Bexatamig / 6iap

A4DAB045_6iap_H_L | Source PDB: 6iap | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7781
Max Score
1.0011
Min Score
-3.9176
Total Score
-335.37
Score CDR
-0.6564
Score non-CDR
-0.793

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGSSVKVSCKASGYTFSDYVINWVRQAPGQGLEWMGEIYPGSGTNYYNEKFKAKATITADKSTSTAYMELSSLRSEDTAVYYCARRGRYGLYAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPDIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQQGNTRPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.9176
Maximum Score 1.0011
Average Score -0.7781
Total Score -335.3664

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.4840 Soluble
2 V H -0.6938 Soluble
3 Q H -1.1228 Soluble
4 L H 0.0000 Buried
5 V H 0.8301 Aggregation-prone
6 Q H 0.0000 Buried
7 S H -0.3496 Soluble
8 G H -0.7543 Soluble
9 A H -0.9163 Soluble
11 E H -1.6540 Soluble
12 V H -0.8668 Soluble
13 K H -1.5498 Soluble
14 K H -2.3473 Soluble
15 P H -1.8507 Soluble
16 G H -1.4029 Soluble
17 S H -1.1115 Soluble
18 S H -1.2340 Soluble
19 V H 0.0000 Buried
20 K H -1.9815 Soluble
21 V H 0.0000 Buried
22 S H -0.3397 Soluble
23 C H 0.0000 Buried
24 K H -0.5114 Soluble
25 A H 0.0000 Buried
26 S H -0.6916 Soluble
27 G H -0.9648 Soluble
28 Y H -0.6135 Soluble
29 T H -0.7808 Soluble
30 F H 0.0000 Buried
35 S H -1.4402 Soluble
36 D H -2.0093 Soluble
37 Y H -1.1386 Soluble
38 V H 0.0000 Buried
39 I H 0.0000 Buried
40 N H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.5028 Soluble
44 Q H -0.6655 Soluble
45 A H 0.0000 Buried
46 P H -0.8524 Soluble
47 G H -1.2683 Soluble
48 Q H -1.7349 Soluble
49 G H -1.1624 Soluble
50 L H 0.0000 Buried
51 E H -0.7587 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 E H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H -0.1865 Soluble
58 P H 0.0000 Buried
59 G H -1.1614 Soluble
62 S H -0.8307 Soluble
63 G H -0.8317 Soluble
64 T H -0.2765 Soluble
65 N H -0.1590 Soluble
66 Y H -0.1611 Soluble
67 Y H -0.9792 Soluble
68 N H 0.0000 Buried
69 E H -3.3139 Soluble
70 K H -3.0395 Soluble
71 F H 0.0000 Buried
72 K H -2.7960 Soluble
74 A H -1.6218 Soluble
75 K H -1.1143 Soluble
76 A H 0.0000 Buried
77 T H -0.7728 Soluble
78 I H 0.0000 Buried
79 T H -0.4100 Soluble
80 A H -0.9103 Soluble
81 D H -1.6157 Soluble
82 K H -2.2515 Soluble
83 S H -1.2599 Soluble
84 T H -1.0234 Soluble
85 S H -1.2162 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.4605 Soluble
89 M H 0.0000 Buried
90 E H -1.2222 Soluble
91 L H 0.0000 Buried
92 S H -0.9439 Soluble
93 S H -0.9598 Soluble
94 L H 0.0000 Buried
95 R H -2.2778 Soluble
96 S H -2.0003 Soluble
97 E H -2.2996 Soluble
98 D H 0.0000 Buried
99 T H -0.9317 Soluble
100 A H 0.0000 Buried
101 V H 0.1104 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 R H 0.0000 Buried
108 G H -1.2731 Soluble
109 R H -1.9862 Soluble
110 Y H -0.7624 Soluble
111 G H -0.6373 Soluble
112 L H 0.0095 Aggregation-prone
113 Y H 0.1412 Aggregation-prone
114 A H 0.0000 Buried
115 M H 0.0000 Buried
116 D H 0.0000 Buried
117 Y H -0.1283 Soluble
118 W H -0.2817 Soluble
119 G H 0.0000 Buried
120 Q H -1.2538 Soluble
121 G H -0.6242 Soluble
122 T H 0.0000 Buried
123 T H -0.3473 Soluble
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.2789 Soluble
128 S H -1.0115 Soluble
129 A H -0.7073 Soluble
130 S H -0.7855 Soluble
131 T H -0.8578 Soluble
132 K H -1.4492 Soluble
133 G H -1.5788 Soluble
134 P H 0.0000 Buried
135 S H -0.5392 Soluble
136 V H 0.0000 Buried
137 F H -0.7079 Soluble
138 P H -1.0953 Soluble
139 L H 0.0000 Buried
140 A H -0.8122 Soluble
141 P H 0.0000 Buried
142 S H -0.8406 Soluble
143 S H -1.1438 Soluble
144 K H -1.8541 Soluble
145 S H 0.0000 Buried
146 T H -0.9501 Soluble
147 S H -0.9409 Soluble
148 G H -0.8841 Soluble
149 G H -0.8967 Soluble
150 T H -0.6397 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.8984 Soluble
160 Y H 0.0000 Buried
161 F H 0.0000 Buried
162 P H 0.0000 Buried
163 E H -0.5675 Soluble
164 P H -0.7426 Soluble
165 V H -0.5893 Soluble
166 T H -0.5851 Soluble
167 V H -0.3325 Soluble
168 S H -0.3396 Soluble
169 W H 0.0000 Buried
170 N H -0.6797 Soluble
171 S H -0.5828 Soluble
172 G H -0.5215 Soluble
173 A H -0.2140 Soluble
174 L H 0.0183 Aggregation-prone
175 T H -0.1837 Soluble
176 S H -0.2361 Soluble
177 G H -0.2220 Soluble
178 V H 0.1203 Aggregation-prone
179 H H -0.3369 Soluble
180 T H 0.0204 Aggregation-prone
181 F H 0.0000 Buried
182 P H -0.4655 Soluble
183 A H 0.1957 Aggregation-prone
184 V H 0.5386 Aggregation-prone
185 L H 1.0011 Aggregation-prone
186 Q H 0.1770 Aggregation-prone
187 S H -0.1626 Soluble
188 S H -0.3896 Soluble
189 G H -0.2762 Soluble
190 L H -0.2195 Soluble
191 Y H 0.2399 Aggregation-prone
192 S H 0.0000 Buried
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.1449 Soluble
199 V H 0.0000 Buried
200 P H -0.6101 Soluble
201 S H -0.5865 Soluble
202 S H -0.5604 Soluble
203 S H -0.5546 Soluble
204 L H -0.7370 Soluble
205 G H -0.9557 Soluble
206 T H -0.6832 Soluble
207 Q H -1.1632 Soluble
208 T H -1.1627 Soluble
209 Y H 0.0000 Buried
210 I H -1.2065 Soluble
211 C H 0.0000 Buried
212 N H -1.4248 Soluble
213 V H 0.0000 Buried
214 N H -1.9750 Soluble
215 H H 0.0000 Buried
216 K H -2.9011 Soluble
217 P H -1.8376 Soluble
218 S H -1.9533 Soluble
219 N H -2.5541 Soluble
220 T H -2.1370 Soluble
221 K H -2.6273 Soluble
222 V H -1.3618 Soluble
223 D H -2.2882 Soluble
224 K H -2.0541 Soluble
225 R H -2.7500 Soluble
226 V H 0.0000 Buried
227 E H -2.5713 Soluble
228 P H -1.3800 Soluble
1 D L -2.7240 Soluble
2 I L 0.0000 Buried
3 Q L -2.2777 Soluble
4 M L 0.0000 Buried
5 T L -1.4839 Soluble
6 Q L -1.0430 Soluble
7 S L -0.8499 Soluble
8 P L -0.6298 Soluble
9 S L -0.8661 Soluble
10 S L -0.9990 Soluble
11 L L -0.6974 Soluble
12 S L -1.1175 Soluble
13 A L -1.2471 Soluble
14 S L -1.2034 Soluble
15 V L -0.4188 Soluble
16 G L -0.7848 Soluble
17 D L -1.6808 Soluble
18 R L -2.2882 Soluble
19 V L 0.0000 Buried
20 T L -0.6081 Soluble
21 I L 0.0000 Buried
22 T L -0.9634 Soluble
23 C L 0.0000 Buried
24 R L -3.1876 Soluble
25 A L 0.0000 Buried
26 S L -2.4170 Soluble
27 Q L -2.9465 Soluble
28 D L -3.0749 Soluble
29 I L 0.0000 Buried
36 S L -1.3341 Soluble
37 N L -0.6097 Soluble
38 Y L -0.0840 Soluble
39 L L 0.0000 Buried
40 N L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -1.4478 Soluble
45 K L -2.0095 Soluble
46 P L -1.6621 Soluble
47 G L -1.8985 Soluble
48 K L -2.6005 Soluble
49 A L -1.6236 Soluble
50 P L 0.0000 Buried
51 K L -1.6343 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.1204 Aggregation-prone
56 Y L 0.0640 Aggregation-prone
57 T L 0.0000 Buried
65 S L -0.7243 Soluble
66 R L -0.9709 Soluble
67 L L -0.0385 Soluble
68 H L 0.0000 Buried
69 S L -0.4179 Soluble
70 G L -0.5179 Soluble
71 V L 0.0000 Buried
72 P L -0.4073 Soluble
74 S L -0.4090 Soluble
75 R L -0.8172 Soluble
76 F L 0.0000 Buried
77 S L -0.4554 Soluble
78 G L 0.0000 Buried
79 S L -0.8695 Soluble
80 G L -1.3432 Soluble
83 S L -1.3026 Soluble
84 G L -2.0848 Soluble
85 T L -2.6563 Soluble
86 D L -2.8523 Soluble
87 F L 0.0000 Buried
88 T L -0.8884 Soluble
89 F L 0.0000 Buried
90 T L -0.6117 Soluble
91 I L 0.0000 Buried
92 S L -1.3217 Soluble
93 S L -1.1724 Soluble
94 L L 0.0000 Buried
95 Q L -1.0663 Soluble
96 P L -1.8884 Soluble
97 E L -2.3250 Soluble
98 D L 0.0000 Buried
99 I L 0.0000 Buried
100 A L 0.0000 Buried
101 T L -1.0795 Soluble
102 Y L 0.0000 Buried
103 F L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 G L 0.0000 Buried
108 N L -1.1997 Soluble
109 T L -1.3703 Soluble
114 R L -1.7429 Soluble
115 P L -1.7464 Soluble
116 W L 0.0000 Buried
117 T L -1.0534 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -1.2211 Soluble
121 G L -0.8456 Soluble
122 T L 0.0000 Buried
123 K L -1.9146 Soluble
124 V L 0.0000 Buried
125 E L -1.7033 Soluble
126 I L 0.0000 Buried
127 K L -2.0075 Soluble
128 R L -1.5682 Soluble
129 T L -0.4744 Soluble
130 V L -0.0848 Soluble
131 A L -0.0034 Soluble
132 A L -0.1618 Soluble
133 P L 0.0000 Buried
134 S L -0.1561 Soluble
135 V L 0.0000 Buried
136 F L 0.0000 Buried
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -1.0141 Soluble
140 P L 0.0000 Buried
141 S L -1.5418 Soluble
142 D L -2.9190 Soluble
143 E L -2.9222 Soluble
144 Q L 0.0000 Buried
145 L L -2.1787 Soluble
146 K L -2.8326 Soluble
147 S L -1.6749 Soluble
148 G L -1.2798 Soluble
149 T L -0.9889 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.8234 Soluble
159 F L 0.0000 Buried
160 Y L -1.3224 Soluble
161 P L -1.8513 Soluble
162 R L -2.9760 Soluble
163 E L -3.1625 Soluble
164 A L -2.3741 Soluble
165 K L -2.8064 Soluble
166 V L 0.0000 Buried
167 Q L -1.0551 Soluble
168 W L 0.0000 Buried
169 K L -0.9629 Soluble
170 V L 0.0000 Buried
171 D L -2.0455 Soluble
172 N L -1.7101 Soluble
173 A L -0.5891 Soluble
174 L L -0.1009 Soluble
175 Q L -0.7243 Soluble
176 S L -0.6298 Soluble
177 G L -0.8347 Soluble
178 N L -0.9170 Soluble
179 S L -1.1336 Soluble
180 Q L -1.1150 Soluble
181 E L -2.0203 Soluble
182 S L -0.7884 Soluble
183 V L -1.0766 Soluble
184 T L -1.2006 Soluble
185 E L -2.3251 Soluble
186 Q L 0.0000 Buried
187 D L -2.1433 Soluble
188 S L -2.4071 Soluble
189 K L -2.7546 Soluble
190 D L -2.2557 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.5777 Soluble
199 L L 0.0000 Buried
200 T L -0.5128 Soluble
201 L L 0.0000 Buried
202 S L -1.3386 Soluble
203 K L -2.0545 Soluble
204 A L -2.0188 Soluble
205 D L -2.8266 Soluble
206 Y L 0.0000 Buried
207 E L -3.9176 Soluble
208 K L -3.8830 Soluble
209 H L -3.4334 Soluble
210 K L -3.6715 Soluble
211 V L -2.0277 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.8576 Soluble
216 V L 0.0000 Buried
217 T L -1.3442 Soluble
218 H L 0.0000 Buried
219 Q L -1.8255 Soluble
220 G L -0.5531 Soluble
221 L L -0.3085 Soluble
222 S L -0.4805 Soluble
223 S L -0.4073 Soluble
224 P L -0.5939 Soluble
225 V L 0.0913 Aggregation-prone
226 T L -0.3912 Soluble
227 K L -0.8204 Soluble
228 S L -0.8873 Soluble
229 F L 0.0000 Buried
230 N L -2.6973 Soluble
231 R L -3.4960 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.9071 1.5888 CSV PDB
4.5 -0.9507 1.5283 CSV PDB
5.0 -1.0009 1.4845 CSV PDB
5.5 -1.0475 1.4845 CSV PDB
6.0 -1.0787 1.4845 CSV PDB
6.5 -1.0853 1.4845 CSV PDB
7.0 -1.0671 1.4845 CSV PDB
7.5 -1.0321 1.4845 CSV PDB
8.0 -0.9877 1.4845 CSV PDB
8.5 -0.9366 1.4845 CSV PDB
9.0 -0.8787 1.4845 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH