Elipovimab / 4fqc

A4DAB100_4fqc_H_L | Source PDB: 4fqc | Chains: H, L | Done
96.61
Yes
10 Å
Yes
Avg A4D Score
-0.6352
Max Score
3.0608
Min Score
-3.1777
Total Score
-274.43
Score CDR
-0.2187
Score non-CDR
-0.7051

Calculation Parameters

Chain Sequence(s) QMQLQESGPGLVKPSETLSLTCSVSGASISDSYWSWIRRSPGKGLEWIGYVHKSGDTNYSPSLKSRVNLSLDTSKNQVSLSLVAATAADSGKYYCARTLHGRRIYGIVAFNEWFTYFYMDVWGNGTQVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPISVAPGETARISCGEKSLGSRAVQWYQHRAGQAPSLIIYNNQDRPSGIPERFSGSPDSPFGTTATLTITSVEAGDEADYYCHIWDSRVPTKWVFGGGTTLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAP input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1777
Maximum Score 3.0608
Average Score -0.6352
Total Score -274.4273

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.4939 Soluble
2 M H -1.2501 Soluble
3 Q H -1.8087 Soluble
4 L H 0.0000 Buried
5 Q H -1.2412 Soluble
6 E H 0.0000 Buried
7 S H -0.7853 Soluble
8 G H -0.5883 Soluble
9 P H -0.3724 Soluble
11 G H -0.0736 Soluble
12 L H 0.8508 Aggregation-prone
13 V H 0.0000 Buried
14 K H -1.0832 Soluble
15 P H -0.8948 Soluble
16 S H -0.6985 Soluble
17 E H -0.7931 Soluble
18 T H -0.2497 Soluble
19 L H 0.0000 Buried
20 S H -0.2942 Soluble
21 L H 0.0000 Buried
22 T H -0.4886 Soluble
23 C H 0.0000 Buried
24 S H -1.1844 Soluble
25 V H 0.0000 Buried
26 S H -1.1931 Soluble
27 G H -1.1197 Soluble
28 A H -1.0244 Soluble
29 S H -1.0734 Soluble
30 I H 0.0000 Buried
35 S H -1.5405 Soluble
36 D H -2.1004 Soluble
37 S H 0.0000 Buried
38 Y H -0.7423 Soluble
39 W H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H 0.0000 Buried
44 R H -1.2744 Soluble
45 S H -1.4040 Soluble
46 P H -1.5552 Soluble
47 G H -1.8671 Soluble
48 K H -2.3692 Soluble
49 G H -1.3777 Soluble
50 L H 0.0000 Buried
51 E H -0.4890 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 Y H -0.2934 Soluble
56 V H 0.0000 Buried
57 H H -1.6412 Soluble
58 K H -2.5044 Soluble
59 S H -1.5836 Soluble
63 G H -1.6535 Soluble
64 D H -1.6299 Soluble
65 T H -1.0544 Soluble
66 N H -1.0438 Soluble
67 Y H -0.9693 Soluble
68 S H 0.0000 Buried
69 P H -0.9652 Soluble
70 S H -0.8640 Soluble
71 L H 0.0000 Buried
72 K H -2.3031 Soluble
74 S H -1.3160 Soluble
75 R H -0.9397 Soluble
76 V H 0.0000 Buried
77 N H -1.6082 Soluble
78 L H 0.0000 Buried
79 S H -0.8572 Soluble
80 L H -1.0156 Soluble
81 D H -1.9099 Soluble
82 T H -1.5297 Soluble
83 S H -1.4830 Soluble
84 K H -2.3817 Soluble
85 N H -1.7300 Soluble
86 Q H -1.5774 Soluble
87 V H 0.0000 Buried
88 S H -0.6400 Soluble
89 L H 0.0000 Buried
90 S H -0.4150 Soluble
91 L H 0.0000 Buried
92 V H 0.5019 Aggregation-prone
93 A H -0.0112 Soluble
94 A H 0.0000 Buried
95 T H -0.2723 Soluble
96 A H -0.2084 Soluble
97 A H -0.2997 Soluble
98 D H 0.0000 Buried
99 S H 0.0000 Buried
100 G H -1.1604 Soluble
101 K H -1.3582 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.4279 Soluble
107 T H 0.0000 Buried
108 L H -0.0175 Soluble
109 H H -0.8760 Soluble
110 G H -0.9069 Soluble
111 R H -1.1122 Soluble
111A R H -0.2930 Soluble
111B I H 1.3805 Aggregation-prone
111C Y H 1.2453 Aggregation-prone
111D G H 1.7044 Aggregation-prone
111E I H 3.0608 Aggregation-prone
111F V H 2.5472 Aggregation-prone
112G A H 1.6690 Aggregation-prone
112F F H 2.1746 Aggregation-prone
112E N H 0.5139 Aggregation-prone
112D E H 0.9206 Aggregation-prone
112C W H 0.8698 Aggregation-prone
112B F H -0.0004 Soluble
112A T H -0.4885 Soluble
112 Y H 0.0000 Buried
113 F H 0.0000 Buried
114 Y H -0.0482 Soluble
115 M H 0.0000 Buried
116 D H -0.2944 Soluble
117 V H -0.3846 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 N H -1.7337 Soluble
121 G H -1.3199 Soluble
122 T H -1.1886 Soluble
123 Q H -1.6547 Soluble
124 V H 0.0000 Buried
125 T H -0.3350 Soluble
126 V H 0.0000 Buried
127 S H 0.0000 Buried
128 S H -0.4588 Soluble
129 A H -0.3813 Soluble
130 S H -0.6198 Soluble
131 T H -0.9577 Soluble
132 K H -1.7605 Soluble
133 G H -1.7979 Soluble
134 P H 0.0000 Buried
135 S H -0.3664 Soluble
136 V H 0.0000 Buried
137 F H -0.6072 Soluble
138 P H -1.0455 Soluble
139 L H 0.0000 Buried
140 A H -0.6834 Soluble
141 P H -0.5553 Soluble
142 S H -0.6317 Soluble
143 G H -0.9213 Soluble
144 G H -0.8865 Soluble
145 T H -0.5839 Soluble
146 A H -0.3411 Soluble
147 A H -0.1464 Soluble
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H -0.3123 Soluble
154 D H -0.6144 Soluble
155 Y H 0.0000 Buried
156 F H -0.6223 Soluble
157 P H -0.9258 Soluble
158 E H -1.0445 Soluble
159 P H -1.1221 Soluble
160 V H -0.8279 Soluble
161 T H -0.9157 Soluble
162 V H -0.3461 Soluble
163 S H -0.5160 Soluble
164 W H 0.0000 Buried
165 N H -0.8451 Soluble
166 S H -0.6872 Soluble
167 G H -0.6798 Soluble
168 A H -0.3581 Soluble
169 L H 0.0000 Buried
170 T H -0.3572 Soluble
171 S H -0.4173 Soluble
172 G H -0.4598 Soluble
173 V H -0.0091 Soluble
174 H H -0.2612 Soluble
175 T H -0.1225 Soluble
176 F H 0.0000 Buried
177 P H -0.1400 Soluble
178 A H -0.0855 Soluble
179 V H 0.0000 Buried
180 L H 0.2647 Aggregation-prone
181 Q H -0.0933 Soluble
182 S H -0.2357 Soluble
183 S H -0.2136 Soluble
184 G H 0.0000 Buried
185 L H -0.2279 Soluble
186 Y H -0.0736 Soluble
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.2837 Soluble
194 V H 0.0000 Buried
195 P H -0.5407 Soluble
196 S H -0.6001 Soluble
197 S H -0.6183 Soluble
198 S H -0.4034 Soluble
199 L H -0.5669 Soluble
200 G H -0.8042 Soluble
201 T H -0.5332 Soluble
202 Q H -0.7033 Soluble
203 T H -0.9448 Soluble
204 Y H 0.0000 Buried
205 I H -1.2991 Soluble
206 C H 0.0000 Buried
207 N H -1.6309 Soluble
208 V H 0.0000 Buried
209 N H -2.6798 Soluble
210 H H 0.0000 Buried
211 K H -3.0135 Soluble
212 P H -1.9039 Soluble
213 S H -2.0857 Soluble
214 N H -2.8358 Soluble
215 T H -2.4030 Soluble
216 K H -2.9246 Soluble
217 V H -1.6495 Soluble
218 D H -2.2608 Soluble
219 K H -2.0445 Soluble
220 R H -2.5836 Soluble
221 V H 0.0000 Buried
222 E H -2.3853 Soluble
223 P H -1.1709 Soluble
11 I L 1.4831 Aggregation-prone
12 S L 0.7017 Aggregation-prone
13 V L 0.0000 Buried
14 A L -0.9787 Soluble
15 P L -1.6215 Soluble
16 G L -1.9879 Soluble
17 E L -2.4351 Soluble
18 T L -1.8280 Soluble
19 A L 0.0000 Buried
20 R L -1.6433 Soluble
21 I L 0.0000 Buried
22 S L -0.9848 Soluble
23 C L 0.0000 Buried
24 G L -1.5653 Soluble
25 E L -2.3623 Soluble
26 K L -1.9866 Soluble
27 S L 0.0000 Buried
28 L L 0.2516 Aggregation-prone
29 G L 0.0000 Buried
36 S L 0.0000 Buried
37 R L 0.0000 Buried
38 A L 0.0000 Buried
39 V L 0.0000 Buried
40 Q L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 H L -1.1856 Soluble
45 R L -1.8691 Soluble
46 A L -1.2046 Soluble
47 G L -1.4914 Soluble
48 Q L -2.0381 Soluble
49 A L -1.2415 Soluble
50 P L 0.0000 Buried
51 S L -0.4212 Soluble
52 L L 0.0000 Buried
53 I L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.6284 Soluble
56 N L -1.0995 Soluble
57 N L 0.0000 Buried
65 Q L -1.4337 Soluble
66 D L -1.7288 Soluble
67 R L -1.4637 Soluble
68 P L -0.6385 Soluble
69 S L -0.6276 Soluble
70 G L -0.7256 Soluble
71 I L -0.7431 Soluble
72 P L -1.2412 Soluble
74 E L -2.2821 Soluble
75 R L -1.4285 Soluble
76 F L 0.0000 Buried
77 S L -1.2654 Soluble
78 G L 0.0000 Buried
79 S L -0.5952 Soluble
80 P L -0.5758 Soluble
81 D L -0.1390 Soluble
82 S L 0.0804 Aggregation-prone
82A P L 0.5219 Aggregation-prone
83 F L 1.5516 Aggregation-prone
84 G L 0.0674 Aggregation-prone
85 T L -0.3898 Soluble
86 T L -1.0509 Soluble
87 A L 0.0000 Buried
88 T L -0.6268 Soluble
89 L L 0.0000 Buried
90 T L -0.9001 Soluble
91 I L 0.0000 Buried
92 T L -1.6359 Soluble
93 S L -1.6750 Soluble
94 V L 0.0000 Buried
95 E L -2.4535 Soluble
96 A L -1.2374 Soluble
97 G L -1.1743 Soluble
98 D L 0.0000 Buried
99 E L -1.1392 Soluble
100 A L 0.0000 Buried
101 D L -0.9061 Soluble
102 Y L 0.0000 Buried
103 Y L -0.2922 Soluble
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 I L -0.1394 Soluble
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.5444 Soluble
110 R L -1.4769 Soluble
112 V L -0.5098 Soluble
113 P L -0.6643 Soluble
114 T L -0.5608 Soluble
115 K L -0.6140 Soluble
116 W L -0.1774 Soluble
117 V L -0.1577 Soluble
118 F L 0.0000 Buried
119 G L -0.6027 Soluble
120 G L -0.8540 Soluble
121 G L -0.5593 Soluble
122 T L -0.0451 Soluble
123 T L -0.1359 Soluble
124 L L 0.0000 Buried
125 T L -0.0990 Soluble
126 V L 0.0000 Buried
127 L L -0.2452 Soluble
128 G L -0.7920 Soluble
129 Q L -0.8421 Soluble
130 P L -0.9006 Soluble
131 K L -1.3192 Soluble
132 A L -0.7391 Soluble
133 A L -0.4017 Soluble
134 P L 0.0000 Buried
135 S L -0.5808 Soluble
136 V L 0.0000 Buried
137 T L -0.4861 Soluble
138 L L 0.0000 Buried
139 F L 0.0000 Buried
140 P L -0.1294 Soluble
141 P L -0.5603 Soluble
142 S L -0.9186 Soluble
143 S L -1.4826 Soluble
144 E L -2.2840 Soluble
145 E L 0.0000 Buried
146 L L -2.0837 Soluble
147 Q L -2.3375 Soluble
148 A L -1.9281 Soluble
149 N L -2.7521 Soluble
150 K L -2.7369 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.7846 Soluble
159 D L -1.5724 Soluble
160 F L 0.0000 Buried
161 Y L -0.5636 Soluble
162 P L -0.5849 Soluble
163 G L -0.6536 Soluble
164 A L 0.0213 Aggregation-prone
165 V L 0.2694 Aggregation-prone
166 T L 0.0908 Aggregation-prone
167 V L 0.0653 Aggregation-prone
168 A L -0.4497 Soluble
169 W L 0.0000 Buried
170 K L -0.8345 Soluble
171 A L 0.0000 Buried
172 D L -1.2878 Soluble
173 S L -0.8744 Soluble
174 S L -0.7474 Soluble
175 P L -0.8116 Soluble
176 V L -0.7588 Soluble
177 K L -1.9145 Soluble
178 A L -0.8738 Soluble
179 G L -0.5975 Soluble
180 V L -0.3202 Soluble
181 E L -0.3765 Soluble
182 T L -0.0468 Soluble
183 T L -0.1075 Soluble
184 T L -0.3402 Soluble
185 P L -0.5173 Soluble
186 S L -1.2247 Soluble
187 K L -2.5340 Soluble
188 Q L -2.1787 Soluble
189 S L -1.6160 Soluble
190 N L -2.2395 Soluble
191 N L -2.6117 Soluble
192 K L -2.2422 Soluble
193 Y L -1.3992 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.4938 Soluble
201 L L 0.0000 Buried
202 T L -1.8753 Soluble
203 P L -2.5277 Soluble
204 E L -3.1777 Soluble
205 Q L -2.4731 Soluble
206 W L 0.0000 Buried
207 K L -3.1464 Soluble
208 S L -2.4495 Soluble
209 H L -2.4032 Soluble
210 R L -2.5811 Soluble
211 S L -1.5883 Soluble
212 Y L 0.0000 Buried
213 S L 0.0000 Buried
214 C L 0.0000 Buried
215 Q L -1.0272 Soluble
216 V L 0.0000 Buried
217 T L -0.3376 Soluble
218 H L 0.0000 Buried
219 E L -0.6013 Soluble
220 G L -0.2372 Soluble
221 S L -0.3632 Soluble
222 T L -0.5104 Soluble
223 V L -0.7446 Soluble
224 E L -2.1461 Soluble
225 K L -1.7499 Soluble
226 T L -0.9526 Soluble
227 V L -0.3294 Soluble
228 A L -0.8313 Soluble
229 P L -1.1623 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5077 5.3953 CSV PDB
4.5 -0.5413 5.3595 CSV PDB
5.0 -0.5803 5.3114 CSV PDB
5.5 -0.6156 5.259 CSV PDB
6.0 -0.6369 5.2104 CSV PDB
6.5 -0.6355 5.1737 CSV PDB
7.0 -0.6122 5.1531 CSV PDB
7.5 -0.5755 5.1443 CSV PDB
8.0 -0.532 5.1412 CSV PDB
8.5 -0.4842 5.1402 CSV PDB
9.0 -0.4328 5.1399 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH