Calculation Parameters
| Chain Sequence(s) |
EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWMNWVRQAPGKGLEWVAAINQDGSEKYYVGSVKGRFTISRDNAKNSLYLQMNSLRVEDTAVYYCVRDYYDILTDYYIHYWYFDLWGRGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPCTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGE
input.pdb
|
| Selected Chain(s) | A (Heavy), B (Light) |
| Distance of Aggregation | 10 Å |
| FoldX Energy Minimization | Yes |
| pH Calculations | Yes |
| Downloads | Download all data (.tar.gz) |
Aggrescan4D Profile
Per-Residue A4D Scores
Download CSVResidues with A4D score > 0.0 are highlighted as aggregation-prone.
| Index | Residue | Chain | A4D Score | Classification |
|---|---|---|---|---|
| 1 | E | A | -1.8744 | Soluble |
| 2 | V | A | -0.7596 | Soluble |
| 3 | Q | A | -1.4691 | Soluble |
| 4 | L | A | 0.0000 | Buried |
| 5 | V | A | -0.0793 | Soluble |
| 6 | E | A | 0.0000 | Buried |
| 7 | S | A | -0.5768 | Soluble |
| 8 | G | A | -0.7996 | Soluble |
| 9 | G | A | -0.3552 | Soluble |
| 11 | G | A | -0.0666 | Soluble |
| 12 | L | A | -0.0099 | Soluble |
| 13 | V | A | -0.4690 | Soluble |
| 14 | Q | A | -1.4024 | Soluble |
| 15 | P | A | -1.3497 | Soluble |
| 16 | G | A | -1.3062 | Soluble |
| 17 | G | A | -1.1742 | Soluble |
| 18 | S | A | -1.2396 | Soluble |
| 19 | L | A | -1.0307 | Soluble |
| 20 | R | A | -2.0479 | Soluble |
| 21 | L | A | 0.0000 | Buried |
| 22 | S | A | -0.5156 | Soluble |
| 23 | C | A | 0.0000 | Buried |
| 24 | A | A | -0.4756 | Soluble |
| 25 | A | A | 0.0000 | Buried |
| 26 | S | A | -0.8368 | Soluble |
| 27 | G | A | -0.9686 | Soluble |
| 28 | F | A | -0.4101 | Soluble |
| 29 | T | A | -0.3682 | Soluble |
| 30 | F | A | 0.0000 | Buried |
| 35 | S | A | -1.1900 | Soluble |
| 36 | N | A | -0.8440 | Soluble |
| 37 | Y | A | -0.3263 | Soluble |
| 38 | W | A | -0.3149 | Soluble |
| 39 | M | A | 0.0000 | Buried |
| 40 | N | A | 0.0000 | Buried |
| 41 | W | A | 0.0000 | Buried |
| 42 | V | A | 0.0000 | Buried |
| 43 | R | A | 0.0000 | Buried |
| 44 | Q | A | -0.8181 | Soluble |
| 45 | A | A | -1.2028 | Soluble |
| 46 | P | A | -0.9293 | Soluble |
| 47 | G | A | -1.4836 | Soluble |
| 48 | K | A | -2.3979 | Soluble |
| 49 | G | A | -1.6303 | Soluble |
| 50 | L | A | 0.0000 | Buried |
| 51 | E | A | -1.1497 | Soluble |
| 52 | W | A | 0.0000 | Buried |
| 53 | V | A | 0.0000 | Buried |
| 54 | A | A | 0.0000 | Buried |
| 55 | A | A | 0.0000 | Buried |
| 56 | I | A | 0.0000 | Buried |
| 57 | N | A | 0.0000 | Buried |
| 58 | Q | A | -1.5268 | Soluble |
| 59 | D | A | -2.4183 | Soluble |
| 62 | G | A | -1.8315 | Soluble |
| 63 | S | A | -1.5005 | Soluble |
| 64 | E | A | -1.6761 | Soluble |
| 65 | K | A | -1.1805 | Soluble |
| 66 | Y | A | -0.0257 | Soluble |
| 67 | Y | A | 0.0306 | Aggregation-prone |
| 68 | V | A | -0.1515 | Soluble |
| 69 | G | A | -0.7928 | Soluble |
| 70 | S | A | -0.9626 | Soluble |
| 71 | V | A | 0.0000 | Buried |
| 72 | K | A | -1.8920 | Soluble |
| 74 | G | A | -1.4053 | Soluble |
| 75 | R | A | 0.0000 | Buried |
| 76 | F | A | 0.0000 | Buried |
| 77 | T | A | -0.7977 | Soluble |
| 78 | I | A | 0.0000 | Buried |
| 79 | S | A | -0.7571 | Soluble |
| 80 | R | A | -1.2950 | Soluble |
| 81 | D | A | -1.8059 | Soluble |
| 82 | N | A | -2.1026 | Soluble |
| 83 | A | A | -1.4482 | Soluble |
| 84 | K | A | -2.3977 | Soluble |
| 85 | N | A | -2.0705 | Soluble |
| 86 | S | A | -1.1967 | Soluble |
| 87 | L | A | 0.0000 | Buried |
| 88 | Y | A | -0.5754 | Soluble |
| 89 | L | A | 0.0000 | Buried |
| 90 | Q | A | -1.1645 | Soluble |
| 91 | M | A | 0.0000 | Buried |
| 92 | N | A | -1.3353 | Soluble |
| 93 | S | A | -1.2649 | Soluble |
| 94 | L | A | 0.0000 | Buried |
| 95 | R | A | -1.6787 | Soluble |
| 96 | V | A | -0.0986 | Soluble |
| 97 | E | A | -1.4888 | Soluble |
| 98 | D | A | 0.0000 | Buried |
| 99 | T | A | -0.2179 | Soluble |
| 100 | A | A | 0.0000 | Buried |
| 101 | V | A | 0.1394 | Aggregation-prone |
| 102 | Y | A | 0.0000 | Buried |
| 103 | Y | A | 0.0000 | Buried |
| 104 | C | A | 0.0000 | Buried |
| 105 | V | A | 0.0000 | Buried |
| 106 | R | A | -0.2396 | Soluble |
| 107 | D | A | 0.0000 | Buried |
| 108 | Y | A | 0.3511 | Aggregation-prone |
| 109 | Y | A | 0.5024 | Aggregation-prone |
| 110 | D | A | 1.0941 | Aggregation-prone |
| 111 | I | A | 1.9263 | Aggregation-prone |
| 111A | L | A | 2.0404 | Aggregation-prone |
| 111B | T | A | 0.5961 | Aggregation-prone |
| 111C | D | A | -0.4399 | Soluble |
| 112D | Y | A | 1.3606 | Aggregation-prone |
| 112C | Y | A | 1.2162 | Aggregation-prone |
| 112B | I | A | 1.1112 | Aggregation-prone |
| 112A | H | A | 0.5399 | Aggregation-prone |
| 112 | Y | A | 0.4279 | Aggregation-prone |
| 113 | W | A | 0.2253 | Aggregation-prone |
| 114 | Y | A | 0.0000 | Buried |
| 115 | F | A | 0.0000 | Buried |
| 116 | D | A | -0.4826 | Soluble |
| 117 | L | A | -0.3286 | Soluble |
| 118 | W | A | 0.0000 | Buried |
| 119 | G | A | 0.0000 | Buried |
| 120 | R | A | -2.0625 | Soluble |
| 121 | G | A | 0.0000 | Buried |
| 122 | T | A | -0.2024 | Soluble |
| 123 | L | A | 0.1032 | Aggregation-prone |
| 124 | V | A | 0.0000 | Buried |
| 125 | T | A | 0.0000 | Buried |
| 126 | V | A | 0.0000 | Buried |
| 127 | S | A | -0.5111 | Soluble |
| 128 | S | A | -0.4950 | Soluble |
| 129 | A | A | -0.5519 | Soluble |
| 130 | S | A | -0.6507 | Soluble |
| 131 | T | A | -0.6983 | Soluble |
| 132 | K | A | -1.1892 | Soluble |
| 133 | G | A | -1.3981 | Soluble |
| 134 | P | A | 0.0000 | Buried |
| 135 | S | A | -0.4146 | Soluble |
| 136 | V | A | -0.6232 | Soluble |
| 137 | F | A | 0.0000 | Buried |
| 138 | P | A | -1.2509 | Soluble |
| 139 | L | A | 0.0000 | Buried |
| 140 | A | A | -0.5582 | Soluble |
| 141 | P | A | -0.6658 | Soluble |
| 142 | C | A | -0.9033 | Soluble |
| 143 | S | A | -1.0195 | Soluble |
| 144 | R | A | -1.5696 | Soluble |
| 145 | S | A | -0.9945 | Soluble |
| 146 | T | A | -1.0480 | Soluble |
| 147 | S | A | -1.4324 | Soluble |
| 148 | E | A | -2.2522 | Soluble |
| 149 | S | A | -1.2808 | Soluble |
| 150 | T | A | -0.8968 | Soluble |
| 151 | A | A | -0.7806 | Soluble |
| 152 | A | A | 0.0000 | Buried |
| 153 | L | A | 0.0000 | Buried |
| 154 | G | A | 0.0000 | Buried |
| 155 | C | A | 0.0000 | Buried |
| 156 | L | A | 0.0000 | Buried |
| 157 | V | A | 0.0000 | Buried |
| 158 | K | A | -0.1973 | Soluble |
| 159 | D | A | -0.4327 | Soluble |
| 160 | Y | A | 0.0000 | Buried |
| 161 | F | A | 0.0000 | Buried |
| 162 | P | A | 0.0000 | Buried |
| 163 | E | A | -0.6284 | Soluble |
| 164 | P | A | -0.8164 | Soluble |
| 165 | V | A | 0.0000 | Buried |
| 166 | T | A | -0.6277 | Soluble |
| 167 | V | A | -0.3222 | Soluble |
| 168 | S | A | -0.4439 | Soluble |
| 169 | W | A | 0.0000 | Buried |
| 170 | N | A | -0.9357 | Soluble |
| 171 | S | A | -0.7158 | Soluble |
| 172 | G | A | -0.5570 | Soluble |
| 173 | A | A | -0.2617 | Soluble |
| 174 | L | A | -0.1396 | Soluble |
| 175 | T | A | -0.2464 | Soluble |
| 176 | S | A | -0.2711 | Soluble |
| 177 | G | A | -0.3471 | Soluble |
| 178 | V | A | 0.0720 | Aggregation-prone |
| 179 | H | A | -0.3426 | Soluble |
| 180 | T | A | -0.1780 | Soluble |
| 181 | F | A | 0.0000 | Buried |
| 182 | P | A | -0.2279 | Soluble |
| 183 | A | A | 0.2758 | Aggregation-prone |
| 184 | V | A | 0.5527 | Aggregation-prone |
| 185 | L | A | 0.9886 | Aggregation-prone |
| 186 | Q | A | 0.1342 | Aggregation-prone |
| 187 | S | A | -0.1986 | Soluble |
| 188 | S | A | -0.2383 | Soluble |
| 189 | G | A | -0.0383 | Soluble |
| 190 | L | A | 0.0381 | Aggregation-prone |
| 191 | Y | A | 0.3448 | Aggregation-prone |
| 192 | S | A | 0.2609 | Aggregation-prone |
| 193 | L | A | 0.2065 | Aggregation-prone |
| 194 | S | A | 0.0000 | Buried |
| 195 | S | A | 0.0000 | Buried |
| 196 | V | A | 0.0000 | Buried |
| 197 | V | A | 0.0000 | Buried |
| 198 | T | A | -0.1367 | Soluble |
| 199 | V | A | 0.0000 | Buried |
| 200 | P | A | -0.6449 | Soluble |
| 201 | S | A | -0.9985 | Soluble |
| 202 | S | A | -0.8292 | Soluble |
| 203 | S | A | -0.8296 | Soluble |
| 204 | L | A | 0.0000 | Buried |
| 205 | G | A | -1.3015 | Soluble |
| 206 | T | A | -1.0346 | Soluble |
| 207 | K | A | -1.8139 | Soluble |
| 208 | T | A | -1.6453 | Soluble |
| 209 | Y | A | 0.0000 | Buried |
| 210 | T | A | -1.9689 | Soluble |
| 211 | C | A | 0.0000 | Buried |
| 212 | N | A | -1.5809 | Soluble |
| 213 | V | A | 0.0000 | Buried |
| 214 | D | A | -1.9069 | Soluble |
| 215 | H | A | 0.0000 | Buried |
| 216 | K | A | -2.8089 | Soluble |
| 217 | P | A | -1.6434 | Soluble |
| 218 | S | A | -1.9100 | Soluble |
| 219 | N | A | -2.5063 | Soluble |
| 220 | T | A | -2.0650 | Soluble |
| 221 | K | A | -2.7352 | Soluble |
| 222 | V | A | -1.6948 | Soluble |
| 223 | D | A | -2.7666 | Soluble |
| 224 | K | A | -2.6057 | Soluble |
| 225 | R | A | -3.0124 | Soluble |
| 226 | V | A | 0.0000 | Buried |
| 227 | E | A | -2.7794 | Soluble |
| 228 | S | A | -1.6496 | Soluble |
| 1 | E | B | -1.6296 | Soluble |
| 2 | I | B | 0.0000 | Buried |
| 3 | V | B | 0.6200 | Aggregation-prone |
| 4 | L | B | 0.0000 | Buried |
| 5 | T | B | -0.8655 | Soluble |
| 6 | Q | B | 0.0000 | Buried |
| 7 | S | B | -0.9240 | Soluble |
| 8 | P | B | -0.5174 | Soluble |
| 9 | G | B | -0.8172 | Soluble |
| 10 | T | B | -0.3896 | Soluble |
| 11 | L | B | -0.1565 | Soluble |
| 12 | S | B | -0.4225 | Soluble |
| 13 | L | B | -0.9827 | Soluble |
| 14 | S | B | -1.6662 | Soluble |
| 15 | P | B | -2.2032 | Soluble |
| 16 | G | B | -2.6247 | Soluble |
| 17 | E | B | -3.2964 | Soluble |
| 18 | R | B | -3.2877 | Soluble |
| 19 | A | B | 0.0000 | Buried |
| 20 | T | B | -0.7158 | Soluble |
| 21 | L | B | 0.0000 | Buried |
| 22 | S | B | -1.0560 | Soluble |
| 23 | C | B | 0.0000 | Buried |
| 24 | R | B | -2.5728 | Soluble |
| 25 | A | B | 0.0000 | Buried |
| 26 | S | B | -1.0297 | Soluble |
| 27 | Q | B | -1.6964 | Soluble |
| 28 | S | B | -1.4285 | Soluble |
| 29 | V | B | 0.0000 | Buried |
| 30 | S | B | -0.4580 | Soluble |
| 36 | S | B | -0.3143 | Soluble |
| 37 | S | B | -0.3931 | Soluble |
| 38 | Y | B | 0.2751 | Aggregation-prone |
| 39 | L | B | 0.0000 | Buried |
| 40 | A | B | 0.0000 | Buried |
| 41 | W | B | 0.0000 | Buried |
| 42 | Y | B | 0.0000 | Buried |
| 43 | Q | B | 0.0000 | Buried |
| 44 | Q | B | 0.0000 | Buried |
| 45 | K | B | -1.1883 | Soluble |
| 46 | P | B | -1.3519 | Soluble |
| 47 | G | B | -1.4884 | Soluble |
| 48 | Q | B | -2.0976 | Soluble |
| 49 | A | B | -1.4852 | Soluble |
| 50 | P | B | 0.0000 | Buried |
| 51 | R | B | -1.1055 | Soluble |
| 52 | L | B | 0.0000 | Buried |
| 53 | L | B | 0.0000 | Buried |
| 54 | I | B | 0.0000 | Buried |
| 55 | Y | B | 0.0450 | Aggregation-prone |
| 56 | G | B | -0.1610 | Soluble |
| 57 | A | B | 0.0000 | Buried |
| 65 | S | B | -0.6452 | Soluble |
| 66 | S | B | -0.7739 | Soluble |
| 67 | R | B | -1.7894 | Soluble |
| 68 | A | B | -0.8919 | Soluble |
| 69 | T | B | -0.6384 | Soluble |
| 70 | G | B | -0.8260 | Soluble |
| 71 | I | B | -0.9500 | Soluble |
| 72 | P | B | -1.2641 | Soluble |
| 74 | D | B | -2.2002 | Soluble |
| 75 | R | B | -2.0633 | Soluble |
| 76 | F | B | 0.0000 | Buried |
| 77 | S | B | -0.9521 | Soluble |
| 78 | G | B | -0.5927 | Soluble |
| 79 | S | B | -0.7601 | Soluble |
| 80 | G | B | -1.2655 | Soluble |
| 83 | S | B | -0.9897 | Soluble |
| 84 | G | B | -1.3498 | Soluble |
| 85 | T | B | -1.8892 | Soluble |
| 86 | D | B | -2.8759 | Soluble |
| 87 | F | B | 0.0000 | Buried |
| 88 | T | B | -0.9572 | Soluble |
| 89 | L | B | 0.0000 | Buried |
| 90 | T | B | -0.8014 | Soluble |
| 91 | I | B | 0.0000 | Buried |
| 92 | S | B | -2.5505 | Soluble |
| 93 | R | B | -3.4526 | Soluble |
| 94 | L | B | 0.0000 | Buried |
| 95 | E | B | -2.3195 | Soluble |
| 96 | P | B | -1.4638 | Soluble |
| 97 | E | B | -1.9669 | Soluble |
| 98 | D | B | 0.0000 | Buried |
| 99 | F | B | -0.5241 | Soluble |
| 100 | A | B | 0.0000 | Buried |
| 101 | V | B | -0.1366 | Soluble |
| 102 | Y | B | 0.0000 | Buried |
| 103 | Y | B | 0.0000 | Buried |
| 104 | C | B | 0.0000 | Buried |
| 105 | Q | B | 0.0000 | Buried |
| 106 | Q | B | 0.0000 | Buried |
| 107 | Y | B | 0.0000 | Buried |
| 108 | G | B | -0.1692 | Soluble |
| 109 | S | B | -0.7408 | Soluble |
| 114 | S | B | -0.5936 | Soluble |
| 115 | P | B | -0.4721 | Soluble |
| 116 | C | B | 0.0000 | Buried |
| 117 | T | B | -0.2435 | Soluble |
| 118 | F | B | -0.0265 | Soluble |
| 119 | G | B | 0.0000 | Buried |
| 120 | Q | B | -1.4664 | Soluble |
| 121 | G | B | -1.0276 | Soluble |
| 122 | T | B | 0.0000 | Buried |
| 123 | R | B | -0.4236 | Soluble |
| 124 | L | B | 0.0000 | Buried |
| 125 | E | B | 0.0000 | Buried |
| 126 | I | B | -0.7131 | Soluble |
| 127 | K | B | -1.0921 | Soluble |
| 128 | R | B | -0.7967 | Soluble |
| 129 | T | B | 0.2615 | Aggregation-prone |
| 130 | V | B | 1.2946 | Aggregation-prone |
| 131 | A | B | 0.6637 | Aggregation-prone |
| 132 | A | B | 0.3661 | Aggregation-prone |
| 133 | P | B | 0.1415 | Aggregation-prone |
| 134 | S | B | -0.1248 | Soluble |
| 135 | V | B | 0.0000 | Buried |
| 136 | F | B | -0.0153 | Soluble |
| 137 | I | B | 0.0000 | Buried |
| 138 | F | B | 0.0000 | Buried |
| 139 | P | B | -0.3920 | Soluble |
| 140 | P | B | -0.7935 | Soluble |
| 141 | S | B | -1.6265 | Soluble |
| 142 | D | B | -2.9740 | Soluble |
| 143 | E | B | -2.9997 | Soluble |
| 144 | Q | B | 0.0000 | Buried |
| 145 | L | B | -2.3917 | Soluble |
| 146 | K | B | -2.8361 | Soluble |
| 147 | S | B | -1.8040 | Soluble |
| 148 | G | B | -1.4943 | Soluble |
| 149 | T | B | -1.2554 | Soluble |
| 150 | A | B | 0.0000 | Buried |
| 151 | S | B | 0.0000 | Buried |
| 152 | V | B | 0.0000 | Buried |
| 153 | V | B | 0.0000 | Buried |
| 154 | C | B | 0.0000 | Buried |
| 155 | L | B | 0.0000 | Buried |
| 156 | L | B | 0.0000 | Buried |
| 157 | N | B | 0.0000 | Buried |
| 158 | N | B | -0.6084 | Soluble |
| 159 | F | B | 0.0000 | Buried |
| 160 | Y | B | 0.0000 | Buried |
| 161 | P | B | -1.0678 | Soluble |
| 162 | R | B | -2.2841 | Soluble |
| 163 | E | B | -2.8590 | Soluble |
| 164 | A | B | -2.1381 | Soluble |
| 165 | K | B | -2.5221 | Soluble |
| 166 | V | B | 0.0000 | Buried |
| 167 | Q | B | -0.8836 | Soluble |
| 168 | W | B | 0.0000 | Buried |
| 169 | K | B | -0.3615 | Soluble |
| 170 | V | B | 0.0000 | Buried |
| 171 | D | B | -1.4449 | Soluble |
| 172 | N | B | -1.2778 | Soluble |
| 173 | A | B | -0.0446 | Soluble |
| 174 | L | B | 0.7740 | Aggregation-prone |
| 175 | Q | B | -0.0598 | Soluble |
| 176 | S | B | -0.5024 | Soluble |
| 177 | G | B | -0.9000 | Soluble |
| 178 | N | B | -0.8225 | Soluble |
| 179 | S | B | -1.1257 | Soluble |
| 180 | Q | B | -1.3525 | Soluble |
| 181 | E | B | -1.3029 | Soluble |
| 182 | S | B | -0.5031 | Soluble |
| 183 | V | B | -0.6812 | Soluble |
| 184 | T | B | -1.1660 | Soluble |
| 185 | E | B | -2.2453 | Soluble |
| 186 | Q | B | -1.8163 | Soluble |
| 187 | D | B | -1.9387 | Soluble |
| 188 | S | B | -1.8973 | Soluble |
| 189 | K | B | -2.2595 | Soluble |
| 190 | D | B | -1.6840 | Soluble |
| 191 | S | B | -1.6277 | Soluble |
| 192 | T | B | 0.0000 | Buried |
| 193 | Y | B | 0.0000 | Buried |
| 194 | S | B | 0.0000 | Buried |
| 195 | L | B | 0.0000 | Buried |
| 196 | S | B | 0.0000 | Buried |
| 197 | S | B | 0.0000 | Buried |
| 198 | T | B | -0.5504 | Soluble |
| 199 | L | B | 0.0000 | Buried |
| 200 | T | B | -0.4715 | Soluble |
| 201 | L | B | -0.6648 | Soluble |
| 202 | S | B | -1.1029 | Soluble |
| 203 | K | B | -2.0661 | Soluble |
| 204 | A | B | -1.8986 | Soluble |
| 205 | D | B | -2.7205 | Soluble |
| 206 | Y | B | 0.0000 | Buried |
| 207 | E | B | -3.4109 | Soluble |
| 208 | K | B | -3.5033 | Soluble |
| 209 | H | B | -3.0099 | Soluble |
| 210 | K | B | -3.0476 | Soluble |
| 211 | V | B | -1.2534 | Soluble |
| 212 | Y | B | 0.0000 | Buried |
| 213 | A | B | 0.0000 | Buried |
| 214 | C | B | 0.0000 | Buried |
| 215 | E | B | -0.7709 | Soluble |
| 216 | V | B | 0.0000 | Buried |
| 217 | T | B | -1.0961 | Soluble |
| 218 | Q | B | -0.9885 | Soluble |
| 219 | G | B | -1.0464 | Soluble |
| 220 | T | B | -0.4282 | Soluble |
| 221 | T | B | -0.1339 | Soluble |
| 222 | S | B | -0.2000 | Soluble |
| 223 | V | B | 0.5992 | Aggregation-prone |
| 224 | T | B | -0.1878 | Soluble |
| 225 | K | B | -0.5619 | Soluble |
| 226 | S | B | -0.5180 | Soluble |
| 227 | F | B | 0.0000 | Buried |
| 228 | N | B | -1.9640 | Soluble |
| 229 | R | B | -2.6595 | Soluble |
| 230 | G | B | -2.2559 | Soluble |
| 231 | E | B | -2.5609 | Soluble |
3D Structure — colored by A4D score
pH-Dependent Aggregation Profiles
A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.
| pH | Avg A4D Score | Max A4D Score | Downloads |
|---|---|---|---|
| 4.0 | -0.7232 | 3.324 | CSV PDB |
| 4.5 | -0.7722 | 3.209 | CSV PDB |
| 5.0 | -0.8316 | 3.0733 | CSV PDB |
| 5.5 | -0.8912 | 2.9307 | CSV PDB |
| 6.0 | -0.9397 | 2.8028 | CSV PDB |
| 6.5 | -0.9671 | 2.6742 | CSV PDB |
| 7.0 | -0.9718 | 2.5461 | CSV PDB |
| 7.5 | -0.9602 | 2.4204 | CSV PDB |
| 8.0 | -0.939 | 2.3014 | CSV PDB |
| 8.5 | -0.9106 | 2.1991 | CSV PDB |
| 9.0 | -0.8754 | 2.125 | CSV PDB |