Crexavibart / 7k90

A4DAB075_7k90_H_L | Source PDB: 7k90 | Chains: H, L | Done
99.59
Yes
10 Å
Yes
Avg A4D Score
-0.5117
Max Score
1.671
Min Score
-2.8048
Total Score
-121.28
Score CDR
-0.2504
Score non-CDR
-0.6043

Calculation Parameters

Chain Sequence(s) VQLVESGGGLIQPGGSLRLSCAASGFTVSNNYMSWVRQAPGKGLEWVSVIYSGGSTYYADSVKGRFTISRDKSKNTLYLQMNRLRAEDTAVYYCAREGEVEGYNDFWSGYSRDRYYFDYWGQGTLVTVSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSSTRVFGTGTKVTVL input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.8048
Maximum Score 1.671
Average Score -0.5117
Total Score -121.2789

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 1.1834 Aggregation-prone
3 Q H -0.1781 Soluble
4 L H 0.0000 Buried
5 V H 0.3976 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.4640 Soluble
8 G H -0.8703 Soluble
9 G H 0.0084 Aggregation-prone
11 G H 0.8833 Aggregation-prone
12 L H 1.4724 Aggregation-prone
13 I H 0.1083 Aggregation-prone
14 Q H -1.3511 Soluble
15 P H -1.9007 Soluble
16 G H -1.7653 Soluble
17 G H -1.3695 Soluble
18 S H -1.5437 Soluble
19 L H -1.4211 Soluble
20 R H -2.3169 Soluble
21 L H 0.0000 Buried
22 S H -0.5978 Soluble
23 C H 0.0000 Buried
24 A H -0.3705 Soluble
25 A H 0.0000 Buried
26 S H -0.2484 Soluble
27 G H -0.1999 Soluble
28 F H 0.0000 Buried
29 T H -1.1312 Soluble
30 V H 0.0000 Buried
35 S H -1.2411 Soluble
36 N H -1.5229 Soluble
37 N H 0.0000 Buried
38 Y H 0.0000 Buried
39 M H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.8177 Soluble
45 A H -1.1579 Soluble
46 P H -0.8719 Soluble
47 G H -1.5070 Soluble
48 K H -2.2465 Soluble
49 G H -1.4469 Soluble
50 L H 0.0000 Buried
51 E H -1.2394 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 V H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H -0.1721 Soluble
58 S H -0.6633 Soluble
59 G H -0.8409 Soluble
63 G H -0.6056 Soluble
64 S H -0.1377 Soluble
65 T H 0.1751 Aggregation-prone
66 Y H 0.3091 Aggregation-prone
67 Y H -0.5257 Soluble
68 A H 0.0000 Buried
69 D H -2.4022 Soluble
70 S H -1.8286 Soluble
71 V H 0.0000 Buried
72 K H -2.5071 Soluble
74 G H -1.9608 Soluble
75 R H -2.1683 Soluble
76 F H 0.0000 Buried
77 T H -0.8883 Soluble
78 I H 0.0000 Buried
79 S H -0.8847 Soluble
80 R H -1.4367 Soluble
81 D H -2.2322 Soluble
82 K H -2.8048 Soluble
83 S H -2.1720 Soluble
84 K H -2.6754 Soluble
85 N H -2.1312 Soluble
86 T H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H -0.8429 Soluble
89 L H 0.0000 Buried
90 Q H -1.6617 Soluble
91 M H 0.0000 Buried
92 N H -2.1861 Soluble
93 R H -2.7503 Soluble
94 L H 0.0000 Buried
95 R H -2.6466 Soluble
96 A H -1.7287 Soluble
97 E H -2.2568 Soluble
98 D H 0.0000 Buried
99 T H -0.4417 Soluble
100 A H 0.0000 Buried
101 V H 0.5275 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 E H 0.0000 Buried
108 G H 0.0000 Buried
109 E H -1.3526 Soluble
110 V H -0.8313 Soluble
111 E H -0.7940 Soluble
111A G H -0.8517 Soluble
111B Y H -0.2598 Soluble
111C N H -0.8238 Soluble
111D D H -0.3155 Soluble
111E F H 1.6710 Aggregation-prone
111F W H 1.5278 Aggregation-prone
112F S H 0.3863 Aggregation-prone
112E G H 0.2454 Aggregation-prone
112D Y H 0.5302 Aggregation-prone
112C S H -0.2345 Soluble
112B R H -0.8589 Soluble
112A D H -0.8481 Soluble
112 R H 0.0000 Buried
113 Y H -0.4142 Soluble
114 Y H 0.0000 Buried
115 F H 0.0000 Buried
116 D H 0.0000 Buried
117 Y H 1.0704 Aggregation-prone
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.2452 Soluble
121 G H -0.3521 Soluble
122 T H 0.3264 Aggregation-prone
123 L H 1.3613 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.2470 Aggregation-prone
126 V H 0.0000 Buried
127 S H -0.7204 Soluble
3 A L 0.0637 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.1457 Soluble
6 Q L 0.0000 Buried
7 P L -0.2640 Soluble
8 A L -0.3076 Soluble
9 S L -0.5279 Soluble
11 V L -0.1964 Soluble
12 S L -0.0981 Soluble
13 G L 0.0059 Aggregation-prone
14 S L -0.0947 Soluble
15 P L -0.6625 Soluble
16 G L -1.4065 Soluble
17 Q L -1.7192 Soluble
18 S L -1.0285 Soluble
19 I L 0.0000 Buried
20 T L -0.1471 Soluble
21 I L 0.0000 Buried
22 S L -0.2628 Soluble
23 C L 0.0000 Buried
24 T L -0.4889 Soluble
25 G L -0.4418 Soluble
26 T L -0.5841 Soluble
27 S L -0.7198 Soluble
28 S L -0.4091 Soluble
29 D L 0.0000 Buried
30 V L 0.0000 Buried
31 G L -1.1015 Soluble
35 G L -0.6747 Soluble
36 Y L -0.1372 Soluble
37 N L -1.0304 Soluble
38 Y L -0.4088 Soluble
39 V L 0.0000 Buried
40 S L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 H L -1.7512 Soluble
46 P L -1.3305 Soluble
47 G L -1.5777 Soluble
48 K L -2.4056 Soluble
49 A L -1.3578 Soluble
50 P L 0.0000 Buried
51 K L -1.1617 Soluble
52 L L 0.0000 Buried
53 M L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.0000 Buried
56 D L -1.1150 Soluble
57 V L 0.0000 Buried
65 S L -1.1419 Soluble
66 N L -1.4163 Soluble
67 R L -1.1641 Soluble
68 P L 0.0000 Buried
69 S L -0.5509 Soluble
70 G L -0.6690 Soluble
71 V L -0.5187 Soluble
72 S L -0.9166 Soluble
74 N L -1.6482 Soluble
75 R L -1.1996 Soluble
76 F L 0.0000 Buried
77 S L -0.8373 Soluble
78 G L -0.6611 Soluble
79 S L -0.7880 Soluble
80 K L -1.0593 Soluble
83 S L -0.8367 Soluble
84 G L -1.0682 Soluble
85 N L -1.0853 Soluble
86 T L -0.7760 Soluble
87 A L 0.0000 Buried
88 S L -0.3928 Soluble
89 L L 0.0000 Buried
90 T L -0.2949 Soluble
91 I L 0.0000 Buried
92 S L -1.0893 Soluble
93 G L -1.1625 Soluble
94 L L 0.0000 Buried
95 Q L -1.6154 Soluble
96 A L -1.2927 Soluble
97 E L -2.4447 Soluble
98 D L 0.0000 Buried
99 E L -2.1277 Soluble
100 A L 0.0000 Buried
101 D L -1.0645 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 S L 0.0000 Buried
106 S L 0.0000 Buried
107 Y L 0.0374 Aggregation-prone
108 T L 0.0000 Buried
109 S L -0.0793 Soluble
113 S L -0.1648 Soluble
114 S L 0.0000 Buried
115 T L -0.1300 Soluble
116 R L 0.0000 Buried
117 V L 0.0448 Aggregation-prone
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 T L -0.6061 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.3370 Soluble
124 V L 0.0000 Buried
125 T L -0.2744 Soluble
126 V L 0.0398 Aggregation-prone
127 L L 1.3030 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4988 5.4133 CSV PDB
4.5 -0.5271 5.2878 CSV PDB
5.0 -0.5592 5.1535 CSV PDB
5.5 -0.5893 5.0157 CSV PDB
6.0 -0.6103 4.8788 CSV PDB
6.5 -0.6165 4.7473 CSV PDB
7.0 -0.6081 4.6258 CSV PDB
7.5 -0.5902 4.5187 CSV PDB
8.0 -0.5668 4.4343 CSV PDB
8.5 -0.5392 4.3816 CSV PDB
9.0 -0.5081 4.3568 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH