Bremzalerbart / 7n0u

A4DAB054_7n0u_H_L | Source PDB: 7n0u | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6255
Max Score
1.6519
Min Score
-3.6699
Total Score
-263.34
Score CDR
-0.2207
Score non-CDR
-0.6716

Calculation Parameters

Chain Sequence(s) VQLQESGPGLVKPSETLSLTCSVSGGSITNYFWTWIRQSPGKGLEWIGYIYYSGGTNYNPSLKSRVTISIDTSKNQFSLNMNSVTAADTAVYYCAGSYYYGVDVWGQGTTVTVSSASTKGPSVFPLAPCSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVEIVLTQSPATLSLSPGERATLSCRASQSIKSFLAWYRQKPGQAPRLLIYDASNRPTGIPARFSGSGSGTDFTLTINSLESEDFAVYFCQQRNNWPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6699
Maximum Score 1.6519
Average Score -0.6255
Total Score -263.3442

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 0.2390 Aggregation-prone
3 Q H -1.1734 Soluble
4 L H 0.0000 Buried
5 Q H -1.9192 Soluble
6 E H 0.0000 Buried
7 S H -0.8565 Soluble
8 G H -0.5037 Soluble
9 P H -0.5752 Soluble
11 G H -0.4936 Soluble
12 L H -0.2199 Soluble
13 V H 0.0000 Buried
14 K H -1.4468 Soluble
15 P H -1.2929 Soluble
16 S H -1.4860 Soluble
17 E H -2.2065 Soluble
18 T H -1.5511 Soluble
19 L H 0.0000 Buried
20 S H -0.7027 Soluble
21 L H 0.0000 Buried
22 T H -0.5325 Soluble
23 C H 0.0000 Buried
24 S H -1.2596 Soluble
25 V H 0.0000 Buried
26 S H -0.8085 Soluble
27 G H -0.4835 Soluble
28 G H -0.6322 Soluble
29 S H -0.6391 Soluble
30 I H 0.0000 Buried
35 T H -0.2469 Soluble
36 N H -0.5953 Soluble
37 Y H 0.0000 Buried
38 F H 1.2116 Aggregation-prone
39 W H 0.0000 Buried
40 T H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.5792 Soluble
45 S H -0.8896 Soluble
46 P H -1.0483 Soluble
47 G H -1.4989 Soluble
48 K H -2.1694 Soluble
49 G H -1.3640 Soluble
50 L H 0.0000 Buried
51 E H 0.0000 Buried
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 Y H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H 0.9245 Aggregation-prone
58 Y H 0.9738 Aggregation-prone
59 S H 0.2380 Aggregation-prone
63 G H -0.1103 Soluble
64 G H -0.0525 Soluble
65 T H -0.0489 Soluble
66 N H -0.5566 Soluble
67 Y H -0.6906 Soluble
68 N H 0.0000 Buried
69 P H -1.1695 Soluble
70 S H -1.0085 Soluble
71 L H 0.0000 Buried
72 K H -2.0245 Soluble
74 S H -1.3491 Soluble
75 R H -1.3620 Soluble
76 V H 0.0000 Buried
77 T H -0.7916 Soluble
78 I H 0.0000 Buried
79 S H -0.2486 Soluble
80 I H -0.4027 Soluble
81 D H -1.3982 Soluble
82 T H -1.0596 Soluble
83 S H -1.4510 Soluble
84 K H -2.3141 Soluble
85 N H -1.6002 Soluble
86 Q H -1.4956 Soluble
87 F H 0.0000 Buried
88 S H -0.4112 Soluble
89 L H 0.0000 Buried
90 N H -0.7553 Soluble
91 M H 0.0000 Buried
92 N H -1.5970 Soluble
93 S H -1.3984 Soluble
94 V H 0.0000 Buried
95 T H -0.6296 Soluble
96 A H -0.1223 Soluble
97 A H -0.2343 Soluble
98 D H 0.0000 Buried
99 T H 0.0070 Aggregation-prone
100 A H 0.0000 Buried
101 V H 0.2049 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 G H 0.0000 Buried
107 S H 0.0000 Buried
108 Y H 1.0798 Aggregation-prone
109 Y H 1.6519 Aggregation-prone
113 Y H 0.8438 Aggregation-prone
114 G H 0.0000 Buried
115 V H 0.0000 Buried
116 D H -0.1095 Soluble
117 V H -0.1654 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.8994 Soluble
121 G H -1.0061 Soluble
122 T H -0.5170 Soluble
123 T H -0.1379 Soluble
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -0.4144 Soluble
128 S H -0.5264 Soluble
129 A H -0.4644 Soluble
130 S H -0.6541 Soluble
131 T H -1.0060 Soluble
132 K H -1.7397 Soluble
133 G H -1.6451 Soluble
134 P H -0.7765 Soluble
135 S H -0.6342 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -0.8421 Soluble
139 L H 0.0000 Buried
140 A H 0.2194 Aggregation-prone
141 P H 0.2481 Aggregation-prone
142 C H 0.3914 Aggregation-prone
143 S H -0.4040 Soluble
144 T H -0.3624 Soluble
145 A H -0.1787 Soluble
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H -0.2956 Soluble
153 D H -0.5421 Soluble
154 Y H 0.0000 Buried
155 F H -0.3288 Soluble
156 P H 0.0000 Buried
157 E H -0.4604 Soluble
158 P H -0.5834 Soluble
159 V H -0.5916 Soluble
160 T H -0.5491 Soluble
161 V H -0.3437 Soluble
162 S H -0.4158 Soluble
163 W H 0.0000 Buried
164 N H -0.8355 Soluble
165 S H -0.6669 Soluble
166 G H -0.4817 Soluble
167 A H -0.2035 Soluble
168 L H -0.0431 Soluble
169 T H -0.1587 Soluble
170 S H -0.1855 Soluble
171 G H -0.1888 Soluble
172 V H 0.2024 Aggregation-prone
173 H H -0.2076 Soluble
174 T H 0.0570 Aggregation-prone
175 F H 0.0000 Buried
176 P H -0.1499 Soluble
177 A H 0.3635 Aggregation-prone
178 V H 0.7345 Aggregation-prone
179 L H 1.4177 Aggregation-prone
180 Q H 0.3072 Aggregation-prone
181 S H -0.0629 Soluble
182 S H -0.2634 Soluble
183 G H -0.1030 Soluble
184 L H 0.0839 Aggregation-prone
185 Y H 0.4956 Aggregation-prone
186 S H 0.0000 Buried
187 L H 0.0000 Buried
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.1250 Soluble
193 V H 0.0000 Buried
194 P H -0.3887 Soluble
195 S H -0.4098 Soluble
196 S H -0.5306 Soluble
197 S H -0.5489 Soluble
198 L H -0.2108 Soluble
199 G H -0.6664 Soluble
200 T H -0.7809 Soluble
201 K H -1.2627 Soluble
202 T H -0.8662 Soluble
203 Y H 0.0000 Buried
204 T H -1.2436 Soluble
205 C H 0.0000 Buried
206 N H -1.5888 Soluble
207 V H 0.0000 Buried
208 D H -1.8810 Soluble
209 H H 0.0000 Buried
210 K H -2.7375 Soluble
211 P H -1.6841 Soluble
212 S H -1.9535 Soluble
213 N H -2.6354 Soluble
214 T H -2.1390 Soluble
215 K H -2.6689 Soluble
216 V H -1.6420 Soluble
217 D H -2.5099 Soluble
218 K H -2.0375 Soluble
219 R H -2.0860 Soluble
220 V H -0.4159 Soluble
1 E L -1.5961 Soluble
2 I L -0.4621 Soluble
3 V L 0.8651 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.4957 Soluble
6 Q L 0.0000 Buried
7 S L -0.5392 Soluble
8 P L -0.3408 Soluble
9 A L -0.3166 Soluble
10 T L -0.3929 Soluble
11 L L -0.3138 Soluble
12 S L -0.5946 Soluble
13 L L -1.1374 Soluble
14 S L -1.5959 Soluble
15 P L -1.9799 Soluble
16 G L -1.9930 Soluble
17 E L -2.7158 Soluble
18 R L -2.8169 Soluble
19 A L 0.0000 Buried
20 T L -0.7481 Soluble
21 L L 0.0000 Buried
22 S L -0.7997 Soluble
23 C L 0.0000 Buried
24 R L -2.1062 Soluble
25 A L 0.0000 Buried
26 S L -0.9309 Soluble
27 Q L -1.8614 Soluble
28 S L -1.8795 Soluble
29 I L 0.0000 Buried
36 K L -2.1389 Soluble
37 S L -1.0580 Soluble
38 F L -0.3474 Soluble
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 R L -1.0658 Soluble
44 Q L -1.1637 Soluble
45 K L -1.4373 Soluble
46 P L -1.1547 Soluble
47 G L -1.4084 Soluble
48 Q L -1.8706 Soluble
49 A L -1.3906 Soluble
50 P L 0.0000 Buried
51 R L -1.8339 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.1959 Soluble
56 D L -0.4885 Soluble
57 A L 0.0000 Buried
65 S L -0.9012 Soluble
66 N L -1.4279 Soluble
67 R L -1.2982 Soluble
68 P L -0.7030 Soluble
69 T L -0.5406 Soluble
70 G L -0.5282 Soluble
71 I L -0.4585 Soluble
72 P L -0.3755 Soluble
74 A L -0.3673 Soluble
75 R L -0.7090 Soluble
76 F L 0.0000 Buried
77 S L -0.5994 Soluble
78 G L -0.6047 Soluble
79 S L -0.7650 Soluble
80 G L -1.1215 Soluble
83 S L -1.3849 Soluble
84 G L -1.6762 Soluble
85 T L -1.9767 Soluble
86 D L -2.2767 Soluble
87 F L 0.0000 Buried
88 T L -0.7220 Soluble
89 L L 0.0000 Buried
90 T L -0.6919 Soluble
91 I L 0.0000 Buried
92 N L -1.8231 Soluble
93 S L -1.9573 Soluble
94 L L 0.0000 Buried
95 E L -2.1308 Soluble
96 S L -2.2069 Soluble
97 E L -2.2252 Soluble
98 D L 0.0000 Buried
99 F L 0.0000 Buried
100 A L 0.0000 Buried
101 V L -0.3595 Soluble
102 Y L 0.0000 Buried
103 F L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 R L -0.4785 Soluble
108 N L -1.3877 Soluble
109 N L -1.6278 Soluble
114 W L -0.8485 Soluble
115 P L 0.0000 Buried
116 F L -0.2412 Soluble
117 T L -0.0708 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 P L -0.4676 Soluble
121 G L -0.4431 Soluble
122 T L 0.0000 Buried
123 K L -1.0016 Soluble
124 V L 0.0000 Buried
125 D L -0.9763 Soluble
126 I L 0.0000 Buried
127 K L -1.2175 Soluble
128 R L -0.9420 Soluble
129 T L 0.2059 Aggregation-prone
130 V L 0.9857 Aggregation-prone
131 A L 0.4646 Aggregation-prone
132 A L 0.0595 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.0540 Soluble
135 V L 0.0000 Buried
136 F L -0.1323 Soluble
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.1928 Soluble
140 P L 0.0000 Buried
141 S L -1.6079 Soluble
142 D L -2.9688 Soluble
143 E L -3.2404 Soluble
144 Q L 0.0000 Buried
145 L L -2.2791 Soluble
146 K L -2.8803 Soluble
147 S L -1.8432 Soluble
148 G L -1.3333 Soluble
149 T L -0.9412 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7787 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.3728 Soluble
162 R L -2.5526 Soluble
163 E L -2.6728 Soluble
164 A L -2.0447 Soluble
165 K L -1.9198 Soluble
166 V L -0.9468 Soluble
167 Q L -0.4307 Soluble
168 W L 0.0000 Buried
169 K L -0.5387 Soluble
170 V L 0.0000 Buried
171 D L -1.4754 Soluble
172 N L -1.2626 Soluble
173 A L -0.2280 Soluble
174 L L 0.8094 Aggregation-prone
175 Q L -0.0846 Soluble
176 S L -0.3591 Soluble
177 G L -0.8648 Soluble
178 N L -0.6954 Soluble
179 S L -0.9781 Soluble
180 Q L -1.2360 Soluble
181 E L -1.4509 Soluble
182 S L -0.6520 Soluble
183 V L -0.5034 Soluble
184 T L -0.8672 Soluble
185 E L -1.8958 Soluble
186 Q L 0.0000 Buried
187 D L -1.9596 Soluble
188 S L -2.2015 Soluble
189 K L -2.6540 Soluble
190 D L -1.9017 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L -1.1418 Soluble
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.5846 Soluble
199 L L 0.0000 Buried
200 T L -0.2597 Soluble
201 L L -0.4984 Soluble
202 S L -1.1721 Soluble
203 K L -2.1959 Soluble
204 A L -2.1090 Soluble
205 D L -2.9774 Soluble
206 Y L 0.0000 Buried
207 E L -3.5181 Soluble
208 K L -3.6699 Soluble
209 H L -3.1222 Soluble
210 K L -3.0607 Soluble
211 V L -1.1932 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.6860 Soluble
216 V L 0.0000 Buried
217 T L -0.9524 Soluble
218 H L 0.0000 Buried
219 Q L -1.5371 Soluble
220 G L -0.2143 Soluble
221 L L -0.1105 Soluble
222 S L -0.4054 Soluble
223 S L -0.3387 Soluble
224 P L -0.3332 Soluble
225 V L 0.3132 Aggregation-prone
226 T L -0.4230 Soluble
227 K L -1.0107 Soluble
228 S L -0.7034 Soluble
229 F L 0.0000 Buried
230 N L -1.6030 Soluble
231 R L -2.2422 Soluble
232 G L -2.0135 Soluble
233 E L -2.0425 Soluble
234 C L -0.5046 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6577 3.1527 CSV PDB
4.5 -0.6941 3.1527 CSV PDB
5.0 -0.7368 3.1527 CSV PDB
5.5 -0.7768 3.1527 CSV PDB
6.0 -0.8034 3.1527 CSV PDB
6.5 -0.808 3.1527 CSV PDB
7.0 -0.7905 3.1527 CSV PDB
7.5 -0.7585 3.1527 CSV PDB
8.0 -0.7188 3.1527 CSV PDB
8.5 -0.6739 3.1527 CSV PDB
9.0 -0.6238 3.1527 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH