Apitegromab / 6umx

A4DAB023_6umx_H_L | Source PDB: 6umx | Chains: H, L | Done
95.75
Yes
10 Å
Yes
Avg A4D Score
-0.6688
Max Score
2.9681
Min Score
-3.2159
Total Score
-294.29
Score CDR
-0.1479
Score non-CDR
-0.7448

Calculation Parameters

Chain Sequence(s) IQLVQSGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYDGSRKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDLLVRFLYWSHYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKQPVLTQPPSASGTPGQRVTISCSGSSSNIGSNPVHWYQQLPGTAPKLLIYDDNQRPSGVPDRFSGSKSGTSASLVISGLQSDDEADYYCAAWDDSLNSVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.2159
Maximum Score 2.9681
Average Score -0.6688
Total Score -294.292

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 I H 1.3575 Aggregation-prone
3 Q H -0.1315 Soluble
4 L H 0.0000 Buried
5 V H 0.6566 Aggregation-prone
6 Q H 0.0000 Buried
7 S H -0.5834 Soluble
8 G H -1.1038 Soluble
9 G H -0.4763 Soluble
11 G H 0.2518 Aggregation-prone
12 V H 1.3580 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.7976 Soluble
15 P H -2.0319 Soluble
16 G H -2.1739 Soluble
17 R H -2.7946 Soluble
18 S H -2.0638 Soluble
19 L H -1.2799 Soluble
20 R H -2.1380 Soluble
21 L H 0.0000 Buried
22 S H -0.5071 Soluble
23 C H 0.0000 Buried
24 A H -0.3360 Soluble
25 A H 0.0000 Buried
26 S H -0.0436 Soluble
27 G H 0.1859 Aggregation-prone
28 F H 0.2333 Aggregation-prone
29 T H 0.0497 Aggregation-prone
30 F H 0.0000 Buried
35 S H -0.6649 Soluble
36 S H 0.1784 Aggregation-prone
37 Y H 0.2885 Aggregation-prone
38 G H 0.0000 Buried
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.8195 Soluble
45 A H -1.2095 Soluble
46 P H -0.9811 Soluble
47 G H -1.4693 Soluble
48 K H -2.2567 Soluble
49 G H -1.5064 Soluble
50 L H 0.0000 Buried
51 E H -0.7272 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 A H 0.0000 Buried
55 V H 0.0000 Buried
56 I H 0.0000 Buried
57 S H -1.3271 Soluble
58 Y H -0.7045 Soluble
59 D H -2.0704 Soluble
62 G H -1.7762 Soluble
63 S H -1.7450 Soluble
64 R H -2.4885 Soluble
65 K H -1.4875 Soluble
66 Y H -0.7833 Soluble
67 Y H -0.8549 Soluble
68 A H 0.0000 Buried
69 D H -2.7632 Soluble
70 S H -1.9613 Soluble
71 V H 0.0000 Buried
72 K H -2.6205 Soluble
74 G H -1.7879 Soluble
75 R H -1.5155 Soluble
76 F H 0.0000 Buried
77 T H -0.9147 Soluble
78 I H 0.0000 Buried
79 S H -0.9087 Soluble
80 R H -1.2122 Soluble
81 D H -1.8485 Soluble
82 N H -1.8962 Soluble
83 S H -1.6327 Soluble
84 K H -2.3462 Soluble
85 N H -1.6837 Soluble
86 T H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H -0.5609 Soluble
89 L H 0.0000 Buried
90 Q H -1.2330 Soluble
91 M H 0.0000 Buried
92 N H -1.8374 Soluble
93 S H -1.7478 Soluble
94 L H 0.0000 Buried
95 R H -2.4425 Soluble
96 A H -1.7515 Soluble
97 E H -2.2043 Soluble
98 D H 0.0000 Buried
99 T H -0.6317 Soluble
100 A H 0.0000 Buried
101 V H -0.0090 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 D H 0.0000 Buried
108 L H 0.2493 Aggregation-prone
109 L H 1.2277 Aggregation-prone
110 V H 1.5363 Aggregation-prone
111 R H 1.2974 Aggregation-prone
111A F H 2.8408 Aggregation-prone
111B L H 2.9681 Aggregation-prone
111C Y H 2.8352 Aggregation-prone
112C W H 2.2961 Aggregation-prone
112B S H 0.0000 Buried
112A H H 0.5967 Aggregation-prone
112 Y H 0.0000 Buried
113 Y H 0.3305 Aggregation-prone
114 G H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.6541 Soluble
117 V H -0.1101 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.1513 Soluble
121 G H -0.5640 Soluble
122 T H 0.0000 Buried
123 T H 0.0741 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0475 Aggregation-prone
126 V H 0.0000 Buried
127 S H -0.6746 Soluble
128 S H -0.8761 Soluble
129 A H -0.4833 Soluble
130 S H -0.4590 Soluble
131 T H -0.8525 Soluble
132 K H -1.1421 Soluble
133 G H -1.3358 Soluble
134 P H 0.0000 Buried
135 S H -0.3402 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -0.8456 Soluble
139 L H 0.0000 Buried
140 A H -1.2362 Soluble
141 P H 0.0000 Buried
142 S H -1.3587 Soluble
143 S H -0.9551 Soluble
144 K H -1.4197 Soluble
145 S H -1.0032 Soluble
146 T H -0.7210 Soluble
147 S H -0.8777 Soluble
148 G H -0.8632 Soluble
149 G H -0.9391 Soluble
150 T H -0.7954 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H -0.3769 Soluble
159 D H -0.5918 Soluble
160 Y H 0.0000 Buried
161 F H -0.6655 Soluble
162 P H -1.2263 Soluble
163 E H -1.7110 Soluble
164 P H -1.3288 Soluble
165 V H -0.9937 Soluble
166 T H -0.7360 Soluble
167 V H -0.1614 Soluble
168 S H -0.3688 Soluble
169 W H 0.0000 Buried
170 N H -0.6475 Soluble
171 S H -0.6239 Soluble
172 G H -0.4987 Soluble
173 A H -0.2394 Soluble
174 L H -0.0348 Soluble
175 T H -0.2338 Soluble
176 S H -0.3052 Soluble
177 G H -0.3517 Soluble
178 V H 0.0950 Aggregation-prone
179 H H -0.1771 Soluble
180 T H -0.0251 Soluble
181 F H 0.0000 Buried
182 P H -0.2115 Soluble
183 A H -0.1038 Soluble
184 V H 0.0000 Buried
185 L H 0.3690 Aggregation-prone
186 Q H -0.1818 Soluble
187 S H -0.5697 Soluble
188 S H -0.3198 Soluble
189 G H -0.0789 Soluble
190 L H -0.2818 Soluble
191 Y H -0.1794 Soluble
192 S H 0.0000 Buried
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.2230 Soluble
199 V H 0.0000 Buried
200 P H -0.6070 Soluble
201 S H -0.6070 Soluble
202 S H -0.5911 Soluble
203 S H -0.6414 Soluble
204 L H -0.8142 Soluble
205 G H -1.0570 Soluble
206 T H -0.9721 Soluble
207 Q H -1.4170 Soluble
208 T H -1.1080 Soluble
209 Y H 0.0000 Buried
210 I H -0.8440 Soluble
211 C H 0.0000 Buried
212 N H -1.4392 Soluble
213 V H 0.0000 Buried
214 N H -1.9705 Soluble
215 H H 0.0000 Buried
216 K H -2.8702 Soluble
217 P H -1.7780 Soluble
218 S H -1.8122 Soluble
219 N H -2.5932 Soluble
220 T H -2.0865 Soluble
221 K H -2.7147 Soluble
222 V H -1.5157 Soluble
223 D H -2.4269 Soluble
224 K H -1.7655 Soluble
225 K H -2.0211 Soluble
226 V H 0.0000 Buried
227 E H -2.7483 Soluble
228 P H -1.9631 Soluble
229 K H -2.2916 Soluble
1 Q L -1.2526 Soluble
2 P L -0.1141 Soluble
3 V L 1.1892 Aggregation-prone
4 L L 0.0000 Buried
5 T L 0.0189 Aggregation-prone
6 Q L 0.0000 Buried
7 P L -0.4497 Soluble
8 P L -0.6066 Soluble
9 S L -0.6649 Soluble
11 A L -0.6036 Soluble
12 S L -0.5513 Soluble
13 G L 0.0000 Buried
14 T L -1.2213 Soluble
15 P L -1.7734 Soluble
16 G L -1.9621 Soluble
17 Q L -2.5144 Soluble
18 R L -2.6686 Soluble
19 V L 0.0000 Buried
20 T L -0.3495 Soluble
21 I L 0.0000 Buried
22 S L -0.2636 Soluble
23 C L 0.0000 Buried
24 S L -0.2161 Soluble
25 G L -0.1277 Soluble
26 S L -0.2468 Soluble
27 S L -0.7937 Soluble
28 S L -0.9956 Soluble
29 N L 0.0000 Buried
30 I L 0.0000 Buried
35 G L -0.7465 Soluble
36 S L -0.7179 Soluble
37 N L 0.0000 Buried
38 P L -0.3953 Soluble
39 V L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 L L -0.5700 Soluble
46 P L -0.5027 Soluble
47 G L -0.6257 Soluble
48 T L -0.6357 Soluble
49 A L -0.6145 Soluble
50 P L 0.0000 Buried
51 K L -1.1861 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -1.0130 Soluble
56 D L -1.3803 Soluble
57 D L -1.6664 Soluble
65 N L -2.3371 Soluble
66 Q L -2.3019 Soluble
67 R L -2.0211 Soluble
68 P L -0.8399 Soluble
69 S L -0.6974 Soluble
70 G L -0.8256 Soluble
71 V L -1.0449 Soluble
72 P L -1.3073 Soluble
74 D L -2.3283 Soluble
75 R L -1.4798 Soluble
76 F L 0.0000 Buried
77 S L -1.3086 Soluble
78 G L -1.2968 Soluble
79 S L -1.1695 Soluble
80 K L -1.2265 Soluble
83 S L -0.8027 Soluble
84 G L -0.8863 Soluble
85 T L -0.7350 Soluble
86 S L -0.6862 Soluble
87 A L 0.0000 Buried
88 S L -0.4626 Soluble
89 L L 0.0000 Buried
90 V L -0.1585 Soluble
91 I L 0.0000 Buried
92 S L -1.8160 Soluble
93 G L -1.8932 Soluble
94 L L 0.0000 Buried
95 Q L -2.5950 Soluble
96 S L -2.0632 Soluble
97 D L -2.4889 Soluble
98 D L 0.0000 Buried
99 E L -1.7234 Soluble
100 A L 0.0000 Buried
101 D L -1.0030 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 A L 0.0000 Buried
106 A L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 D L -1.7732 Soluble
113 S L -0.9321 Soluble
114 L L -0.0467 Soluble
115 N L -0.5821 Soluble
116 S L 0.0000 Buried
117 V L 0.0000 Buried
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.7747 Soluble
121 G L -0.9508 Soluble
122 T L 0.0000 Buried
123 K L -0.9748 Soluble
124 L L 0.0000 Buried
125 T L 0.0000 Buried
126 V L 0.0000 Buried
127 L L -0.5678 Soluble
128 G L -0.8037 Soluble
129 Q L -1.1600 Soluble
130 P L -1.2607 Soluble
131 K L -2.1785 Soluble
132 A L -1.2928 Soluble
133 A L -0.7918 Soluble
134 P L 0.0000 Buried
135 S L -0.4177 Soluble
136 V L 0.0000 Buried
137 T L -0.6164 Soluble
138 L L 0.0000 Buried
139 F L 0.0000 Buried
140 P L -0.3405 Soluble
141 P L 0.0000 Buried
142 S L 0.0000 Buried
143 S L -1.6934 Soluble
144 E L -2.2365 Soluble
145 E L 0.0000 Buried
146 L L -2.1646 Soluble
147 Q L -2.3676 Soluble
148 A L -1.9819 Soluble
149 N L -2.8305 Soluble
150 K L -2.9440 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.4881 Soluble
159 D L -1.3723 Soluble
160 F L 0.0000 Buried
161 Y L 0.0000 Buried
162 P L 0.0000 Buried
163 G L -0.6774 Soluble
164 A L -0.2797 Soluble
165 V L -0.0889 Soluble
166 T L -0.0807 Soluble
167 V L -0.0141 Soluble
168 A L -0.5123 Soluble
169 W L 0.0000 Buried
170 K L -1.0016 Soluble
171 A L 0.0000 Buried
172 D L -1.2679 Soluble
173 S L -0.8863 Soluble
174 S L -0.6081 Soluble
175 P L -0.8794 Soluble
176 V L -0.8452 Soluble
177 K L -1.7414 Soluble
178 A L -0.9038 Soluble
179 G L -0.8044 Soluble
180 V L -0.7949 Soluble
181 E L -1.1354 Soluble
182 T L -0.3569 Soluble
183 T L -0.2653 Soluble
184 T L -0.5315 Soluble
185 P L -0.3971 Soluble
186 S L -0.9649 Soluble
187 K L -1.9911 Soluble
188 Q L -1.7581 Soluble
189 S L -1.4865 Soluble
190 N L -2.0341 Soluble
191 N L -2.4432 Soluble
192 K L -2.0367 Soluble
193 Y L -1.1583 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.7866 Soluble
201 L L 0.0000 Buried
202 T L -1.9841 Soluble
203 P L -2.5791 Soluble
204 E L -3.2159 Soluble
205 Q L -2.3406 Soluble
206 W L 0.0000 Buried
207 K L -3.1169 Soluble
208 S L -2.4039 Soluble
209 H L -2.3029 Soluble
210 R L -2.5052 Soluble
211 S L -1.5314 Soluble
212 Y L 0.0000 Buried
213 S L 0.0000 Buried
214 C L 0.0000 Buried
215 Q L -0.9885 Soluble
216 V L 0.0000 Buried
217 T L -0.6883 Soluble
218 H L 0.0000 Buried
219 E L -2.3120 Soluble
220 G L -1.3916 Soluble
221 S L -0.9329 Soluble
222 T L -0.7376 Soluble
223 V L -0.6537 Soluble
224 E L -1.7858 Soluble
225 K L -1.5481 Soluble
226 T L -0.8562 Soluble
227 V L 0.0000 Buried
228 A L -1.2531 Soluble
229 P L -1.4585 Soluble
230 T L -1.1772 Soluble
231 E L -1.6097 Soluble
232 C L -0.6435 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.628 5.0285 CSV PDB
4.5 -0.6665 5.0285 CSV PDB
5.0 -0.7114 5.0285 CSV PDB
5.5 -0.7546 5.0285 CSV PDB
6.0 -0.7864 5.0285 CSV PDB
6.5 -0.7988 5.0284 CSV PDB
7.0 -0.7909 5.0284 CSV PDB
7.5 -0.7691 5.0284 CSV PDB
8.0 -0.7393 5.0282 CSV PDB
8.5 -0.7037 5.0276 CSV PDB
9.0 -0.6624 5.0257 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH