Crexavibart / 7k90

A4DAB075_7k90_O_P | Source PDB: 7k90 | Chains: O, P | Done
99.59
Yes
10 Å
Yes
Avg A4D Score
-0.5174
Max Score
1.7317
Min Score
-2.8109
Total Score
-122.62
Score CDR
-0.2817
Score non-CDR
-0.6009

Calculation Parameters

Chain Sequence(s) VQLVESGGGLIQPGGSLRLSCAASGFTVSNNYMSWVRQAPGKGLEWVSVIYSGGSTYYADSVKGRFTISRDKSKNTLYLQMNRLRAEDTAVYYCAREGEVEGYNDFWSGYSRDRYYFDYWGQGTLVTVSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSSTRVFGTGTKVTVL input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.8109
Maximum Score 1.7317
Average Score -0.5174
Total Score -122.6219

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V O 1.1826 Aggregation-prone
3 Q O -0.1794 Soluble
4 L O 0.0000 Buried
5 V O 0.3919 Aggregation-prone
6 E O 0.0000 Buried
7 S O -0.4635 Soluble
8 G O -0.8674 Soluble
9 G O 0.0108 Aggregation-prone
11 G O 0.8846 Aggregation-prone
12 L O 1.4731 Aggregation-prone
13 I O 0.1081 Aggregation-prone
14 Q O -1.3512 Soluble
15 P O -1.9003 Soluble
16 G O -1.7650 Soluble
17 G O -1.3657 Soluble
18 S O -1.5397 Soluble
19 L O -1.4189 Soluble
20 R O -2.3163 Soluble
21 L O 0.0000 Buried
22 S O -0.5981 Soluble
23 C O 0.0000 Buried
24 A O -0.3760 Soluble
25 A O 0.0000 Buried
26 S O -0.2527 Soluble
27 G O -0.2026 Soluble
28 F O 0.0000 Buried
29 T O -1.1255 Soluble
30 V O 0.0000 Buried
35 S O -1.2255 Soluble
36 N O -1.4689 Soluble
37 N O 0.0000 Buried
38 Y O -0.5457 Soluble
39 M O 0.0000 Buried
40 S O 0.0000 Buried
41 W O 0.0000 Buried
42 V O 0.0000 Buried
43 R O 0.0000 Buried
44 Q O -0.8063 Soluble
45 A O -1.1496 Soluble
46 P O -0.8672 Soluble
47 G O -1.5005 Soluble
48 K O -2.2327 Soluble
49 G O -1.4152 Soluble
50 L O 0.0000 Buried
51 E O -1.2066 Soluble
52 W O 0.0000 Buried
53 V O 0.0000 Buried
54 S O 0.0000 Buried
55 V O 0.0000 Buried
56 I O 0.0000 Buried
57 Y O -0.1174 Soluble
58 S O -0.6484 Soluble
59 G O -0.8356 Soluble
63 G O -0.6106 Soluble
64 S O -0.1203 Soluble
65 T O 0.1849 Aggregation-prone
66 Y O 0.3300 Aggregation-prone
67 Y O -0.5166 Soluble
68 A O 0.0000 Buried
69 D O -2.3989 Soluble
70 S O -1.8287 Soluble
71 V O 0.0000 Buried
72 K O -2.5053 Soluble
74 G O -1.9598 Soluble
75 R O -2.1658 Soluble
76 F O 0.0000 Buried
77 T O -0.8858 Soluble
78 I O 0.0000 Buried
79 S O -0.8848 Soluble
80 R O -1.4386 Soluble
81 D O -2.2379 Soluble
82 K O -2.8109 Soluble
83 S O -2.1767 Soluble
84 K O -2.6819 Soluble
85 N O -2.1438 Soluble
86 T O 0.0000 Buried
87 L O 0.0000 Buried
88 Y O -0.8438 Soluble
89 L O 0.0000 Buried
90 Q O -1.6626 Soluble
91 M O 0.0000 Buried
92 N O -2.1770 Soluble
93 R O -2.7460 Soluble
94 L O 0.0000 Buried
95 R O -2.6458 Soluble
96 A O -1.7292 Soluble
97 E O -2.2568 Soluble
98 D O 0.0000 Buried
99 T O -0.4409 Soluble
100 A O 0.0000 Buried
101 V O 0.5273 Aggregation-prone
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 R O 0.0000 Buried
107 E O 0.0000 Buried
108 G O 0.0000 Buried
109 E O -1.4035 Soluble
110 V O -0.8878 Soluble
111 E O -0.5286 Soluble
111A G O -0.6233 Soluble
111B Y O 0.0932 Aggregation-prone
111C N O -0.2580 Soluble
111D D O 0.0226 Aggregation-prone
111E F O 1.7317 Aggregation-prone
111F W O 1.4858 Aggregation-prone
112F S O 0.5173 Aggregation-prone
112E G O 0.1385 Aggregation-prone
112D Y O 0.0833 Aggregation-prone
112C S O -0.7823 Soluble
112B R O -2.0261 Soluble
112A D O -1.5268 Soluble
112 R O -1.1069 Soluble
113 Y O -0.6548 Soluble
114 Y O 0.0000 Buried
115 F O 0.0000 Buried
116 D O 0.0000 Buried
117 Y O 1.0622 Aggregation-prone
118 W O 0.0000 Buried
119 G O 0.0000 Buried
120 Q O -1.2695 Soluble
121 G O -0.4132 Soluble
122 T O 0.3278 Aggregation-prone
123 L O 1.3667 Aggregation-prone
124 V O 0.0000 Buried
125 T O 0.2480 Aggregation-prone
126 V O 0.0000 Buried
127 S O -0.7208 Soluble
3 A P -0.0234 Soluble
4 L P 0.0000 Buried
5 T P -0.1461 Soluble
6 Q P 0.0000 Buried
7 P P -0.2559 Soluble
8 A P -0.3121 Soluble
9 S P -0.5118 Soluble
11 V P -0.1375 Soluble
12 S P -0.0507 Soluble
13 G P 0.0537 Aggregation-prone
14 S P -0.0723 Soluble
15 P P -0.6645 Soluble
16 G P -1.3890 Soluble
17 Q P -1.6791 Soluble
18 S P -0.9348 Soluble
19 I P -0.2687 Soluble
20 T P -0.0544 Soluble
21 I P 0.0000 Buried
22 S P -0.2848 Soluble
23 C P 0.0000 Buried
24 T P -0.4995 Soluble
25 G P -0.4307 Soluble
26 T P -0.5746 Soluble
27 S P -0.7114 Soluble
28 S P -0.3926 Soluble
29 D P 0.0000 Buried
30 V P 0.0000 Buried
31 G P -1.0717 Soluble
35 G P -0.6284 Soluble
36 Y P -0.0488 Soluble
37 N P -0.8216 Soluble
38 Y P -0.3348 Soluble
39 V P 0.0000 Buried
40 S P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 Q P 0.0000 Buried
45 H P -1.7505 Soluble
46 P P -1.3308 Soluble
47 G P -1.5908 Soluble
48 K P -2.4199 Soluble
49 A P -1.3794 Soluble
50 P P 0.0000 Buried
51 K P -1.1458 Soluble
52 L P 0.0000 Buried
53 M P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P 0.0000 Buried
56 D P -0.9994 Soluble
57 V P 0.0000 Buried
65 S P -0.9650 Soluble
66 N P -1.0692 Soluble
67 R P -1.0184 Soluble
68 P P 0.0000 Buried
69 S P -0.5167 Soluble
70 G P -0.6718 Soluble
71 V P -0.5237 Soluble
72 S P -0.9216 Soluble
74 N P -1.6508 Soluble
75 R P -1.2006 Soluble
76 F P 0.0000 Buried
77 S P -0.7803 Soluble
78 G P -0.6225 Soluble
79 S P -0.7931 Soluble
80 K P -1.1240 Soluble
83 S P -0.8819 Soluble
84 G P -1.0926 Soluble
85 N P -1.0963 Soluble
86 T P -0.8045 Soluble
87 A P 0.0000 Buried
88 S P -0.4344 Soluble
89 L P 0.0000 Buried
90 T P -0.2444 Soluble
91 I P 0.0000 Buried
92 S P -1.0421 Soluble
93 G P -1.1363 Soluble
94 L P 0.0000 Buried
95 Q P -1.6225 Soluble
96 A P -1.2949 Soluble
97 E P -2.4451 Soluble
98 D P 0.0000 Buried
99 E P -2.1217 Soluble
100 A P 0.0000 Buried
101 D P -1.0590 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 S P 0.0000 Buried
106 S P 0.0000 Buried
107 Y P 0.1124 Aggregation-prone
108 T P 0.0000 Buried
109 S P -0.0600 Soluble
113 S P -0.1465 Soluble
114 S P 0.0000 Buried
115 T P -0.1054 Soluble
116 R P 0.0000 Buried
117 V P 0.0850 Aggregation-prone
118 F P 0.0000 Buried
119 G P 0.0000 Buried
120 T P -0.6301 Soluble
121 G P 0.0000 Buried
122 T P 0.0000 Buried
123 K P -1.3224 Soluble
124 V P 0.0000 Buried
125 T P -0.2648 Soluble
126 V P 0.0443 Aggregation-prone
127 L P 1.3027 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.541 5.4493 CSV PDB
4.5 -0.5685 5.366 CSV PDB
5.0 -0.5996 5.2736 CSV PDB
5.5 -0.6283 5.1782 CSV PDB
6.0 -0.6477 5.083 CSV PDB
6.5 -0.6522 4.9898 CSV PDB
7.0 -0.6425 4.8996 CSV PDB
7.5 -0.6239 4.8128 CSV PDB
8.0 -0.6006 4.7319 CSV PDB
8.5 -0.5735 4.6642 CSV PDB
9.0 -0.543 4.6187 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH