Cilgavimab / 7l7e

A4DAB064_7l7e_C_D | Source PDB: 7l7e | Chains: C, D | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.742
Max Score
1.3448
Min Score
-3.3577
Total Score
-337.6
Score CDR
-0.4724
Score non-CDR
-0.7853

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVKPGGSLRLSCAASGFTFRDVWMSWVRQAPGKGLEWVGRIKSKIDGGTTDYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTAGSYYYDTVGPGLPEGKFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKDIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLMYWASTRESGVPDRFSGSGSGAEFTLTISSLQAEDVAIYYCQQYYSTLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNRGEC input.pdb
Selected Chain(s) C (Heavy), D (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3577
Maximum Score 1.3448
Average Score -0.742
Total Score -337.6043

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E C -2.4847 Soluble
2 V C 0.0000 Buried
3 Q C -1.1172 Soluble
4 L C 0.0000 Buried
5 V C 1.2191 Aggregation-prone
6 E C 0.0000 Buried
7 S C -0.3290 Soluble
8 G C -0.8397 Soluble
9 G C -0.4483 Soluble
11 G C -0.3399 Soluble
12 L C -0.0858 Soluble
13 V C -0.6953 Soluble
14 K C -1.8441 Soluble
15 P C -1.8130 Soluble
16 G C -1.5619 Soluble
17 G C -1.3348 Soluble
18 S C -1.2788 Soluble
19 L C -1.0928 Soluble
20 R C -1.7799 Soluble
21 L C 0.0000 Buried
22 S C -0.2672 Soluble
23 C C 0.0000 Buried
24 A C -0.0075 Soluble
25 A C 0.0000 Buried
26 S C -1.0409 Soluble
27 G C -1.5576 Soluble
28 F C -0.9702 Soluble
29 T C -0.7105 Soluble
30 F C 0.0000 Buried
35 R C -2.3529 Soluble
36 D C -1.1803 Soluble
37 V C 0.0000 Buried
38 W C -0.5973 Soluble
39 M C 0.0000 Buried
40 S C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C -0.7787 Soluble
45 A C -1.1964 Soluble
46 P C -1.0127 Soluble
47 G C -1.4815 Soluble
48 K C -2.2365 Soluble
49 G C -1.3116 Soluble
50 L C 0.0000 Buried
51 E C -0.8904 Soluble
52 W C 0.0000 Buried
53 V C 0.0000 Buried
54 G C 0.0000 Buried
55 R C 0.0000 Buried
56 I C 0.0000 Buried
57 K C -1.0899 Soluble
58 S C 0.0000 Buried
59 K C -1.4872 Soluble
60 I C 0.4144 Aggregation-prone
61 D C -0.4702 Soluble
62 G C -0.8091 Soluble
63 G C -0.9019 Soluble
64 T C -0.9207 Soluble
65 T C -0.5747 Soluble
66 D C -0.9974 Soluble
67 Y C -0.8979 Soluble
68 A C -0.9733 Soluble
69 A C -0.9597 Soluble
70 P C -0.9610 Soluble
71 V C 0.0000 Buried
72 K C -2.1220 Soluble
74 G C -1.6109 Soluble
75 R C -1.5483 Soluble
76 F C 0.0000 Buried
77 T C -0.9565 Soluble
78 I C 0.0000 Buried
79 S C -0.3555 Soluble
80 R C -1.3090 Soluble
81 D C -1.6780 Soluble
82 D C -2.1612 Soluble
83 S C -1.7361 Soluble
84 K C -2.3173 Soluble
85 N C -2.0753 Soluble
86 T C -1.0887 Soluble
87 L C 0.0000 Buried
88 Y C -0.4017 Soluble
89 L C 0.0000 Buried
90 Q C -1.1506 Soluble
91 M C 0.0000 Buried
92 N C -1.8852 Soluble
93 S C -1.4966 Soluble
94 L C 0.0000 Buried
95 K C -2.1850 Soluble
96 T C -1.7462 Soluble
97 E C -2.2234 Soluble
98 D C 0.0000 Buried
99 T C -0.6910 Soluble
100 A C 0.0000 Buried
101 V C 0.1038 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 T C 0.0000 Buried
106 T C 0.0000 Buried
107 A C 0.0000 Buried
108 G C 0.0000 Buried
109 S C 0.0000 Buried
110 Y C 0.5451 Aggregation-prone
111 Y C 0.7207 Aggregation-prone
111A Y C 0.6199 Aggregation-prone
111B D C 0.3255 Aggregation-prone
111C T C 0.1574 Aggregation-prone
111D V C 0.2924 Aggregation-prone
112E G C -0.2632 Soluble
112D P C -0.5986 Soluble
112C G C -0.9085 Soluble
112B L C -0.8885 Soluble
112A P C -1.5728 Soluble
112 E C -2.3813 Soluble
113 G C -1.7017 Soluble
114 K C -1.3858 Soluble
115 F C -0.2365 Soluble
116 D C 0.0000 Buried
117 Y C -0.2323 Soluble
118 W C -0.3179 Soluble
119 G C 0.0000 Buried
120 Q C -1.1538 Soluble
121 G C -0.4148 Soluble
122 T C -0.1183 Soluble
123 L C -0.0935 Soluble
124 V C 0.0000 Buried
125 T C 0.0000 Buried
126 V C 0.0000 Buried
127 S C -1.0081 Soluble
128 S C -0.8154 Soluble
129 A C -0.5138 Soluble
130 S C -0.5997 Soluble
131 T C -0.7706 Soluble
132 K C -1.2975 Soluble
133 G C -1.4164 Soluble
134 P C -0.5941 Soluble
135 S C -0.4005 Soluble
136 V C 0.0000 Buried
137 F C 0.0000 Buried
138 P C -1.1480 Soluble
139 L C 0.0000 Buried
140 A C 0.0000 Buried
141 P C 0.0000 Buried
142 S C -1.1202 Soluble
143 S C -1.0378 Soluble
144 K C -0.8965 Soluble
145 S C 0.0000 Buried
146 T C -0.4995 Soluble
147 S C -0.6905 Soluble
148 G C -0.8557 Soluble
149 G C -0.9221 Soluble
150 T C -0.6281 Soluble
151 A C 0.0000 Buried
152 A C 0.0000 Buried
153 L C 0.0000 Buried
154 G C 0.0000 Buried
155 C C 0.0000 Buried
156 L C 0.0000 Buried
157 V C 0.0000 Buried
158 K C 0.0000 Buried
159 D C -0.4485 Soluble
160 Y C 0.0000 Buried
161 F C -0.2359 Soluble
162 P C 0.0000 Buried
163 E C -0.7365 Soluble
164 P C -0.7651 Soluble
165 V C -0.6221 Soluble
166 T C -0.5225 Soluble
167 V C -0.1119 Soluble
168 S C -0.3707 Soluble
169 W C 0.0000 Buried
170 N C -0.7800 Soluble
171 S C -0.6931 Soluble
172 G C -0.5733 Soluble
173 A C -0.2501 Soluble
174 L C -0.0377 Soluble
175 T C -0.2452 Soluble
176 S C -0.2789 Soluble
177 G C -0.3483 Soluble
178 V C -0.0325 Soluble
179 H C -0.4585 Soluble
180 T C -0.2121 Soluble
181 F C 0.0000 Buried
182 P C -0.3464 Soluble
183 A C 0.2961 Aggregation-prone
184 V C 0.5758 Aggregation-prone
185 L C 1.3448 Aggregation-prone
186 Q C 0.1903 Aggregation-prone
187 S C -0.2190 Soluble
188 S C -0.2193 Soluble
189 G C 0.1031 Aggregation-prone
190 L C 0.2029 Aggregation-prone
191 Y C 0.4741 Aggregation-prone
192 S C 0.2314 Aggregation-prone
193 L C 0.1642 Aggregation-prone
194 S C 0.0000 Buried
195 S C 0.0000 Buried
196 V C 0.0000 Buried
197 V C 0.0000 Buried
198 T C -0.2351 Soluble
199 V C 0.0000 Buried
200 P C -0.6685 Soluble
201 S C -0.7110 Soluble
202 S C -0.6067 Soluble
203 S C -0.6952 Soluble
204 L C -0.8585 Soluble
205 G C -1.0388 Soluble
206 T C -0.8144 Soluble
207 Q C -1.4205 Soluble
208 T C -1.2058 Soluble
209 Y C 0.0000 Buried
210 I C -1.2883 Soluble
211 C C 0.0000 Buried
212 N C -1.4635 Soluble
213 V C 0.0000 Buried
214 N C -1.7389 Soluble
215 H C 0.0000 Buried
216 K C -2.7239 Soluble
217 P C -1.6102 Soluble
218 S C -1.7750 Soluble
219 N C -2.5616 Soluble
220 T C -2.0251 Soluble
221 K C -2.6400 Soluble
222 V C -1.7081 Soluble
223 D C -2.5183 Soluble
224 K C -2.1905 Soluble
225 K C -2.5171 Soluble
226 V C 0.0000 Buried
227 E C -2.7474 Soluble
228 P C -1.8799 Soluble
229 K C -1.7808 Soluble
230 S C -1.4958 Soluble
231 C C 0.0000 Buried
232 D C -2.1369 Soluble
233 K C -2.2716 Soluble
1 D D -1.5226 Soluble
2 I D 0.0000 Buried
3 V D 0.7844 Aggregation-prone
4 M D 0.0000 Buried
5 T D -0.8399 Soluble
6 Q D -1.5617 Soluble
7 S D -1.4285 Soluble
8 P D -1.5676 Soluble
9 D D -2.4386 Soluble
10 S D -1.6355 Soluble
11 L D -0.8726 Soluble
12 A D -0.9482 Soluble
13 V D -0.9830 Soluble
14 S D -0.9438 Soluble
15 L D -0.0619 Soluble
16 G D -0.8285 Soluble
17 E D -2.1863 Soluble
18 R D -2.5052 Soluble
19 A D 0.0000 Buried
20 T D -0.8481 Soluble
21 I D 0.0000 Buried
22 N D -1.7214 Soluble
23 C D 0.0000 Buried
24 K D -2.1442 Soluble
25 S D -1.0626 Soluble
26 S D -0.6911 Soluble
27 Q D -1.5166 Soluble
28 S D -0.9015 Soluble
29 V D 0.0000 Buried
30 L D -0.1500 Soluble
31 Y D 0.0303 Aggregation-prone
32 S D -0.6726 Soluble
33 S D -0.8479 Soluble
34 N D -1.4728 Soluble
35 N D -1.7868 Soluble
36 K D -1.2003 Soluble
37 N D 0.0000 Buried
38 Y D 0.0000 Buried
39 L D 0.0000 Buried
40 A D 0.0000 Buried
41 W D 0.0000 Buried
42 Y D 0.0000 Buried
43 Q D 0.0000 Buried
44 Q D 0.0000 Buried
45 K D -1.6932 Soluble
46 P D -1.4099 Soluble
47 G D -1.4295 Soluble
48 Q D -1.9861 Soluble
49 P D -1.4396 Soluble
50 P D 0.0000 Buried
51 K D -1.5771 Soluble
52 L D 0.0000 Buried
53 L D 0.0000 Buried
54 M D 0.0000 Buried
55 Y D -0.0197 Soluble
56 W D -0.0715 Soluble
57 A D 0.0000 Buried
65 S D -0.5056 Soluble
66 T D -0.5472 Soluble
67 R D -1.3428 Soluble
68 E D 0.0000 Buried
69 S D -0.8780 Soluble
70 G D -0.9962 Soluble
71 V D -0.8636 Soluble
72 P D -1.2998 Soluble
74 D D -2.1852 Soluble
75 R D -1.4774 Soluble
76 F D 0.0000 Buried
77 S D -0.8791 Soluble
78 G D 0.0000 Buried
79 S D -0.7432 Soluble
80 G D -1.2302 Soluble
83 S D -1.0804 Soluble
84 G D -1.1172 Soluble
85 A D -1.7210 Soluble
86 E D -2.7483 Soluble
87 F D 0.0000 Buried
88 T D -1.1211 Soluble
89 L D 0.0000 Buried
90 T D -0.6572 Soluble
91 I D 0.0000 Buried
92 S D -1.5506 Soluble
93 S D -1.5071 Soluble
94 L D 0.0000 Buried
95 Q D -1.2380 Soluble
96 A D -1.7336 Soluble
97 E D -2.4721 Soluble
98 D D 0.0000 Buried
99 V D -1.2469 Soluble
100 A D 0.0000 Buried
101 I D -0.5144 Soluble
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 Q D 0.0000 Buried
106 Q D 0.0000 Buried
107 Y D 0.0000 Buried
108 Y D 0.4855 Aggregation-prone
114 S D -0.1678 Soluble
115 T D -0.2843 Soluble
116 L D 0.0000 Buried
117 T D 0.0160 Aggregation-prone
118 F D 0.0000 Buried
119 G D 0.0000 Buried
120 G D -1.1215 Soluble
121 G D -1.2098 Soluble
122 T D 0.0000 Buried
123 K D -1.8723 Soluble
124 V D 0.0000 Buried
125 E D -1.3482 Soluble
126 I D 0.0000 Buried
127 K D -1.3854 Soluble
128 R D -0.9480 Soluble
129 T D -0.1706 Soluble
130 V D 0.3457 Aggregation-prone
131 A D 0.0267 Aggregation-prone
132 A D -0.3583 Soluble
133 P D 0.0000 Buried
134 S D -0.4158 Soluble
135 V D 0.0000 Buried
136 F D -0.1049 Soluble
137 I D 0.0000 Buried
138 F D 0.0000 Buried
139 P D -0.4577 Soluble
140 P D -0.6723 Soluble
141 S D 0.0000 Buried
142 D D -2.7535 Soluble
143 E D -2.6434 Soluble
144 Q D 0.0000 Buried
145 L D -2.1394 Soluble
146 K D -2.7043 Soluble
147 S D -1.6829 Soluble
148 G D -1.2846 Soluble
149 T D -0.9314 Soluble
150 A D 0.0000 Buried
151 S D 0.0000 Buried
152 V D 0.0000 Buried
153 V D 0.0000 Buried
154 C D 0.0000 Buried
155 L D 0.0000 Buried
156 L D 0.0000 Buried
157 N D -0.7289 Soluble
158 N D -1.5083 Soluble
159 F D 0.0000 Buried
160 Y D 0.0000 Buried
161 P D -1.8641 Soluble
162 R D -2.9754 Soluble
163 E D -3.2926 Soluble
164 A D -2.4257 Soluble
165 K D -2.5148 Soluble
166 V D -1.2887 Soluble
167 Q D -0.7725 Soluble
168 W D 0.0000 Buried
169 K D -0.6298 Soluble
170 V D 0.0000 Buried
171 D D -2.0245 Soluble
172 N D -1.4361 Soluble
173 A D -0.3879 Soluble
174 L D 0.4854 Aggregation-prone
175 Q D -0.3187 Soluble
176 S D -0.6021 Soluble
177 G D -0.9926 Soluble
178 N D -0.9776 Soluble
179 S D -1.4145 Soluble
180 Q D -1.9848 Soluble
181 E D -1.9700 Soluble
182 S D -0.7360 Soluble
183 V D -0.5332 Soluble
184 T D -1.2262 Soluble
185 E D -2.0206 Soluble
186 Q D 0.0000 Buried
187 D D -2.2589 Soluble
188 S D -2.4098 Soluble
189 K D -2.6367 Soluble
190 D D -1.9446 Soluble
191 S D 0.0000 Buried
192 T D 0.0000 Buried
193 Y D 0.0000 Buried
194 S D 0.0000 Buried
195 L D 0.0000 Buried
196 S D 0.0000 Buried
197 S D 0.0000 Buried
198 T D -0.8270 Soluble
199 L D 0.0000 Buried
200 T D -0.3982 Soluble
201 L D -0.4627 Soluble
202 S D -0.8584 Soluble
203 K D -1.8776 Soluble
204 A D -1.5014 Soluble
205 D D -2.0530 Soluble
206 Y D 0.0000 Buried
207 E D -3.1718 Soluble
208 K D -3.3577 Soluble
209 H D -2.8847 Soluble
210 K D -2.9970 Soluble
211 V D -1.4408 Soluble
212 Y D 0.0000 Buried
213 A D 0.0000 Buried
214 C D 0.0000 Buried
215 E D -0.6830 Soluble
216 V D 0.0000 Buried
217 T D -1.4442 Soluble
218 H D 0.0000 Buried
219 Q D -1.9531 Soluble
220 G D -0.6700 Soluble
221 L D -0.9148 Soluble
222 R D -2.0422 Soluble
223 S D -1.1966 Soluble
224 P D -0.9426 Soluble
225 V D -0.2089 Soluble
226 T D -0.3539 Soluble
227 K D -0.5373 Soluble
228 S D -0.3354 Soluble
229 F D 0.0000 Buried
230 N D -1.6464 Soluble
231 R D -1.9753 Soluble
232 G D -1.9037 Soluble
233 E D -2.6550 Soluble
234 C D -1.5761 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7473 2.0858 CSV PDB
4.5 -0.7937 2.0861 CSV PDB
5.0 -0.8476 2.0869 CSV PDB
5.5 -0.8974 2.0892 CSV PDB
6.0 -0.9299 2.0952 CSV PDB
6.5 -0.9348 2.1075 CSV PDB
7.0 -0.9127 2.126 CSV PDB
7.5 -0.8731 2.1481 CSV PDB
8.0 -0.8244 2.1718 CSV PDB
8.5 -0.7693 2.196 CSV PDB
9.0 -0.7081 2.2202 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH