Lirentelimab / 7quh

A4DAB155_7quh_H_L | Source PDB: 7quh | Chains: H, L | Done
99.56
Yes
10 Å
Yes
Avg A4D Score
-0.6027
Max Score
1.4641
Min Score
-3.6932
Total Score
-257.95
Score CDR
0.0883
Score non-CDR
-0.6859

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFSLTIYGAHWVRQAPGKGLEWVSVIWAGGSTNYNSALMSRFTISKDNSKNTVYLQMNSLRAEDTAVYYCARDGSSPYYYSMEYWGQGTTVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKEIVLTQSPATLSLSPGERATLSCSATSSVSYMHWFQQKPGQAPRLLIYSTSNLASGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSSYPFTFGPGTKLDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6932
Maximum Score 1.4641
Average Score -0.6027
Total Score -257.9537

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.0784 Soluble
2 V H -1.1961 Soluble
3 Q H -1.3499 Soluble
4 L H 0.0000 Buried
5 V H 0.3997 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.5241 Soluble
8 G H -0.8190 Soluble
9 G H -0.5165 Soluble
11 G H -0.0974 Soluble
12 L H 0.4130 Aggregation-prone
13 V H -0.3100 Soluble
14 Q H -1.4050 Soluble
15 P H -1.4243 Soluble
16 G H -1.3786 Soluble
17 G H -1.0636 Soluble
18 S H -1.2748 Soluble
19 L H -0.9054 Soluble
20 R H -1.7520 Soluble
21 L H 0.0000 Buried
22 S H -0.3779 Soluble
23 C H 0.0000 Buried
24 A H -0.2797 Soluble
25 A H -0.4463 Soluble
26 S H -0.8446 Soluble
27 G H -1.1674 Soluble
28 F H -0.1956 Soluble
29 S H -0.1372 Soluble
30 L H 0.0000 Buried
35 T H 0.1393 Aggregation-prone
36 I H 1.3625 Aggregation-prone
37 Y H 0.8465 Aggregation-prone
38 G H 0.3385 Aggregation-prone
39 A H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.8507 Soluble
45 A H -1.2557 Soluble
46 P H -1.0305 Soluble
47 G H -1.4961 Soluble
48 K H -2.2365 Soluble
49 G H -1.3406 Soluble
50 L H 0.0000 Buried
51 E H -0.9066 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 V H 0.0000 Buried
56 I H 0.0000 Buried
57 W H 0.0667 Aggregation-prone
58 A H 0.0330 Aggregation-prone
59 G H -0.4036 Soluble
63 G H -0.8750 Soluble
64 S H -0.5480 Soluble
65 T H -0.3339 Soluble
66 N H -0.1423 Soluble
67 Y H 0.2919 Aggregation-prone
68 N H 0.0000 Buried
69 S H -0.0370 Soluble
70 A H 0.0519 Aggregation-prone
71 L H 0.0000 Buried
72 M H 0.8643 Aggregation-prone
74 S H 0.0173 Aggregation-prone
75 R H -0.5906 Soluble
76 F H 0.0000 Buried
77 T H -0.6592 Soluble
78 I H 0.0000 Buried
79 S H -0.5003 Soluble
80 K H -1.1096 Soluble
81 D H -1.8138 Soluble
82 N H -2.3055 Soluble
83 S H -1.8955 Soluble
84 K H -2.4391 Soluble
85 N H -1.7435 Soluble
86 T H 0.0000 Buried
87 V H 0.0000 Buried
88 Y H -0.4667 Soluble
89 L H 0.0000 Buried
90 Q H -1.3580 Soluble
91 M H 0.0000 Buried
92 N H -2.0397 Soluble
93 S H -1.4477 Soluble
94 L H 0.0000 Buried
95 R H -2.1524 Soluble
96 A H -1.5986 Soluble
97 E H -2.1503 Soluble
98 D H 0.0000 Buried
99 T H -0.6924 Soluble
100 A H 0.0000 Buried
101 V H -0.0313 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 D H 0.0000 Buried
108 G H 0.0000 Buried
109 S H 0.5559 Aggregation-prone
110 S H 0.6411 Aggregation-prone
111 P H 0.6676 Aggregation-prone
112A Y H 1.4641 Aggregation-prone
112 Y H 1.1729 Aggregation-prone
113 Y H 0.7411 Aggregation-prone
114 S H 0.0000 Buried
115 M H 0.0000 Buried
116 E H -0.1393 Soluble
117 Y H 0.0540 Aggregation-prone
118 W H -0.3215 Soluble
119 G H 0.0000 Buried
120 Q H -1.3678 Soluble
121 G H -0.6248 Soluble
122 T H -0.3413 Soluble
123 T H -0.2137 Soluble
124 V H 0.0000 Buried
125 T H -0.4166 Soluble
126 V H 0.0000 Buried
127 S H -0.7801 Soluble
128 S H -0.7492 Soluble
129 A H -0.4846 Soluble
130 S H -0.6103 Soluble
131 T H -0.7116 Soluble
132 K H -1.3856 Soluble
133 G H -1.4403 Soluble
134 P H -0.6839 Soluble
135 S H -0.3808 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1032 Soluble
139 L H 0.0000 Buried
140 A H -1.1234 Soluble
141 P H 0.0000 Buried
142 S H -0.8598 Soluble
143 S H -0.4796 Soluble
144 G H -0.6487 Soluble
145 T H -0.4880 Soluble
146 A H -0.2979 Soluble
147 A H 0.0000 Buried
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H 0.0000 Buried
154 D H -0.6307 Soluble
155 Y H 0.0000 Buried
156 F H 0.0000 Buried
157 P H -0.7875 Soluble
158 E H -1.0662 Soluble
159 P H -1.1025 Soluble
160 V H -0.8649 Soluble
161 T H -0.6075 Soluble
162 V H -0.3160 Soluble
163 S H -0.4043 Soluble
164 W H 0.0000 Buried
165 N H -0.8509 Soluble
166 S H -0.7289 Soluble
167 G H -0.5582 Soluble
168 A H -0.2502 Soluble
169 L H -0.0114 Soluble
170 T H -0.1858 Soluble
171 S H -0.2136 Soluble
172 G H -0.2582 Soluble
173 V H 0.1787 Aggregation-prone
174 H H -0.2962 Soluble
175 T H 0.0270 Aggregation-prone
176 F H 0.0000 Buried
177 P H -0.3852 Soluble
178 A H 0.1840 Aggregation-prone
179 V H 0.5526 Aggregation-prone
180 L H 1.1757 Aggregation-prone
181 Q H 0.1576 Aggregation-prone
182 S H -0.0727 Soluble
183 S H -0.2578 Soluble
184 G H 0.0058 Aggregation-prone
185 L H -0.0656 Soluble
186 Y H 0.0000 Buried
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.1437 Soluble
194 V H 0.0000 Buried
195 P H -0.5001 Soluble
196 S H -0.5853 Soluble
197 S H -0.6374 Soluble
198 S H -0.6498 Soluble
199 L H -0.8796 Soluble
200 G H -1.0840 Soluble
201 T H -0.8712 Soluble
202 Q H -1.5356 Soluble
203 T H -1.4328 Soluble
204 Y H 0.0000 Buried
205 I H -1.5767 Soluble
206 C H 0.0000 Buried
207 N H -1.5366 Soluble
208 V H 0.0000 Buried
209 N H -1.8875 Soluble
210 H H 0.0000 Buried
211 K H -2.8919 Soluble
212 P H -1.7553 Soluble
213 S H -1.8962 Soluble
214 N H -2.6416 Soluble
215 T H -2.1022 Soluble
216 K H -2.6265 Soluble
217 V H -1.4872 Soluble
218 D H -2.5504 Soluble
219 K H -2.2825 Soluble
220 R H -2.7909 Soluble
221 V H 0.0000 Buried
222 E H -2.9285 Soluble
223 P H -2.0903 Soluble
224 K H -2.2201 Soluble
1 E L -1.2601 Soluble
2 I L 0.0000 Buried
3 V L 1.1533 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.0235 Soluble
6 Q L 0.0000 Buried
7 S L -0.3943 Soluble
8 P L -0.2982 Soluble
9 A L -0.2380 Soluble
10 T L -0.3320 Soluble
11 L L -0.0329 Soluble
12 S L -0.3427 Soluble
13 L L -0.8981 Soluble
14 S L -1.3692 Soluble
15 P L -1.7543 Soluble
16 G L -1.8085 Soluble
17 E L -2.4403 Soluble
18 R L -2.6544 Soluble
19 A L 0.0000 Buried
20 T L -0.5473 Soluble
21 L L 0.0000 Buried
22 S L -0.6336 Soluble
23 C L 0.0000 Buried
24 S L -0.7509 Soluble
25 A L -0.1369 Soluble
26 T L -0.1410 Soluble
27 S L -0.5271 Soluble
28 S L -0.6705 Soluble
29 V L 0.0000 Buried
37 S L 0.0761 Aggregation-prone
38 Y L 0.7941 Aggregation-prone
39 M L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 F L 0.0000 Buried
43 Q L -0.7219 Soluble
44 Q L -1.0463 Soluble
45 K L -1.4600 Soluble
46 P L -1.3597 Soluble
47 G L -1.4536 Soluble
48 Q L -2.0578 Soluble
49 A L -1.3116 Soluble
50 P L 0.0000 Buried
51 R L -1.2738 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.3610 Aggregation-prone
56 S L 0.2951 Aggregation-prone
57 T L 0.0678 Aggregation-prone
65 S L -0.2920 Soluble
66 N L -0.4695 Soluble
67 L L 0.0536 Aggregation-prone
68 A L 0.0000 Buried
69 S L -0.3770 Soluble
70 G L -0.4016 Soluble
71 I L -0.1589 Soluble
72 P L -0.1816 Soluble
74 A L -0.1265 Soluble
75 R L -0.4745 Soluble
76 F L 0.0000 Buried
77 S L -0.3218 Soluble
78 G L 0.0000 Buried
79 S L -0.6095 Soluble
80 G L -0.9113 Soluble
83 S L -0.9075 Soluble
84 G L -0.9730 Soluble
85 T L -1.1941 Soluble
86 D L -2.1542 Soluble
87 F L 0.0000 Buried
88 T L -0.6623 Soluble
89 L L 0.0000 Buried
90 T L -0.5997 Soluble
91 I L 0.0000 Buried
92 S L -1.2820 Soluble
93 S L -1.7416 Soluble
94 L L 0.0000 Buried
95 E L -2.1132 Soluble
96 P L -1.5476 Soluble
97 E L -2.2407 Soluble
98 D L 0.0000 Buried
99 F L -0.5731 Soluble
100 A L 0.0000 Buried
101 V L -0.0943 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 R L -0.0416 Soluble
108 S L 0.0191 Aggregation-prone
109 S L -0.1674 Soluble
114 Y L 0.2503 Aggregation-prone
115 P L 0.0180 Aggregation-prone
116 F L 0.0000 Buried
117 T L -0.0426 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 P L -0.5306 Soluble
121 G L -0.5718 Soluble
122 T L 0.0000 Buried
123 K L -0.4935 Soluble
124 L L 0.0000 Buried
125 D L 0.0000 Buried
126 I L -0.4894 Soluble
127 K L -1.1059 Soluble
128 R L -0.8984 Soluble
129 T L 0.1308 Aggregation-prone
130 V L 0.9920 Aggregation-prone
131 A L 0.3944 Aggregation-prone
132 A L 0.0259 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.1674 Soluble
135 V L 0.0000 Buried
136 F L 0.0703 Aggregation-prone
137 I L 0.0528 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.4879 Soluble
140 P L 0.0000 Buried
141 S L -1.3382 Soluble
142 D L -2.5193 Soluble
143 E L -2.0426 Soluble
144 Q L 0.0000 Buried
145 L L -2.0205 Soluble
146 K L -2.5558 Soluble
147 S L -1.6441 Soluble
148 G L -1.1729 Soluble
149 T L -0.8544 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.8927 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.5446 Soluble
162 R L -2.8806 Soluble
163 E L -3.1274 Soluble
164 A L -2.3126 Soluble
165 K L -2.3977 Soluble
166 V L -1.0692 Soluble
167 Q L -0.6391 Soluble
168 W L 0.0000 Buried
169 K L -0.5263 Soluble
170 V L 0.0000 Buried
171 D L -1.5177 Soluble
172 N L -1.3479 Soluble
173 A L -0.1706 Soluble
174 L L 0.6918 Aggregation-prone
175 Q L -0.2535 Soluble
176 S L -0.4512 Soluble
177 G L -0.9097 Soluble
178 N L -1.0728 Soluble
179 S L -1.3761 Soluble
180 Q L -1.7829 Soluble
181 E L -1.7709 Soluble
182 S L -0.7537 Soluble
183 V L -0.7949 Soluble
184 T L 0.0000 Buried
185 E L -2.2234 Soluble
186 Q L -1.8823 Soluble
187 D L -2.0435 Soluble
188 S L -1.7972 Soluble
189 K L -2.3931 Soluble
190 D L -2.1032 Soluble
191 S L -1.7659 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7450 Soluble
199 L L 0.0000 Buried
200 T L -0.3856 Soluble
201 L L -0.6869 Soluble
202 S L -0.9867 Soluble
203 K L -1.9215 Soluble
204 A L -1.8863 Soluble
205 D L -2.5940 Soluble
206 Y L 0.0000 Buried
207 E L -3.5710 Soluble
208 K L -3.6932 Soluble
209 H L -2.9527 Soluble
210 K L -3.2549 Soluble
211 V L -1.4503 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.8394 Soluble
216 V L 0.0000 Buried
217 T L -1.2497 Soluble
218 H L 0.0000 Buried
219 Q L -1.4822 Soluble
220 G L -0.3098 Soluble
221 L L -0.2155 Soluble
222 S L -0.4519 Soluble
223 S L -0.4431 Soluble
224 P L -0.6103 Soluble
225 V L -0.1538 Soluble
226 T L -0.5806 Soluble
227 K L -0.8416 Soluble
228 S L -0.5687 Soluble
229 F L 0.0000 Buried
230 N L -2.0476 Soluble
231 R L -2.7465 Soluble
232 G L -2.1482 Soluble
233 E L -2.5501 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5781 2.4597 CSV PDB
4.5 -0.6149 2.4597 CSV PDB
5.0 -0.6597 2.4597 CSV PDB
5.5 -0.7038 2.4597 CSV PDB
6.0 -0.7366 2.4597 CSV PDB
6.5 -0.7497 2.4596 CSV PDB
7.0 -0.7416 2.4596 CSV PDB
7.5 -0.7186 2.4595 CSV PDB
8.0 -0.6875 2.4591 CSV PDB
8.5 -0.6509 2.4578 CSV PDB
9.0 -0.6097 2.4539 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH