171 Soluble
2 I L 0.0000 Buried
3 Q L -2.1899 Soluble
4 M L 0.0000 Buried
5 T L -1.3467 Soluble
6 Q L 0.0000 Buried
7 S L -0.7987 Soluble
8 P L -0.4689 Soluble
9 S L -0.8091 Soluble
10 T L -0.6246 Soluble
11 L L -0.3646 Soluble
12 S L -0.6207 Soluble
13 A L 0.0000 Buried
14 S L -0.0853 Soluble
15 V L 0.7801 Aggregation-prone
16 G L -0.2577 Soluble
17 D L -1.1856 Soluble
18 R L -2.0673 Soluble
19 V L 0.0000 Buried
20 T L -0.5977 Soluble
21 I L 0.0000 Buried
22 T L -0.7067 Soluble
23 C L 0.0000 Buried
24 R L -2.3275 Soluble
25 A L 0.0000 Buried
26 S L -1.7803 Soluble
27 Q L -1.7755 Soluble
28 S L -1.0833 Soluble
29 I L 0.0000 Buried
36 S L -0.6258 Soluble
37 S L -0.5411 Soluble
38 W L 0.0543 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.7529 Soluble
46 P L -1.5382 Soluble
47 G L -1.6771 Soluble
48 K L -2.5486 Soluble
49 A L -1.6343 Soluble
50 P L 0.0000 Buried
51 K L -1.4814 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.0000 Buried
56 K L -0.8481 Soluble
57 A L 0.0000 Buried
65 S L -0.5158 Soluble
66 T L -0.2026 Soluble
67 L L 0.1464 Aggregation-prone
68 E L 0.0000 Buried
69 S L -1.1271 Soluble
70 G L -0.8131 Soluble
71 V L 0.0000 Buried
72 P L -0.3781 Soluble
74 S L -0.4360 Soluble
75 R L -0.7986 Soluble
76 F L 0.0000 Buried
77 S L -0.3422 Soluble
78 G L -0.4234 Soluble
79 S L -0.7470 Soluble
80 G L -1.0999 Soluble
83 S L -0.8258 Soluble
84 G L -0.9688 Soluble
85 T L -1.5079 Soluble
86 E L -1.9044 Soluble
87 F L 0.0000 Buried
88 T L -0.6774 Soluble
89 L L 0.0000 Buried
90 T L -0.6305 Soluble
91 I L 0.0000 Buried
92 S L -1.2771 Soluble
93 S L -0.8945 Soluble
94 L L 0.0000 Buried
95 Q L -0.7007 Soluble
96 P L -0.7670 Soluble
97 D L -1.8359 Soluble
98 D L 0.0000 Buried
99 F L -0.3713 Soluble
100 A L -0.6820 Soluble
101 T L -0.7918 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.1918 Aggregation-prone
108 N L -0.2358 Soluble
114 T L -0.0453 Soluble
115 Y L 0.7262 Aggregation-prone
116 W L 0.0000 Buried
117 T L -0.5823 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.8877 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.3345 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.0531 Soluble
127 K L -0.9003 Soluble
128 R L -0.9986 Soluble
129 T L -0.1210 Soluble
130 V L 0.4610 Aggregation-prone
131 A L 0.0284 Aggregation-prone
132 A L -0.0686 Soluble
133 P L 0.0000 Buried
134 S L 0.0048 Aggregation-prone
135 V L 0.1237 Aggregation-prone
136 F L 0.1848 Aggregation-prone
137 I L 0.1174 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.4685 Soluble
140 P L 0.0000 Buried
141 S L -1.5390 Soluble
142 D L -2.8123 Soluble
143 E L -2.6946 Soluble
144 Q L 0.0000 Buried
145 L L -2.1487 Soluble
146 K L -2.7283 Soluble
147 S L -1.7061 Soluble
148 G L -1.1416 Soluble
149 T L -0.8727 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.6299 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.1473 Soluble
162 R L -1.9161 Soluble
163 E L -2.6867 Soluble
164 A L -2.0838 Soluble
165 K L -2.3154 Soluble
166 V L -1.1909 Soluble
167 Q L -0.5398 Soluble
168 W L 0.0000 Buried
169 K L -0.6377 Soluble
170 V L 0.0000 Buried
171 D L -1.8041 Soluble
172 N L -1.4597 Soluble
173 A L -0.3282 Soluble
174 L L 0.7070 Aggregation-prone
175 Q L -0.2331 Soluble
176 S L -0.5632 Soluble
177 G L -1.1991 Soluble
178 N L -1.3579 Soluble
179 S L -1.4963 Soluble
180 Q L -2.0144 Soluble
181 E L -1.5467 Soluble
182 S L -0.5185 Soluble
183 V L -0.1517 Soluble
184 T L -0.7942 Soluble
185 E L -2.0416 Soluble
186 Q L -1.6078 Soluble
187 D L -1.9629 Soluble
188 S L -1.7304 Soluble
189 K L -2.2219 Soluble
190 D L -1.6288 Soluble
191 S L -1.5607 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7763 Soluble
199 L L 0.0000 Buried
200 T L -0.6367 Soluble
201 L L -0.6479 Soluble
202 S L -0.9873 Soluble
203 K L -2.0597 Soluble
204 A L -1.7082 Soluble
205 D L -2.2694 Soluble
206 Y L 0.0000 Buried
207 E L -3.1777 Soluble
208 K L -3.2882 Soluble
209 H L -2.7121 Soluble
210 K L -2.6524 Soluble
211 V L -1.1714 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7776 Soluble
216 V L 0.0000 Buried
217 T L -1.2079 Soluble
218 H L 0.0000 Buried
219 Q L -1.5847 Soluble
220 G L -0.3836 Soluble
221 L L -0.2448 Soluble
222 S L -0.4536 Soluble
223 S L -0.4444 Soluble
224 P L -0.5419 Soluble
225 V L 0.0171 Aggregation-prone
226 T L -0.4071 Soluble
227 K L -0.5994 Soluble
228 S L -0.4642 Soluble
229 F L -0.8183 Soluble
230 N L -1.6713 Soluble
231 R L -2.1692 Soluble
232 G L -1.9488 Soluble
233 E L -2.3847 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6341 4.6112 CSV PDB
4.5 -0.6707 4.5505 CSV PDB
5.0 -0.7132 4.4652 CSV PDB
5.5 -0.7533 4.3697 CSV PDB
6.0 -0.7814 4.2788 CSV PDB
6.5 -0.79 4.2074 CSV PDB
7.0 -0.7784 4.1651 CSV PDB
7.5 -0.7525 4.1465 CSV PDB
8.0 -0.7182 4.1397 CSV PDB
8.5 -0.678 4.1375 CSV PDB
9.0 -0.6323 4.1368 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH